PubMed

Response to vicriviroc in treatment-experienced subjects, as determined by an enhanced-sensitivity coreceptor tropism assay: reanalysis of AIDS clinical trials group A5211.

Su Z, Gulick RM, Krambrink A, Coakley E, Hughes MD, Han D, Flexner C, Wilkin TJ, Skolnik PR, Greaves WL, Kuritzkes DR, Reeves JD; AIDS Clinical Trials Group A5211 Team.

J Infect Dis. 2009 Dec 1;200(11):1724-8.PMID: 19874179 [PubMed - in process]Related articles

Randomized controlled trial of feeding a concentrated formula to infants born to women infected by human immunodeficiency virus.

Winter HS, Oleske JM, Hughes MD, McKinney RE Jr, Elgie C, Powell C, Purdue L, Puga AM, Jimenez E, Scott GB, Cruz ML, Moye J Jr; Pediatric AIDS Clinical Trials Group Protocol 247 Study Team.

J Pediatr Gastroenterol Nutr. 2009 Aug;49(2):222-32.PMID: 19543114 [PubMed - indexed for MEDLINE]Related articles

Assessing human immunodeficiency virus type 1 tropism: Comparison of assays using replication-competent virus versus plasma-derived pseudotyped virions.

Hosoya N, Su Z, Wilkin T, Gulick RM, Flexner C, Hughes MD, Skolnik PR, Giguel F, Greaves WL, Coakley E, Kuritzkes DR.

J Clin Microbiol. 2009 Aug;47(8):2604-6. Epub 2009 Jun 3.PMID: 19494074 [PubMed - indexed for MEDLINE]Related articles

Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo.

Tsibris AM, Korber B, Arnaout R, Russ C, Lo CC, Leitner T, Gaschen B, Theiler J, Paredes R, Su Z, Hughes MD, Gulick RM, Greaves W, Coakley E, Flexner C, Nusbaum C, Kuritzkes DR.

PLoS One. 2009 May 25;4(5):e5683.PMID: 19479085 [PubMed - indexed for MEDLINE]Related articlesFree article

Optical fibre-based detection of DNA hybridization.

Hine AV, Chen X, Hughes MD, Zhou K, Davies E, Sugden K, Bennion I, Zhang L.

Biochem Soc Trans. 2009 Apr;37(Pt 2):445-9. Review.PMID: 19290879 [PubMed - indexed for MEDLINE]Related articles

Safety and efficacy of nevirapine- and efavirenz-based antiretroviral treatment in adults treated for TB-HIV co-infection in Botswana.

Shipton LK, Wester CW, Stock S, Ndwapi N, Gaolathe T, Thior I, Avalos A, Moffat HJ, Mboya JJ, Widenfelt E, Essex M, Hughes MD, Shapiro RL.

Int J Tuberc Lung Dis. 2009 Mar;13(3):360-6.PMID: 19275797 [PubMed - indexed for MEDLINE]Related articlesFree article

Early initiation of lopinavir/ritonavir in infants less than 6 weeks of age: pharmacokinetics and 24-week safety and efficacy.

Chadwick EG, Pinto J, Yogev R, Alvero CG, Hughes MD, Palumbo P, Robbins B, Hazra R, Serchuck L, Heckman BE, Purdue L, Browning R, Luzuriaga K, Rodman J, Capparelli E; International Maternal Pediatric Adolescent Clinical Trials Group (IMPAACT) P1030 Team.

Pediatr Infect Dis J. 2009 Mar;28(3):215-9.PMID: 19209098 [PubMed - indexed for MEDLINE]Related articles

Lymphoma diagnosis and plasma Epstein-Barr virus load during vicriviroc therapy: results of the AIDS Clinical Trials Group A5211.

Tsibris AM, Paredes R, Chadburn A, Su Z, Henrich TJ, Krambrink A, Hughes MD, Aberg JA, Currier JS, Tashima K, Godfrey C, Greaves W, Flexner C, Skolnik PR, Wilkin TJ, Gulick RM, Kuritzkes DR.

