PubMed

How to make a meandering river.

Howard AD.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17245-6. Epub 2009 Oct 5. No abstract available. PMID: 19805053 [PubMed - indexed for MEDLINE]Related articles

Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.

Pasternak A, Goble SD, deJesus RK, Hreniuk DL, Chung CC, Tota MR, Mazur P, Feighner SD, Howard AD, Mills SG, Yang L.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6237-40. Epub 2009 Aug 26.PMID: 19767208 [PubMed - in process]Related articles

Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes.

Mu J, Petrov A, Eiermann GJ, Woods J, Zhou YP, Li Z, Zycband E, Feng Y, Zhu L, Roy RS, Howard AD, Li C, Thornberry NA, Zhang BB.

Eur J Pharmacol. 2009 Nov 25;623(1-3):148-54. Epub 2009 Sep 16.PMID: 19765579 [PubMed - in process]Related articles

Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice.

Zhao E, Keller MP, Rabaglia ME, Oler AT, Stapleton DS, Schueler KL, Neto EC, Moon JY, Wang P, Wang IM, Lum PY, Ivanovska I, Cleary M, Greenawalt D, Tsang J, Choi YJ, Kleinhanz R, Shang J, Zhou YP, Howard AD, Zhang BB, Kendziorski C, Thornberry NA, Yandell BS, Schadt EE, Attie AD.

Mamm Genome. 2009 Aug;20(8):476-85.PMID: 19727952 [PubMed - in process]Related articles

Expression of lipid storage droplet protein-1 may define the role of AKH as a lipid mobilizing hormone in Manduca sexta.

Arrese EL, Mirza S, Rivera L, Howard AD, Chetty PS, Soulages JL.

Insect Biochem Mol Biol. 2008 Nov;38(11):993-1000. Epub 2008 Aug 26.PMID: 18793726 [PubMed - indexed for MEDLINE]Related articlesFree article

Brefeldin A inhibits cholesterol efflux without affecting the rate of cellular uptake and re-secretion of apolipoprotein A-I in adipocytes.

Verghese PB, Arrese EL, Howard AD, Soulages JL.

Arch Biochem Biophys. 2008 Oct 15;478(2):161-6. Epub 2008 Aug 7.PMID: 18708026 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice.

Tan CP, Feng Y, Zhou YP, Eiermann GJ, Petrov A, Zhou C, Lin S, Salituro G, Meinke P, Mosley R, Akiyama TE, Einstein M, Kumar S, Berger JP, Mills SG, Thornberry NA, Yang L, Howard AD.

Diabetes. 2008 Aug;57(8):2211-9. Epub 2008 May 13.PMID: 18477808 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men.

Liu J, Prudom CE, Nass R, Pezzoli SS, Oliveri MC, Johnson ML, Veldhuis P, Gordon DA, Howard AD, Witcher DR, Geysen HM, Gaylinn BD, Thorner MO.

J Clin Endocrinol Metab. 2008 May;93(5):1980-7. Epub 2008 Mar 18.PMID: 18349056 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of glucose-dependant insulin secretion targets in pancreatic beta cells by combining defined-mechanism compound library screening and siRNA gene silencing.

Wu W, Shang J, Feng Y, Thompson CM, Horwitz S, Thompson JR, MacIntyre ED, Thornberry NA, Chapman K, Zhou YP, Howard AD, Li J.

J Biomol Screen. 2008 Feb;13(2):128-34. Epub 2008 Jan 23.PMID: 18216393 [PubMed - indexed for MEDLINE]Related articles

4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

Jiang J, Lin P, Hoang M, Chang L, Tan C, Feighner S, Palyha OC, Hreniuk DL, Pan J, Sailer AW, Morin NR, MacNeil DJ, Howard AD, Van der Ploeg LH, Goulet MT, DeVita RJ.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5275-9. Epub 2006 Aug 17.PMID: 16919453 [PubMed - indexed for MEDLINE]Related articles

Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.

Mu J, Woods J, Zhou YP, Roy RS, Li Z, Zycband E, Feng Y, Zhu L, Li C, Howard AD, Moller DE, Thornberry NA, Zhang BB.

Diabetes. 2006 Jun;55(6):1695-704.PMID: 16731832 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term posttransplantation care: the expanding role of community nephrologists.

Howard AD.

Am J Kidney Dis. 2006 Apr;47(4 Suppl 2):S111-24. Review.PMID: 16567237 [PubMed - indexed for MEDLINE]Related articles

Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice.

Shearman LP, Wang SP, Helmling S, Stribling DS, Mazur P, Ge L, Wang L, Klussmann S, Macintyre DE, Howard AD, Strack AM.

