PubMed

Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells.

Kawakami T, Inagi R, Takano H, Sato S, Ingelfinger JR, Fujita T, Nangaku M.

Nephrol Dial Transplant. 2009 Sep;24(9):2665-72. Epub 2009 May 19.PMID: 19454529 [PubMed - in process]Related articles

Endoplasmic reticulum stress in the kidney as a novel mediator of kidney injury.

Inagi R.

Nephron Exp Nephrol. 2009;112(1):e1-9. Epub 2009 Apr 3. Review.PMID: 19342868 [PubMed - indexed for MEDLINE]Related articles

Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression.

Eto N, Miyagishi M, Inagi R, Fujita T, Nangaku M.

Am J Pathol. 2009 Apr;174(4):1553-63. Epub 2009 Feb 26.PMID: 19246638 [PubMed - indexed for MEDLINE]Related articlesFree article

Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats.

Kumagai T, Nangaku M, Kojima I, Nagai R, Ingelfinger JR, Miyata T, Fujita T, Inagi R.

Am J Physiol Renal Physiol. 2009 Apr;296(4):F912-21. Epub 2009 Feb 11.PMID: 19211689 [PubMed - indexed for MEDLINE]Related articles

Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney.

Kojima I, Tanaka T, Inagi R, Nishi H, Aburatani H, Kato H, Miyata T, Fujita T, Nangaku M.

Kidney Int. 2009 Feb;75(3):268-77. Epub 2008 Oct 1.PMID: 19148152 [PubMed - indexed for MEDLINE]Related articles

Contribution of T lymphocytes to rat renal ischemia/reperfusion injury.

Noiri E, Doi K, Inagi R, Nangaku M, Fujita T.

Clin Exp Nephrol. 2009 Feb;13(1):25-32. Epub 2008 Oct 1.PMID: 18827964 [PubMed - indexed for MEDLINE]Related articles

Hypoxia and hypoxia-inducible factor in renal disease.

Nangaku M, Inagi R, Miyata T, Fujita T.

Nephron Exp Nephrol. 2008;110(1):e1-7. Epub 2008 Jul 30. Review.PMID: 18667839 [PubMed - indexed for MEDLINE]Related articles

Pathophysiological role of the glyoxalase system in renal hypoxic injury.

Kumagai T, Nangaku M, Inagi R.

Ann N Y Acad Sci. 2008 Apr;1126:265-7.PMID: 18448828 [PubMed - indexed for MEDLINE]Related articles

Hemoglobin is expressed by mesangial cells and reduces oxidant stress.

Nishi H, Inagi R, Kato H, Tanemoto M, Kojima I, Son D, Fujita T, Nangaku M.

J Am Soc Nephrol. 2008 Aug;19(8):1500-8. Epub 2008 Apr 30.PMID: 18448584 [PubMed - indexed for MEDLINE]Related articlesFree article

[Progress in nephrology during this year: Basic research for kidney diseases]

Nangaku M, Inagi R.

Nippon Jinzo Gakkai Shi. 2008;50(1):5-10. Review. Japanese. No abstract available. PMID: 18318237 [PubMed - indexed for MEDLINE]Related articles

Angiotensin-induced hypoxia in the kidney: functional and structural changes of the renal circulation.

Nangaku M, Inagi R, Miyata T, Fujita T.

Adv Exp Med Biol. 2007;618:85-99. Review.PMID: 18269190 [PubMed - indexed for MEDLINE]Related articles

Preconditioning with endoplasmic reticulum stress ameliorates mesangioproliferative glomerulonephritis.

Inagi R, Kumagai T, Nishi H, Kawakami T, Miyata T, Fujita T, Nangaku M.

J Am Soc Nephrol. 2008 May;19(5):915-22. Epub 2008 Feb 6.PMID: 18256359 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress in cardiovascular disease: a new avenue toward future therapeutic approaches.

Inagi R.

Recent Pat Cardiovasc Drug Discov. 2006 Jun;1(2):151-9. Review.PMID: 18221082 [PubMed - indexed for MEDLINE]Related articles

Albumin suppresses vascular endothelial growth factor via alteration of hypoxia-inducible factor/hypoxia-responsive element pathway.

Katavetin P, Inagi R, Miyata T, Tanaka T, Sassa R, Ingelfinger JR, Fujita T, Nangaku M.