Clin Infect Dis. 2009 Mar 1;48(5):642-9.PMID: 19191652 [PubMed - indexed for MEDLINE]Related articlesFree article

The holistic way: John Wesley's practical piety as a resource for integrated healthcare.

Hughes MD.

J Relig Health. 2008 Jun;47(2):237-52. Epub 2007 Sep 25.PMID: 19105014 [PubMed - indexed for MEDLINE]Related articles

Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals.

Singh KK, Hughes MD, Chen J, Phiri K, Rousseau C, Kuhn L, Coutsoudis A, Jackson JB, Guay LA, Musoke P, Mmiro F, Semba RD, Spector SA.

J Acquir Immune Defic Syndr. 2008 Nov 1;49(3):259-65.PMID: 18845960 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor-1 and lean body mass in HIV-infected children.

Chantry CJ, Hughes MD, Alvero C, Cervia JS, Hodge J, Borum P, Moye J Jr; PACTG 1010 Team.

J Acquir Immune Defic Syndr. 2008 Aug 1;48(4):437-43.PMID: 18614924 [PubMed - indexed for MEDLINE]Related articles

Magnetic resonance imaging as a surrogate outcome for multiple sclerosis relapses.

Petkau J, Reingold SC, Held U, Cutter GR, Fleming TR, Hughes MD, Miller DH, McFarland HF, Wolinsky JS.

Mult Scler. 2008 Jul;14(6):770-8. Epub 2008 Jun 5.PMID: 18535021 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid and glucose alterations in HIV-infected children beginning or changing antiretroviral therapy.

Chantry CJ, Hughes MD, Alvero C, Cervia JS, Meyer WA 3rd, Hodge J, Borum P, Moye J Jr; PACTG 1010 Team.

Pediatrics. 2008 Jul;122(1):e129-38. Epub 2008 Jun 2.PMID: 18519448 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetics and safety of nelfinavir when used in combination with zidovudine and lamivudine in HIV-infected pregnant women: Pediatric AIDS Clinical Trials Group (PACTG) Protocol 353.

Bryson YJ, Mirochnick M, Stek A, Mofenson LM, Connor J, Capparelli E, Watts DH, Huang S, Hughes MD, Kaiser K, Purdue L, Asfaw Y, Keller M, Smith E; PACTG 353 Team.

HIV Clin Trials. 2008 Mar-Apr;9(2):115-25.PMID: 18474496 [PubMed - indexed for MEDLINE]Related articlesFree article

The search for data on when to start treatment for HIV infection.

Hughes MD, Ribaudo HR.

J Infect Dis. 2008 Apr 15;197(8):1084-6. No abstract available. PMID: 18462158 [PubMed - indexed for MEDLINE]Related articles

Practical issues arising in an exploratory analysis evaluating progression-free survival as a surrogate endpoint for overall survival in advanced colorectal cancer.

Hughes MD.

Stat Methods Med Res. 2008 Oct;17(5):487-95. Epub 2008 Feb 19.PMID: 18285440 [PubMed - indexed for MEDLINE]Related articles

A statistical framework for quantile equivalence clinical trials with application to pharmacokinetic studies that bridge from HIV-infected adults to children.

Pei L, Hughes MD.

Biometrics. 2008 Dec;64(4):1117-25. Epub 2008 Feb 7.PMID: 18261161 [PubMed - indexed for MEDLINE]Related articles

Long-term observation of adolescents initiating HAART therapy: three-year follow-up.

Flynn PM, Rudy BJ, Lindsey JC, Douglas SD, Lathey J, Spector SA, Martinez J, Silio M, Belzer M, Friedman L, D'Angelo L, Smith E, Hodge J, Hughes MD; PACTG 381 Study Team.

AIDS Res Hum Retroviruses. 2007 Oct;23(10):1208-14.PMID: 17961106 [PubMed - indexed for MEDLINE]Related articles

A prospective, randomized trial of clear liquids versus low-fat solid diet as the initial meal in mild acute pancreatitis.

Jacobson BC, Vander Vliet MB, Hughes MD, Maurer R, McManus K, Banks PA.

