PubMed

A Systematic Review and Empirical Analysis of the Relation Between Dose and Duration of Drug Action.

Hughes DA, Aronson JK.

J Clin Pharmacol. 2009 Oct 1. [Epub ahead of print]PMID: 19797537 [PubMed - as supplied by publisher]Related articles

Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.

Jorgensen AL, Al-Zubiedi S, Zhang JE, Keniry A, Hanson A, Hughes DA, Eker D, Stevens L, Hawkins K, Toh CH, Kamali F, Daly AK, Fitzmaurice D, Coffey A, Williamson PR, Park BK, Deloukas P, Pirmohamed M.

Pharmacogenet Genomics. 2009 Oct;19(10):800-12.PMID: 19752777 [PubMed - in process]Related articles

Vitamin D and respiratory health.

Hughes DA, Norton R.

Clin Exp Immunol. 2009 Oct;158(1):20-5. Review.PMID: 19737226 [PubMed - indexed for MEDLINE]Related articles

Estimating drug costs in economic evaluations in Ireland and the UK: an analysis of practice and research recommendations.

Hughes DA, Tilson L, Drummond M.

Pharmacoeconomics. 2009;27(8):635-43. doi: 10.2165/10899570-000000000-00000. Review.PMID: 19712007 [PubMed - indexed for MEDLINE]Related articles

Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.

Bell DJ, Wootton D, Mukaka M, Montgomery J, Kayange N, Chimpeni P, Hughes DA, Molyneux ME, Ward SA, Winstanley PA, Lalloo DG.

Malar J. 2009 Aug 26;8:204.PMID: 19709418 [PubMed - indexed for MEDLINE]Related articlesFree article

Patients' and healthcare professionals' views of cancer follow-up: systematic review.

Lewis RA, Neal RD, Hendry M, France B, Williams NH, Russell D, Hughes DA, Russell I, Stuart NS, Weller D, Wilkinson C.

Br J Gen Pract. 2009 Jul;59(564):e248-59. Review.PMID: 19566991 [PubMed - indexed for MEDLINE]Related articles

Follow-up of cancer in primary care versus secondary care: systematic review.

Lewis RA, Neal RD, Williams NH, France B, Hendry M, Russell D, Hughes DA, Russell I, Stuart NS, Weller D, Wilkinson C.

Br J Gen Pract. 2009 Jul;59(564):e234-47. Review.PMID: 19566990 [PubMed - indexed for MEDLINE]Related articles

The female Gaucher patient: the impact of enzyme replacement therapy around key reproductive events (menstruation, pregnancy and menopause).

Zimran A, Morris E, Mengel E, Kaplan P, Belmatoug N, Hughes DA, Malinova V, Heitner R, Sobreira E, Mrsić M, Granovsky-Grisaru S, Amato D, vom Dahl S.

Blood Cells Mol Dis. 2009 Nov-Dec;43(3):264-88. Epub 2009 Jun 6.PMID: 19502088 [PubMed - in process]Related articles

Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness.

Hillmer AM, Freudenberg J, Myles S, Herms S, Tang K, Hughes DA, Brockschmidt FF, Ruan Y, Stoneking M, Nöthen MM.

Hum Genet. 2009 Aug;126(2):255-64. Epub 2009 Apr 17.PMID: 19373488 [PubMed - indexed for MEDLINE]Related articles

Gaucher disease and pregnancy.

Mamopoulos AM, Hughes DA, Tuck SM, Mehta AB.

J Obstet Gynaecol. 2009 Apr;29(3):240-2. No abstract available. PMID: 19358035 [PubMed - indexed for MEDLINE]Related articles

A framework for planning and critiquing medication compliance and persistence research using prospective study designs.

Gwadry-Sridhar FH, Manias E, Zhang Y, Roy A, Yu-Isenberg K, Hughes DA, Nichol MB.

Clin Ther. 2009 Feb;31(2):421-35. Review.PMID: 19302915 [PubMed - indexed for MEDLINE]Related articles

Enzyme, substrate, and myeloma in Gaucher disease.

Hughes DA.

Am J Hematol. 2009 Apr;84(4):199-201. No abstract available. PMID: 19291728 [PubMed - indexed for MEDLINE]Related articles

Nurse-led vs. conventional physician-led follow-up for patients with cancer: systematic review.

Lewis R, Neal RD, Williams NH, France B, Wilkinson C, Hendry M, Russell D, Russell I, Hughes DA, Stuart NS, Weller D.

