PubMed

AAV-Mediated Rhodopsin Replacement Provides Therapeutic Benefit in Mice with a Targeted Disruption of the Rhodopsin Gene.

Palfi A, Millington-Ward S, Chadderton N, O'Reilly M, Goldmann T, Humphries MM, Wolfrum U, Humphries P, Kenna PF, Farrar GJ.

Hum Gene Ther. 2009 Oct 13. [Epub ahead of print]PMID: 19824806 [PubMed - as supplied by publisher]Related articles

An experimental platform for systemic drug delivery to the retina.

Campbell M, Nguyen AT, Kiang AS, Tam LC, Gobbo OL, Kerskens C, Ni Dhubhghaill S, Humphries MM, Farrar GJ, Kenna PF, Humphries P.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17817-22. Epub 2009 Oct 12.PMID: 19822744 [PubMed - in process]Related articlesFree article

Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration.

Huber G, Beck SC, Grimm C, Sahaboglu-Tekgoz A, Paquet-Durand F, Wenzel A, Humphries P, Redmond TM, Seeliger M, Fischer MD.

Invest Ophthalmol Vis Sci. 2009 Aug 6. [Epub ahead of print]PMID: 19661229 [PubMed - as supplied by publisher]Related articles

Study of gene targeted mouse models of splicing factor gene Prpf31 implicated in human autosomal dominant retinitis pigmentosa (RP).

Bujakowska KM, Maubaret C, Chakarova CF, Tanimoto N, Beck SC, Fahl E, Humphries MM, Kenna P, Makarov E, Makarova O, Paquet-Durand F, Ekström P, van Veen T, Leveillard T, Humphries P, Seeliger M, Bhattacharya SS.

Invest Ophthalmol Vis Sci. 2009 Jul 2. [Epub ahead of print]PMID: 19578015 [PubMed - as supplied by publisher]Related articles

The discovery of novel calcium sensing receptor negative allosteric modulators.

Balan G, Bauman J, Bhattacharya S, Castrodad M, Healy DR, Herr M, Humphries P, Jennings S, Kalgutkar AS, Kapinos B, Khot V, Lazarra K, Li M, Li Y, Neagu C, Oliver R, Piotrowski DW, Price D, Qi H, Simmons HA, Southers J, Wei L, Zhang Y, Paralkar VM.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3328-32. Epub 2009 Apr 18.PMID: 19442519 [PubMed - indexed for MEDLINE]Related articles

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.

Humphries PS, Benbow JW, Bonin PD, Boyer D, Doran SD, Frisbie RK, Piotrowski DW, Balan G, Bechle BM, Conn EL, Dirico KJ, Oliver RM, Soeller WC, Southers JA, Yang X.

Bioorg Med Chem Lett. 2009 May 1;19(9):2400-3. Epub 2009 Mar 25.PMID: 19346127 [PubMed - indexed for MEDLINE]Related articles

Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.

Humphries PS, Lafontaine JA, Agree CS, Alexander D, Chen P, Do QQ, Li LY, Lunney EA, Rajapakse RJ, Siegel K, Timofeevski SL, Wang T, Wilhite DM.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2099-102. Epub 2009 Mar 13.PMID: 19327989 [PubMed - indexed for MEDLINE]Related articles

Vision tests in the mouse: Functional phenotyping with electroretinography.

Tanimoto N, Muehlfriedel RL, Fischer MD, Fahl E, Humphries P, Biel M, Seeliger MW.

Front Biosci. 2009 Jan 1;14:2730-7.PMID: 19273231 [PubMed - indexed for MEDLINE]Related articles

Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy.

Chadderton N, Millington-Ward S, Palfi A, O'Reilly M, Tuohy G, Humphries MM, Li T, Humphries P, Kenna PF, Farrar GJ.

Mol Ther. 2009 Apr;17(4):593-9. Epub 2009 Jan 27.PMID: 19174761 [PubMed - indexed for MEDLINE]Related articles

A common microRNA signature in mouse models of retinal degeneration.

Loscher CJ, Hokamp K, Wilson JH, Li T, Humphries P, Farrar GJ, Palfi A.

Exp Eye Res. 2008 Dec;87(6):529-34. Epub 2008 Sep 13.PMID: 18834879 [PubMed - indexed for MEDLINE]Related articles

Rod and cone contributions to horizontal cell light responses in the mouse retina.

Trümpler J, Dedek K, Schubert T, de Sevilla Müller LP, Seeliger M, Humphries P, Biel M, Weiler R.

