PubMed

Viewpoints on the way to the consensus session: where does insulin resistance start? The adipose tissue.

Iozzo P.

Diabetes Care. 2009 Nov;32 Suppl 2:S168-73. No abstract available. PMID: 19875546 [PubMed - in process]Related articles

Contribution of glucose tolerance and gender to cardiac adiposity.

Iozzo P, Lautamaki R, Borra R, Lehto HR, Bucci M, Viljanen A, Parkka J, Lepomaki V, Maggio R, Parkkola R, Knuuti J, Nuutila P.

J Clin Endocrinol Metab. 2009 Nov;94(11):4472-82. Epub 2009 Oct 9.PMID: 19820028 [PubMed - in process]Related articles

Higher Free Fatty Acid Uptake in Visceral Than in Abdominal Subcutaneous Fat Tissue in Men.

Hannukainen JC, Kalliokoski KK, Borra RJ, Viljanen AP, Janatuinen T, Kujala UM, Kaprio J, Heinonen OJ, Viljanen T, Haaparanta M, Iozzo P, Parkkola R, Nuutila P.

Obesity (Silver Spring). 2009 Aug 20. [Epub ahead of print]PMID: 19696757 [PubMed - as supplied by publisher]Related articles

Effect of caloric restriction on myocardial fatty acid uptake, left ventricular mass, and cardiac work in obese adults.

Viljanen AP, Karmi A, Borra R, Pärkkä JP, Lepomäki V, Parkkola R, Lautamäki R, Järvisalo M, Taittonen M, Rönnemaa T, Iozzo P, Knuuti J, Nuutila P, Raitakari OT.

Am J Cardiol. 2009 Jun 15;103(12):1721-6. Epub 2009 Apr 16.PMID: 19539082 [PubMed - indexed for MEDLINE]Related articles

Non-invasive estimation of hepatic glucose uptake from [(18)F]FDG PET images using tissue-derived input functions.

Kudomi N, Järvisalo MJ, Kiss J, Borra R, Viljanen A, Viljanen T, Savunen T, Knuuti J, Iida H, Nuutila P, Iozzo P.

Eur J Nucl Med Mol Imaging. 2009 Jun 13. [Epub ahead of print]PMID: 19526238 [PubMed - as supplied by publisher]Related articles

The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus.

Honka MJ, Vänttinen M, Iozzo P, Virtanen KA, Lautamäki R, Hällsten K, Borra RJ, Takala T, Viljanen AP, Kemppainen J, Pihlajamäki J, Knuuti J, Nuutila P, Laakso M.

Metabolism. 2009 Apr;58(4):541-6.PMID: 19303976 [PubMed - indexed for MEDLINE]Related articles

Non-invasive diagnosis of acute mesenteric ischaemia using PET.

Kiss J, Naum A, Kudomi N, Knuuti J, Iozzo P, Savunen T, Nuutila P.

Eur J Nucl Med Mol Imaging. 2009 Aug;36(8):1338-45. Epub 2009 Mar 11.PMID: 19280187 [PubMed - indexed for MEDLINE]Related articles

m.3243A>G mutation in mitochondrial DNA leads to decreased insulin sensitivity in skeletal muscle and to progressive beta-cell dysfunction.

Lindroos MM, Majamaa K, Tura A, Mari A, Kalliokoski KK, Taittonen MT, Iozzo P, Nuutila P.

Diabetes. 2009 Mar;58(3):543-9. Epub 2008 Dec 10.PMID: 19073775 [PubMed - indexed for MEDLINE]Related articlesFree article

Parametric renal blood flow imaging using [15O]H2O and PET.

Kudomi N, Koivuviita N, Liukko KE, Oikonen VJ, Tolvanen T, Iida H, Tertti R, Metsärinne K, Iozzo P, Nuutila P.

Eur J Nucl Med Mol Imaging. 2009 Apr;36(4):683-91. Epub 2008 Dec 3.PMID: 19050876 [PubMed - indexed for MEDLINE]Related articles

Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance.

