PubMed

Basal, pulsatile, entropic (patterned), and spiky (staccato-like) properties of ACTH secretion: impact of age, gender, and body mass index.

Veldhuis JD, Roelfsema F, Iranmanesh A, Carroll BJ, Keenan DM, Pincus SM.

J Clin Endocrinol Metab. 2009 Oct;94(10):4045-52. Epub 2009 Sep 15.PMID: 19755477 [PubMed - indexed for MEDLINE]Related articles

Sex defines the age dependence of endogenous ACTH-cortisol dose responsiveness.

Keenan DM, Roelfsema F, Carroll BJ, Iranmanesh A, Veldhuis JD.

Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R515-23. Epub 2009 Jun 17.PMID: 19535673 [PubMed - indexed for MEDLINE]Related articles

Computing the Szeged and PI Indices of VCC[p,q] and HCC[p,q] Nanotubes.

Iranmanesh A, Alizadeh Y, Taherkhani B.

Int J Mol Sci. 2008 Feb;9(2):131-44. Epub 2008 Feb 5.PMID: 19325738 [PubMed - in process]Related articlesFree article

The aging male hypothalamic-pituitary-gonadal axis: pulsatility and feedback.

Veldhuis JD, Keenan DM, Liu PY, Iranmanesh A, Takahashi PY, Nehra AX.

Mol Cell Endocrinol. 2009 Feb 5;299(1):14-22. Epub 2008 Sep 17. Review.PMID: 18838102 [PubMed - indexed for MEDLINE]Related articles

Hypocortisolemic clamp unmasks jointly feedforward- and feedback-dependent control of overnight ACTH secretion.

Iranmanesh A, Veldhuis JD.

Eur J Endocrinol. 2008 Nov;159(5):561-8. Epub 2008 Aug 19.PMID: 18713842 [PubMed - indexed for MEDLINE]Related articlesFree article

SERENADE: the Study Evaluating Rimonabant Efficacy in Drug-naive Diabetic Patients: effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight, and lipid profile in drug-naive type 2 diabetes.

Rosenstock J, Hollander P, Chevalier S, Iranmanesh A; SERENADE Study Group.

Diabetes Care. 2008 Nov;31(11):2169-76. Epub 2008 Aug 4.PMID: 18678611 [PubMed - indexed for MEDLINE]Related articlesFree article

Twenty-four hour continuous ghrelin infusion augments physiologically pulsatile, nycthemeral, and entropic (feedback-regulated) modes of growth hormone secretion.

Veldhuis JD, Reynolds GA, Iranmanesh A, Bowers CY.

J Clin Endocrinol Metab. 2008 Sep;93(9):3597-603. Epub 2008 Jul 1.PMID: 18593763 [PubMed - indexed for MEDLINE]Related articlesFree article

A noninvasive measure of negative-feedback strength, approximate entropy, unmasks strong diurnal variations in the regularity of LH secretion.

Liu PY, Iranmanesh A, Keenan DM, Pincus SM, Veldhuis JD.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1409-15. Epub 2007 Sep 11.PMID: 17848633 [PubMed - indexed for MEDLINE]Related articlesFree article

Putative somatostatin suppression potentiates adrenocorticotropin secretion driven by ghrelin and human corticotropin-releasing hormone.

Iranmanesh A, Carpenter PC, Mielke K, Bowers CY, Veldhuis JD.

J Clin Endocrinol Metab. 2007 Sep;92(9):3653-9. Epub 2007 Jun 12.PMID: 17566099 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuated pulse size, disorderly growth hormone and prolactin secretion with preserved nyctohemeral rhythm distinguish irradiated from surgically treated acromegaly patients.

van der Klaauw AA, Pereira AM, van Thiel SW, Frolich M, Iranmanesh A, Veldhuis JD, Roelfsema F, Romijn JA.

Clin Endocrinol (Oxf). 2007 Apr;66(4):489-98.PMID: 17371464 [PubMed - indexed for MEDLINE]Related articles

Pathophysiology of hypercortisolism in depression.

Carroll BJ, Cassidy F, Naftolowitz D, Tatham NE, Wilson WH, Iranmanesh A, Liu PY, Veldhuis JD.

Acta Psychiatr Scand Suppl. 2007;(433):90-103.PMID: 17280575 [PubMed - indexed for MEDLINE]Related articles

Thigh intermuscular fat is inversely associated with spontaneous GH release in post-menopausal women with abdominal obesity.

Franco C, Veldhuis JD, Iranmanesh A, Brandberg J, Lönn L, Andersson B, Bengtsson BA, Svensson J, Johannsson G.

