PubMed

Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation.

Isakson P, Hammarstedt A, Gustafson B, Smith U.

Diabetes. 2009 Jul;58(7):1550-7. Epub 2009 Apr 7.PMID: 19351711 [PubMed - indexed for MEDLINE]Related articlesFree article

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.

Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD.

Autophagy. 2008 Feb 16;4(2):176-84. Epub 2007 Nov 6.PMID: 18059160 [PubMed - indexed for MEDLINE]Related articles

Wnt-signaling is maintained and adipogenesis inhibited by TNFalpha but not MCP-1 and resistin.

Hammarstedt A, Isakson P, Gustafson B, Smith U.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):700-6. Epub 2007 Apr 10.PMID: 17442272 [PubMed - indexed for MEDLINE]Related articles

c-erbB2-induced epithelial-mesenchymal transition in mammary epithelial cells is suppressed by cell-cell contact and initiated prior to E-cadherin downregulation.

Jenndahl LE, Isakson P, Baeckström D.

Int J Oncol. 2005 Aug;27(2):439-48.PMID: 16010426 [PubMed - indexed for MEDLINE]Related articles

Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity.

Gierse JK, Zhang Y, Hood WF, Walker MC, Trigg JS, Maziasz TJ, Koboldt CM, Muhammad JL, Zweifel BS, Masferrer JL, Isakson PC, Seibert K.

J Pharmacol Exp Ther. 2005 Mar;312(3):1206-12. Epub 2004 Oct 19.PMID: 15494548 [PubMed - indexed for MEDLINE]Related articlesFree article

Uptake of analogs of penetratin, Tat(48-60) and oligoarginine in live cells.

Thorén PE, Persson D, Isakson P, Goksör M, Onfelt A, Nordén B.

Biochem Biophys Res Commun. 2003 Jul 18;307(1):100-7.PMID: 12849987 [PubMed - indexed for MEDLINE]Related articles

Pharmacology of COX-2 inhibitors.

Isakson PC.

Prog Exp Tumor Res. 2003;37:25-51. Review. No abstract available. PMID: 12795047 [PubMed - indexed for MEDLINE]Related articles

Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib.

Gyllfors P, Bochenek G, Overholt J, Drupka D, Kumlin M, Sheller J, Nizankowska E, Isakson PC, Mejza F, Lefkowith JB, Dahlén SE, Szczeklik A, Murray JJ, Dahlén B.

J Allergy Clin Immunol. 2003 May;111(5):1116-21.PMID: 12743579 [PubMed - indexed for MEDLINE]Related articles

Neuronal overexpression of COX-2 results in dominant production of PGE2 and altered fever response.

Vidensky S, Zhang Y, hand T, Goellner J, Shaffer A, Isakson P, Andreasson K.

Neuromolecular Med. 2003;3(1):15-28.PMID: 12665673 [PubMed - indexed for MEDLINE]Related articles

Mechanism of inhibition of novel COX-2 inhibitors.

Gierse J, Kurumbail R, Walker M, Hood B, Monahan J, Pawlitz J, Stegeman R, Stevens A, Kiefer J, Koboldt C, Moreland K, Rowlinson S, Marnett L, Pierce J, Carter J, Talley J, Isakson P, Seibert K.

Adv Exp Med Biol. 2002;507:365-9. No abstract available. PMID: 12664611 [PubMed - indexed for MEDLINE]Related articles

Cyclooxygenase-2 in human pathological disease.

Koki A, Khan NK, Woerner BM, Dannenberg AJ, Olson L, Seibert K, Edwards D, Hardy M, Isakson P, Masferrer JL.

Adv Exp Med Biol. 2002;507:177-84. Review.PMID: 12664583 [PubMed - indexed for MEDLINE]Related articles

Characterization of celecoxib and valdecoxib binding to cyclooxygenase.

Hood WF, Gierse JK, Isakson PC, Kiefer JR, Kurumbail RG, Seibert K, Monahan JB.