J Neurosci. 2008 Jul 2;28(27):6818-25.PMID: 18596157 [PubMed - indexed for MEDLINE]Related articlesFree article

RNAi-mediated reversible opening of the blood-brain barrier.

Campbell M, Kiang AS, Kenna PF, Kerskens C, Blau C, O'Dwyer L, Tivnan A, Kelly JA, Brankin B, Farrar GJ, Humphries P.

J Gene Med. 2008 Aug;10(8):930-47.PMID: 18509865 [PubMed - indexed for MEDLINE]Related articles

Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).

Tam LC, Kiang AS, Kennan A, Kenna PF, Chadderton N, Ader M, Palfi A, Aherne A, Ayuso C, Campbell M, Reynolds A, McKee A, Humphries MM, Farrar GJ, Humphries P.

Hum Mol Genet. 2008 Jul 15;17(14):2084-100. Epub 2008 Apr 1.PMID: 18385099 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of a quantitative trait locus on mouse chromosome 19 to the light-adapted electroretinogram.

Reynolds AL, Danciger M, Farrar GJ, Humphries P, Kenna PF.

Invest Ophthalmol Vis Sci. 2008 Sep;49(9):4058-63. Epub 2008 Mar 14.PMID: 18344449 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice.

Bartsch U, Oriyakhel W, Kenna PF, Linke S, Richard G, Petrowitz B, Humphries P, Farrar GJ, Ader M.

Exp Eye Res. 2008 Apr;86(4):691-700. Epub 2008 Feb 3.PMID: 18329018 [PubMed - indexed for MEDLINE]Related articles

MRI in the assessment of congenital vaginal anomalies.

Humphries PD, Simpson JC, Creighton SM, Hall-Craggs MA.

Clin Radiol. 2008 Apr;63(4):442-8. Epub 2008 Feb 1.PMID: 18325365 [PubMed - indexed for MEDLINE]Related articles

Ultrastructural morphology of platelets and fibrin networks of lactating and non-pregnant rabbits.

Humphries P, Smit E, Pretorius E.

Anat Histol Embryol. 2008 Aug;37(4):285-8. Epub 2008 Feb 14.PMID: 18279493 [PubMed - indexed for MEDLINE]Related articles

Variation in the electroretinogram of C57BL/6 substrains of mouse.

Reynolds AL, Farrar GJ, Humphries P, Kenna PF.

Adv Exp Med Biol. 2008;613:383-91. No abstract available. PMID: 18188968 [PubMed - indexed for MEDLINE]Related articles

Paediatric CT: the effects of increasing image noise on pulmonary nodule detection.

Punwani S, Zhang J, Davies W, Greenhalgh R, Humphries P.

Pediatr Radiol. 2008 Feb;38(2):192-201. Epub 2007 Dec 8.PMID: 18066542 [PubMed - indexed for MEDLINE]Related articles

Reference gene selection for real-time rtPCR in human epidermal keratinocytes.

Allen D, Winters E, Kenna PF, Humphries P, Farrar GJ.

J Dermatol Sci. 2008 Mar;49(3):217-25. Epub 2007 Dec 3.PMID: 18061409 [PubMed - indexed for MEDLINE]Related articles

Blind ambition: Geoffroy St-Hilaire's theory of everything.

Humphries P.

Endeavour. 2007 Dec;31(4):134-9. Epub 2007 Nov 26.PMID: 18037488 [PubMed - indexed for MEDLINE]Related articles

Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa.

Loscher CJ, Hokamp K, Kenna PF, Ivens AC, Humphries P, Palfi A, Farrar GJ.

Genome Biol. 2007;8(11):R248.PMID: 18034880 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumors in pediatric patients at diffusion-weighted MR imaging: apparent diffusion coefficient and tumor cellularity.

Humphries PD, Sebire NJ, Siegel MJ, Olsen ØE.

Radiology. 2007 Dec;245(3):848-54. Epub 2007 Oct 19.PMID: 17951348 [PubMed - indexed for MEDLINE]Related articlesFree article

A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa.

O'Reilly M, Millington-Ward S, Palfi A, Chadderton N, Cronin T, McNally N, Humphries MM, Humphries P, Kenna PF, Farrar GJ.

Vision Res. 2008 Feb;48(3):386-91. Epub 2007 Oct 24.PMID: 17920651 [PubMed - indexed for MEDLINE]Related articles

Altered expression and interaction of adherens junction proteins in the developing OLM of the Rho(-/-) mouse.

Campbell M, Humphries M, Kenna P, Humphries P, Brankin B.