Viljanen AP, Iozzo P, Borra R, Kankaanpää M, Karmi A, Lautamäki R, Järvisalo M, Parkkola R, Rönnemaa T, Guiducci L, Lehtimäki T, Raitakari OT, Mari A, Nuutila P.

J Clin Endocrinol Metab. 2009 Jan;94(1):50-5. Epub 2008 Oct 28.PMID: 18957499 [PubMed - indexed for MEDLINE]Related articles

Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects.

Viljanen AP, Lautamäki R, Järvisalo M, Parkkola R, Huupponen R, Lehtimäki T, Rönnemaa T, Raitakari OT, Iozzo P, Nuutila P.

Ann Med. 2009;41(2):152-60.PMID: 18855190 [PubMed - indexed for MEDLINE]Related articles

Inverse association between liver fat content and hepatic glucose uptake in patients with type 2 diabetes mellitus.

Borra R, Lautamäki R, Parkkola R, Komu M, Sijens PE, Hällsten K, Bergman J, Iozzo P, Nuutila P.

Metabolism. 2008 Oct;57(10):1445-51.PMID: 18803951 [PubMed - indexed for MEDLINE]Related articles

Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy.

Tuunanen H, Engblom E, Naum A, Någren K, Scheinin M, Hesse B, Juhani Airaksinen KE, Nuutila P, Iozzo P, Ukkonen H, Opie LH, Knuuti J.

Circulation. 2008 Sep 16;118(12):1250-8. Epub 2008 Sep 2.PMID: 18765391 [PubMed - indexed for MEDLINE]Related articlesFree article

The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans.

Rigazio S, Lehto HR, Tuunanen H, Någren K, Kankaanpaa M, Simi C, Borra R, Naum AG, Parkkola R, Knuuti J, Nuutila P, Iozzo P.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E413-9. Epub 2008 May 27.PMID: 18505832 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-invasive estimation of hepatic blood perfusion from H2 15O PET images using tissue-derived arterial and portal input functions.

Kudomi N, Slimani L, Järvisalo MJ, Kiss J, Lautamäki R, Naum GA, Savunen T, Knuuti J, Iida H, Nuutila P, Iozzo P.

Eur J Nucl Med Mol Imaging. 2008 Oct;35(10):1899-911. Epub 2008 May 6.PMID: 18458902 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantification of liver perfusion with [(15)O]H(2)O-PET and its relationship with glucose metabolism and substrate levels.

Slimani L, Kudomi N, Oikonen V, Jarvisalo M, Kiss J, Naum A, Borra R, Viljanen A, Sipila H, Ferrannini E, Savunen T, Nuutila P, Iozzo P.

J Hepatol. 2008 Jun;48(6):974-82. Epub 2008 Mar 4.PMID: 18384905 [PubMed - indexed for MEDLINE]Related articles

Pancreatic glucose uptake in vivo in men with newly diagnosed type 1 diabetes.

Kalliokoski T, Nuutila P, Virtanen KA, Iozzo P, Bucci M, Svedström E, Roivainen A, Någren K, Viljanen T, Minn H, Knuuti J, Rönnemaa T, Simell O.

J Clin Endocrinol Metab. 2008 May;93(5):1909-14. Epub 2008 Feb 19.PMID: 18285422 [PubMed - indexed for MEDLINE]Related articlesFree article

Low serum adiponectin is associated with high circulating oxidized low-density lipoprotein in patients with type 2 diabetes mellitus and coronary artery disease.

Lautamäki R, Rönnemaa T, Huupponen R, Lehtimäki T, Iozzo P, Airaksinen KE, Knuuti J, Nuutila P.

Metabolism. 2007 Jul;56(7):881-6.PMID: 17570246 [PubMed - indexed for MEDLINE]Related articles

Biodistribution of the fatty acid analogue 18F-FTHA: plasma and tissue partitioning between lipid pools during fasting and hyperinsulinemia.

Guiducci L, Grönroos T, Järvisalo MJ, Kiss J, Viljanen A, Naum AG, Viljanen T, Savunen T, Knuuti J, Ferrannini E, Salvadori PA, Nuutila P, Iozzo P.