Eur J Endocrinol. 2006 Aug;155(2):261-8.PMID: 16868139 [PubMed - indexed for MEDLINE]Related articlesFree article

Estradiol potentiates ghrelin-stimulated pulsatile growth hormone secretion in postmenopausal women.

Veldhuis JD, Keenan DM, Iranmanesh A, Mielke K, Miles JM, Bowers CY.

J Clin Endocrinol Metab. 2006 Sep;91(9):3559-65. Epub 2006 Jun 27.PMID: 16804038 [PubMed - indexed for MEDLINE]Related articlesFree article

GH secretory pattern in young adults who discontinued GH treatment for GH deficiency and decreased longitudinal growth in childhood.

Svensson J, Johannsson G, Iranmanesh A, Albertsson-Wikland K, Veldhuis JD, Bengtsson BA.

Eur J Endocrinol. 2006 Jul;155(1):91-9.PMID: 16793954 [PubMed - indexed for MEDLINE]Related articlesFree article

GH deficiency in patients irradiated for acromegaly: significance of GH stimulatory tests in relation to the 24 h GH secretion.

van der Klaauw AA, Pereira AM, van Thiel SW, Smit JW, Corssmit EP, Biermasz NR, Frolich M, Iranmanesh A, Veldhuis JD, Roelfsema F, Romijn JA.

Eur J Endocrinol. 2006 Jun;154(6):851-8.PMID: 16728545 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin potentiates growth hormone secretion driven by putative somatostatin withdrawal and resists inhibition by human corticotropin-releasing hormone.

Veldhuis JD, Iranmanesh A, Mielke K, Miles JM, Carpenter PC, Bowers CY.

J Clin Endocrinol Metab. 2006 Jun;91(6):2441-6. Epub 2006 Mar 14.PMID: 16537682 [PubMed - indexed for MEDLINE]Related articlesFree article

An ensemble model of the male gonadal axis: illustrative application in aging men.

Keenan DM, Takahashi PY, Liu PY, Roebuck PD, Nehra AX, Iranmanesh A, Veldhuis JD.

Endocrinology. 2006 Jun;147(6):2817-28. Epub 2006 Mar 2.PMID: 16513832 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade.

Liu PY, Pincus SM, Takahashi PY, Roebuck PD, Iranmanesh A, Keenan DM, Veldhuis JD.

Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E34-E41.PMID: 16339924 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging-related adaptations in the corticotropic axis: modulation by gender.

Veldhuis JD, Keenan DM, Roelfsema F, Iranmanesh A.

Endocrinol Metab Clin North Am. 2005 Dec;34(4):993-1014, x-xi. Review. No abstract available. PMID: 16310635 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of hypoandrogenemia in healthy aging men.

Liu PY, Iranmanesh A, Nehra AX, Keenan DM, Veldhuis JD.

Endocrinol Metab Clin North Am. 2005 Dec;34(4):935-55, ix. Review. No abstract available. PMID: 16310632 [PubMed - indexed for MEDLINE]Related articles

Sex-steroid control of the aging somatotropic axis.

Veldhuis JD, Erickson D, Iranmanesh A, Miles JM, Bowers CY.

Endocrinol Metab Clin North Am. 2005 Dec;34(4):877-93, viii. Review. No abstract available. PMID: 16310628 [PubMed - indexed for MEDLINE]Related articles

Utility of ultrasensitive growth hormone assays in assessing aging-related hyposomatotropism.

Iranmanesh A, Veldhuis JD.

Endocrinol Metab Clin North Am. 2005 Dec;34(4):853-64, vii-viii. Review. No abstract available. PMID: 16310626 [PubMed - indexed for MEDLINE]Related articles

Primary gonadal failure in men selectively amplifies the mass of follicle stimulating hormone (FSH) secreted per burst and increases the disorderliness of FSH release patterns: reversibility with testosterone replacement.

Veldhuis JD, Iranmanesh A, Urban RJ.

Int J Androl. 1997 Oct;20(5):297-305.PMID: 16130274 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of ensemble failure of the male gonadal axis in aging.

Veldhuis JD, Keenan DM, Iranmanesh A.

J Endocrinol Invest. 2005;28(3 Suppl):8-13. Review.PMID: 16044581 [PubMed - indexed for MEDLINE]Related articles

Aging in healthy men impairs recombinant human luteinizing hormone (LH)-stimulated testosterone secretion monitored under a two-day intravenous pulsatile LH clamp.

