PubMed

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.

Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP.

Nat Med. 2009 Aug;15(8):940-5. Epub 2009 Jul 26.PMID: 19633655 [PubMed - indexed for MEDLINE]Related articles

CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.

Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig A, Zorzano A, Langin D, Fajas L.

Cell Metab. 2009 Apr;9(4):339-49.PMID: 19356715 [PubMed - indexed for MEDLINE]Related articles

Inflammation and endoplasmic reticulum stress in obesity and diabetes.

Hotamisligil GS.

Int J Obes (Lond). 2008 Dec;32 Suppl 7:S52-4. Review.PMID: 19136991 [PubMed - indexed for MEDLINE]Related articles

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss.

Gregor MF, Yang L, Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S.

Diabetes. 2009 Mar;58(3):693-700. Epub 2008 Dec 9.PMID: 19066313 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutrient sensing and inflammation in metabolic diseases.

Hotamisligil GS, Erbay E.

Nat Rev Immunol. 2008 Dec;8(12):923-34. Review.PMID: 19029988 [PubMed - indexed for MEDLINE]Related articles

Stressing the brain, fattening the body.

Yang L, Hotamisligil GS.

Cell. 2008 Oct 3;135(1):20-2.PMID: 18854151 [PubMed - indexed for MEDLINE]Related articles

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.

Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS.

Cell. 2008 Sep 19;134(6):933-44.PMID: 18805087 [PubMed - indexed for MEDLINE]Related articlesFree article

A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity.

Vallerie SN, Furuhashi M, Fucho R, Hotamisligil GS.

PLoS One. 2008 Sep 5;3(9):e3151. Erratum in: PLoS ONE. 2009;4(1). doi: 10.1371/annotation/1074cd39-708b-45ef-943a-e9d1c5bbdedd. PMID: 18773087 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.

Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS.

J Clin Invest. 2008 Jul;118(7):2640-50.PMID: 18551191 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets.

Furuhashi M, Hotamisligil GS.

Nat Rev Drug Discov. 2008 Jun;7(6):489-503. Review.PMID: 18511927 [PubMed - indexed for MEDLINE]Related articles

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS.

Mol Cell. 2008 Mar 14;29(5):541-51.PMID: 18342602 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes.

Hotamisligil GS.

Novartis Found Symp. 2007;286:86-94; discussion 94-8, 162-3, 196-203.PMID: 18269176 [PubMed - indexed for MEDLINE]Related articles

Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome.

Erbay E, Cao H, Hotamisligil GS.

Curr Atheroscler Rep. 2007 Sep;9(3):222-9. Review.PMID: 18241617 [PubMed - indexed for MEDLINE]Related articles

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.

Gregor MF, Hotamisligil GS.

J Lipid Res. 2007 Sep;48(9):1905-14. Epub 2007 May 9. Review.PMID: 17699733 [PubMed - indexed for MEDLINE]Related articlesFree article

A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women.

Liu S, Tinker L, Song Y, Rifai N, Bonds DE, Cook NR, Heiss G, Howard BV, Hotamisligil GS, Hu FB, Kuller LH, Manson JE.

Arch Intern Med. 2007 Aug 13-27;167(15):1676-85.PMID: 17698692 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis.

Reynolds JM, Liu Q, Brittingham KC, Liu Y, Gruenthal M, Gorgun CZ, Hotamisligil GS, Stout RD, Suttles J.

J Immunol. 2007 Jul 1;179(1):313-21.PMID: 17579051 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS.

Nature. 2007 Jun 21;447(7147):959-65. Epub 2007 Jun 6.PMID: 17554340 [PubMed - indexed for MEDLINE]Related articles

Adipocyte stress: The endoplasmic reticulum and metabolic disease.

Gregor MG, Hotamisligil GS.

J Lipid Res. 2007 May 9. [Epub ahead of print]PMID: 17494945 [PubMed - as supplied by publisher]Related articlesFree article

Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.

Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS.

Cell. 2007 May 4;129(3):537-48.PMID: 17482547 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women.

Song Y, Manson JE, Tinker L, Rifai N, Cook NR, Hu FB, Hotamisligil GS, Ridker PM, Rodriguez BL, Margolis KL, Oberman A, Liu S.

Diabetes. 2007 Jul;56(7):1898-904. Epub 2007 Mar 27.PMID: 17389327 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental biology: cell fate in the mammary gland.

Tong Q, Hotamisligil GS.

Nature. 2007 Feb 15;445(7129):724-6. No abstract available. PMID: 17301782 [PubMed - indexed for MEDLINE]Related articles

Inflammation and metabolic disorders.

Hotamisligil GS.

Nature. 2006 Dec 14;444(7121):860-7. Review.PMID: 17167474 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling.

Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Görgün CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE.

Cell Metab. 2006 Dec;4(6):465-74.PMID: 17141630 [PubMed - indexed for MEDLINE]Related articles

Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2.

Rolph MS, Young TR, Shum BO, Gorgun CZ, Schmitz-Peiffer C, Ramshaw IA, Hotamisligil GS, Mackay CR.

