PubMed

APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians.

Lahiry P, Cao H, Ban MR, Pollex RL, Mamakeesick M, Zinman B, Harris SB, Hanley AJ, Huff MW, Connelly PW, Hegele RA.

J Lipid Res. 2009 Oct 6. [Epub ahead of print]PMID: 19812053 [PubMed - as supplied by publisher]Related articlesFree article

Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice.

Johnson CL, Weston JY, Chadi SA, Fazio EN, Huff MW, Kharitonenkov A, Köester A, Pin CL.

Gastroenterology. 2009 Nov;137(5):1795-804. Epub 2009 Aug 5.PMID: 19664632 [PubMed - in process]Related articles

A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

Hegele RA, Ban MR, Hsueh N, Kennedy BA, Cao H, Zou GY, Anand S, Yusuf S, Huff MW, Wang J.

Hum Mol Genet. 2009 Nov 1;18(21):4189-94. Epub 2009 Aug 5.PMID: 19656773 [PubMed - in process]Related articlesFree article

Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance.

Mulvihill EE, Allister EM, Sutherland BG, Telford DE, Sawyez CG, Edwards JY, Markle JM, Hegele RA, Huff MW.

Diabetes. 2009 Oct;58(10):2198-210. Epub 2009 Jul 10.PMID: 19592617 [PubMed - indexed for MEDLINE]Related articles

Lipid incorporation inhibits Src-dependent assembly of fibronectin and type I collagen by vascular smooth muscle cells.

Frontini MJ, O'Neil C, Sawyez C, Chan BM, Huff MW, Pickering JG.

Circ Res. 2009 Apr 10;104(7):832-41. Epub 2009 Feb 19.PMID: 19229059 [PubMed - indexed for MEDLINE]Related articles

APOA5 genetic variants are markers for classic hyperlipoproteinemia phenotypes and hypertriglyceridemia.

Wang J, Ban MR, Kennedy BA, Anand S, Yusuf S, Huff MW, Pollex RL, Hegele RA.

Nat Clin Pract Cardiovasc Med. 2008 Nov;5(11):730-7. Epub 2008 Sep 9.PMID: 18779834 [PubMed - indexed for MEDLINE]Related articles

Lipoprotein(a) is associated differentially with carotid stenosis, occlusion, and total plaque area.

Klein JH, Hegele RA, Hackam DG, Koschinsky ML, Huff MW, Spence JD.

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1851-6. Epub 2008 Jul 3.PMID: 18599799 [PubMed - indexed for MEDLINE]Related articlesFree article

Polygenic determinants of severe hypertriglyceridemia.

Wang J, Ban MR, Zou GY, Cao H, Lin T, Kennedy BA, Anand S, Yusuf S, Huff MW, Pollex RL, Hegele RA.

Hum Mol Genet. 2008 Sep 15;17(18):2894-9. Epub 2008 Jul 1.PMID: 18596051 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptor.

Allister EM, Mulvihill EE, Barrett PH, Edwards JY, Carter LP, Huff MW.

J Lipid Res. 2008 Oct;49(10):2218-29. Epub 2008 Jun 27.PMID: 18587069 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample.

Al-Attar SA, Pollex RL, Ban MR, Young TK, Bjerregaard P, Anand SS, Yusuf S, Zinman B, Harris SB, Hanley AJ, Connelly PW, Huff MW, Hegele RA.

Cardiovasc Diabetol. 2008 Mar 13;7:5.PMID: 18339204 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants APOC3, APOA5, APOE and PON1 are associated with variation in plasma lipoprotein traits in Greenlanders.

Lahiry P, Ban MR, Pollex RL, Feldman RD, Sawyez CG, Huff MW, Young TK, Bjerregaard P, Hegele RA.

Int J Circumpolar Health. 2007 Dec;66(5):390-400.PMID: 18274205 [PubMed - indexed for MEDLINE]Related articles

Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample.

