PubMed

Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF.

Kirchmair R, Tietz AB, Panagiotou E, Walter DH, Silver M, Yoon YS, Schratzberger P, Weber A, Kusano K, Weinberg DH, Ropper AH, Isner JM, Losordo DW.

Mol Ther. 2007 Jan;15(1):69-75.PMID: 17164777 [PubMed - indexed for MEDLINE]Related articles

Intramuscular gene transfer of fibroblast growth factor-1 using improved pCOR plasmid design stimulates collateral formation in a rabbit ischemic hindlimb model.

Witzenbichler B, Mahfoudi A, Soubrier F, Le Roux A, Branellec D, Schultheiss HP, Isner JM.

J Mol Med. 2006 Jun;84(6):491-502. Epub 2005 Dec 31.PMID: 16389546 [PubMed - indexed for MEDLINE]Related articles

Hyperhomocyst(e)inemia impairs angiogenesis in a murine model of limb ischemia.

Bosch-Marcé M, Pola R, Wecker AB, Silver M, Weber A, Luedemann C, Curry C, Murayama T, Kearney M, Yoon YS, Malinow MR, Asahara T, Isner JM, Losordo DW.

Vasc Med. 2005 Feb;10(1):15-22.PMID: 15920995 [PubMed - indexed for MEDLINE]Related articles

Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth.

Kirchmair R, Walter DH, Ii M, Rittig K, Tietz AB, Murayama T, Emanueli C, Silver M, Wecker A, Amant C, Schratzberger P, Yoon YS, Weber A, Panagiotou E, Rosen KM, Bahlmann FH, Adelman LS, Weinberg DH, Ropper AH, Isner JM, Losordo DW.

Circulation. 2005 May 24;111(20):2662-70. Epub 2005 May 16.PMID: 15897348 [PubMed - indexed for MEDLINE]Related articlesFree article

Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor.

Yoon YS, Uchida S, Masuo O, Cejna M, Park JS, Gwon HC, Kirchmair R, Bahlman F, Walter D, Curry C, Hanley A, Isner JM, Losordo DW.

Circulation. 2005 Apr 26;111(16):2073-85.PMID: 15851615 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization.

Hayashi S, Asahara T, Masuda H, Isner JM, Losordo DW.

Circulation. 2005 May 3;111(17):2210-8. Epub 2005 Apr 25.PMID: 15851594 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term (2-year) clinical events following transthoracic intramyocardial gene transfer of VEGF-2 in no-option patients.

Reilly JP, Grise MA, Fortuin FD, Vale PR, Schaer GL, Lopez J, VAN Camp JR, Henry T, Richenbacher WE, Losordo DW, Schatz RA, Isner JM.

J Interv Cardiol. 2005 Feb;18(1):27-31.PMID: 15788051 [PubMed - indexed for MEDLINE]Related articles

Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves.

Pola R, Aprahamian TR, Bosch-Marcé M, Curry C, Gaetani E, Flex A, Smith RC, Isner JM, Losordo DW.

Neurobiol Aging. 2004 Nov-Dec;25(10):1361-8.PMID: 15465634 [PubMed - indexed for MEDLINE]Related articles

Local gene transfer of phVEGF-2 plasmid by gene-eluting stents: an alternative strategy for inhibition of restenosis.

Walter DH, Cejna M, Diaz-Sandoval L, Willis S, Kirkwood L, Stratford PW, Tietz AB, Kirchmair R, Silver M, Curry C, Wecker A, Yoon YS, Heidenreich R, Hanley A, Kearney M, Tio FO, Kuenzler P, Isner JM, Losordo DW.

Circulation. 2004 Jul 6;110(1):36-45. Epub 2004 Jun 21.PMID: 15210598 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury.

Iwakura A, Luedemann C, Shastry S, Hanley A, Kearney M, Aikawa R, Isner JM, Asahara T, Losordo DW.

Circulation. 2003 Dec 23;108(25):3115-21. Epub 2003 Dec 15.PMID: 14676142 [PubMed - indexed for MEDLINE]Related articlesFree article

One-year follow-up of direct myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotomy in no-option patients.

