PubMed

Glucose-6-phosphatase catalytic subunit gene family.

Hutton JC, O'Brien RM.

J Biol Chem. 2009 Oct 23;284(43):29241-5. Epub 2009 Aug 20.PMID: 19700406 [PubMed - in process]Related articles

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.

Pound LD, Sarkar SA, Benninger RK, Wang Y, Suwanichkul A, Shadoan MK, Printz RL, Oeser JK, Lee CE, Piston DW, McGuinness OP, Hutton JC, Powell DR, O'Brien RM.

Biochem J. 2009 Jul 15;421(3):371-6.PMID: 19450229 [PubMed - indexed for MEDLINE]Related articles

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line.

Sarkar SA, Kutlu B, Velmurugan K, Kizaka-Kondoh S, Lee CE, Wong R, Valentine A, Davidson HW, Hutton JC, Pugazhenthi S.

Diabetologia. 2009 Jun;52(6):1092-101. Epub 2009 Apr 3.PMID: 19343319 [PubMed - indexed for MEDLINE]Related articles

Novel antigens in type 1 diabetes: the importance of ZnT8.

Wenzlau JM, Frisch LM, Gardner TJ, Sarkar S, Hutton JC, Davidson HW.

Curr Diab Rep. 2009 Apr;9(2):105-12. Review.PMID: 19323954 [PubMed - indexed for MEDLINE]Related articles

Isolation of dense core secretory vesicles from pancreatic endocrine cells by differential and density gradient centrifugation.

Hutton JC, Wong R, Davidson HW.

Curr Protoc Cell Biol. 2009 Mar;Chapter 3:Unit 3.32.PMID: 19283733 [PubMed - indexed for MEDLINE]Related articles

SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes.

Wenzlau JM, Moua O, Sarkar SA, Yu L, Rewers M, Eisenbarth GS, Davidson HW, Hutton JC.

Ann N Y Acad Sci. 2008 Dec;1150:256-9.PMID: 19120307 [PubMed - indexed for MEDLINE]Related articles

Identification of a major humoral epitope in Slc30A8 (ZnT8).

Wenzlau JM, Moua O, Liu Y, Eisenbarth GS, Hutton JC, Davidson HW.

Ann N Y Acad Sci. 2008 Dec;1150:252-5.PMID: 19120306 [PubMed - indexed for MEDLINE]Related articles

Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigens.

Liu Y, Wenzlau JM, Yu L, Patel C, Eisenbarth GS, Hutton JC, Davidson HW.

Ann N Y Acad Sci. 2008 Dec;1150:245-7.PMID: 19120304 [PubMed - indexed for MEDLINE]Related articles

Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes.

Kawasaki E, Uga M, Nakamura K, Kuriya G, Satoh T, Fujishima K, Ozaki M, Abiru N, Yamasaki H, Wenzlau JM, Davidson HW, Hutton JC, Eguchi K.

Diabetologia. 2008 Dec;51(12):2299-302. Epub 2008 Oct 11.PMID: 18850084 [PubMed - indexed for MEDLINE]Related articles

GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist.

Quayum N, Kutchma A, Sarkar SA, Juhl K, Gradwohl G, Mellitzer G, Hutton JC, Jensen J.

Exp Diabetes Res. 2008;2008:312060.PMID: 18795106 [PubMed - indexed for MEDLINE]Related articlesFree article

Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse.

Juhl K, Sarkar SA, Wong R, Jensen J, Hutton JC.

Diabetes. 2008 Oct;57(10):2755-61. Epub 2008 Jul 3.PMID: 18599526 [PubMed - indexed for MEDLINE]Related articlesFree article

New antigenic targets in type 1 diabetes.

Wenzlau JM, Hutton JC, Davidson HW.

Curr Opin Endocrinol Diabetes Obes. 2008 Aug;15(4):315-20. Review.PMID: 18594270 [PubMed - indexed for MEDLINE]Related articles

A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes.