Pollex RL, Ban MR, Young TK, Bjerregaard P, Anand SS, Yusuf S, Zinman B, Harris SB, Hanley AJ, Connelly PW, Huff MW, Hegele RA.

BMC Med Genet. 2007 Dec 20;8:80.PMID: 18096054 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol.

Beyea MM, Heslop CL, Sawyez CG, Edwards JY, Markle JG, Hegele RA, Huff MW.

J Biol Chem. 2007 Feb 23;282(8):5207-16. Epub 2006 Dec 23.PMID: 17186944 [PubMed - indexed for MEDLINE]Related articlesFree article

The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin.

Telford DE, Sutherland BG, Edwards JY, Andrews JD, Barrett PH, Huff MW.

J Lipid Res. 2007 Mar;48(3):699-708. Epub 2006 Nov 27.PMID: 17130282 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesterol absorption inhibitors as a therapeutic option for hypercholesterolaemia.

Burnett JR, Huff MW.

Expert Opin Investig Drugs. 2006 Nov;15(11):1337-51. Review.PMID: 17040195 [PubMed - indexed for MEDLINE]Related articles

Ankyrin G overexpression in Hutchinson-Gilford progeria syndrome fibroblasts identified through biological filtering of expression profiles.

Wang J, Robinson JF, O'Neil CH, Edwards JY, Williams CM, Huff MW, Pickering JG, Hegele RA.

J Hum Genet. 2006;51(11):934-42. Epub 2006 Oct 11.PMID: 17033732 [PubMed - indexed for MEDLINE]Related articles

NPC1L1: evolution from pharmacological target to physiological sterol transporter.

Huff MW, Pollex RL, Hegele RA.

Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2433-8. Epub 2006 Sep 14. Review.PMID: 16973966 [PubMed - indexed for MEDLINE]Related articlesFree article

The ACAT inhibitor avasimibe increases the fractional clearance rate of postprandial triglyceride-rich lipoproteins in miniature pigs.

Burnett JR, Telford DE, Barrett PH, Huff MW.

Biochim Biophys Acta. 2005 Dec 30;1738(1-3):10-8. Epub 2005 Dec 22.PMID: 16427354 [PubMed - indexed for MEDLINE]Related articles

A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content.

Telford DE, Lipson SM, Barrett PH, Sutherland BG, Edwards JY, Aebi JD, Dehmlow H, Morand OH, Huff MW.

Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2608-14. Epub 2005 Oct 6.PMID: 16210564 [PubMed - indexed for MEDLINE]Related articlesFree article

Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear.

Huff MW, Telford DE.

Trends Pharmacol Sci. 2005 Jul;26(7):335-40. Review.PMID: 15951028 [PubMed - indexed for MEDLINE]Related articles

Quality assessment of microarray experiments.

Carter DE, Robinson JF, Allister EM, Huff MW, Hegele RA.

Clin Biochem. 2005 Jul;38(7):639-42.PMID: 15923000 [PubMed - indexed for MEDLINE]Related articles

Inhibition of microsomal triglyceride transfer protein expression and apolipoprotein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes.

Allister EM, Borradaile NM, Edwards JY, Huff MW.

Diabetes. 2005 Jun;54(6):1676-83.PMID: 15919788 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.

Argmann CA, Edwards JY, Sawyez CG, O'Neil CH, Hegele RA, Pickering JG, Huff MW.

J Biol Chem. 2005 Jun 10;280(23):22212-21. Epub 2005 Apr 6.PMID: 15817453 [PubMed - indexed for MEDLINE]Related articlesFree article

Human smooth muscle cell subpopulations differentially accumulate cholesteryl ester when exposed to native and oxidized lipoproteins.

Argmann CA, Sawyez CG, Li S, Nong Z, Hegele RA, Pickering JG, Huff MW.

Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1290-6. Epub 2004 May 6.PMID: 15130914 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary cholesterol, cholesterol absorption, postprandial lipemia and atherosclerosis.

Huff MW.