J Nucl Med. 2007 Mar;48(3):455-62.PMID: 17332624 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs.

Iozzo P, Jarvisalo MJ, Kiss J, Borra R, Naum GA, Viljanen A, Viljanen T, Gastaldelli A, Buzzigoli E, Guiducci L, Barsotti E, Savunen T, Knuuti J, Haaparanta-Solin M, Ferrannini E, Nuutila P.

Gastroenterology. 2007 Feb;132(2):531-42. Epub 2006 Dec 21.PMID: 17258736 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure.

Tuunanen H, Engblom E, Naum A, Någren K, Hesse B, Airaksinen KE, Nuutila P, Iozzo P, Ukkonen H, Opie LH, Knuuti J.

Circulation. 2006 Nov 14;114(20):2130-7. Epub 2006 Nov 6.PMID: 17088453 [PubMed - indexed for MEDLINE]Related articlesFree article

Simultaneous evaluation of myocardial blood flow, cardiac function and lung water content using [15O]H2O and positron emission tomography.

Naum A, Tuunanen H, Engblom E, Oikonen V, Sipilä H, Iozzo P, Nuutila P, Knuuti J.

Eur J Nucl Med Mol Imaging. 2007 Apr;34(4):563-72. Epub 2006 Oct 24.PMID: 17061129 [PubMed - indexed for MEDLINE]Related articles

Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction.

Tuunanen H, Engblom E, Naum A, Scheinin M, Någren K, Airaksinen J, Nuutila P, Iozzo P, Ukkonen H, Knuuti J.

J Card Fail. 2006 Oct;12(8):644-52.PMID: 17045185 [PubMed - indexed for MEDLINE]Related articles

Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels.

Kankaanpää M, Lehto HR, Pärkkä JP, Komu M, Viljanen A, Ferrannini E, Knuuti J, Nuutila P, Parkkola R, Iozzo P.

J Clin Endocrinol Metab. 2006 Nov;91(11):4689-95. Epub 2006 Aug 22.PMID: 16926257 [PubMed - indexed for MEDLINE]Related articlesFree article

Is insulin resistance atherogenic? A review of the evidence.

Ferrannini E, Iozzo P.

Atheroscler Suppl. 2006 Aug;7(4):5-10. Epub 2006 Jul 7. Review.PMID: 16824807 [PubMed - indexed for MEDLINE]Related articles

Exercise restores skeletal muscle glucose delivery but not insulin-mediated glucose transport and phosphorylation in obese subjects.

Slimani L, Oikonen V, Hällsten K, Savisto N, Knuuti J, Nuutila P, Iozzo P.

J Clin Endocrinol Metab. 2006 Sep;91(9):3394-403. Epub 2006 Jun 13.PMID: 16772346 [PubMed - indexed for MEDLINE]Related articlesFree article

18F-FDG assessment of glucose disposal and production rates during fasting and insulin stimulation: a validation study.

Iozzo P, Gastaldelli A, Järvisalo MJ, Kiss J, Borra R, Buzzigoli E, Viljanen A, Naum G, Viljanen T, Oikonen V, Knuuti J, Savunen T, Salvadori PA, Ferrannini E, Nuutila P.

J Nucl Med. 2006 Jun;47(6):1016-22.PMID: 16741312 [PubMed - indexed for MEDLINE]Related articlesFree article

[11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia.

Guiducci L, Järvisalo M, Kiss J, Någren K, Viljanen A, Naum AG, Gastaldelli A, Savunen T, Knuuti J, Salvadori PA, Ferrannini E, Nuutila P, Iozzo P.

Nucl Med Biol. 2006 May;33(4):521-8. Epub 2006 May 2.PMID: 16720244 [PubMed - indexed for MEDLINE]Related articles

Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes.

Lautamäki R, Borra R, Iozzo P, Komu M, Lehtimäki T, Salmi M, Jalkanen S, Airaksinen KE, Knuuti J, Parkkola R, Nuutila P.

Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E282-90. Epub 2006 Feb 14.PMID: 16478772 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone treatment increases subcutaneous adipose tissue glucose uptake in parallel with perfusion in patients with type 2 diabetes: a double-blind, randomized study with metformin.

Viljanen AP, Virtanen KA, Järvisalo MJ, Hällsten K, Parkkola R, Rönnemaa T, Lönnqvist F, Iozzo P, Ferrannini E, Nuutila P.

J Clin Endocrinol Metab. 2005 Dec;90(12):6523-8. Epub 2005 Sep 27.PMID: 16189256 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone improves myocardial glucose uptake in patients with type 2 diabetes and coronary artery disease: a 16-week randomized, double-blind, placebo-controlled study.

Lautamäki R, Airaksinen KE, Seppänen M, Toikka J, Luotolahti M, Ball E, Borra R, Härkönen R, Iozzo P, Stewart M, Knuuti J, Nuutila P.

Diabetes. 2005 Sep;54(9):2787-94.PMID: 16123370 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased fat mass compensates for insulin resistance in abdominal obesity and type 2 diabetes: a positron-emitting tomography study.

Virtanen KA, Iozzo P, Hällsten K, Huupponen R, Parkkola R, Janatuinen T, Lönnqvist F, Viljanen T, Rönnemaa T, Lönnroth P, Knuuti J, Ferrannini E, Nuutila P.

Diabetes. 2005 Sep;54(9):2720-6.PMID: 16123362 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of training status on regional disposal of circulating free fatty acids in the liver and skeletal muscle during physiological hyperinsulinemia.

Iozzo P, Takala T, Oikonen V, Bergman J, Grönroos T, Ferrannini E, Nuutila P, Knuuti J.

Diabetes Care. 2004 Sep;27(9):2172-7.PMID: 15333480 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver.

Iozzo P, Lautamaki R, Geisler F, Virtanen KA, Oikonen V, Haaparanta M, Yki-Jarvinen H, Ferrannini E, Knuuti J, Nuutila P.

Diabetologia. 2004 Jul;47(7):1149-56. Epub 2004 Jul 9.PMID: 15243703 [PubMed - indexed for MEDLINE]Related articles

Defective liver disposal of free fatty acids in patients with impaired glucose tolerance.

Iozzo P, Turpeinen AK, Takala T, Oikonen V, Bergman J, Grönroos T, Ferrannini E, Nuutila P, Knuuti J.

J Clin Endocrinol Metab. 2004 Jul;89(7):3496-502.PMID: 15240637 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of metformin and rosiglitazone monotherapy on insulin-mediated hepatic glucose uptake and their relation to visceral fat in type 2 diabetes.

Iozzo P, Hallsten K, Oikonen V, Virtanen KA, Parkkola R, Kemppainen J, Solin O, Lonnqvist F, Ferrannini E, Knuuti J, Nuutila P.

Diabetes Care. 2003 Jul;26(7):2069-74.PMID: 12832315 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver uptake of free fatty acids in vivo in humans as determined with 14( R, S)-[18F]fluoro-6-thia-heptadecanoic acid and PET.

Iozzo P, Turpeinen AK, Takala T, Oikonen V, Solin O, Ferrannini E, Nuutila P, Knuuti J.

Eur J Nucl Med Mol Imaging. 2003 Aug;30(8):1160-4. Epub 2003 Jun 17.PMID: 12811532 [PubMed - indexed for MEDLINE]Related articles

Insulin stimulates liver glucose uptake in humans: an 18F-FDG PET Study.

Iozzo P, Geisler F, Oikonen V, Mäki M, Takala T, Solin O, Ferrannini E, Knuuti J, Nuutila P; 18F-FDG PET Study.

J Nucl Med. 2003 May;44(5):682-9.PMID: 12732668 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-mediated hepatic glucose uptake is impaired in type 2 diabetes: evidence for a relationship with glycemic control.

Iozzo P, Hallsten K, Oikonen V, Virtanen KA, Kemppainen J, Solin O, Ferrannini E, Knuuti J, Nuutila P.

