PubMed

Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm.

Thompson AR, Cooper JA, Jones GT, Drenos F, van Bockxmeer FM, Biros E, Walker PJ, van Rij AM, Golledge J, Norman PE, Hafez H, Humphries SE.

Atherosclerosis. 2009 Oct 15. [Epub ahead of print]PMID: 19897194 [PubMed - as supplied by publisher]Related articles

Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation.

Salpea KD, Talmud PJ, Cooper JA, Maubaret CG, Stephens JW, Abelak K, Humphries SE.

Atherosclerosis. 2009 Oct 6. [Epub ahead of print]PMID: 19889414 [PubMed - as supplied by publisher]Related articles

Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, Engert JC, Fisher E, Francès F, Froguel P, Hebebrand J, Hegele RA, Hinney A, Hoehe MR, Hu FB, Hubacek JA, Humphries SE, Hunt SC, Illig T, Järvelin MR, Kaakinen M, Kollerits B, Krude H, Kumar J, Lange LA, Langer B, Li S, Luchner A, Lyon HN, Meyre D, Mohlke KL, Mooser V, Nebel A, Nguyen TT, Paulweber B, Perusse L, Qi L, Rankinen T, Rosskopf D, Schreiber S, Sengupta S, Sorice R, Suk A, Thorleifsson G, Thorsteinsdottir U, Völzke H, Vimaleswaran KS, Wareham NJ, Waterworth D, Yusuf S, Lindgren C, McCarthy MI, Lange C, Hirschhorn JN, Laird N, Wichmann HE.

PLoS Genet. 2009 Oct;5(10):e1000694. Epub 2009 Oct 23.PMID: 19851442 [PubMed - in process]Related articlesFree article

Mutation screening in patients for familial hypercholesterolaemia (ADH).

Taylor A, Patel K, Tsedeke J, Humphries SE, Norbury G.

Clin Genet. 2009 Oct 15. [Epub ahead of print] No abstract available. PMID: 19843101 [PubMed - as supplied by publisher]Related articles

Development of a high-resolution melting method for mutation detection in familial hypercholesterolaemia patients.

Whittall RA, Scartezini M, Li K, Hubbart C, Reiner Z, Abraha A, Neil HA, Dedoussis G, Humphries SE.

Ann Clin Biochem. 2009 Oct 16. [Epub ahead of print]PMID: 19837725 [PubMed - as supplied by publisher]Related articles

C-Reactive Protein Gene Variant and the Human Left Ventricular Growth Response to Exercise: Data from the LARGE Heart Study.

Mann JJ, Payne1 JR, Shah T, Pennell DJ, Humphries SE, Montgomery HE.

J Cardiovasc Pharmacol. 2009 Oct 9. [Epub ahead of print]PMID: 19834334 [PubMed - as supplied by publisher]Related articles

Realising the potential of the family history in risk assessment and primary prevention of coronary heart disease in primary care: ADDFAM study protocol.

Qureshi N, Armstrong S, Saukko P, Sach T, Middlemass J, Evans PH, Kai J, Farrimond H, Humphries SE.

BMC Health Serv Res. 2009 Oct 12;9:184.PMID: 19821989 [PubMed - in process]Related articlesFree article

Healthy Individuals Carrying the PCSK9 p.R46L Variant and Familial Hypercholesterolemia Patients Carrying PCSK9 p.D374Y Exhibit Lower Plasma Concentrations of PCSK9.

Humphries SE, Neely RD, Whittall RA, Troutt JS, Konrad RJ, Scartezini M, Li KW, Cooper JA, Acharya J, Neil A.

Clin Chem. 2009 Oct 1. [Epub ahead of print]PMID: 19797716 [PubMed - as supplied by publisher]Related articles

Identification and management of familial hypercholesterolaemia: what does it mean to primary care?

Qureshi N, Humphries SE, Seed M, Rowlands P, Minhas R; NICE Guideline Development Group.