Fortuin FD, Vale P, Losordo DW, Symes J, DeLaria GA, Tyner JJ, Schaer GL, March R, Snell RJ, Henry TD, Van Camp J, Lopez JJ, Richenbacher W, Isner JM, Schatz RA.

Am J Cardiol. 2003 Aug 15;92(4):436-9.PMID: 12914874 [PubMed - indexed for MEDLINE]Related articles

Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia.

Pola R, Ling LE, Aprahamian TR, Barban E, Bosch-Marce M, Curry C, Corbley M, Kearney M, Isner JM, Losordo DW.

Circulation. 2003 Jul 29;108(4):479-85. Epub 2003 Jul 14.PMID: 12860919 [PubMed - indexed for MEDLINE]Related articlesFree article

Engineering the response to vascular injury: divergent effects of deregulated E2F1 expression on vascular smooth muscle cells and endothelial cells result in endothelial recovery and inhibition of neointimal growth.

Goukassian DA, Kishore R, Krasinski K, Dolan C, Luedemann C, Yoon YS, Kearney M, Hanley A, Ma H, Asahara T, Isner JM, Losordo DW.

Circ Res. 2003 Jul 25;93(2):162-9. Epub 2003 Jun 26.PMID: 12829616 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial recovery: the next target in restenosis prevention.

Losordo DW, Isner JM, Diaz-Sandoval LJ.

Circulation. 2003 Jun 3;107(21):2635-7. No abstract available. PMID: 12782613 [PubMed - indexed for MEDLINE]Related articlesFree article

Synergistic effect of angiopoietin-1 and vascular endothelial growth factor on neoangiogenesis in hypercholesterolemic rabbit model with acute hindlimb ischemia.

Shyu KG, Chang H, Isner JM.

Life Sci. 2003 Jun 20;73(5):563-79.PMID: 12770612 [PubMed - indexed for MEDLINE]Related articles

Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization.

Yamaguchi J, Kusano KF, Masuo O, Kawamoto A, Silver M, Murasawa S, Bosch-Marce M, Masuda H, Losordo DW, Isner JM, Asahara T.

Circulation. 2003 Mar 11;107(9):1322-8.PMID: 12628955 [PubMed - indexed for MEDLINE]Related articlesFree article

VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema.

Yoon YS, Murayama T, Gravereaux E, Tkebuchava T, Silver M, Curry C, Wecker A, Kirchmair R, Hu CS, Kearney M, Ashare A, Jackson DG, Kubo H, Isner JM, Losordo DW.

J Clin Invest. 2003 Mar;111(5):717-25.PMID: 12618526 [PubMed - indexed for MEDLINE]Related articlesFree article

Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia.

Kawamoto A, Tkebuchava T, Yamaguchi J, Nishimura H, Yoon YS, Milliken C, Uchida S, Masuo O, Iwaguro H, Ma H, Hanley A, Silver M, Kearney M, Losordo DW, Isner JM, Asahara T.

Circulation. 2003 Jan 28;107(3):461-8.PMID: 12551872 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcutaneous ultrasound augments naked DNA transfection of skeletal muscle.

Schratzberger P, Krainin JG, Schratzberger G, Silver M, Ma H, Kearney M, Zuk RF, Brisken AF, Losordo DW, Isner JM.

Mol Ther. 2002 Nov;6(5):576-83.PMID: 12409255 [PubMed - indexed for MEDLINE]Related articles

Plasma vascular endothelial growth factor (VEGF) levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA.

Freedman SB, Vale P, Kalka C, Kearney M, Pieczek A, Symes J, Losordo D, Isner JM.

Hum Gene Ther. 2002 Sep 1;13(13):1595-603.PMID: 12228014 [PubMed - indexed for MEDLINE]Related articles

Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells.

Murasawa S, Llevadot J, Silver M, Isner JM, Losordo DW, Asahara T.

Circulation. 2002 Aug 27;106(9):1133-9.PMID: 12196341 [PubMed - indexed for MEDLINE]Related articlesFree article

Determination of bone marrow-derived endothelial progenitor cell significance in angiogenic growth factor-induced neovascularization in vivo.

Murayama T, Tepper OM, Silver M, Ma H, Losordo DW, Isner JM, Asahara T, Kalka C.