Exp Eye Res. 2007 Nov;85(5):714-20. Epub 2007 Aug 15.PMID: 17888904 [PubMed - indexed for MEDLINE]Related articles

Direct and indirect cellular effects of aspartame on the brain.

Humphries P, Pretorius E, Naudé H.

Eur J Clin Nutr. 2008 Apr;62(4):451-62. Epub 2007 Aug 8. Review.PMID: 17684524 [PubMed - indexed for MEDLINE]Related articles

Ultrastructural changes to rabbit fibrin and platelets due to aspartame.

Pretorius E, Humphries P.

Ultrastruct Pathol. 2007 Mar-Apr;31(2):77-83.PMID: 17613990 [PubMed - indexed for MEDLINE]Related articles

Comparative ultrastructural analyses of mouse, rabbit, and human platelets and fibrin networks.

Pretorius E, Humphries P, Ekpo OE, Smit E, van der Merwe CF.

Microsc Res Tech. 2007 Sep;70(9):823-7.PMID: 17576129 [PubMed - indexed for MEDLINE]Related articles

RNA interference-mediated suppression and replacement of human rhodopsin in vivo.

O'Reilly M, Palfi A, Chadderton N, Millington-Ward S, Ader M, Cronin T, Tuohy T, Auricchio A, Hildinger M, Tivnan A, McNally N, Humphries MM, Kiang AS, Humphries P, Kenna PF, Farrar GJ.

Am J Hum Genet. 2007 Jul;81(1):127-35. Epub 2007 May 23.PMID: 17564969 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of strategies for conditional RNA interference.

Allen D, Kenna PF, Palfi A, McMahon HP, Millington-Ward S, O'Reilly M, Humphries P, Farrar GJ.

J Gene Med. 2007 Apr;9(4):287-98.PMID: 17397092 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms of photoreceptor degeneration in RP caused by IMPDH1 mutations.

Aherne A, Kennan A, Kenna PF, McNally N, Farrar GJ, Humphries P.

Adv Exp Med Biol. 2006;572:81-7. No abstract available. PMID: 17249559 [PubMed - indexed for MEDLINE]Related articles

Retinopathy is reduced during experimental diabetes in a mouse model of outer retinal degeneration.

de Gooyer TE, Stevenson KA, Humphries P, Simpson DA, Gardiner TA, Stitt AW.

Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5561-8.PMID: 17122149 [PubMed - indexed for MEDLINE]Related articlesFree article

Rod photoreceptor loss in Rho-/- mice reduces retinal hypoxia and hypoxia-regulated gene expression.

de Gooyer TE, Stevenson KA, Humphries P, Simpson DA, Curtis TM, Gardiner TA, Stitt AW.

Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5553-60.PMID: 17122148 [PubMed - indexed for MEDLINE]Related articlesFree article

ADDP and PS-PPh3: an efficient Mitsunobu protocol for the preparation of pyridine ether PPAR agonists.

Humphries PS, Do QQ, Wilhite DM.

Beilstein J Org Chem. 2006 Oct 31;2:21.PMID: 17076898 [PubMed]Related articlesFree article

Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.

Humphries PS, Almaden JV, Barnum SJ, Carlson TJ, Do QQ, Fraser JD, Hess M, Kim YH, Ogilvie KM, Sun S.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):6116-9. Epub 2006 Sep 18.PMID: 16979341 [PubMed - indexed for MEDLINE]Related articles

Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.

Humphries PS, Bailey S, Almaden JV, Barnum SJ, Carlson TJ, Christie LC, Do QQ, Fraser JD, Hess M, Kellum J, Kim YH, McClellan GA, Ogilvie KM, Simmons BH, Skalitzky D, Sun S, Wilhite D, Zehnder LR.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):6120-3. Epub 2006 Sep 14.PMID: 16973358 [PubMed - indexed for MEDLINE]Related articles

Synaptic plasticity in CNGA3(-/-) mice: cone bipolar cells react on the missing cone input and form ectopic synapses with rods.

Haverkamp S, Michalakis S, Claes E, Seeliger MW, Humphries P, Biel M, Feigenspan A.

J Neurosci. 2006 May 10;26(19):5248-55.PMID: 16687517 [PubMed - indexed for MEDLINE]Related articlesFree article

Atypical abdominal paediatric lymphangiomatosis: diagnosis aided by diffusion-weighted MRI.

Humphries PD, Wynne CS, Sebire NJ, Olsen ØE.