Biochem Biophys Res Commun. 2008 Mar 7;367(2):305-10. Epub 2007 Dec 26.PMID: 18155159 [PubMed - indexed for MEDLINE]Related articles

Chronic hypoxia aggravates renal injury via suppression of Cu/Zn-SOD: a proteomic analysis.

Son D, Kojima I, Inagi R, Matsumoto M, Fujita T, Nangaku M.

Am J Physiol Renal Physiol. 2008 Jan;294(1):F62-72. Epub 2007 Oct 24.PMID: 17959751 [PubMed - indexed for MEDLINE]Related articlesFree article

Receptor-independent intracellular radical scavenging activity of an angiotensin II receptor blocker.

Shao J, Nangaku M, Inagi R, Kato H, Miyata T, Matsusaka T, Noiri E, Fujita T.

J Hypertens. 2007 Aug;25(8):1643-9.PMID: 17620961 [PubMed - indexed for MEDLINE]Related articles

Establishment of a sandwich ELISA for human megsin, a kidney-specific serine protease inhibitor.

Inagi R, Izuhara Y, Tominaga N, Nangaku M, Kurokawa K, Miyata T.

Nephrol Dial Transplant. 2007 Nov;22(11):3311-7. Epub 2007 Jun 25.PMID: 17595191 [PubMed - indexed for MEDLINE]Related articlesFree article

Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress.

Katavetin P, Inagi R, Miyata T, Shao J, Sassa R, Adler S, Eto N, Kato H, Fujita T, Nangaku M.

Biochem Biophys Res Commun. 2007 Aug 10;359(4):928-34. Epub 2007 Jun 6.PMID: 17560935 [PubMed - indexed for MEDLINE]Related articles

Podocyte protection by darbepoetin: preservation of the cytoskeleton and nephrin expression.

Eto N, Wada T, Inagi R, Takano H, Shimizu A, Kato H, Kurihara H, Kawachi H, Shankland SJ, Fujita T, Nangaku M.

Kidney Int. 2007 Aug;72(4):455-63. Epub 2007 Apr 25.PMID: 17457371 [PubMed - indexed for MEDLINE]Related articles

Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney.

Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, Ohneda O, Takeda N, Sata M, Miyata T, Fujita T, Nangaku M.

J Am Soc Nephrol. 2007 Apr;18(4):1218-26. Epub 2007 Mar 7.PMID: 17344427 [PubMed - indexed for MEDLINE]Related articlesFree article

Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells.

Ohse T, Inagi R, Tanaka T, Ota T, Miyata T, Kojima I, Ingelfinger JR, Ogawa S, Fujita T, Nangaku M.

Kidney Int. 2006 Oct;70(8):1447-55. Epub 2006 Sep 6.PMID: 16955111 [PubMed - indexed for MEDLINE]Related articles

Hypoxia and expression of hypoxia-inducible factor in the aging kidney.

Tanaka T, Kato H, Kojima I, Ohse T, Son D, Tawakami T, Yatagawa T, Inagi R, Fujita T, Nangaku M.

J Gerontol A Biol Sci Med Sci. 2006 Aug;61(8):795-805.PMID: 16912095 [PubMed - indexed for MEDLINE]Related articles

A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies).

Takano K, Kitao Y, Inagi R, Momoi T, Matsuyama T, Miyata T, Yoneda Y, Iso H, Stern DM, Hori O, Ogawa S.

Biochem Biophys Res Commun. 2006 Aug 4;346(3):1040-7. Epub 2006 Jun 12.PMID: 16782060 [PubMed - indexed for MEDLINE]Related articles

High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway.

Katavetin P, Miyata T, Inagi R, Tanaka T, Sassa R, Ingelfinger JR, Fujita T, Nangaku M.

J Am Soc Nephrol. 2006 May;17(5):1405-13. Epub 2006 Apr 5.PMID: 16597689 [PubMed - indexed for MEDLINE]Related articlesFree article

[Post-genome research on megsin, a kidney-specific serpin gene]

Tominaga N, Inagi R, Miyata T.

Nippon Rinsho. 2006 Feb;64 Suppl 2:371-4. Review. Japanese. No abstract available. PMID: 16523917 [PubMed - indexed for MEDLINE]Related articles

A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice.

Inagi R, Yamamoto Y, Nangaku M, Usuda N, Okamato H, Kurokawa K, van Ypersele de Strihou C, Yamamoto H, Miyata T.