Can J Clin Pharmacol. 2003 Winter;10 Suppl A:26A-32A. Review.PMID: 14571303 [PubMed - indexed for MEDLINE]Related articles

Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation.

Borradaile NM, de Dreu LE, Huff MW.

Diabetes. 2003 Oct;52(10):2554-61.PMID: 14514640 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation.

Rowe AH, Argmann CA, Edwards JY, Sawyez CG, Morand OH, Hegele RA, Huff MW.

Circ Res. 2003 Oct 17;93(8):717-25. Epub 2003 Sep 25.PMID: 14512442 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of peroxisome proliferator-activated receptor gamma and retinoid X receptor results in net depletion of cellular cholesteryl esters in macrophages exposed to oxidized lipoproteins.

Argmann CA, Sawyez CG, McNeil CJ, Hegele RA, Huff MW.

Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):475-82. Epub 2003 Jan 30.PMID: 12615696 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation.

Borradaile NM, de Dreu LE, Barrett PH, Behrsin CD, Huff MW.

Biochemistry. 2003 Feb 11;42(5):1283-91.PMID: 12564931 [PubMed - indexed for MEDLINE]Related articles

Inhibition of both the apical sodium-dependent bile acid transporter and HMG-CoA reductase markedly enhances the clearance of LDL apoB.

Telford DE, Edwards JY, Lipson SM, Sutherland B, Barrett PH, Burnett JR, Krul ES, Keller BT, Huff MW.

J Lipid Res. 2003 May;44(5):943-52. Epub 2003 Feb 1.PMID: 12562847 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated serum C-reactive protein and free fatty acids among nondiabetic carriers of missense mutations in the gene encoding lamin A/C (LMNA) with partial lipodystrophy.

Hegele RA, Kraw ME, Ban MR, Miskie BA, Huff MW, Cao H.

Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):111-6.PMID: 12524233 [PubMed - indexed for MEDLINE]Related articlesFree article

Avasimibe Pfizer.

Burnett JR, Huff MW.

Curr Opin Investig Drugs. 2002 Sep;3(9):1328-33. Review.PMID: 12498009 [PubMed - indexed for MEDLINE]Related articles

Inhibition of the apical sodium-dependent bile acid transporter reduces LDL cholesterol and apoB by enhanced plasma clearance of LDL apoB.

Huff MW, Telford DE, Edwards JY, Burnett JR, Barrett PH, Rapp SR, Napawan N, Keller BT.

Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1884-91.PMID: 12426220 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters.

Borradaile NM, de Dreu LE, Barrett PH, Huff MW.

J Lipid Res. 2002 Sep;43(9):1544-54.PMID: 12235187 [PubMed - indexed for MEDLINE]Related articlesFree article

Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms.

Borradaile NM, de Dreu LE, Wilcox LJ, Edwards JY, Huff MW.

Biochem J. 2002 Sep 1;366(Pt 2):531-9.PMID: 12030847 [PubMed - indexed for MEDLINE]Related articlesFree article

Successful pregnancy outcome in a patient with severe chylomicronemia due to compound heterozygosity for mutant lipoprotein lipase.

Al-Shali K, Wang J, Fellows F, Huff MW, Wolfe BM, Hegele RA.

Clin Biochem. 2002 Mar;35(2):125-30.PMID: 11983347 [PubMed - indexed for MEDLINE]Related articles

Transforming growth factor-beta1 inhibits macrophage cholesteryl ester accumulation induced by native and oxidized VLDL remnants.

Argmann CA, Van Den Diepstraten CH, Sawyez CG, Edwards JY, Hegele RA, Wolfe BM, Huff MW.

Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):2011-8.PMID: 11742878 [PubMed - indexed for MEDLINE]Related articlesFree article

Common genomic variation in LMNA modulates indexes of obesity in Inuit.

Hegele RA, Huff MW, Young TK.

J Clin Endocrinol Metab. 2001 Jun;86(6):2747-51.PMID: 11397881 [PubMed - indexed for MEDLINE]Related articlesFree article

Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.