Br J Gen Pract. 2009 Oct;59(567):773-6.PMID: 19765358 [PubMed - in process]Related articles

FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men.

Ireland HA, Cooper JA, Drenos F, Acharya J, Mitchell JP, Bauer KA, Morrissey JH, Esnouf MP, Humphries SE.

Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1968-74. Epub 2009 Aug 20.PMID: 19696402 [PubMed - in process]Related articles

Multiplex ligation-dependent probe amplification analysis to screen for deletions and duplications of the LDLR gene in patients with familial hypercholesterolaemia.

Taylor A, Martin B, Wang D, Patel K, Humphries SE, Norbury G.

Clin Genet. 2009 Jul;76(1):69-75. Epub 2009 Jun 16.PMID: 19538517 [PubMed - indexed for MEDLINE]Related articles

APOE, CETP and LPL genes show strong association with lipid levels in Greek children.

Smart MC, Dedoussis G, Louizou E, Yannakoulia M, Drenos F, Papoutsakis C, Maniatis N, Humphries SE, Talmud PJ.

Nutr Metab Cardiovasc Dis. 2009 Apr 28. [Epub ahead of print]PMID: 19403283 [PubMed - as supplied by publisher]Related articles

Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

Drenos F, Talmud PJ, Casas JP, Smeeth L, Palmen J, Humphries SE, Hingorani AD.

Hum Mol Genet. 2009 Jun 15;18(12):2305-16. Epub 2009 Mar 31.PMID: 19336475 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus.

Prior SL, Gable DR, Cooper JA, Bain SC, Hurel SJ, Humphries SE, Stephens JW.

Eur Heart J. 2009 May;30(10):1263-9. Epub 2009 Mar 26.PMID: 19324915 [PubMed - in process]Related articles

Increased C-reactive protein levels in overweight and obese women taking exogenous hormones: the United Kingdom Women's Heart Study (UKWHS).

Kwok S, Canoy D, Ashton WD, Lowe GD, Wood D, Humphries SE, Charlton-Menys V, Durrington PN.

Clin Endocrinol (Oxf). 2009 Nov;71(5):727-32. Epub 2009 Mar 6.PMID: 19320647 [PubMed - in process]Related articles

Commentary PCSK9 variants: A new database.

Leigh SE, Leren TP, Humphries SE.

Atherosclerosis. 2009 Mar;203(1):32-3. No abstract available. PMID: 19249440 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts.

Kotronen A, Yki-Järvinen H, Aminoff A, Bergholm R, Pietiläinen KH, Westerbacka J, Talmud PJ, Humphries SE, Hamsten A, Isomaa B, Groop L, Orho-Melander M, Ehrenborg E, Fisher RM.

Eur J Endocrinol. 2009 Apr;160(4):593-602. Epub 2009 Feb 10.PMID: 19208777 [PubMed - indexed for MEDLINE]Related articles

Controversies in familial hypercholesterolaemia: recommendations of the NICE Guideline Development Group for the identification and management of familial hypercholesterolaemia.

Minhas R, Humphries SE, Qureshi N, Neil HA; NICE Guideline Development Group.

Heart. 2009 Apr;95(7):584-7; discussion 587-91. Epub 2009 Jan 23. No abstract available. PMID: 19168470 [PubMed - indexed for MEDLINE]Related articles

Statins and familial hypercholesterolaemia.

Neil A, Humphries SE.

BMJ. 2009 Jan 21;338:a3041. doi: 10.1136/bmj.a3041. No abstract available. PMID: 19158168 [PubMed - indexed for MEDLINE]Related articles

C-reactive protein and coronary heart disease: predictive test or therapeutic target?

Hingorani AD, Shah T, Casas JP, Humphries SE, Talmud PJ.

Clin Chem. 2009 Feb;55(2):239-55. Epub 2008 Dec 29. Review.PMID: 19114670 [PubMed - indexed for MEDLINE]Related articles

Association between periodontitis and common variants in the promoter of the interleukin-6 gene.