J Adv Nurs. 2009 Apr;65(4):706-23. Review.PMID: 19278415 [PubMed - indexed for MEDLINE]Related articles

To see a world in a grain of sand: elucidating the pathophysiology of Anderson-Fabry disease through investigations of a cellular model.

Pastores GM, Hughes DA.

Kidney Int. 2009 Feb;75(4):351-3.PMID: 19180148 [PubMed - indexed for MEDLINE]Related articles

Patients with Gaucher disease living in England show a high prevalence of vitamin D insufficiency with correlation to osteodensitometry.

Mikosch P, Reed M, Stettner H, Baker R, Mehta AB, Hughes DA.

Mol Genet Metab. 2009 Mar;96(3):113-20. Epub 2009 Jan 14.PMID: 19147383 [PubMed - indexed for MEDLINE]Related articles

Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis.

Hughes DA, Jastroch M, Stoneking M, Klingenspor M.

BMC Evol Biol. 2009 Jan 7;9:4.PMID: 19128480 [PubMed - indexed for MEDLINE]Related articlesFree article

Is there a role for scintigraphic imaging of bone manifestations in Gaucher disease? A review of the literature.

Mikosch P, Kohlfürst S, Gallowitsch HJ, Kresnik E, Lind P, Mehta AB, Hughes DA.

Nuklearmedizin. 2008;47(6):239-47. Review.PMID: 19057797 [PubMed - indexed for MEDLINE]Related articles

Absence of telomere shortening and oxidative DNA damage in the young adult offspring of women with pre-gestational type 1 diabetes.

Cross JA, Brennan C, Gray T, Temple RC, Dozio N, Hughes JC, Levell NJ, Murphy H, Fowler D, Hughes DA, Sampson MJ.

Diabetologia. 2009 Feb;52(2):226-34. Epub 2008 Nov 26.PMID: 19034420 [PubMed - indexed for MEDLINE]Related articles

Increased constraints on MC4R during primate and human evolution.

Hughes DA, Hinney A, Brumm H, Wermter AK, Biebermann H, Hebebrand J, Stoneking M.

Hum Genet. 2009 Jan;124(6):633-47. Epub 2008 Nov 15.PMID: 19011902 [PubMed - indexed for MEDLINE]Related articles

Investigation of dental samples using a 35MHz focussed ultrasound piezocomposite transducer.

Hughes DA, Girkin JM, Poland S, Longbottom C, Button TW, Elgoyhen J, Hughes H, Meggs C, Cochran S.

Ultrasonics. 2009 Feb;49(2):212-8. Epub 2008 Sep 9.PMID: 18930302 [PubMed - indexed for MEDLINE]Related articles

Lack of association of colonic epithelium telomere length and oxidative DNA damage in Type 2 diabetes under good metabolic control.

Kejariwal D, Stepien KM, Smith T, Kennedy H, Hughes DA, Sampson MJ.

BMC Endocr Disord. 2008 Oct 10;8:12.PMID: 18847490 [PubMed - in process]Related articlesFree article

Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta.

Lodi F, Jimenez R, Moreno L, Kroon PA, Needs PW, Hughes DA, Santos-Buelga C, Gonzalez-Paramas A, Cogolludo A, Lopez-Sepulveda R, Duarte J, Perez-Vizcaino F.

Atherosclerosis. 2009 May;204(1):34-9. Epub 2008 Aug 14.PMID: 18801486 [PubMed - indexed for MEDLINE]Related articles

Bone- and bone marrow scintigraphy in Gaucher disease type 1.

Mikosch P, Zitter F, Gallowitsch HJ, Würtz F, Lind P, Mehta AB, Hughes DA.

Nuklearmedizin. 2008;47(4):N39-43. No abstract available. PMID: 18763370 [PubMed - indexed for MEDLINE]Related articles

Natural selection and the molecular basis of electrophoretic variation at the coagulation F13B locus.

Ryan AW, Hughes DA, Tang K, Kelleher DP, Ryan T, McManus R, Stoneking M.

Eur J Hum Genet. 2009 Feb;17(2):219-27. Epub 2008 Aug 20.PMID: 18716611 [PubMed - indexed for MEDLINE]Related articles

Multicentre prospective randomised trial of tacrolimus, azathioprine and prednisolone with or without basiliximab: two-year follow-up data.

