PubMed

Tyrosine Kinase 2 Plays Critical Roles in the Pathogenic CD4 T Cell Responses for the Development of Experimental Autoimmune Encephalomyelitis.

Oyamada A, Ikebe H, Itsumi M, Saiwai H, Okada S, Shimoda K, Iwakura Y, Nakayama KI, Iwamoto Y, Yoshikai Y, Yamada H.

J Immunol. 2009 Dec 1;183(11):7539-7546. Epub 2009 Nov 16.PMID: 19917699 [PubMed - as supplied by publisher]Related articles

Role of T Cell TGF{beta} Signaling and IL-17 in Allograft Acceptance and Fibrosis Associated with Chronic Rejection.

Faust SM, Lu G, Marini BL, Zou W, Gordon D, Iwakura Y, Laouar Y, Bishop DK.

J Immunol. 2009 Dec 1;183(11):7297-7306. Epub 2009 Nov 16.PMID: 19917689 [PubMed - as supplied by publisher]Related articles

Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1B and by down-regulation of suppressor of cytokine signaling 1 (SOCS1).

Shikama Y, Kuroishi T, Nagai Y, Iwakura Y, Shimauchi H, Takada H, Sugawara S, Endo Y.

Innate Immun. 2009 Nov 6. [Epub ahead of print]PMID: 19897531 [PubMed - as supplied by publisher]Related articles

Natural Occurring IL-17 Producing T Cells Regulate the Initial Phase of Neutrophil Mediated Airway Responses.

Tanaka S, Yoshimoto T, Naka T, Nakae S, Iwakura YI, Cua D, Kubo M.

J Immunol. 2009 Dec 1;183(11):7523-7530. Epub 2009 Nov 4.PMID: 19890042 [PubMed - as supplied by publisher]Related articles

Interleukin-17 Is Required for T Helper 1 Cell Immunity and Host Resistance to the Intracellular Pathogen Francisella tularensis.

Lin Y, Ritchea S, Logar A, Slight S, Messmer M, Rangel-Moreno J, Guglani L, Alcorn JF, Strawbridge H, Park SM, Onishi R, Nyugen N, Walter MJ, Pociask D, Randall TD, Gaffen SL, Iwakura Y, Kolls JK, Khader SA.

Immunity. 2009 Oct 21. [Epub ahead of print]PMID: 19853481 [PubMed - as supplied by publisher]Related articles

Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.

Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T.

EMBO J. 2009 Oct 15. [Epub ahead of print]PMID: 19834457 [PubMed - as supplied by publisher]Related articles

T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice.

Horie I, Abiru N, Nagayama Y, Kuriya G, Saitoh O, Ichikawa T, Iwakura Y, Eguchi K.

Endocrinology. 2009 Nov;150(11):5135-42. Epub 2009 Sep 24.PMID: 19797122 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1 deficiency in combination with macrophage depletion increases susceptibility to Pseudomonas aeruginosa bacteremia.

Horino T, Matsumoto T, Ishikawa H, Kimura S, Uramatsu M, Tanabe M, Tateda K, Miyazaki S, Aramaki Y, Iwakura Y, Yoshida M, Onodera S, Yamaguchi K.

Microbiol Immunol. 2009 Sep;53(9):502-11.PMID: 19703244 [PubMed - indexed for MEDLINE]Related articles

Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury.

Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, Iwaki T, Okada Y, Iida M, Cua DJ, Iwakura Y, Yoshimura A.

Nat Med. 2009 Aug;15(8):946-50. Epub 2009 Aug 2.PMID: 19648929 [PubMed - indexed for MEDLINE]Related articles

Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A.

Okiyama N, Sugihara T, Iwakura Y, Yokozeki H, Miyasaka N, Kohsaka H.

Arthritis Rheum. 2009 Aug;60(8):2505-12.PMID: 19644888 [PubMed - indexed for MEDLINE]Related articles

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease.

Yi T, Chen Y, Wang L, Du G, Huang D, Zhao D, Johnston H, Young J, Todorov I, Umetsu DT, Chen L, Iwakura Y, Kandeel F, Forman S, Zeng D.

Blood. 2009 Oct 1;114(14):3101-12. Epub 2009 Jul 14.PMID: 19602708 [PubMed - in process]Related articles

Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.

Di Paolo NC, Miao EA, Iwakura Y, Murali-Krishna K, Aderem A, Flavell RA, Papayannopoulou T, Shayakhmetov DM.