Nibali L, D'Aiuto F, Donos N, Griffiths GS, Parkar M, Tonetti MS, Humphries SE, Brett PM.

Cytokine. 2009 Jan;45(1):50-4. Epub 2008 Dec 11.PMID: 19084430 [PubMed - indexed for MEDLINE]Related articles

Awareness of lifestyle risk factors for cancer and heart disease among adults in the UK.

Sanderson SC, Waller J, Jarvis MJ, Humphries SE, Wardle J.

Patient Educ Couns. 2009 Feb;74(2):221-7. Epub 2008 Dec 6.PMID: 19059747 [PubMed - indexed for MEDLINE]Related articles

Characterization of DNA-binding proteins using multiplexed competitor EMSA.

Smith AJ, Humphries SE.

J Mol Biol. 2009 Jan 23;385(3):714-7. Epub 2008 Nov 27.PMID: 19059416 [PubMed - indexed for MEDLINE]Related articles

Cytokine and cytokine receptor gene polymorphisms and their functionality.

Smith AJ, Humphries SE.

Cytokine Growth Factor Rev. 2009 Feb;20(1):43-59. Epub 2008 Nov 28. Review.PMID: 19038572 [PubMed - indexed for MEDLINE]Related articles

Family tracing to identify patients with familial hypercholesterolaemia: the second audit of the Department of Health Familial Hypercholesterolaemia Cascade Testing Project.

Hadfield SG, Horara S, Starr BJ, Yazdgerdi S, Marks D, Bhatnagar D, Cramb R, Egan S, Everdell R, Ferns G, Jones A, Marenah CB, Marples J, Prinsloo P, Sneyd A, Stewart MF, Sandle L, Wang T, Watson MS, Humphries SE; Steering Group for the Department of Health Familial Hypercholesterolaemia Cascade Testing Audit Project.

Ann Clin Biochem. 2009 Jan;46(Pt 1):24-32. Epub 2008 Nov 21.PMID: 19028807 [PubMed - indexed for MEDLINE]Related articles

Association between IL6 gene variants -174G>C and -572G>C and serum IL-6 levels: interactions with social position in the Whitehall II cohort.

Sanderson SC, Kumari M, Brunner EJ, Miller MA, Rumley A, Lowe GD, Marmot MG, Humphries SE.

Atherosclerosis. 2009 Jun;204(2):459-64. Epub 2008 Sep 27.PMID: 19019369 [PubMed - indexed for MEDLINE]Related articles

ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.

Talmud PJ, Smart M, Presswood E, Cooper JA, Nicaud V, Drenos F, Palmen J, Marmot MG, Boekholdt SM, Wareham NJ, Khaw KT, Kumari M, Humphries SE; EARSII Consortium; HIFMECH Consortium.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2319-25. Epub 2008 Oct 30.PMID: 18974381 [PubMed - indexed for MEDLINE]Related articles

Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts.

Shah T, Casas JP, Cooper JA, Tzoulaki I, Sofat R, McCormack V, Smeeth L, Deanfield JE, Lowe GD, Rumley A, Fowkes FG, Humphries SE, Hingorani AD.

Int J Epidemiol. 2009 Feb;38(1):217-31. Epub 2008 Oct 17. Review. Erratum in: Int J Epidemiol. 2009 Jun;38(3):890. PMID: 18930961 [PubMed - indexed for MEDLINE]Related articles

Higher IL-6 levels but not IL6 -174G>C or -572G>C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery.

Sanders J, Hawe E, Brull DJ, Hubbart C, Lowe GD, Rumley A, Humphries SE, Montgomery HE.

Atherosclerosis. 2009 May;204(1):196-201. Epub 2008 Sep 4.PMID: 18922529 [PubMed - indexed for MEDLINE]Related articles

Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion.