Wenzlau JM, Liu Y, Yu L, Moua O, Fowler KT, Rangasamy S, Walters J, Eisenbarth GS, Davidson HW, Hutton JC.

Diabetes. 2008 Oct;57(10):2693-7. Epub 2008 Jun 30.PMID: 18591387 [PubMed - indexed for MEDLINE]Related articlesFree article

Global gene expression profiling and histochemical analysis of the developing human fetal pancreas.

Sarkar SA, Kobberup S, Wong R, Lopez AD, Quayum N, Still T, Kutchma A, Jensen JN, Gianani R, Beattie GM, Jensen J, Hayek A, Hutton JC.

Diabetologia. 2008 Feb;51(2):285-97. Epub 2007 Dec 18.PMID: 18094957 [PubMed - indexed for MEDLINE]Related articles

Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo.

Wang Y, Flemming BP, Martin CC, Allen SR, Walters J, Oeser JK, Hutton JC, O'Brien RM.

Diabetes. 2008 Jan;57(1):133-41. Epub 2007 Oct 17.PMID: 17942825 [PubMed - indexed for MEDLINE]Related articlesFree article

The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes.

Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5. Epub 2007 Oct 17.PMID: 17942684 [PubMed - indexed for MEDLINE]Related articlesFree article

Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets.

Sarkar SA, Gunter J, Bouchard R, Reusch JE, Wiseman A, Gill RG, Hutton JC, Pugazhenthi S.

Diabetologia. 2007 Aug;50(8):1649-59. Epub 2007 Jun 26.PMID: 17593347 [PubMed - indexed for MEDLINE]Related articles

Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype.

Wang Y, Martin CC, Oeser JK, Sarkar S, McGuinness OP, Hutton JC, O'Brien RM.

Diabetologia. 2007 Apr;50(4):774-8. Epub 2007 Jan 31.PMID: 17265032 [PubMed - indexed for MEDLINE]Related articles

Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets.

Sarkar SA, Wong R, Hackl SI, Moua O, Gill RG, Wiseman A, Davidson HW, Hutton JC.

Diabetes. 2007 Jan;56(1):72-9.PMID: 17192467 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.

Wang Y, Oeser JK, Yang C, Sarkar S, Hackl SI, Hasty AH, McGuinness OP, Paradee W, Hutton JC, Powell DR, O'Brien RM.

J Biol Chem. 2006 Dec 29;281(52):39982-9. Epub 2006 Oct 5.PMID: 17023421 [PubMed - indexed for MEDLINE]Related articlesFree article

A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2.

Babaya N, Nakayama M, Moriyama H, Gianani R, Still T, Miao D, Yu L, Hutton JC, Eisenbarth GS.

Diabetologia. 2006 Jun;49(6):1222-8. Epub 2006 Apr 13.PMID: 16612590 [PubMed - indexed for MEDLINE]Related articles

Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas.

Dogra RS, Vaidyanathan P, Prabakar KR, Marshall KE, Hutton JC, Pugliese A.

Diabetologia. 2006 May;49(5):953-7. Epub 2006 Mar 7.PMID: 16520917 [PubMed - indexed for MEDLINE]Related articles

Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction.

Limesand SW, Rozance PJ, Zerbe GO, Hutton JC, Hay WW Jr.

Endocrinology. 2006 Mar;147(3):1488-97. Epub 2005 Dec 8.PMID: 16339204 [PubMed - indexed for MEDLINE]Related articlesFree article

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.

Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, Wegmann DR, Hutton JC, Elliott JF, Eisenbarth GS.

Nature. 2005 May 12;435(7039):220-3.PMID: 15889095 [PubMed - indexed for MEDLINE]Related articlesFree article

An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin.

Wasmeier C, Burgos PV, Trudeau T, Davidson HW, Hutton JC.

Traffic. 2005 Jun;6(6):474-87.PMID: 15882444 [PubMed - indexed for MEDLINE]Related articles

Establishment of native insulin-negative NOD mice and the methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgene.