Exp Hematol. 2002 Aug;30(8):967-72.PMID: 12160849 [PubMed - indexed for MEDLINE]Related articles

Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells.

Walter DH, Rittig K, Bahlmann FH, Kirchmair R, Silver M, Murayama T, Nishimura H, Losordo DW, Asahara T, Isner JM.

Circulation. 2002 Jun 25;105(25):3017-24.PMID: 12081997 [PubMed - indexed for MEDLINE]Related articlesFree article

Divergence of angiogenic and vascular permeability signaling by VEGF: inhibition of protein kinase C suppresses VEGF-induced angiogenesis, but promotes VEGF-induced, NO-dependent vascular permeability.

Spyridopoulos I, Luedemann C, Chen D, Kearney M, Chen D, Murohara T, Principe N, Isner JM, Losordo DW.

Arterioscler Thromb Vasc Biol. 2002 Jun 1;22(6):901-6.PMID: 12067896 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic angiogenesis in critical limb and myocardial ischemia.

Vale PR, Isner JM, Rosenfield K.

J Interv Cardiol. 2001 Oct;14(5):511-28. Review.PMID: 12053643 [PubMed - indexed for MEDLINE]Related articles

Oncogenic ras induces premature senescence in endothelial cells: role of p21(Cip1/Waf1).

Spyridopoulos I, Isner JM, Losordo DW.

Basic Res Cardiol. 2002 Mar;97(2):117-24.PMID: 12002258 [PubMed - indexed for MEDLINE]Related articles

[Cardiac and vascular gene therapy in cardiology. Current status and future prospects]

Kalka C, Isner JM.

Internist (Berl). 2002 Apr;43 Suppl 1:S66-75. Review. German. No abstract available. PMID: 11993001 [PubMed - indexed for MEDLINE]Related articles

Endothelial progenitor cells for vascular regeneration.

Asahara T, Isner JM.

J Hematother Stem Cell Res. 2002 Apr;11(2):171-8. Review.PMID: 11983091 [PubMed - indexed for MEDLINE]Related articles

Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia.

Losordo DW, Vale PR, Hendel RC, Milliken CE, Fortuin FD, Cummings N, Schatz RA, Asahara T, Isner JM, Kuntz RE.

Circulation. 2002 Apr 30;105(17):2012-8.PMID: 11980678 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteinuria in a placebo-controlled study of basic fibroblast growth factor for intermittent claudication.

Cooper LT Jr, Hiatt WR, Creager MA, Regensteiner JG, Casscells W, Isner JM, Cooke JP, Hirsch AT.

Vasc Med. 2001 Nov;6(4):235-9.PMID: 11958389 [PubMed - indexed for MEDLINE]Related articles

Angiogenic gene therapy: pre-clinical studies and phase I clinical data.

Bashir R, Vale PR, Isner JM, Losordo DW.

Kidney Int. 2002 Jan;61(1 Suppl):S110-4. Review.PMID: 11841623 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration.

Iwaguro H, Yamaguchi J, Kalka C, Murasawa S, Masuda H, Hayashi S, Silver M, Li T, Isner JM, Asahara T.

Circulation. 2002 Feb 12;105(6):732-8.PMID: 11839630 [PubMed - indexed for MEDLINE]Related articlesFree article

Bone marrow as a source of endothelial cells for natural and iatrogenic vascular repair.

Isner JM, Kalka C, Kawamoto A, Asahara T.

Ann N Y Acad Sci. 2001 Dec;953:75-84. Review.PMID: 11795425 [PubMed - indexed for MEDLINE]Related articles

Myocardial gene therapy.

Isner JM.

Nature. 2002 Jan 10;415(6868):234-9. Review.PMID: 11805848 [PubMed - indexed for MEDLINE]Related articles

Targeting kinin B(1) receptor for therapeutic neovascularization.

Emanueli C, Bonaria Salis M, Stacca T, Pintus G, Kirchmair R, Isner JM, Pinna A, Gaspa L, Regoli D, Cayla C, Pesquero JB, Bader M, Madeddu P.

Circulation. 2002 Jan 22;105(3):360-6.PMID: 11804993 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic angiogenesis for coronary artery disease.

Freedman SB, Isner JM.