Thompson AR, Golledge J, Cooper JA, Hafez H, Norman PE, Humphries SE.

Eur J Hum Genet. 2009 Mar;17(3):391-4. Epub 2008 Oct 15.PMID: 18854858 [PubMed - indexed for MEDLINE]Related articles

CETP TaqIB polymorphism in Turkish adults: association with dyslipidemia and metabolic syndrome.

Ozsait B, Kömürcü Bayrak E, Poda M, Can G, Hergenç G, Onat A, Humphries SE, Erginel Unaltuna N.

Anadolu Kardiyol Derg. 2008 Oct;8(5):324-30.PMID: 18849221 [PubMed - indexed for MEDLINE]Related articlesFree article

Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study.

Neil A, Cooper J, Betteridge J, Capps N, McDowell I, Durrington P, Seed M, Humphries SE.

Eur Heart J. 2008 Nov;29(21):2625-33. Epub 2008 Oct 7.PMID: 18840879 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children.

Plunkett A, Agbeko RS, Li K, Humphries SE, Klein NJ, Peters MJ.

Intensive Care Med. 2008 Dec;34(12):2279-83. Epub 2008 Sep 12.PMID: 18787808 [PubMed - indexed for MEDLINE]Related articles

Familial hypercholesterolaemia: summary of NICE guidance.

Wierzbicki AS, Humphries SE, Minhas R; Guideline Development Group.

BMJ. 2008 Aug 27;337:a1095. doi: 10.1136/bmj.a1095. No abstract available. PMID: 18753174 [PubMed - indexed for MEDLINE]Related articles

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.

Huth C, Illig T, Herder C, Gieger C, Grallert H, Vollmert C, Rathmann W, Hamid YH, Pedersen O, Hansen T, Thorand B, Meisinger C, Doring A, Klopp N, Gohlke H, Lieb W, Hengstenberg C, Lyssenko V, Groop L, Ireland H, Stephens JW, Wernstedt Asterholm I, Jansson JO, Boeing H, Mohlig M, Stringham HM, Boehnke M, Tuomilehto J, Fernandez-Real JM, Lopez-Bermejo A, Gallart L, Vendrell J, Humphries SE, Kronenberg F, Wichmann HE, Heid IM.

Ann Med. 2009;41(2):128-38.PMID: 18752089 [PubMed - indexed for MEDLINE]Related articles

Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study.

Kivimäki M, Lawlor DA, Smith GD, Kumari M, Donald A, Britton A, Casas JP, Shah T, Brunner E, Timpson NJ, Halcox JP, Miller MA, Humphries SE, Deanfield J, Marmot MG, Hingorani AD.

PLoS One. 2008 Aug 20;3(8):e3013.PMID: 18714381 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure.

Hosseini-Khalili AR, Thompson J, Kehoe A, Hopkinson NS, Khoshbaten A, Soroush MR, Humphries SE, Montgomery H, Ghanei M.

BMC Pulm Med. 2008 Aug 14;8:15.PMID: 18702808 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiplex MassARRAY spectrometry (iPLEX) produces a fast and economical test for 56 familial hypercholesterolaemia-causing mutations.

Wright WT, Heggarty SV, Young IS, Nicholls DP, Whittall R, Humphries SE, Graham CA.

Clin Genet. 2008 Nov;74(5):463-8. Epub 2008 Aug 12.PMID: 18700895 [PubMed - indexed for MEDLINE]Related articles

Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream.

Brunner EJ, Kivimäki M, Witte DR, Lawlor DA, Davey Smith G, Cooper JA, Miller M, Lowe GD, Rumley A, Casas JP, Shah T, Humphries SE, Hingorani AD, Marmot MG, Timpson NJ, Kumari M.

PLoS Med. 2008 Aug 12;5(8):e155.PMID: 18700811 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.