Nakayama M, Moriyama H, Abiru N, Babu SR, Sikora K, Li M, Miao D, Hutton JC, Elliott JF, Eisenbarth GS.

Ann N Y Acad Sci. 2004 Dec;1037:193-8.PMID: 15699516 [PubMed - indexed for MEDLINE]Related articles

Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction.

Limesand SW, Jensen J, Hutton JC, Hay WW Jr.

Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1297-305. Epub 2005 Jan 13.PMID: 15650129 [PubMed - indexed for MEDLINE]Related articles

Recycling of the dense-core vesicle membrane protein phogrin in Min6 beta-cells.

Vo YP, Hutton JC, Angleson JK.

Biochem Biophys Res Commun. 2004 Nov 19;324(3):1004-10.PMID: 15485654 [PubMed - indexed for MEDLINE]Related articles

The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo.

Frigeri C, Martin CC, Svitek CA, Oeser JK, Hutton JC, Gannon M, O'Brien RM.

Diabetes. 2004 Jul;53(7):1754-64.PMID: 15220199 [PubMed - indexed for MEDLINE]Related articlesFree article

Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104.

Zahn TR, Angleson JK, MacMorris MA, Domke E, Hutton JF, Schwartz C, Hutton JC.

Traffic. 2004 Jul;5(7):544-59.PMID: 15180830 [PubMed - indexed for MEDLINE]Related articles

HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes.

Kelemen K, Gottlieb PA, Putnam AL, Davidson HW, Wegmann DR, Hutton JC.

J Immunol. 2004 Mar 15;172(6):3955-62.PMID: 15004204 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein.

Boustead JN, Martin CC, Oeser JK, Svitek CA, Hunter SI, Hutton JC, O'Brien RM.

J Mol Endocrinol. 2004 Feb;32(1):33-53.PMID: 14765991 [PubMed - indexed for MEDLINE]Related articlesFree article

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.

Jackson RS, Creemers JW, Farooqi IS, Raffin-Sanson ML, Varro A, Dockray GJ, Holst JJ, Brubaker PL, Corvol P, Polonsky KS, Ostrega D, Becker KL, Bertagna X, Hutton JC, White A, Dattani MT, Hussain K, Middleton SJ, Nicole TM, Milla PJ, Lindley KJ, O'Rahilly S.

J Clin Invest. 2003 Nov;112(10):1550-60.PMID: 14617756 [PubMed - indexed for MEDLINE]Related articlesFree article

A pancreatic beta-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes.

Hutton JC, Eisenbarth GS.

Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8626-8. Epub 2003 Jul 14. No abstract available. PMID: 12861077 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets.

Nicolls MR, D'Antonio JM, Hutton JC, Gill RG, Czwornog JL, Duncan MW.

J Proteome Res. 2003 Mar-Apr;2(2):199-205.PMID: 12716134 [PubMed - indexed for MEDLINE]Related articles

Targeting of a phogrin-green fluorescent protein chimaera to insulin secretory granules of pancreatic beta-cells in transgenic mice.

Bright NA, Walters J, Wasmeier C, Hutton JC.

Diabetes Metab. 2002 Dec;28(6 Pt 2):3S29-36; discussion 3S108-12.PMID: 12688631 [PubMed - indexed for MEDLINE]Related articles

Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells.

Jambal P, Masterson S, Nesterova A, Bouchard R, Bergman B, Hutton JC, Boxer LM, Reusch JE, Pugazhenthi S.

J Biol Chem. 2003 Jun 20;278(25):23055-65. Epub 2003 Apr 5.PMID: 12679364 [PubMed - indexed for MEDLINE]Related articlesFree article

Proinsulin processing in the diabetic Goto-Kakizaki rat.

Guest PC, Abdel-Halim SM, Gross DJ, Clark A, Poitout V, Amaria R, Ostenson CG, Hutton JC.