Mol Pharmacol. 2003 Apr;63(4):870-7.PMID: 12644588 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacology of celecoxib in rat brain after kainate administration.

Ciceri P, Zhang Y, Shaffer AF, Leahy KM, Woerner MB, Smith WG, Seibert K, Isakson PC.

J Pharmacol Exp Ther. 2002 Sep;302(3):846-52.PMID: 12183639 [PubMed - indexed for MEDLINE]Related articlesFree article

Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice.

Andreasson KI, Savonenko A, Vidensky S, Goellner JJ, Zhang Y, Shaffer A, Kaufmann WE, Worley PF, Isakson P, Markowska AL.

J Neurosci. 2001 Oct 15;21(20):8198-209.PMID: 11588192 [PubMed - indexed for MEDLINE]Related articlesFree article

The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1.

Yaksh TL, Dirig DM, Conway CM, Svensson C, Luo ZD, Isakson PC.

J Neurosci. 2001 Aug 15;21(16):5847-53.PMID: 11487607 [PubMed - indexed for MEDLINE]Related articlesFree article

A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors.

Walker MC, Kurumbail RG, Kiefer JR, Moreland KT, Koboldt CM, Isakson PC, Seibert K, Gierse JK.

Biochem J. 2001 Aug 1;357(Pt 3):709-18.PMID: 11463341 [PubMed - indexed for MEDLINE]Related articlesFree article

Cox-2-specific inhibitors: definition of a new therapeutic concept.

Verburg KM, Maziasz TJ, Weiner E, Loose L, Geis GS, Isakson PC.

Am J Ther. 2001 Jan-Feb;8(1):49-64. Review.PMID: 11304658 [PubMed - indexed for MEDLINE]Related articles

Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.

Khanna IK, Yu Y, Huff RM, Weier RM, Xu X, Koszyk FJ, Collins PW, Cogburn JN, Isakson PC, Koboldt CM, Masferrer JL, Perkins WE, Seibert K, Veenhuizen AW, Yuan J, Yang DC, Zhang YY.

J Med Chem. 2000 Aug 10;43(16):3168-85.PMID: 10956225 [PubMed - indexed for MEDLINE]Related articles

Effects of celecoxib and naproxen on renal function in the elderly.

Whelton A, Schulman G, Wallemark C, Drower EJ, Isakson PC, Verburg KM, Geis GS.

Arch Intern Med. 2000 May 22;160(10):1465-70.PMID: 10826459 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of in vivo prostaglandin biosynthesis by glutathione.

Margalit A, Hauser SD, Isakson PC.

Adv Exp Med Biol. 1999;469:165-8. No abstract available. PMID: 10667326 [PubMed - indexed for MEDLINE]Related articles

Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: a randomized, controlled trial.

Leese PT, Hubbard RC, Karim A, Isakson PC, Yu SS, Geis GS.

J Clin Pharmacol. 2000 Feb;40(2):124-32.PMID: 10664917 [PubMed - indexed for MEDLINE]Related articles

Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison.

Emery P, Zeidler H, Kvien TK, Guslandi M, Naudin R, Stead H, Verburg KM, Isakson PC, Hubbard RC, Geis GS.

Lancet. 1999 Dec 18-25;354(9196):2106-11.PMID: 10609815 [PubMed - indexed for MEDLINE]Related articles

Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.

Simon LS, Weaver AL, Graham DY, Kivitz AJ, Lipsky PE, Hubbard RC, Isakson PC, Verburg KM, Yu SS, Zhao WW, Geis GS.

JAMA. 1999 Nov 24;282(20):1921-8.PMID: 10580457 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of osteoarthritis with celecoxib, a cyclooxygenase-2 inhibitor: a randomized controlled trial.

Bensen WG, Fiechtner JJ, McMillen JI, Zhao WW, Yu SS, Woods EM, Hubbard RC, Isakson PC, Verburg KM, Geis GS.