Clin Gastroenterol Hepatol. 2007 Aug;5(8):946-51; quiz 886. Epub 2007 Jul 5.PMID: 17613280 [PubMed - indexed for MEDLINE]Related articlesFree article

HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation.

Hughes MD, Kapllani E, Alexander AE, Burk RD, Schoenfeld AR.

Cancer Cell Int. 2007 Jun 28;7:13.PMID: 17598890 [PubMed]Related articlesFree article

Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211.

Gulick RM, Su Z, Flexner C, Hughes MD, Skolnik PR, Wilkin TJ, Gross R, Krambrink A, Coakley E, Greaves WL, Zolopa A, Reichman R, Godfrey C, Hirsch M, Kuritzkes DR; AIDS Clinical Trials Group 5211 Team.

J Infect Dis. 2007 Jul 15;196(2):304-12. Epub 2007 Jun 5.PMID: 17570119 [PubMed - indexed for MEDLINE]Related articles

Challenges in using observational studies to evaluate adverse effects of treatment.

Hughes MD, Williams PL.

N Engl J Med. 2007 Apr 26;356(17):1705-7. No abstract available. PMID: 17460224 [PubMed - indexed for MEDLINE]Related articles

In utero nucleoside reverse transcriptase inhibitor exposure and signs of possible mitochondrial dysfunction in HIV-uninfected children.

Brogly SB, Ylitalo N, Mofenson LM, Oleske J, Van Dyke R, Crain MJ, Abzug MJ, Brady M, Jean-Philippe P, Hughes MD, Seage GR 3rd.

AIDS. 2007 May 11;21(8):929-38.PMID: 17457086 [PubMed - indexed for MEDLINE]Related articles

Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants.

Zorrilla CD, Van Dyke R, Bardeguez A, Acosta EP, Smith B, Hughes MD, Huang S, Watts DH, Heckman B, Jiménez E, McSherry G, Mofenson L.

Antimicrob Agents Chemother. 2007 Jun;51(6):2208-10. Epub 2007 Apr 9.PMID: 17420209 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurodevelopmental functioning in HIV-infected infants and young children before and after the introduction of protease inhibitor-based highly active antiretroviral therapy.

Lindsey JC, Malee KM, Brouwers P, Hughes MD; PACTG 219C Study Team.

Pediatrics. 2007 Mar;119(3):e681-93. Epub 2007 Feb 12.PMID: 17296781 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetics and safety of indinavir in human immunodeficiency virus-infected pregnant women.

Unadkat JD, Wara DW, Hughes MD, Mathias AA, Holland DT, Paul ME, Connor J, Huang S, Nguyen BY, Watts DH, Mofenson LM, Smith E, Deutsch P, Kaiser KA, Tuomala RE.

Antimicrob Agents Chemother. 2007 Feb;51(2):783-6. Epub 2006 Dec 11.PMID: 17158945 [PubMed - indexed for MEDLINE]Related articlesFree article

A platform for both solid-phase peptide nucleic acid oligomer synthesis and subsequent in situ detection and quantification of nucleic acid sequences.

McCairn MC, Hughes MD, Hine AV, Sutherland AJ.

J Comb Chem. 2006 Sep-Oct;8(5):639-42. No abstract available. PMID: 16961397 [PubMed - indexed for MEDLINE]Related articles

Initial treatment of HIV infection: randomized trials with clinical end points are still needed.

Hughes MD.

J Infect Dis. 2006 Sep 1;194(5):542-4. Epub 2006 Jul 31. No abstract available. PMID: 16897649 [PubMed - indexed for MEDLINE]Related articles

Risk factors for opportunistic illnesses in children with human immunodeficiency virus in the era of highly active antiretroviral therapy.

Ylitalo N, Brogly S, Hughes MD, Nachman S, Dankner W, Van Dyke R, Seage GR 3rd; Pediatric AIDS Clincial Trials Group Protocol 219C Team.