Endocrinology. 2006 Mar;147(3):1517-26. Epub 2005 Dec 8.PMID: 16339202 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased melanin concentrating hormone receptor type I in the human hypothalamic infundibular nucleus in cachexia.

Unmehopa UA, van Heerikhuize JJ, Spijkstra W, Woods JW, Howard AD, Zycband E, Feighner SD, Hreniuk DL, Palyha OC, Guan XM, Macneil DJ, Van der Ploeg LH, Swaab DF.

J Clin Endocrinol Metab. 2005 Apr;90(4):2412-9. Epub 2005 Jan 25.PMID: 15671106 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the bombesin-like peptide receptor family in primates.

Sano H, Feighner SD, Hreniuk DL, Iwaasa H, Sailer AW, Pan J, Reitman ML, Kanatani A, Howard AD, Tan CP.

Genomics. 2004 Jul;84(1):139-46.PMID: 15203211 [PubMed - indexed for MEDLINE]Related articles

Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein.

Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, Frazier EG, Shen Z, Marsh DJ, Feighner SD, Guan XM, Ye Z, Nargund RP, Smith RG, Van der Ploeg LH, Howard AD, MacNeil DJ, Qian S.

Endocrinology. 2004 Jun;145(6):2607-12. Epub 2004 Feb 12.PMID: 14962995 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats.

Shearman LP, Camacho RE, Sloan Stribling D, Zhou D, Bednarek MA, Hreniuk DL, Feighner SD, Tan CP, Howard AD, Van der Ploeg LH, MacIntyre DE, Hickey GJ, Strack AM.

Eur J Pharmacol. 2003 Aug 15;475(1-3):37-47.PMID: 12954357 [PubMed - indexed for MEDLINE]Related articles

Activation of melanocortin MC(4) receptors increases erectile activity in rats ex copula.

Martin WJ, McGowan E, Cashen DE, Gantert LT, Drisko JE, Hom GJ, Nargund R, Sebhat I, Howard AD, Van der Ploeg LH, MacIntyre DE.

Eur J Pharmacol. 2002 Nov 1;454(1):71-9.PMID: 12409007 [PubMed - indexed for MEDLINE]Related articles

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist.

Sebhat IK, Martin WJ, Ye Z, Barakat K, Mosley RT, Johnston DB, Bakshi R, Palucki B, Weinberg DH, MacNeil T, Kalyani RN, Tang R, Stearns RA, Miller RR, Tamvakopoulos C, Strack AM, McGowan E, Cashen DE, Drisko JE, Hom GJ, Howard AD, MacIntyre DE, van der Ploeg LH, Patchett AA, Nargund RP.

J Med Chem. 2002 Oct 10;45(21):4589-93.PMID: 12361385 [PubMed - indexed for MEDLINE]Related articles

Tracking the martian climate.

Howard AD.

Nature. 2002 Sep 26;419(6905):350-1. No abstract available. PMID: 12353018 [PubMed]Related articles

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.

MacNeil DJ, Howard AD, Guan X, Fong TM, Nargund RP, Bednarek MA, Goulet MT, Weinberg DH, Strack AM, Marsh DJ, Chen HY, Shen CP, Chen AS, Rosenblum CI, MacNeil T, Tota M, MacIntyre ED, Van der Ploeg LH.

Eur J Pharmacol. 2002 Aug 16;450(1):93-109. Review.PMID: 12176114 [PubMed - indexed for MEDLINE]Related articles

A role for the melanocortin 4 receptor in sexual function.

Van der Ploeg LH, Martin WJ, Howard AD, Nargund RP, Austin CP, Guan X, Drisko J, Cashen D, Sebhat I, Patchett AA, Figueroa DJ, DiLella AG, Connolly BM, Weinberg DH, Tan CP, Palyha OC, Pong SS, MacNeil T, Rosenblum C, Vongs A, Tang R, Yu H, Sailer AW, Fong TM, Huang C, Tota MR, Chang RS, Stearns R, Tamvakopoulos C, Christ G, Drazen DL, Spar BD, Nelson RJ, MacIntyre DE.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11381-6. Epub 2002 Aug 9.PMID: 12172010 [PubMed - indexed for MEDLINE]Related articlesFree article

A large paleolake basin at the head of Ma'adim Vallis, Mars.

Irwin RP 3rd, Maxwell TA, Howard AD, Craddock RA, Leverington DW.

Science. 2002 Jun 21;296(5576):2209-12.PMID: 12077414 [PubMed - indexed for MEDLINE]Related articlesFree article

Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression.

Tan CP, Sano H, Iwaasa H, Pan J, Sailer AW, Hreniuk DL, Feighner SD, Palyha OC, Pong SS, Figueroa DJ, Austin CP, Jiang MM, Yu H, Ito J, Ito M, Ito M, Guan XM, MacNeil DJ, Kanatani A, Van der Ploeg LH, Howard AD.