Mayo Clin Proc. 1999 Nov;74(11):1095-105.PMID: 10560596 [PubMed - indexed for MEDLINE]Related articles

COX-2 inhibitors--is there cause for concern?

Seibert K, Lefkowith J, Tripp C, Isakson P, Needleman P.

Nat Med. 1999 Jun;5(6):621-2. No abstract available. PMID: 10371498 [PubMed - indexed for MEDLINE]Related articles

Kinetic basis for selective inhibition of cyclo-oxygenases.

Gierse JK, Koboldt CM, Walker MC, Seibert K, Isakson PC.

Biochem J. 1999 May 1;339 ( Pt 3):607-14.PMID: 10215599 [PubMed - indexed for MEDLINE]Related articlesFree article

Transformation of intestinal epithelial cells by chronic TGF-beta1 treatment results in downregulation of the type II TGF-beta receptor and induction of cyclooxygenase-2.

Sheng H, Shao J, O'Mahony CA, Lamps L, Albo D, Isakson PC, Berger DH, DuBois RN, Beauchamp RD.

Oncogene. 1999 Jan 28;18(4):855-67.PMID: 10023661 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological analysis of cyclooxygenase-1 in inflammation.

Smith CJ, Zhang Y, Koboldt CM, Muhammad J, Zweifel BS, Shaffer A, Talley JJ, Masferrer JL, Seibert K, Isakson PC.

Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13313-8.PMID: 9789085 [PubMed - indexed for MEDLINE]Related articlesFree article

Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects.

Simon LS, Lanza FL, Lipsky PE, Hubbard RC, Talwalker S, Schwartz BD, Isakson PC, Geis GS.

Arthritis Rheum. 1998 Sep;41(9):1591-602.PMID: 9751091 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia.

Nakayama M, Uchimura K, Zhu RL, Nagayama T, Rose ME, Stetler RA, Isakson PC, Chen J, Graham SH.

Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10954-9.PMID: 9724811 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats.

Dirig DM, Isakson PC, Yaksh TL.

J Pharmacol Exp Ther. 1998 Jun;285(3):1031-8.PMID: 9618405 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of prostaglandin biosynthesis in vivo by glutathione.

Margalit A, Hauser SD, Zweifel BS, Anderson MA, Isakson PC.

Am J Physiol. 1998 Feb;274(2 Pt 2):R294-302.PMID: 9486284 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production.

Zhang Y, Shaffer A, Portanova J, Seibert K, Isakson PC.

J Pharmacol Exp Ther. 1997 Dec;283(3):1069-75.PMID: 9399978 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-steroidal anti-inflammatory drug-induced renal failure: a brief review of the role of cyclo-oxygenase isoforms.

Venturini CM, Isakson P, Needleman P.

Curr Opin Nephrol Hypertens. 1998 Jan;7(1):79-82. Review.PMID: 9442367 [PubMed - indexed for MEDLINE]Related articles

A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells.

Sheng GG, Shao J, Sheng H, Hooton EB, Isakson PC, Morrow JD, Coffey RJ Jr, DuBois RN, Beauchamp RD.

Gastroenterology. 1997 Dec;113(6):1883-91.PMID: 9394727 [PubMed - indexed for MEDLINE]Related articles

Cyclooxygenases and the central nervous system.

Kaufmann WE, Andreasson KI, Isakson PC, Worley PF.

Prostaglandins. 1997 Sep;54(3):601-24. Review.PMID: 9373877 [PubMed - indexed for MEDLINE]Related articles

Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release.

Dirig DM, Konin GP, Isakson PC, Yaksh TL.

Eur J Pharmacol. 1997 Jul 23;331(2-3):155-60.PMID: 9274974 [PubMed - indexed for MEDLINE]Related articles

Outcome of specific COX-2 inhibition in rheumatoid arthritis.