Ann Intern Med. 2002 Jan 1;136(1):54-71. Review.PMID: 11777364 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic targeting for cardiovascular therapeutics: are we near the summit or just beginning the climb?

Francis SC, Raizada MK, Mangi AA, Melo LG, Dzau VJ, Vale PR, Isner JM, Losordo DW, Chao J, Katovich MJ, Berecek KH.

Physiol Genomics. 2001 Dec 21;7(2):79-94. Review.PMID: 11773594 [PubMed - indexed for MEDLINE]Related articles

Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease.

Henry TD, Rocha-Singh K, Isner JM, Kereiakes DJ, Giordano FJ, Simons M, Losordo DW, Hendel RC, Bonow RO, Eppler SM, Zioncheck TF, Holmgren EB, McCluskey ER.

Am Heart J. 2001 Nov;142(5):872-80.PMID: 11685177 [PubMed - indexed for MEDLINE]Related articles

[Growth factors for therapeutic angiogenesis in cardiovascular diseases]

Vale PR, Losordo DW, Symes JF, Isner JM.

Rev Esp Cardiol. 2001 Oct;54(10):1210-24. Spanish. PMID: 11591302 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of p27(Kip1) by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis.

Goukassian D, Díez-Juan A, Asahara T, Schratzberger P, Silver M, Murayama T, Isner JM, Andrés V.

FASEB J. 2001 Sep;15(11):1877-85.PMID: 11532967 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of risks associated with cardiovascular gene therapy in human subjects.

Isner JM, Vale PR, Symes JF, Losordo DW.

Circ Res. 2001 Aug 31;89(5):389-400. Review.PMID: 11532899 [PubMed - indexed for MEDLINE]Related articlesFree article

VEGF gene transfer for diabetic neuropathy.

Isner JM, Ropper A, Hirst K.

Hum Gene Ther. 2001 Aug 10;12(12):1593-4.PMID: 11529248 [PubMed - indexed for MEDLINE]Related articles

In vivo analysis of intramuscular gene transfer in human subjects studied by on-line ultrasound imaging.

Rauh G, Pieczek A, Irwin W, Schainfeld R, Isner JM.

Hum Gene Ther. 2001 Aug 10;12(12):1543-9.PMID: 11506696 [PubMed - indexed for MEDLINE]Related articles

HMG-CoA reductase inhibitor mobilizes bone marrow--derived endothelial progenitor cells.

Llevadot J, Murasawa S, Kureishi Y, Uchida S, Masuda H, Kawamoto A, Walsh K, Isner JM, Asahara T.

J Clin Invest. 2001 Aug;108(3):399-405.PMID: 11489933 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular endothelial growth factor-induced angiogenesis: crouching tiger or hidden dragon?

Losordo DW, Isner JM.

J Am Coll Cardiol. 2001 Jun 15;37(8):2131-5. No abstract available. PMID: 11419899 [PubMed - indexed for MEDLINE]Related articles

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors.

Pola R, Ling LE, Silver M, Corbley MJ, Kearney M, Blake Pepinsky R, Shapiro R, Taylor FR, Baker DP, Asahara T, Isner JM.

Nat Med. 2001 Jun;7(6):706-11.PMID: 11385508 [PubMed - indexed for MEDLINE]Related articles

Still more debate over VEGF.

Isner JM.

Nat Med. 2001 Jun;7(6):639-41. No abstract available. PMID: 11385475 [PubMed - indexed for MEDLINE]Related articles

Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia.

Vale PR, Losordo DW, Milliken CE, McDonald MC, Gravelin LM, Curry CM, Esakof DD, Maysky M, Symes JF, Isner JM.

Circulation. 2001 May 1;103(17):2138-43.PMID: 11331253 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischemia.

Simovic D, Isner JM, Ropper AH, Pieczek A, Weinberg DH.

Arch Neurol. 2001 May;58(5):761-8.PMID: 11346371 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of experimental diabetic neuropathy by VEGF gene transfer.

Schratzberger P, Walter DH, Rittig K, Bahlmann FH, Pola R, Curry C, Silver M, Krainin JG, Weinberg DH, Ropper AH, Isner JM.

J Clin Invest. 2001 May;107(9):1083-92.PMID: 11342572 [PubMed - indexed for MEDLINE]Related articlesFree article