Genomics. 2002 Jun;79(6):785-92.PMID: 12036292 [PubMed - indexed for MEDLINE]Related articles

Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.

Bednarek MA, Hreniuk DL, Tan C, Palyha OC, MacNeil DJ, Van der Ploeg LH, Howard AD, Feighner SD.

Biochemistry. 2002 May 21;41(20):6383-90.PMID: 12009900 [PubMed - indexed for MEDLINE]Related articles

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.

MacNeil DJ, Howard AD, Guan X, Fong TM, Nargund RP, Bednarek MA, Goulet MT, Weinberg DH, Strack AM, Marsh DJ, Chen HY, Shen CP, Chen AS, Rosenblum CI, MacNeil T, Tota M, MacIntyre ED, Van der Ploeg LH.

Eur J Pharmacol. 2002 Apr 12;440(2-3):141-57. Review. Corrected and republished in: Eur J Pharmacol. 2002 Aug 16;450(1):93-109. PMID: 12007532 [PubMed - indexed for MEDLINE]Related articles

Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.

Bednarek MA, Tan C, Hreniuk DL, Palyha OC, MacNeil DJ, Van Der Ploeg LH, Howard AD, Feighner SD.

J Biol Chem. 2002 Apr 19;277(16):13821-6. Epub 2002 Feb 11.PMID: 11839762 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term management of the renal transplant recipient: optimizing the relationship between the transplant center and the community nephrologist.

Howard AD.

Am J Kidney Dis. 2001 Dec;38(6 Suppl 6):S51-7.PMID: 11729006 [PubMed - indexed for MEDLINE]Related articles

Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.

Bednarek MA, Feighner SD, Hreniuk DL, Palyha OC, Morin NR, Sadowski SJ, MacNeil DJ, Howard AD, Van der Ploeg LH.

Biochemistry. 2001 Aug 7;40(31):9379-86.PMID: 11478907 [PubMed - indexed for MEDLINE]Related articles

Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.

Coulie B, Matsuura B, Dong M, Hadac EM, Pinon DI, Feighner SD, Howard AD, Miller LJ.

J Biol Chem. 2001 Sep 21;276(38):35518-22. Epub 2001 Jul 18.PMID: 11461914 [PubMed - indexed for MEDLINE]Related articlesFree article

Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics.

Palucki BL, Feighner SD, Pong S, McKee KK, Hreniuk DL, Tan C, Howard AD, Van der Ploeg LH, Patchett AA, Nargund RP.

Bioorg Med Chem Lett. 2001 Jul 23;11(14):1955-7.PMID: 11459669 [PubMed - indexed for MEDLINE]Related articles

Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.

Sailer AW, Sano H, Zeng Z, McDonald TP, Pan J, Pong SS, Feighner SD, Tan CP, Fukami T, Iwaasa H, Hreniuk DL, Morin NR, Sadowski SJ, Ito M, Ito M, Bansal A, Ky B, Figueroa DJ, Jiang Q, Austin CP, MacNeil DJ, Ishihara A, Ihara M, Kanatani A, Van der Ploeg LH, Howard AD, Liu Q.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9. Epub 2001 Jun 12.PMID: 11404457 [PubMed - indexed for MEDLINE]Related articlesFree article

Orphan G-protein-coupled receptors and natural ligand discovery.

Howard AD, McAllister G, Feighner SD, Liu Q, Nargund RP, Van der Ploeg LH, Patchett AA.

Trends Pharmacol Sci. 2001 Mar;22(3):132-40. Review.PMID: 11239576 [PubMed - indexed for MEDLINE]Related articles

Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a.

Bednarek MA, Feighner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV, Warren VA, Howard AD, Van Der Ploeg LH, Heck JV.

J Med Chem. 2000 Nov 16;43(23):4370-6.PMID: 11087562 [PubMed - indexed for MEDLINE]Related articles

Adenosine: A partial agonist of the growth hormone secretagogue receptor.

Smith RG, Griffin PR, Xu Y, Smith AG, Liu K, Calacay J, Feighner SD, Pong C, Leong D, Pomés A, Cheng K, Van der Ploeg LH, Howard AD, Schaeffer J, Leonard RJ.

Biochem Biophys Res Commun. 2000 Oct 5;276(3):1306-13.PMID: 11027627 [PubMed - indexed for MEDLINE]Related articles

Identification of receptors for neuromedin U and its role in feeding.

Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q.

Nature. 2000 Jul 6;406(6791):70-4.PMID: 10894543 [PubMed - indexed for MEDLINE]Related articles

Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.