Immunity. 2009 Jul 17;31(1):110-21. Epub 2009 Jul 2.PMID: 19576795 [PubMed - indexed for MEDLINE]Related articles

Pulmonary inflammation triggered by ricin toxin requires macrophages and IL-1 signaling.

Lindauer ML, Wong J, Iwakura Y, Magun BE.

J Immunol. 2009 Jul 15;183(2):1419-26. Epub 2009 Jun 26.PMID: 19561099 [PubMed - indexed for MEDLINE]Related articles

The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice.

Honore P, Donnelly-Roberts D, Namovic M, Zhong C, Wade C, Chandran P, Zhu C, Carroll W, Perez-Medrano A, Iwakura Y, Jarvis MF.

Behav Brain Res. 2009 Dec 1;204(1):77-81. Epub 2009 May 21.PMID: 19464323 [PubMed - in process]Related articles

IL-17 is involved in bone resorption in mouse periapical lesions.

Oseko F, Yamamoto T, Akamatsu Y, Kanamura N, Iwakura Y, Imanishi J, Kita M.

Microbiol Immunol. 2009 May;53(5):287-94. Epub 2009 Feb 9.PMID: 19457170 [PubMed - indexed for MEDLINE]Related articles

A protective function for interleukin 17A in T cell-mediated intestinal inflammation.

O'Connor W Jr, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA.

Nat Immunol. 2009 Jun;10(6):603-9.PMID: 19448631 [PubMed - indexed for MEDLINE]Related articles

Hepatic platelet accumulation in Fas-mediated hepatitis in mice.

Ohtaki Y, Yamaguchi K, Yu Z, Kumamoto H, Shimauchi H, Iwakura Y, Sugawara S, Endo Y.

Int Immunopharmacol. 2009 Aug;9(9):1071-8. Epub 2009 May 9.PMID: 19439197 [PubMed - in process]Related articles

Toll-like receptor 9-dependent activation of myeloid dendritic cells by Deoxynucleic acids from Candida albicans.

Miyazato A, Nakamura K, Yamamoto N, Mora-Montes HM, Tanaka M, Abe Y, Tanno D, Inden K, Gang X, Ishii K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Mitsutake K, Gow NA, Kaku M, Kawakami K.

Infect Immun. 2009 Jul;77(7):3056-64. Epub 2009 May 11.PMID: 19433551 [PubMed - indexed for MEDLINE]Related articles

Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells.

Elkabets M, Krelin Y, Dotan S, Cerwenka A, Porgador A, Lichtenstein RG, White MR, Zoller M, Iwakura Y, Dinarello CA, Voronov E, Apte RN.

J Immunol. 2009 Apr 15;182(8):4874-81.PMID: 19342666 [PubMed - indexed for MEDLINE]Related articles

Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis.

Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, Iwakura Y, Suda T, Matsuo K.

J Biol Chem. 2009 May 22;284(21):14637-44. Epub 2009 Mar 19.PMID: 19299512 [PubMed - indexed for MEDLINE]Related articles

Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice.

Kuroishi T, Kinbara M, Sato N, Tanaka Y, Nagai Y, Iwakura Y, Endo Y, Sugawara S.

J Nutr. 2009 May;139(5):1031-6. Epub 2009 Mar 4.PMID: 19261731 [PubMed - indexed for MEDLINE]Related articles

Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation.

Inoue A, Setoguchi K, Matsubara Y, Okada K, Sato N, Iwakura Y, Higuchi O, Yamanashi Y.

Sci Signal. 2009 Feb 24;2(59):ra7.PMID: 19244212 [PubMed - indexed for MEDLINE]Related articles

IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice.

Lopez Kostka S, Dinges S, Griewank K, Iwakura Y, Udey MC, von Stebut E.

J Immunol. 2009 Mar 1;182(5):3039-46.PMID: 19234200 [PubMed - indexed for MEDLINE]Related articles

IL-17 is involved in Helicobacter pylori-induced gastric inflammatory responses in a mouse model.

Shiomi S, Toriie A, Imamura S, Konishi H, Mitsufuji S, Iwakura Y, Yamaoka Y, Ota H, Yamamoto T, Imanishi J, Kita M.

Helicobacter. 2008 Dec;13(6):518-24.PMID: 19166417 [PubMed - indexed for MEDLINE]Related articles

The roles of IL-17A in inflammatory immune responses and host defense against pathogens.

Iwakura Y, Nakae S, Saijo S, Ishigame H.