J Endocrinol. 2002 Dec;175(3):637-47.PMID: 12475375 [PubMed - indexed for MEDLINE]Related articlesFree article

Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice.

Achenbach P, Kelemen K, Wegmann DR, Hutton JC.

J Autoimmun. 2002 Nov;19(3):111-6.PMID: 12419281 [PubMed - indexed for MEDLINE]Related articles

Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein.

Martin CC, Oeser JK, Svitek CA, Hunter SI, Hutton JC, O'Brien RM.

J Mol Endocrinol. 2002 Oct;29(2):205-22.PMID: 12370122 [PubMed - indexed for MEDLINE]Related articlesFree article

The lumenal domain of the integral membrane protein phogrin mediates targeting to secretory granules.

Wasmeier C, Bright NA, Hutton JC.

Traffic. 2002 Sep;3(9):654-65.PMID: 12191017 [PubMed - indexed for MEDLINE]Related articles

T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the nonobese diabetic mouse.

Kelemen K, Wegmann DR, Hutton JC.

Diabetes. 2001 Aug;50(8):1729-34.PMID: 11473031 [PubMed - indexed for MEDLINE]Related articlesFree article

Secretagogue-dependent phosphorylation of the insulin granule membrane protein phogrin is mediated by cAMP-dependent protein kinase.

Wasmeier C, Hutton JC.

J Biol Chem. 2001 Aug 24;276(34):31919-28. Epub 2001 May 15.PMID: 11353772 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes.

Martin CC, Bischof LJ, Bergman B, Hornbuckle LA, Hilliker C, Frigeri C, Wahl D, Svitek CA, Wong R, Goldman JK, Oeser JK, Leprêtre F, Froguel P, O'Brien RM, Hutton JC.

J Biol Chem. 2001 Jul 6;276(27):25197-207. Epub 2001 Apr 10.PMID: 11297555 [PubMed - indexed for MEDLINE]Related articles

Characterization of the mouse islet-specific glucose-6-phosphatase catalytic subunit-related protein gene promoter by in situ footprinting: correlation with fusion gene expression in the islet-derived betaTC-3 and hamster insulinoma tumor cell lines.

Bischof LJ, Martin CC, Svitek CA, Stadelmaier BT, Hornbuckle LA, Goldman JK, Oeser JK, Hutton JC, O'Brien RM.

Diabetes. 2001 Mar;50(3):502-14.PMID: 11246869 [PubMed - indexed for MEDLINE]Related articlesFree article

Chromogranin A and its derived peptides in the rat and porcine gastro-entero-pancreatic system. Expression, localization, and characterization.

Curry WJ, Norlén P, Barkatullah SC, Johnston CF, Håkanson R, Hutton JC.

Adv Exp Med Biol. 2000;482:205-13. Review. No abstract available. PMID: 11192581 [PubMed - indexed for MEDLINE]Related articles

Cell-specific processing of chromogranin A in endocrine cells of the rat stomach.

Norlén P, Curry WJ, Björkqvist M, Maule A, Cunningham RT, Hogg RB, Harriott P, Johnston CF, Hutton JC, Håkanson R.

J Histochem Cytochem. 2001 Jan;49(1):9-18.PMID: 11118474 [PubMed - indexed for MEDLINE]Related articlesFree article

IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm.

Zahn TR, Macmorris MA, Dong W, Day R, Hutton JC.

J Comp Neurol. 2001 Jan 1;429(1):127-43.PMID: 11086294 [PubMed - indexed for MEDLINE]Related articles

Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes.

Park YS, Kawasaki E, Kelemen K, Yu L, Schiller MR, Rewers M, Mizuta M, Eisenbarth GS, Hutton JC.

Diabetologia. 2000 Oct;43(10):1293-301.PMID: 11079748 [PubMed - indexed for MEDLINE]Related articles

Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell.

Goodge KA, Hutton JC.

Semin Cell Dev Biol. 2000 Aug;11(4):235-42. Review.PMID: 10966857 [PubMed - indexed for MEDLINE]Related articles