Wilcox LJ, Borradaile NM, de Dreu LE, Huff MW.

J Lipid Res. 2001 May;42(5):725-34.PMID: 11352979 [PubMed - indexed for MEDLINE]Related articlesFree article

LMNA R482Q mutation in partial lipodystrophy associated with reduced plasma leptin concentration.

Hegele RA, Cao H, Huff MW, Anderson CM.

J Clin Endocrinol Metab. 2000 Sep;85(9):3089-93.PMID: 10999791 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of amlodipine on hemodynamic and endocrine responses to mental stress.

Spence JD, Munoz C, Huff MW, Tokmakjian S.

Am J Hypertens. 2000 May;13(5 Pt 1):518-22.PMID: 10826403 [PubMed - indexed for MEDLINE]Related articles

Effects of continuous conjugated estrogen and micronized progesterone therapy upon lipoprotein metabolism in postmenopausal women.

Wolfe BM, Barrett PH, Laurier L, Huff MW.

J Lipid Res. 2000 Mar;41(3):368-75.PMID: 10706584 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of valsartan and captopril on lipid parameters in patients with type II diabetes mellitus and nephropathy.

Cheung R, Lewanczuk RZ, Rodger NW, Huff MW, Oddou-Stock P, Botteri F, Pecher E, Muirhead N.

Int J Clin Pract. 1999 Dec;53(8):584-92.PMID: 10692751 [PubMed - indexed for MEDLINE]Related articles

The magnitude of decrease in hepatic very low density lipoprotein apolipoprotein B secretion is determined by the extent of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition in miniature pigs.

Burnett JR, Wilcox LJ, Telford DE, Kleinstiver SJ, Barrett PH, Newton RS, Huff MW.

Endocrinology. 1999 Nov;140(11):5293-302.PMID: 10537160 [PubMed - indexed for MEDLINE]Related articlesFree article

Acyl coenzyme A: cholesterol acyltransferase inhibition and hepatic apolipoprotein B secretion.

Burnett JR, Wilcox LJ, Huff MW.

Clin Chim Acta. 1999 Aug;286(1-2):231-42. Review.PMID: 10511295 [PubMed - indexed for MEDLINE]Related articles

Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs.

Burnett JR, Wilcox LJ, Telford DE, Kleinstiver SJ, Barrett PH, Newton RS, Huff MW.

J Lipid Res. 1999 Jul;40(7):1317-27.PMID: 10393217 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin.

Wilcox LJ, Barrett PH, Huff MW.

J Lipid Res. 1999 Jun;40(6):1078-89.PMID: 10357840 [PubMed - indexed for MEDLINE]Related articlesFree article

Uptake of type IV hypertriglyceridemic VLDL by cultured macrophages is enhanced by interferon-gamma.

Whitman SC, Argmann CA, Sawyez CG, Miller DB, Hegele RA, Huff MW.

J Lipid Res. 1999 Jun;40(6):1017-28.PMID: 10357833 [PubMed - indexed for MEDLINE]Related articlesFree article

Modification of type III VLDL, their remnants, and VLDL from ApoE-knockout mice by p-hydroxyphenylacetaldehyde, a product of myeloperoxidase activity, causes marked cholesteryl ester accumulation in macrophages.

Whitman SC, Hazen SL, Miller DB, Hegele RA, Heinecke JW, Huff MW.

Arterioscler Thromb Vasc Biol. 1999 May;19(5):1238-49.PMID: 10323775 [PubMed - indexed for MEDLINE]Related articlesFree article

ApoB100 secretion from HepG2 cells is decreased by the ACAT inhibitor CI-1011: an effect associated with enhanced intracellular degradation of ApoB.

Wilcox LJ, Barrett PH, Newton RS, Huff MW.

Arterioscler Thromb Vasc Biol. 1999 Apr;19(4):939-49.PMID: 10195921 [PubMed - indexed for MEDLINE]Related articlesFree article