Immunol Rev. 2008 Dec;226:57-79. Review.PMID: 19161416 [PubMed - indexed for MEDLINE]Related articles

CXC chemokine ligand 12 promotes CCR7-dependent naive T cell trafficking to lymph nodes and Peyer's patches.

Bai Z, Hayasaka H, Kobayashi M, Li W, Guo Z, Jang MH, Kondo A, Choi BI, Iwakura Y, Miyasaka M.

J Immunol. 2009 Feb 1;182(3):1287-95.PMID: 19155474 [PubMed - indexed for MEDLINE]Related articles

Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.

Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y.

Immunity. 2009 Jan 16;30(1):108-19.PMID: 19144317 [PubMed - indexed for MEDLINE]Related articles

MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice.

Yamada J, Hamuro J, Fukushima A, Ohteki T, Terai K, Iwakura Y, Yagita H, Kinoshita S.

Invest Ophthalmol Vis Sci. 2009 May;50(5):2139-46. Epub 2009 Jan 10.PMID: 19136699 [PubMed - indexed for MEDLINE]Related articles

IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice.

Kojima M, Ashino T, Yoshida T, Iwakura Y, Sekimoto M, Degawa M.

Biochem Biophys Res Commun. 2009 Feb 6;379(2):239-42. Epub 2008 Dec 25.PMID: 19101514 [PubMed - indexed for MEDLINE]Related articles

Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.

Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, Sudo K, Iwakura Y, Shibutani M, Mitsumori K, Yokota J, Yamamoto T.

Cancer Sci. 2008 Dec 8. [Epub ahead of print]PMID: 19068083 [PubMed - as supplied by publisher]Related articles

Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells.

Eigenbrod T, Park JH, Harder J, Iwakura Y, Núñez G.

J Immunol. 2008 Dec 15;181(12):8194-8.PMID: 19050234 [PubMed - indexed for MEDLINE]Related articles

IFN-gamma expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death.

Atsumi T, Sato M, Kamimura D, Moroi A, Iwakura Y, Betz UA, Yoshimura A, Nishihara M, Hirano T, Murakami M.

Int Immunol. 2009 Jan;21(1):73-80. Epub 2008 Dec 2.PMID: 19050105 [PubMed - indexed for MEDLINE]Related articles

Characterization of mice deficient in melanocortin 2 receptor on a B6/Balbc mix background.

Chida D, Sato T, Sato Y, Kubo M, Yoda T, Suzuki H, Iwakura Y.

Mol Cell Endocrinol. 2009 Mar 5;300(1-2):32-6. Epub 2008 Oct 31.PMID: 19022343 [PubMed - indexed for MEDLINE]Related articles

Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17.

Schulz SM, Köhler G, Schütze N, Knauer J, Straubinger RK, Chackerian AA, Witte E, Wolk K, Sabat R, Iwakura Y, Holscher C, Müller U, Kastelein RA, Alber G.

J Immunol. 2008 Dec 1;181(11):7891-901.PMID: 19017979 [PubMed - indexed for MEDLINE]Related articles

Optimum second screening point for detection of coronary artery disease in hemodialysis patients without advanced coronary artery disease.

Joki N, Tanaka Y, Ishikawa H, Takahashi Y, Iwakura Y, Masuda H, Inishi Y, Hase H.

Am J Nephrol. 2009;29(5):420-5. Epub 2008 Nov 7.PMID: 18997458 [PubMed - indexed for MEDLINE]Related articles

IL-17 contributes to CD4-mediated graft-versus-host disease.

Kappel LW, Goldberg GL, King CG, Suh DY, Smith OM, Ligh C, Holland AM, Grubin J, Mark NM, Liu C, Iwakura Y, Heller G, van den Brink MR.

Blood. 2009 Jan 22;113(4):945-52. Epub 2008 Oct 17.PMID: 18931341 [PubMed - indexed for MEDLINE]Related articles

Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction.

Ogura H, Murakami M, Okuyama Y, Tsuruoka M, Kitabayashi C, Kanamoto M, Nishihara M, Iwakura Y, Hirano T.

Immunity. 2008 Oct 17;29(4):628-36. Epub 2008 Oct 9.PMID: 18848474 [PubMed - indexed for MEDLINE]Related articles

Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules.

Teruya H, Tomita M, Senba M, Ishikawa C, Tamayose M, Miyazato A, Yara S, Tanaka Y, Iwakura Y, Fujita J, Mori N.

Retrovirology. 2008 Sep 22;5:86.PMID: 18808681 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice.