J Immunol. 2006 Dec 1;177(11):7794-801.PMID: 17114450 [PubMed - indexed for MEDLINE]Related articlesFree article

JNK1 deficiency does not enhance muscle glucose metabolism in lean mice.

Witczak CA, Hirshman MF, Jessen N, Fujii N, Seifert MM, Brandauer J, Hotamisligil GS, Goodyear LJ.

Biochem Biophys Res Commun. 2006 Dec 1;350(4):1063-8. Epub 2006 Oct 6.PMID: 17045576 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance.

Tilg H, Hotamisligil GS.

Gastroenterology. 2006 Sep;131(3):934-45. Review. No abstract available. PMID: 16952562 [PubMed - indexed for MEDLINE]Related articles

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.

Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS.

Science. 2006 Aug 25;313(5790):1137-40.PMID: 16931765 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuronal PTP1B regulates body weight, adiposity and leptin action.

Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB.

Nat Med. 2006 Aug;12(8):917-24. Epub 2006 Jul 16.PMID: 16845389 [PubMed - indexed for MEDLINE]Related articles

The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation.

Shum BO, Mackay CR, Gorgun CZ, Frost MJ, Kumar RK, Hotamisligil GS, Rolph MS.

J Clin Invest. 2006 Aug;116(8):2183-2192.PMID: 16841093 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.

Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS.

Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10741-6. Epub 2006 Jul 3.PMID: 16818881 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice.

Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS.

Diabetes. 2006 Jul;55(7):1915-22.PMID: 16804058 [PubMed - indexed for MEDLINE]Related articlesFree article

A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease.

Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):6970-5. Epub 2006 Apr 25.PMID: 16641093 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of adiponectin in adipocytes upon exposure to HIV-1.

Sankalé JL, Tong Q, Hadigan CM, Tan G, Grinspoon SK, Kanki PJ, Hotamisligil GS.

HIV Med. 2006 May;7(4):268-74.PMID: 16630040 [PubMed - indexed for MEDLINE]Related articles

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.

Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JC.

Cell Metab. 2006 Apr;3(4):247-56. Erratum in: Cell Metab. 2006 Jun;3(6):469. Tobe, Kazuyuki [added]; Kadowaki, Takashi [added]. PMID: 16581002 [PubMed - indexed for MEDLINE]Related articles

Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice.

Neels JG, Pandey M, Hotamisligil GS, Samad F.

Am J Pathol. 2006 Feb;168(2):435-44.PMID: 16436658 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes.

Hotamisligil GS.

Diabetes. 2005 Dec;54 Suppl 2:S73-8. Review.PMID: 16306344 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis.

Makowski L, Hotamisligil GS.

Curr Opin Lipidol. 2005 Oct;16(5):543-8. Review.PMID: 16148539 [PubMed - indexed for MEDLINE]Related articles

The transcription factor GATA2 regulates differentiation of brown adipocytes.

Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS.

EMBO Rep. 2005 Sep;6(9):879-84.PMID: 16082385 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.

Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS.

Cell Metab. 2005 Feb;1(2):107-19.PMID: 16054052 [PubMed - indexed for MEDLINE]Related articles

Inflammation, stress, and diabetes.

Wellen KE, Hotamisligil GS.

J Clin Invest. 2005 May;115(5):1111-9. Review.PMID: 15864338 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between dietary factors and plasma adiponectin concentrations in men.

Pischon T, Girman CJ, Rifai N, Hotamisligil GS, Rimm EB.

Am J Clin Nutr. 2005 Apr;81(4):780-6.PMID: 15817852 [PubMed - indexed for MEDLINE]Related articlesFree article

The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.

Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS.

J Biol Chem. 2005 Apr 1;280(13):12888-95. Epub 2005 Jan 31.PMID: 15684432 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation.

Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GS.

Mol Cell Biol. 2005 Jan;25(2):706-15.PMID: 15632071 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS.

Science. 2004 Oct 15;306(5695):457-61.PMID: 15486293 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.

Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS.

Circulation. 2004 Sep 14;110(11):1492-8. Epub 2004 Sep 7.PMID: 15353487 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses.

Makowski L, Hotamisligil GS.

J Nutr. 2004 Sep;134(9):2464S-2468S. Review.PMID: 15333743 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma adiponectin levels and risk of myocardial infarction in men.

Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB.

JAMA. 2004 Apr 14;291(14):1730-7.PMID: 15082700 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity.

Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, Hotamisligil GS.

Endocrinology. 2004 May;145(5):2214-20. Epub 2004 Feb 5.PMID: 14764635 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammatory pathways and insulin action.

Hotamisligil GS.

Int J Obes Relat Metab Disord. 2003 Dec;27 Suppl 3:S53-5. Review.PMID: 14704746 [PubMed - indexed for MEDLINE]Related articles

GATA transcription factors and fat cell formation.

Tong Q, Tsai J, Hotamisligil GS.

Drug News Perspect. 2003 Nov;16(9):585-8. Review.PMID: 14702139 [PubMed - indexed for MEDLINE]Related articles