Diabetes. 2006 Feb;55(2):356-66.PMID: 16443768 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis.

Tanaka T, Matsumoto M, Inagi R, Miyata T, Kojima I, Ohse T, Fujita T, Nangaku M.

Kidney Int. 2005 Dec;68(6):2714-25.PMID: 16316346 [PubMed - indexed for MEDLINE]Related articles

Involvement of endoplasmic reticulum (ER) stress in podocyte injury induced by excessive protein accumulation.

Inagi R, Nangaku M, Onogi H, Ueyama H, Kitao Y, Nakazato K, Ogawa S, Kurokawa K, Couser WG, Miyata T.

Kidney Int. 2005 Dec;68(6):2639-50.PMID: 16316340 [PubMed - indexed for MEDLINE]Related articles

Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering.

Izuhara Y, Nangaku M, Inagi R, Tominaga N, Aizawa T, Kurokawa K, van Ypersele de Strihou C, Miyata T.

J Am Soc Nephrol. 2005 Dec;16(12):3631-41. Epub 2005 Oct 19.PMID: 16236804 [PubMed - indexed for MEDLINE]Related articlesFree article

In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy.

Nangaku M, Izuhara Y, Usuda N, Inagi R, Shibata T, Sugiyama S, Kurokawa K, van Ypersele de Strihou C, Miyata T.

Nephrol Dial Transplant. 2005 Dec;20(12):2661-9. Epub 2005 Sep 27.PMID: 16188903 [PubMed - indexed for MEDLINE]Related articlesFree article

Pyridoxamine improves functional, structural, and biochemical alterations of peritoneal membranes in uremic peritoneal dialysis rats.

Kakuta T, Tanaka R, Satoh Y, Izuhara Y, Inagi R, Nangaku M, Saito A, Miyata T.

Kidney Int. 2005 Sep;68(3):1326-36.PMID: 16105068 [PubMed - indexed for MEDLINE]Related articles

Protection of endothelial cells by dextran sulfate in rats with thrombotic microangiopathy.

Eto N, Kojima I, Uesugi N, Inagi R, Miyata T, Fujita T, Johnson RJ, Shankland SJ, Nangaku M.

J Am Soc Nephrol. 2005 Oct;16(10):2997-3005. Epub 2005 Aug 10.PMID: 16093450 [PubMed - indexed for MEDLINE]Related articlesFree article

Synergistic contributions of carbonyl stress and megsin in diabetic nephropathy.

Inagi R, Nangaku M, Miyata T.

Ann N Y Acad Sci. 2005 Jun;1043:605-8. Review.PMID: 16037283 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity.

Tanaka T, Kojima I, Ohse T, Inagi R, Miyata T, Ingelfinger JR, Fujita T, Nangaku M.

Am J Physiol Renal Physiol. 2005 Nov;289(5):F1123-33. Epub 2005 Jun 14.PMID: 15956779 [PubMed - indexed for MEDLINE]Related articlesFree article

Serpinopathy and endoplasmic reticulum stress.

Miyata T, Inagi R, Sugiyama S, Usuda N.

Med Mol Morphol. 2005 Jun;38(2):73-8. Review.PMID: 15944813 [PubMed - indexed for MEDLINE]Related articles

Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin.

Inagi R, Nangaku M, Usuda N, Shimizu A, Onogi H, Izuhara Y, Nakazato K, Ueda Y, Oishi H, Takahashi S, Yamamoto M, Suzuki D, Kurokawa K, van Ypersele de Strihou C, Miyata T.

J Am Soc Nephrol. 2005 May;16(5):1339-49. Epub 2005 Mar 23.PMID: 15788472 [PubMed - indexed for MEDLINE]Related articlesFree article

A biologic role of HIF-1 in the renal medulla.

Manotham K, Tanaka T, Ohse T, Kojima I, Miyata T, Inagi R, Tanaka H, Sassa R, Fujita T, Nangaku M.

Kidney Int. 2005 Apr;67(4):1428-39.PMID: 15780095 [PubMed - indexed for MEDLINE]Related articles

Hypoxia in renal disease with proteinuria and/or glomerular hypertension.

Tanaka T, Miyata T, Inagi R, Fujita T, Nangaku M.