Ito R, Kita M, Shin-Ya M, Kishida T, Urano A, Takada R, Sakagami J, Imanishi J, Iwakura Y, Okanoue T, Yoshikawa T, Kataoka K, Mazda O.

Biochem Biophys Res Commun. 2008 Dec 5;377(1):12-6. Epub 2008 Sep 15.PMID: 18796297 [PubMed - indexed for MEDLINE]Related articles

Deficiency of tumour necrosis factor-alpha and interferon-gamma in bone marrow cells synergistically inhibits neointimal formation following vascular injury.

Murayama H, Takahashi M, Takamoto M, Shiba Y, Ise H, Koyama J, Tagawa Y, Iwakura Y, Ikeda U.

Cardiovasc Res. 2008 Nov 1;80(2):175-80. Epub 2008 Sep 13.PMID: 18791204 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice.

Wakashin H, Hirose K, Maezawa Y, Kagami S, Suto A, Watanabe N, Saito Y, Hatano M, Tokuhisa T, Iwakura Y, Puccetti P, Iwamoto I, Nakajima H.

Am J Respir Crit Care Med. 2008 Nov 15;178(10):1023-32. Epub 2008 Sep 11.PMID: 18787221 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver.

Hamada S, Umemura M, Shiono T, Tanaka K, Yahagi A, Begum MD, Oshiro K, Okamoto Y, Watanabe H, Kawakami K, Roark C, Born WK, O'Brien R, Ikuta K, Ishikawa H, Nakae S, Iwakura Y, Ohta T, Matsuzaki G.

J Immunol. 2008 Sep 1;181(5):3456-63.PMID: 18714018 [PubMed - indexed for MEDLINE]Related articlesFree article

Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei.

Nakamura K, Miyazato A, Koguchi Y, Adachi Y, Ohno N, Saijo S, Iwakura Y, Takeda K, Akira S, Fujita J, Ishii K, Kaku M, Kawakami K.

Microbes Infect. 2008 Aug-Sep;10(10-11):1223-7. Epub 2008 Jul 3.PMID: 18652908 [PubMed - indexed for MEDLINE]Related articles

IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance.

Schulz SM, Köhler G, Holscher C, Iwakura Y, Alber G.

Int Immunol. 2008 Sep;20(9):1129-38. Epub 2008 Jul 3.PMID: 18599501 [PubMed - indexed for MEDLINE]Related articles

Contribution of IL-1 to resistance to Streptococcus pneumoniae infection.

Kafka D, Ling E, Feldman G, Benharroch D, Voronov E, Givon-Lavi N, Iwakura Y, Dagan R, Apte RN, Mizrachi-Nebenzahl Y.

Int Immunol. 2008 Sep;20(9):1139-46. Epub 2008 Jul 1.PMID: 18596024 [PubMed - indexed for MEDLINE]Related articles

Increased fat:carbohydrate oxidation ratio in Il1ra (-/-) mice on a high-fat diet is associated with increased sympathetic tone.

Chida D, Hashimoto O, Kuwahara M, Sagara H, Osaka T, Tsubone H, Iwakura Y.

Diabetologia. 2008 Sep;51(9):1698-706. Epub 2008 Jul 2.PMID: 18594791 [PubMed - indexed for MEDLINE]Related articles

Endogenous IL-17 does not play a significant role in the development of experimental murine allergic conjunctivitis.

Fukushima A, Sumi T, Ishida W, Yamada J, Iwakura Y, Ueno H.

Int Arch Allergy Immunol. 2008;147(3):206-12. Epub 2008 Jul 2.PMID: 18594150 [PubMed - indexed for MEDLINE]Related articles

Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.

Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Nagai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T.

Cell Metab. 2008 Jul;8(1):49-64.PMID: 18590692 [PubMed - indexed for MEDLINE]Related articles

CCL2 recruitment of IL-6-producing CD11b+ monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity.

Bai Y, Liu R, Huang D, La Cava A, Tang YY, Iwakura Y, Campagnolo DI, Vollmer TL, Ransohoff RM, Shi FD.

Eur J Immunol. 2008 Jul;38(7):1877-88.PMID: 18581322 [PubMed - indexed for MEDLINE]Related articles

Crystal form and phase structure of poly(vinylidene fluoride)/polyamide 11/clay nanocomposites by high-shear processing.

Li Y, Iwakura Y, Shimizu H.

J Nanosci Nanotechnol. 2008 Apr;8(4):1714-20.PMID: 18572569 [PubMed - indexed for MEDLINE]Related articles