Webb NJ, Prokurat S, Vondrak K, Watson AR, Hughes DA, Marks SD, Moghal NE, Fitzpatrick MM, Milford DV, Saleem MA, Jones CA, Friman S, Van Damme-Lombaerts R, Janssen F, Hamer C, Rhodes S.

Pediatr Nephrol. 2009 Jan;24(1):177-82. Epub 2008 Aug 8.PMID: 18688657 [PubMed - indexed for MEDLINE]Related articles

A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro.

Suri S, Taylor MA, Verity A, Tribolo S, Needs PW, Kroon PA, Hughes DA, Wilson VG.

Biochem Pharmacol. 2008 Sep 1;76(5):645-53. Epub 2008 Jul 1.PMID: 18639531 [PubMed - indexed for MEDLINE]Related articles

Changes of bone metabolism in seven patients with Gaucher disease treated consecutively with imiglucerase and miglustat.

Mikosch P, Reed M, Baker R, Holloway B, Berger L, Mehta AB, Hughes DA.

Calcif Tissue Int. 2008 Jul;83(1):43-54. Epub 2008 Jun 14.PMID: 18553043 [PubMed - indexed for MEDLINE]Related articles

Early therapeutic intervention in females with Fabry disease?

Hughes DA.

Acta Paediatr Suppl. 2008 Apr;97(457):41-7. Review.PMID: 18339187 [PubMed - indexed for MEDLINE]Related articles

Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells.

Winterbone MS, Tribolo S, Needs PW, Kroon PA, Hughes DA.

Atherosclerosis. 2009 Feb;202(2):431-8. Epub 2008 May 1.PMID: 18489909 [PubMed - indexed for MEDLINE]Related articles

NHS and charitable funding for children and young people with cancer in England and Wales.

Linck P, Tunnage B, Hughes DA, Edwards RT.

J Child Health Care. 2008 Jun;12(2):156-68.PMID: 18469299 [PubMed - indexed for MEDLINE]Related articles

An ancient look at UCP1.

Klingenspor M, Fromme T, Hughes DA Jr, Manzke L, Polymeropoulos E, Riemann T, Trzcionka M, Hirschberg V, Jastroch M.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):637-41. Epub 2008 Mar 18. Review.PMID: 18396149 [PubMed - indexed for MEDLINE]Related articles

Estimation of the impact of noncompliance on pharmacokinetics: an analysis of the influence of dosing regimens.

Hughes DA.

Br J Clin Pharmacol. 2008 Jun;65(6):871-8. Epub 2008 Apr 1.PMID: 18384445 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of an incremental increase in exercise on appetite, eating behaviour and energy balance in lean men and women feeding ad libitum.

Whybrow S, Hughes DA, Ritz P, Johnstone AM, Horgan GW, King N, Blundell JE, Stubbs RJ.

Br J Nutr. 2008 Nov;100(5):1109-15. Epub 2008 Apr 1.PMID: 18377694 [PubMed - indexed for MEDLINE]Related articles

Home therapy for lysosomal storage disorders.

Hughes DA, Mlilligan A, Mehta A.

Br J Nurs. 2007 Dec 13-2008 Jan 9;16(22):1384, 1386-9. Review.PMID: 18361386 [PubMed - indexed for MEDLINE]Related articles

Parallel selection on TRPV6 in human populations.

Hughes DA, Tang K, Strotmann R, Schöneberg T, Prenen J, Nilius B, Stoneking M.

PLoS One. 2008 Feb 27;3(2):e1686.PMID: 18301763 [PubMed - indexed for MEDLINE]Related articlesFree article

Understanding medication compliance and persistence from an economics perspective.

Elliott RA, Shinogle JA, Peele P, Bhosle M, Hughes DA.

Value Health. 2008 Jul-Aug;11(4):600-10. Epub 2008 Jan 8.PMID: 18194403 [PubMed - indexed for MEDLINE]Related articles

Depression in adults with Fabry disease: a common and under-diagnosed problem.

Cole AL, Lee PJ, Hughes DA, Deegan PB, Waldek S, Lachmann RH.

J Inherit Metab Dis. 2007 Nov;30(6):943-51. Epub 2007 Nov 12.PMID: 17994284 [PubMed - indexed for MEDLINE]Related articles

Intracardiac thrombosis and embolism in patients with cardiac amyloidosis.

Feng D, Edwards WD, Oh JK, Chandrasekaran K, Grogan M, Martinez MW, Syed IS, Hughes DA, Lust JA, Jaffe AS, Gertz MA, Klarich KW.