J Clin Endocrinol Metab. 2003 May;88(5):2055-60.PMID: 12727954 [PubMed - indexed for MEDLINE]Related articlesFree article

Mismatch between insulin-mediated glucose uptake and blood flow in the heart of patients with Type II diabetes.

Iozzo P, Chareonthaitawee P, Rimoldi O, Betteridge DJ, Camici PG, Ferrannini E.

Diabetologia. 2002 Oct;45(10):1404-9. Epub 2002 Jul 27.PMID: 12378381 [PubMed - indexed for MEDLINE]Related articles

Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance.

Iozzo P, Chareonthaitawee P, Dutka D, Betteridge DJ, Ferrannini E, Camici PG.

Diabetes. 2002 Oct;51(10):3020-4.PMID: 12351442 [PubMed - indexed for MEDLINE]Related articlesFree article

Myocardial metabolic and receptor imaging in idiopathic dilated cardiomyopathy.

Neglia D, Sambuceti G, Iozzo P, L'Abbate A, Strauss HW.

Eur J Nucl Med Mol Imaging. 2002 Oct;29(10):1403-13. Epub 2002 Jul 27. Review.PMID: 12271427 [PubMed - indexed for MEDLINE]Related articles

Regional myocardial blood flow and glucose utilization during fasting and physiological hyperinsulinemia in humans.

Iozzo P, Chareonthaitawee P, Di Terlizzi M, Betteridge DJ, Ferrannini E, Camici PG.

Am J Physiol Endocrinol Metab. 2002 May;282(5):E1163-71.PMID: 11934683 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of infarct size by positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose: a new absolute threshold technique.

Chareonthaitawee P, Schaefers K, Baker CS, Turkheimer F, Stegger L, Banner NR, Yacoub M, Bonser RS, Iozzo P, Camici PG, Rimoldi O.

Eur J Nucl Med Mol Imaging. 2002 Feb;29(2):203-15.PMID: 11930884 [PubMed - indexed for MEDLINE]Related articles

In vivo imaging of insulin receptors by PET: preclinical evaluation of iodine-125 and iodine-124 labelled human insulin.

Iozzo P, Osman S, Glaser M, Knickmeier M, Ferrannini E, Pike VW, Camici PG, Law MP.

Nucl Med Biol. 2002 Jan;29(1):73-82.PMID: 11786278 [PubMed - indexed for MEDLINE]Related articles

Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis.

Iozzo P, Pratipanawatr T, Pijl H, Vogt C, Kumar V, Pipek R, Matsuda M, Mandarino LJ, Cusi KJ, DeFronzo RA.

Am J Physiol Endocrinol Metab. 2001 May;280(5):E712-9.PMID: 11287353 [PubMed - indexed for MEDLINE]Related articlesFree article

Bromocriptine: a novel approach to the treatment of type 2 diabetes.

Pijl H, Ohashi S, Matsuda M, Miyazaki Y, Mahankali A, Kumar V, Pipek R, Iozzo P, Lancaster JL, Cincotta AH, DeFronzo RA.

Diabetes Care. 2000 Aug;23(8):1154-61.PMID: 10937514 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of hexokinase II expression in human skeletal muscle in vivo.

Vogt C, Ardehali H, Iozzo P, Yki-Järvinen H, Koval J, Maezono K, Pendergrass M, Printz R, Granner D, DeFronzo R, Mandarino L.

Metabolism. 2000 Jun;49(6):814-8.PMID: 10877213 [PubMed - indexed for MEDLINE]Related articles

Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance.

Iozzo P, Beck-Nielsen H, Laakso M, Smith U, Yki-Järvinen H, Ferrannini E.

J Clin Endocrinol Metab. 1999 Mar;84(3):863-8.PMID: 10084562 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.

Pendergrass M, Koval J, Vogt C, Yki-Jarvinen H, Iozzo P, Pipek R, Ardehali H, Printz R, Granner D, DeFronzo RA, Mandarino LJ.

Diabetes. 1998 Mar;47(3):387-94.PMID: 9519744 [PubMed - indexed for MEDLINE]Related articlesFree article