Arch Pediatr Adolesc Med. 2006 Aug;160(8):778-87.PMID: 16894075 [PubMed - indexed for MEDLINE]Related articlesFree article

Sexual behavior, psychosocial and knowledge differences between consistent, inconsistent and non-users of condoms: a study of female bar and hotel workers in Moshi, Tanzania.

Tassiopoulos KK, Seage GR 3rd, Sam NE, Ao TT, Masenga EJ, Hughes MD, Kapiga SH.

AIDS Behav. 2006 Jul;10(4):405-13.PMID: 16752083 [PubMed - indexed for MEDLINE]Related articles

Accelerated wound healing: multidisciplinary advances in the care of venous leg ulcers.

Bongiovanni CM, Hughes MD, Bomengen RW.

Angiology. 2006 Mar-Apr;57(2):139-44.PMID: 16518520 [PubMed - indexed for MEDLINE]Related articles

Quality of life for children and adolescents: impact of HIV infection and antiretroviral treatment.

Lee GM, Gortmaker SL, McIntosh K, Hughes MD, Oleske JM; Pediatric AIDS Clinical Trials Group Protocol 219C Team.

Pediatrics. 2006 Feb;117(2):273-83.PMID: 16452344 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of MCP-1-2518-G allele on the HIV-1 disease of children in the United States.

Singh KK, Hughes MD, Chen J, Spector SA.

AIDS. 2006 Feb 14;20(3):475-8. No abstract available. PMID: 16439891 [PubMed - indexed for MEDLINE]Related articles

The role of social networks and support in postpartum women's depression: a multiethnic urban sample.

Surkan PJ, Peterson KE, Hughes MD, Gottlieb BR.

Matern Child Health J. 2006 Jul;10(4):375-83.PMID: 16404681 [PubMed - indexed for MEDLINE]Related articles

Solid-phase PNA synthesis and in situ scintillation proximity assay for the detection of PNA-DNA hybridization.

McCairn MC, Hughes MD, Hine AV, Sutherland AJ.

J Comb Chem. 2006 Jan-Feb;8(1):1-3. No abstract available. PMID: 16398544 [PubMed - indexed for MEDLINE]Related articles

A sequential design to estimate sensitivity and specificity of a diagnostic or screening test.

Wruck LM, Yiannoutsos CT, Hughes MD.

Stat Med. 2006 Oct 30;25(20):3458-73.PMID: 16374904 [PubMed - indexed for MEDLINE]Related articles

Tunable gold catalysts for selective hydrocarbon oxidation under mild conditions.

Hughes MD, Xu YJ, Jenkins P, McMorn P, Landon P, Enache DI, Carley AF, Attard GA, Hutchings GJ, King F, Stitt EH, Johnston P, Griffin K, Kiely CJ.

Nature. 2005 Oct 20;437(7062):1132-5.PMID: 16237439 [PubMed]Related articles

Splanchnic and peripheral vascular resistance during lower body negative pressure (LBNP) and tilt.

Hughson RL, Shoemaker JK, Arbeille P, O'Leary DD, Pizzolitto KS, Hughes MD.

J Gravit Physiol. 2004 Jul;11(2):P95-6.PMID: 16235431 [PubMed - indexed for MEDLINE]Related articles

Efficacy, tolerability and pharmacokinetics of two nelfinavir-based regimens in human immunodeficiency virus-infected children and adolescents: pediatric AIDS clinical trials group protocol 403.

King JR, Nachman S, Yogev R, Hodge J, Aldrovandi G, Hughes MD, Chen J, Wiznia A, Damle B, Acosta EP.

Pediatr Infect Dis J. 2005 Oct;24(10):880-5.PMID: 16220085 [PubMed - indexed for MEDLINE]Related articles

Genetic polymorphisms in CX3CR1 predict HIV-1 disease progression in children independently of CD4+ lymphocyte count and HIV-1 RNA load.

Singh KK, Hughes MD, Chen J, Spector SA.

J Infect Dis. 2005 Jun 1;191(11):1971-80. Epub 2005 Apr 28.PMID: 15871132 [PubMed - indexed for MEDLINE]Related articles

Discovery of active proteins directly from combinatorial randomized protein libraries without display, purification or sequencing: identification of novel zinc finger proteins.