Circulation. 2007 Nov 20;116(21):2420-6. Epub 2007 Nov 5. Erratum in: Circulation. 2008 Aug 19;118(8):e131. Syed, Imran I [corrected to Syed, Imran S]. PMID: 17984380 [PubMed - indexed for MEDLINE]Related articlesFree article

Warfarin pharmacogenetics: economic considerations.

Hughes DA, Pirmohamed M.

Pharmacoeconomics. 2007;25(11):899-902. No abstract available. PMID: 17960949 [PubMed - indexed for MEDLINE]Related articles

A global survey of antibiotic leftovers in the outpatient setting.

Kardas P, Pechère JC, Hughes DA, Cornaglia G.

Int J Antimicrob Agents. 2007 Dec;30(6):530-6. Epub 2007 Oct 22. Erratum in: Int J Antimicrob Agents. 2008 Feb;31(2):188. PMID: 17933498 [PubMed - indexed for MEDLINE]Related articles

Correlation between finger-prick and venous ciclosporin levels: association with gingival overgrowth and hypertrichosis.

Webb NJ, Coulthard MG, Trompeter RS, Fitzpatrick MM, Stephens S, Dudley J, Maxwell H, Waller S, Smith GC, Watson AR, Hughes DA, Keevil BG, Ellis JS.

Pediatr Nephrol. 2007 Dec;22(12):2111-8. Epub 2007 Sep 26.PMID: 17899211 [PubMed - indexed for MEDLINE]Related articles

Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells.

Tribolo S, Lodi F, Connor C, Suri S, Wilson VG, Taylor MA, Needs PW, Kroon PA, Hughes DA.

Atherosclerosis. 2008 Mar;197(1):50-6. Epub 2007 Sep 18.PMID: 17880982 [PubMed - indexed for MEDLINE]Related articles

Multiple myeloma: causes and consequences of delay in diagnosis.

Kariyawasan CC, Hughes DA, Jayatillake MM, Mehta AB.

QJM. 2007 Oct;100(10):635-40. Epub 2007 Sep 10.PMID: 17846059 [PubMed - indexed for MEDLINE]Related articlesFree article

Reticulated platelets interfere with flow cytometric reticulocyte counts.

Ivory K, Sarria B, Fairweather-Tait SJ, Hughes DA.

Int J Lab Hematol. 2007 Oct;29(5):352-60.PMID: 17824916 [PubMed - indexed for MEDLINE]Related articles

Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors.

Mayor NP, Shaw BE, Hughes DA, Maldonado-Torres H, Madrigal JA, Keshav S, Marsh SG.

J Clin Oncol. 2007 Sep 20;25(27):4262-9. Epub 2007 Aug 27.PMID: 17724347 [PubMed - indexed for MEDLINE]Related articles

Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes.

Worley JR, Hughes DA, Dozio N, Gavrilovic J, Sampson MJ.

Cardiovasc Diabetol. 2007 Aug 22;6:21.PMID: 17714581 [PubMed - indexed for MEDLINE]Related articlesFree article

Feasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire.

Hughes DA.

Qual Life Res. 2007 Oct;16(8):1419-23. Epub 2007 Jul 25.PMID: 17653613 [PubMed - indexed for MEDLINE]Related articles

Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?

Hughes DA, Bayoumi AM, Pirmohamed M.

Clin Pharmacol Ther. 2007 Aug;82(2):123-7.PMID: 17632534 [PubMed - indexed for MEDLINE]Related articles

Fabry disease and the skin: data from FOS, the Fabry outcome survey.

Orteu CH, Jansen T, Lidove O, Jaussaud R, Hughes DA, Pintos-Morell G, Ramaswami U, Parini R, Sunder-Plassman G, Beck M, Mehta AB; FOS Investigators.

Br J Dermatol. 2007 Aug;157(2):331-7. Epub 2007 Jun 15.PMID: 17573884 [PubMed - indexed for MEDLINE]Related articles

Effects of enzyme replacement therapy on the cardiomyopathy of Anderson-Fabry disease: a randomised, double-blind, placebo-controlled clinical trial of agalsidase alfa.

Hughes DA, Elliott PM, Shah J, Zuckerman J, Coghlan G, Brookes J, Mehta AB.

Heart. 2008 Feb;94(2):153-8. Epub 2007 May 4.PMID: 17483124 [PubMed - indexed for MEDLINE]Related articles