Pediatr Radiol. 2006 Aug;36(8):857-9. Epub 2006 Apr 28.PMID: 16645836 [PubMed - indexed for MEDLINE]Related articles

Aberrant retinal tight junction and adherens junction protein expression in an animal model of autosomal dominant Retinitis pigmentosa: the Rho(-/-) mouse.

Campbell M, Humphries M, Kennan A, Kenna P, Humphries P, Brankin B.

Exp Eye Res. 2006 Sep;83(3):484-92. Epub 2006 Apr 27.PMID: 16643895 [PubMed - indexed for MEDLINE]Related articles

RNAi-based suppression and replacement of rds-peripherin in retinal organotypic culture.

Palfi A, Ader M, Kiang AS, Millington-Ward S, Clark G, O'Reilly M, McMahon HP, Kenna PF, Humphries P, Farrar GJ.

Hum Mutat. 2006 Mar;27(3):260-8.PMID: 16419083 [PubMed - indexed for MEDLINE]Related articles

Cone opsin mislocalization in Rpe65-/- mice: a defect that can be corrected by 11-cis retinal.

Rohrer B, Lohr HR, Humphries P, Redmond TM, Seeliger MW, Crouch RK.

Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3876-82.PMID: 16186377 [PubMed - indexed for MEDLINE]Related articlesFree article

Where Canadian family physicians learn procedural skills.

Crutcher RA, Szafran O, Woloschuk W, Chaytors RG, Topps DA, Humphries PW, Norton PG.

Fam Med. 2005 Jul-Aug;37(7):491-5.PMID: 15988634 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward a gene therapy for dominant disease: validation of an RNA interference-based mutation-independent approach.

Kiang AS, Palfi A, Ader M, Kenna PF, Millington-Ward S, Clark G, Kennan A, O'reilly M, Tam LC, Aherne A, McNally N, Humphries P, Farrar GJ.

Mol Ther. 2005 Sep;12(3):555-61.PMID: 15967729 [PubMed - indexed for MEDLINE]Related articles

Residual photosensitivity in mice lacking both rod opsin and cone photoreceptor cyclic nucleotide gated channel 3 alpha subunit.

Barnard AR, Appleford JM, Sekaran S, Chinthapalli K, Jenkins A, Seeliger M, Biel M, Humphries P, Douglas RH, Wenzel A, Foster RG, Hankins MW, Lucas RJ.

Vis Neurosci. 2004 Sep-Oct;21(5):675-83.PMID: 15683556 [PubMed - indexed for MEDLINE]Related articles

Light in retinitis pigmentosa.

Kennan A, Aherne A, Humphries P.

Trends Genet. 2005 Feb;21(2):103-10. Review.PMID: 15661356 [PubMed - indexed for MEDLINE]Related articles

Grating acuity at different luminances in wild-type mice and in mice lacking rod or cone function.

Schmucker C, Seeliger M, Humphries P, Biel M, Schaeffel F.

Invest Ophthalmol Vis Sci. 2005 Jan;46(1):398-407.PMID: 15623801 [PubMed - indexed for MEDLINE]Related articlesFree article

RNAi of COL1A1 in mesenchymal progenitor cells.

Millington-Ward S, McMahon HP, Allen D, Tuohy G, Kiang AS, Palfi A, Kenna PF, Humphries P, Farrar GJ.

Eur J Hum Genet. 2004 Oct;12(10):864-6.PMID: 15241481 [PubMed - indexed for MEDLINE]Related articlesFree article

On the role of IMPDH1 in retinal degeneration.

Kennan A, Aherne A, Bowne SJ, Daiger SP, Farrar GJ, Kenna PF, Humphries P.

Adv Exp Med Biol. 2003;533:13-8. No abstract available. PMID: 15180242 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the RP1 and RP10 (IMPDH1) genes causing autosomal dominant RP.

Daiger SP, Sullivan LS, Bowne SJ, Kennan A, Humphries P, Birch DG, Heckenlively JR; RP1 Consortium.

Adv Exp Med Biol. 2003;533:1-11. Review. No abstract available. PMID: 15180241 [PubMed - indexed for MEDLINE]Related articlesFree article

Morphological characterization of the retina of the CNGA3(-/-)Rho(-/-) mutant mouse lacking functional cones and rods.

Claes E, Seeliger M, Michalakis S, Biel M, Humphries P, Haverkamp S.

Invest Ophthalmol Vis Sci. 2004 Jun;45(6):2039-48.PMID: 15161873 [PubMed - indexed for MEDLINE]Related articlesFree article