Liu PY, Takahashi PY, Roebuck PD, Iranmanesh A, Veldhuis JD.

J Clin Endocrinol Metab. 2005 Oct;90(10):5544-50. Epub 2005 Jul 19.PMID: 16030163 [PubMed - indexed for MEDLINE]Related articlesFree article

Age-specific changes in the regulation of LH-dependent testosterone secretion: assessing responsiveness to varying endogenous gonadotropin output in normal men.

Liu PY, Takahashi PY, Roebuck PD, Iranmanesh A, Veldhuis JD.

Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R721-8. Epub 2005 May 12.PMID: 15890794 [PubMed - indexed for MEDLINE]Related articles

Combined inhibition of types I and II 5 alpha-reductase selectively augments the basal (nonpulsatile) mode of testosterone secretion in young men.

Iranmanesh A, Veldhuis JD.

J Clin Endocrinol Metab. 2005 Jul;90(7):4232-7. Epub 2005 Apr 5.PMID: 15811930 [PubMed - indexed for MEDLINE]Related articlesFree article

Joint mechanisms of impaired growth-hormone pulse renewal in aging men.

Veldhuis JD, Iranmanesh A, Bowers CY.

J Clin Endocrinol Metab. 2005 Jul;90(7):4177-83. Epub 2005 Apr 5.PMID: 15811926 [PubMed - indexed for MEDLINE]Related articlesFree article

Graded inhibition of pulsatile luteinizing hormone secretion by a selective gonadotropin-releasing hormone (GnRH)-receptor antagonist in healthy men: evidence that age attenuates hypothalamic GnRH outflow.

Takahashi PY, Liu PY, Roebuck PD, Iranmanesh A, Veldhuis JD.

J Clin Endocrinol Metab. 2005 May;90(5):2768-74. Epub 2005 Mar 1.PMID: 15741251 [PubMed - indexed for MEDLINE]Related articlesFree article

Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I/IGFBP-1 concentrations.

Veldhuis JD, Frystyk J, Iranmanesh A, Ørskov H.

J Clin Endocrinol Metab. 2005 May;90(5):2941-7. Epub 2005 Feb 15.PMID: 15713723 [PubMed - indexed for MEDLINE]Related articlesFree article

Disturbances of the stress response: the role of the HPA axis during alcohol withdrawal and abstinence.

Adinoff B, Iranmanesh A, Veldhuis J, Fisher L.

Alcohol Health Res World. 1998;22(1):67-72. Review.PMID: 15706736 [PubMed - indexed for MEDLINE]Related articles

Limited oral opening in a 43-year-old man.

Lee JS, Iranmanesh A, Schmidt BL, Fischbein NJ, McKenna SJ.

J Oral Maxillofac Surg. 2005 Jan;63(1):103-8. No abstract available. PMID: 15635564 [PubMed - indexed for MEDLINE]Related articles

Testosterone blunts feedback inhibition of growth hormone secretion by experimentally elevated insulin-like growth factor-I concentrations.

Veldhuis JD, Anderson SM, Iranmanesh A, Bowers CY.

J Clin Endocrinol Metab. 2005 Mar;90(3):1613-7. Epub 2004 Dec 7.PMID: 15585557 [PubMed - indexed for MEDLINE]Related articlesFree article

Age diminishes the testicular steroidogenic response to repeated intravenous pulses of recombinant human LH during acute GnRH-receptor blockade in healthy men.

Veldhuis JD, Veldhuis NJ, Keenan DM, Iranmanesh A.

Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E775-81. Epub 2004 Nov 30.PMID: 15572655 [PubMed - indexed for MEDLINE]Related articlesFree article

Experimentally induced androgen depletion accentuates ethnicity-related contrasts in luteinizing hormone secretion in asian and caucasian men.

Veldhuis JD, Bae A, Swerdloff RS, Iranmanesh A, Wang C.

J Clin Endocrinol Metab. 2005 Mar;90(3):1632-8. Epub 2004 Nov 30.PMID: 15572414 [PubMed - indexed for MEDLINE]Related articlesFree article

Erosion of endogenous testosterone-driven negative feedback on pulsatile luteinizing hormone secretion in healthy aging men.

Veldhuis JD, Iranmanesh A, Keenan DM.

J Clin Endocrinol Metab. 2004 Nov;89(11):5753-61.PMID: 15531539 [PubMed - indexed for MEDLINE]Related articlesFree article

Age and secretagogue type jointly determine dynamic growth hormone responses to exogenous insulin-like growth factor-negative feedback in healthy men.