Am J Pathol. 2004 Dec;165(6):1979-92.PMID: 15579441 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockade of calcium influx through L-type calcium channels attenuates mitochondrial injury and apoptosis in hypoxic renal tubular cells.

Tanaka T, Nangaku M, Miyata T, Inagi R, Ohse T, Ingelfinger JR, Fujita T.

J Am Soc Nephrol. 2004 Sep;15(9):2320-33.PMID: 15339981 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis.

Matsumoto M, Tanaka T, Yamamoto T, Noiri E, Miyata T, Inagi R, Fujita T, Nangaku M.

J Am Soc Nephrol. 2004 Jun;15(6):1574-81.PMID: 15153568 [PubMed - indexed for MEDLINE]Related articlesFree article

Accelerated glomerular injury in hemi-nephrectomized transgenic mice of mesangial cell-predominant serpin, megsin.

Onogi H, Inagi R, Nangaku M, Ueda Y, Miyata T, Kurokawa K.

Nephron Exp Nephrol. 2004;96(4):e127-33.PMID: 15122062 [PubMed - indexed for MEDLINE]Related articles

Evidence of tubular hypoxia in the early phase in the remnant kidney model.

Manotham K, Tanaka T, Matsumoto M, Ohse T, Miyata T, Inagi R, Kurokawa K, Fujita T, Nangaku M.

J Am Soc Nephrol. 2004 May;15(5):1277-88.PMID: 15100368 [PubMed - indexed for MEDLINE]Related articlesFree article

Transdifferentiation of cultured tubular cells induced by hypoxia.

Manotham K, Tanaka T, Matsumoto M, Ohse T, Inagi R, Miyata T, Kurokawa K, Fujita T, Ingelfinger JR, Nangaku M.

Kidney Int. 2004 Mar;65(3):871-80.PMID: 14871406 [PubMed - indexed for MEDLINE]Related articles

Proteomics and mesangial cell: serpin, megsin and plasmin.

Onogi H, Inagi R, Miyata T, Nangaku M, Kurokawa K.

Contrib Nephrol. 2004;141:212-20. Review. No abstract available. PMID: 14650234 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-induced apoptosis in cultured glomerular endothelial cells: involvement of mitochondrial pathways.

Tanaka T, Miyata T, Inagi R, Kurokawa K, Adler S, Fujita T, Nangaku M.

Kidney Int. 2003 Dec;64(6):2020-32.PMID: 14633124 [PubMed - indexed for MEDLINE]Related articles

Mesangial cell-predominant functional gene, megsin.

Inagi R, Nangaku M, Miyata T, Kurokawa K.

Clin Exp Nephrol. 2003 Jun;7(2):87-92. Review.PMID: 14586725 [PubMed - indexed for MEDLINE]Related articles

Imbalance of T-cell subsets in angiotensin II-infused hypertensive rats with kidney injury.

Shao J, Nangaku M, Miyata T, Inagi R, Yamada K, Kurokawa K, Fujita T.

Hypertension. 2003 Jul;42(1):31-8. Epub 2003 May 27.PMID: 12771047 [PubMed - indexed for MEDLINE]Related articlesFree article

Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded vMIP-I and vMIP-II induce signal transduction and chemotaxis in monocytic cells.

Nakano K, Isegawa Y, Zou P, Tadagaki K, Inagi R, Yamanishi K.

Arch Virol. 2003 May;148(5):871-90.PMID: 12721796 [PubMed - indexed for MEDLINE]Related articles

Anti-hypertensive agents inhibit in vivo the formation of advanced glycation end products and improve renal damage in a type 2 diabetic nephropathy rat model.

Nangaku M, Miyata T, Sada T, Mizuno M, Inagi R, Ueda Y, Ishikawa N, Yuzawa H, Koike H, van Ypersele de Strihou C, Kurokawa K.

J Am Soc Nephrol. 2003 May;14(5):1212-22.PMID: 12707391 [PubMed - indexed for MEDLINE]Related articlesFree article

Human herpesvirus 6B infection of the large intestine of patients with diarrhea.

Amo K, Tanaka-Taya K, Inagi R, Miyagawa H, Miyoshi H, Okusu I, Sashihara J, Hara J, Nakayama M, Yamanishi K, Okada S.

Clin Infect Dis. 2003 Jan 1;36(1):120-3. Epub 2002 Dec 12.PMID: 12491213 [PubMed - indexed for MEDLINE]Related articles