Lipsky PE, Isakson PC.

J Rheumatol Suppl. 1997 Jul;49:9-14. Review.PMID: 9249645 [PubMed - indexed for MEDLINE]Related articles

The discovery and function of COX-2.

Needleman P, Isakson PC.

J Rheumatol Suppl. 1997 Jul;49:6-8. Review. No abstract available. PMID: 9249644 [PubMed - indexed for MEDLINE]Related articles

1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.

Khanna IK, Weier RM, Yu Y, Xu XD, Koszyk FJ, Collins PW, Koboldt CM, Veenhuizen AW, Perkins WE, Casler JJ, Masferrer JL, Zhang YY, Gregory SA, Seibert K, Isakson PC.

J Med Chem. 1997 May 23;40(11):1634-47.PMID: 9171873 [PubMed - indexed for MEDLINE]Related articles

1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2.

Khanna IK, Weier RM, Yu Y, Collins PW, Miyashiro JM, Koboldt CM, Veenhuizen AW, Currie JL, Seibert K, Isakson PC.

J Med Chem. 1997 May 23;40(11):1619-33.PMID: 9171872 [PubMed - indexed for MEDLINE]Related articles

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

Sheng H, Shao J, Kirkland SC, Isakson P, Coffey RJ, Morrow J, Beauchamp RD, DuBois RN.

J Clin Invest. 1997 May 1;99(9):2254-9.PMID: 9151799 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM, Rogers RS, Rogier DJ, Yu SS, AndersonGD, Burton EG, Cogburn JN, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Veenhuizen AW, Zhang YY, Isakson PC.

J Med Chem. 1997 Apr 25;40(9):1347-65.PMID: 9135032 [PubMed - indexed for MEDLINE]Related articles

Altered arachidonic acid metabolism in urate crystal induced inflammation.

Margalit A, Duffin KL, Shaffer AF, Gregory SA, Isakson PC.

Inflammation. 1997 Apr;21(2):205-22.PMID: 9187963 [PubMed - indexed for MEDLINE]Related articles

Distribution of COX-1 and COX-2 in normal and inflamed tissues.

Seibert K, Zhang Y, Leahy K, Hauser S, Masferrer J, Isakson P.

Adv Exp Med Biol. 1997;400A:167-70.PMID: 9547553 [PubMed - indexed for MEDLINE]Related articles

Cyclooxygenase-2 expression during rat neocortical development and in Rett syndrome.

Kaufmann WE, Worley PF, Taylor CV, Bremer M, Isakson PC.

Brain Dev. 1997 Jan;19(1):25-34.PMID: 9071487 [PubMed - indexed for MEDLINE]Related articles

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.

Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, Gildehaus D, Miyashiro JM, Penning TD, Seibert K, Isakson PC, Stallings WC.

Nature. 1996 Dec 19-26;384(6610):644-8. Erratum in: Nature 1997 Feb 6;385(6616):555. PMID: 8967954 [PubMed - indexed for MEDLINE]Related articles

IL-5 receptor expression and Ig secretion from murine B lymphocytes requires coordinated signaling by membrane Ig, IL-4, and IL-5.

Weber JD, Isakson PC, Purkerson JM.

J Immunol. 1996 Nov 15;157(10):4428-35.PMID: 8906818 [PubMed - indexed for MEDLINE]Related articles

Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo.

Portanova JP, Zhang Y, Anderson GD, Hauser SD, Masferrer JL, Seibert K, Gregory SA, Isakson PC.

J Exp Med. 1996 Sep 1;184(3):883-91.PMID: 9064348 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclooxygenase-2 inhibitors: a new class of anti-inflammatory agents that spare the gastrointestinal tract.

Masferrer JL, Isakson PC, Seibert K.

Gastroenterol Clin North Am. 1996 Jun;25(2):363-72. Review.PMID: 9229578 [PubMed - indexed for MEDLINE]Related articles