Dorfmeister B, Zeng WW, Dichlberger A, Nilsson SK, Schaap FG, Hubacek JA, Merkel M, Cooper JA, Lookene A, Putt W, Whittall R, Lee PJ, Lins L, Delsaux N, Nierman M, Kuivenhoven JA, Kastelein JJ, Vrablik M, Olivecrona G, Schneider WJ, Heeren J, Humphries SE, Talmud PJ.

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1866-71. Epub 2008 Jul 17.PMID: 18635818 [PubMed - indexed for MEDLINE]Related articlesFree article

Sex hormone receptor gene variation associated with phenotype in male hypertrophic cardiomyopathy patients.

Lind JM, Chiu C, Ingles J, Yeates L, Humphries SE, Heather AK, Semsarian C.

J Mol Cell Cardiol. 2008 Aug;45(2):217-22. Epub 2008 Jul 9.PMID: 18617186 [PubMed - indexed for MEDLINE]Related articles

What is the clinical utility of DNA testing in patients with familial hypercholesterolaemia?

Humphries SE, Norbury G, Leigh S, Hadfield SG, Nair D.

Curr Opin Lipidol. 2008 Aug;19(4):362-8. Review.PMID: 18607183 [PubMed - indexed for MEDLINE]Related articles

Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing.

Starr B, Hadfield SG, Hutten BA, Lansberg PJ, Leren TP, Damgaard D, Neil HA, Humphries SE.

Clin Chem Lab Med. 2008;46(6):791-803.PMID: 18601600 [PubMed - indexed for MEDLINE]Related articles

Gender-modulated impact of apolipoprotein A5 gene (APOA5) -1131T>C and c.56C>G polymorphisms on lipids, dyslipidemia and metabolic syndrome in Turkish adults.

Komurcu-Bayrak E, Onat A, Poda M, Humphries SE, Palmen J, Guclu F, Can G, Erginel-Unaltuna N.

Clin Chem Lab Med. 2008;46(6):778-84.PMID: 18601598 [PubMed - indexed for MEDLINE]Related articles

Coronary calcium measurement improves prediction of cardiovascular events in asymptomatic patients with type 2 diabetes: the PREDICT study.

Elkeles RS, Godsland IF, Feher MD, Rubens MB, Roughton M, Nugara F, Humphries SE, Richmond W, Flather MD; PREDICT Study Group.

Eur Heart J. 2008 Sep;29(18):2244-51. Epub 2008 Jun 23.PMID: 18573867 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects.

Salpea KD, Gable DR, Cooper JA, Stephens JW, Hurel SJ, Ireland HA, Feher MD, Godsland IF, Humphries SE.

Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):140-5. Epub 2008 Jun 13.PMID: 18555673 [PubMed - indexed for MEDLINE]Related articles

Gene-environment interaction and oxidative stress in cardiovascular disease.

Stephens JW, Bain SC, Humphries SE.

Atherosclerosis. 2008 Oct;200(2):229-38. Epub 2008 Apr 12. Review.PMID: 18490019 [PubMed - indexed for MEDLINE]Related articles

Identifying patients with familial hypercholesterolaemia in primary care.

Humphries SE, Hadfield G.

Heart. 2008 Jun;94(6):695-6. No abstract available. PMID: 18480347 [PubMed - indexed for MEDLINE]Related articles

Psychological and behavioural impact of genetic testing smokers for lung cancer risk: a phase II exploratory trial.

Sanderson SC, Humphries SE, Hubbart C, Hughes E, Jarvis MJ, Wardle J.

J Health Psychol. 2008 May;13(4):481-94.PMID: 18420756 [PubMed - indexed for MEDLINE]Related articles

The association of telomere length with paternal history of premature myocardial infarction in the European Atherosclerosis Research Study II.

Salpea KD, Nicaud V, Tiret L, Talmud PJ, Humphries SE; EARS II group.

J Mol Med. 2008 Jul;86(7):815-24. Epub 2008 Apr 15.PMID: 18414821 [PubMed - indexed for MEDLINE]Related articlesFree article