Veldhuis JD, Weltman JY, Weltman AL, Iranmanesh A, Muller EE, Bowers CY.

J Clin Endocrinol Metab. 2004 Nov;89(11):5542-8.PMID: 15531509 [PubMed - indexed for MEDLINE]Related articlesFree article

Age and testosterone feedback jointly control the dose-dependent actions of gonadotropin-releasing hormone in healthy men.

Veldhuis JD, Iranmanesh A, Mulligan T.

J Clin Endocrinol Metab. 2005 Jan;90(1):302-9. Epub 2004 Oct 19.PMID: 15494457 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term aromatase-enzyme blockade unmasks impaired feedback adaptations in luteinizing hormone and testosterone secretion in older men.

Veldhuis JD, Iranmanesh A.

J Clin Endocrinol Metab. 2005 Jan;90(1):211-8. Epub 2004 Oct 13.PMID: 15483079 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of somatostatin-receptor subtype-2/-5 suppresses the mass, frequency, and irregularity of growth hormone (GH)-releasing peptide-2-stimulated GH secretion in men.

Iranmanesh A, Bowers CY, Veldhuis JD.

J Clin Endocrinol Metab. 2004 Sep;89(9):4581-7.PMID: 15356066 [PubMed - indexed for MEDLINE]Related articlesFree article

Pulsatile intravenous infusion of recombinant human luteinizing hormone under acute gonadotropin-releasing hormone receptor blockade reconstitutes testosterone secretion in young men.

Veldhuis JD, Iranmanesh A.

J Clin Endocrinol Metab. 2004 Sep;89(9):4474-9.PMID: 15356050 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men.

Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, Weber T, Berman N, Hull L, Swerdloff RS.

J Clin Endocrinol Metab. 2004 May;89(5):2085-98.PMID: 15126525 [PubMed - indexed for MEDLINE]Related articlesFree article

Estradiol supplementation modulates growth hormone (GH) secretory-burst waveform and recombinant human insulin-like growth factor-I-enforced suppression of endogenously driven GH release in postmenopausal women.

Veldhuis JD, Anderson SM, Kok P, Iranmanesh A, Frystyk J, Ørskov H, Keenan DM.

J Clin Endocrinol Metab. 2004 Mar;89(3):1312-8.PMID: 15001627 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term testosterone supplementation relieves growth hormone autonegative feedback in men.

Veldhuis JD, Evans WS, Iranmanesh A, Weltman AL, Bowers CY.

J Clin Endocrinol Metab. 2004 Mar;89(3):1285-90.PMID: 15001624 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased salivary cortisol concentrations during chronic alcohol intoxication in a naturalistic clinical sample of men.

Adinoff B, Ruether K, Krebaum S, Iranmanesh A, Williams MJ.

Alcohol Clin Exp Res. 2003 Sep;27(9):1420-7.PMID: 14506402 [PubMed - indexed for MEDLINE]Related articles

Increased orderliness of growth hormone (GH) secretion in GH-deficient adults with low serum insulin-like growth factor I.

Svensson J, Veldhuis JD, Iranmanesh A, Bengtsson BA, Johannsson G.

J Clin Endocrinol Metab. 2002 Jun;87(6):2863-9.PMID: 12050264 [PubMed - indexed for MEDLINE]Related articlesFree article

The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone.

Van den Berghe G, Baxter RC, Weekers F, Wouters P, Bowers CY, Iranmanesh A, Veldhuis JD, Bouillon R.

Clin Endocrinol (Oxf). 2002 May;56(5):655-69.PMID: 12030918 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of conjoint failure of the somatotropic and gonadal axes in ageing men.

Veldhuis JD, Iranmanesh A, Mulligan T, Bowers CY.

Novartis Found Symp. 2002;242:98-118; discussion 118-24. Review.PMID: 11855697 [PubMed - indexed for MEDLINE]Related articles

Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men.

Gentili A, Mulligan T, Godschalk M, Clore J, Patrie J, Iranmanesh A, Veldhuis JD.

J Clin Endocrinol Metab. 2002 Feb;87(2):825-34.PMID: 11836328 [PubMed - indexed for MEDLINE]Related articlesFree article

Corticotropin secretory dynamics in humans under low glucocorticoid feedback.

Veldhuis JD, Iranmanesh A, Naftolowitz D, Tatham N, Cassidy F, Carroll BJ.

J Clin Endocrinol Metab. 2001 Nov;86(11):5554-63.PMID: 11701735 [PubMed - indexed for MEDLINE]Related articlesFree article