Hughes MD, Zhang ZR, Sutherland AJ, Santos AF, Hine AV.

Nucleic Acids Res. 2005 Feb 18;33(3):e32.PMID: 15722478 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple sclerosis and pregnancy.

Hughes MD.

Neurol Clin. 2004 Nov;22(4):757-69. Review.PMID: 15474765 [PubMed - indexed for MEDLINE]Related articles

Virologic and immunologic outcomes after 24 weeks in HIV type 1-infected adolescents receiving highly active antiretroviral therapy.

Flynn PM, Rudy BJ, Douglas SD, Lathey J, Spector SA, Martinez J, Silio M, Belzer M, Friedman L, D'Angelo L, McNamara J, Hodge J, Hughes MD, Lindsey JC; Pediatric AIDS Clinical Trial Group 381 Study Team.

J Infect Dis. 2004 Jul 15;190(2):271-9. Epub 2004 Jun 18.PMID: 15216461 [PubMed - indexed for MEDLINE]Related articles

Psychiatric hospitalizations among children and youths with human immunodeficiency virus infection.

Gaughan DM, Hughes MD, Oleske JM, Malee K, Gore CA, Nachman S; Pediatric AIDS Clinical Trials Group 219C Team.

Pediatrics. 2004 Jun;113(6):e544-51.PMID: 15173535 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence of chemokine and chemokine receptor polymorphisms in seroprevalent children with symptomatic HIV-1 infection in the United States.

Singh KK, Barroga CF, Hughes MD, Chen J, Raskino C, McKinney RE Jr, Spector SA.

J Acquir Immune Defic Syndr. 2004 Mar 1;35(3):309-13.PMID: 15076247 [PubMed - indexed for MEDLINE]Related articles

Relationship of plasma HIV-1 RNA dynamics to baseline factors and virological responses to highly active antiretroviral therapy in adolescents (aged 12-22 years) infected through high-risk behavior.

Wu H, Lathey J, Ruan P, Douglas SD, Spector SA, Lindsey J, Hughes MD, Rudy BJ, Flynn PM; PACTG 381 Team.

J Infect Dis. 2004 Feb 15;189(4):593-601. Epub 2004 Jan 29.PMID: 14767811 [PubMed - indexed for MEDLINE]Related articles

Lack of protective effects of interleukin-4 -589-C/T polymorphism against HIV-1-related disease progression and central nervous system impairment, in children.

Singh KK, Hughes MD, Chen J, Spector SA.

J Infect Dis. 2004 Feb 15;189(4):587-92. Epub 2004 Jan 29.PMID: 14767810 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics of saquinavir plus low-dose ritonavir in human immunodeficiency virus-infected pregnant women.

Acosta EP, Bardeguez A, Zorrilla CD, Van Dyke R, Hughes MD, Huang S, Pompeo L, Stek AM, Pitt J, Watts DH, Smith E, Jiménez E, Mofenson L; Pediatric AIDS Clinical Trials Group 386 Protocol Team,.

Antimicrob Agents Chemother. 2004 Feb;48(2):430-6.PMID: 14742191 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term effects of protease-inhibitor-based combination therapy on CD4 T-cell recovery in HIV-1-infected children and adolescents.

Soh CH, Oleske JM, Brady MT, Spector SA, Borkowsky W, Burchett SK, Foca MD, Handelsman E, Jiménez E, Dankner WM, Hughes MD; Pediatric AIDS Clinical Trials Group.

Lancet. 2003 Dec 20;362(9401):2045-51.PMID: 14697803 [PubMed - indexed for MEDLINE]Related articles

Fluorescent microplate-based analysis of protein-DNA interactions. II: Immobilized DNA.

Zhang ZR, Hughes MD, Morgan LJ, Santos AF, Hine AV.

Biotechniques. 2003 Nov;35(5):988-90, 992, 994 passim.PMID: 14628673 [PubMed - indexed for MEDLINE]Related articles