Ye Z, Gao Y, Bakshi RK, Chen MH, Rohrer SP, Feighner SD, Pong SS, Howard AD, Blake A, Birzin ET, Locco L, Parmar RM, Chan WW, Schaeffer JM, Smith RG, Patchett AA, Nargund RP.

Bioorg Med Chem Lett. 2000 Jan 3;10(1):5-8.PMID: 10636230 [PubMed - indexed for MEDLINE]Related articles

Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans.

Palyha OC, Feighner SD, Tan CP, McKee KK, Hreniuk DL, Gao YD, Schleim KD, Yang L, Morriello GJ, Nargund R, Patchett AA, Howard AD, Smith RG.

Mol Endocrinol. 2000 Jan;14(1):160-9.PMID: 10628755 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone releasing substances: types and their receptors.

Smith RG, Palyha OC, Feighner SD, Tan CP, McKee KK, Hreniuk DL, Yang L, Morriello G, Nargund R, Patchett AA, Howard AD.

Horm Res. 1999;51 Suppl 3:1-8. Review.PMID: 10592437 [PubMed - indexed for MEDLINE]Related articles

Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14.

Liu Q, Pong SS, Zeng Z, Zhang Q, Howard AD, Williams DL Jr, Davidoff M, Wang R, Austin CP, McDonald TP, Bai C, George SR, Evans JF, Caskey CT.

Biochem Biophys Res Commun. 1999 Dec 9;266(1):174-8.PMID: 10581185 [PubMed - indexed for MEDLINE]Related articles

Expression of the galanin receptor subtype Gal-R2 mRNA in the rat hypothalamus.

Mitchell V, Bouret S, Howard AD, Beauvillain JC.

J Chem Neuroanat. 1999 Jun;16(4):265-77.PMID: 10450874 [PubMed - indexed for MEDLINE]Related articles

Receptor for motilin identified in the human gastrointestinal system.

Feighner SD, Tan CP, McKee KK, Palyha OC, Hreniuk DL, Pong SS, Austin CP, Figueroa D, MacNeil D, Cascieri MA, Nargund R, Bakshi R, Abramovitz M, Stocco R, Kargman S, O'Neill G, Van Der Ploeg LH, Evans J, Patchett AA, Smith RG, Howard AD.

Science. 1999 Jun 25;284(5423):2184-8.PMID: 10381885 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular analysis of a new splice variant of the human melanocortin-1 receptor.

Tan CP, McKee KK, Weinberg DH, MacNeil T, Palyha OC, Feighner SD, Hreniuk DL, Van Der Ploeg LH, MacNeil DJ, Howard AD.

FEBS Lett. 1999 May 21;451(2):137-41.PMID: 10371153 [PubMed - indexed for MEDLINE]Related articles

Reactivation of tuberculosis is associated with a shift from type 1 to type 2 cytokines.

Howard AD, Zwilling BS.

Clin Exp Immunol. 1999 Mar;115(3):428-34.PMID: 10193414 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery of a receptor related to the galanin receptors.

Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF.

FEBS Lett. 1999 Mar 5;446(1):103-7.PMID: 10100623 [PubMed - indexed for MEDLINE]Related articles

Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.

Kolakowski LF Jr, O'Neill GP, Howard AD, Broussard SR, Sullivan KA, Feighner SD, Sawzdargo M, Nguyen T, Kargman S, Shiao LL, Hreniuk DL, Tan CP, Evans J, Abramovitz M, Chateauneuf A, Coulombe N, Ng G, Johnson MP, Tharian A, Khoshbouei H, George SR, Smith RG, O'Dowd BF.

J Neurochem. 1998 Dec;71(6):2239-51.PMID: 9832121 [PubMed - indexed for MEDLINE]Related articles

Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors.

Tan CP, McKee KK, Liu Q, Palyha OC, Feighner SD, Hreniuk DL, Smith RG, Howard AD.

Genomics. 1998 Sep 1;52(2):223-9.PMID: 9782091 [PubMed - indexed for MEDLINE]Related articles

Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus.

Tannenbaum GS, Lapointe M, Beaudet A, Howard AD.

Endocrinology. 1998 Oct;139(10):4420-3.PMID: 9751527 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine production by CD4 and CD8 T cells during the growth of Mycobacterium tuberculosis in mice.

Howard AD, Zwilling BS.

Clin Exp Immunol. 1998 Sep;113(3):443-9.PMID: 9737675 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessing the value of blood volume monitoring to improve outcomes. A comparative observational study.

Howard AD, Palmer B, Howard RS, Goldberger SG, Shabshab SF.

Nephrol News Issues. 1998 May;12(5 Suppl):24-6. No abstract available. PMID: 9652296 [PubMed - indexed for MEDLINE]Related articles