PubMed

Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells.

Peyot ML, Gray JP, Lamontagne J, Smith PJ, Holz GG, Madiraju SR, Prentki M, Heart E.

PLoS One. 2009 Jul 13;4(7):e6221.PMID: 19593440 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.

Chepurny OG, Leech CA, Kelley GG, Dzhura I, Dzhura E, Li X, Rindler MJ, Schwede F, Genieser HG, Holz GG.

J Biol Chem. 2009 Apr 17;284(16):10728-36. Epub 2009 Feb 25.PMID: 19244230 [PubMed - indexed for MEDLINE]Related articles

Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells.

Stanojevic V, Habener JF, Holz GG, Leech CA.

Biochem Biophys Res Commun. 2008 Apr 11;368(3):614-9. Epub 2008 Feb 1.PMID: 18243136 [PubMed - indexed for MEDLINE]Related articles

Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells.

Kang G, Leech CA, Chepurny OG, Coetzee WA, Holz GG.

J Physiol. 2008 Mar 1;586(5):1307-19. Epub 2008 Jan 17.PMID: 18202100 [PubMed - indexed for MEDLINE]Related articlesFree article

Synchronizing Ca2+ and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on "regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach".

Holz GG, Heart E, Leech CA.

Am J Physiol Cell Physiol. 2008 Jan;294(1):C4-6. Epub 2007 Nov 7. No abstract available. PMID: 17989206 [PubMed - indexed for MEDLINE]Related articlesFree article

Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors.

Holz GG, Chepurny OG, Schwede F.

Cell Signal. 2008 Jan;20(1):10-20. Epub 2007 Jul 25. Review.PMID: 17716863 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts.

Chepurny OG, Holz GG.

J Biomol Screen. 2007 Aug;12(5):740-6. Epub 2007 May 16.PMID: 17507637 [PubMed - indexed for MEDLINE]Related articles

Simultaneous optical measurements of cytosolic Ca2+ and cAMP in single cells.

Harbeck MC, Chepurny O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW.

Sci STKE. 2006 Sep 19;2006(353):pl6.PMID: 16985238 [PubMed - indexed for MEDLINE]Related articles

Cell physiology of cAMP sensor Epac.

Holz GG, Kang G, Harbeck M, Roe MW, Chepurny OG.

J Physiol. 2006 Nov 15;577(Pt 1):5-15. Epub 2006 Sep 14. Review.PMID: 16973695 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.

Kang G, Chepurny OG, Malester B, Rindler MJ, Rehmann H, Bos JL, Schwede F, Coetzee WA, Holz GG.

J Physiol. 2006 Jun 15;573(Pt 3):595-609. Epub 2006 Apr 13.PMID: 16613879 [PubMed - indexed for MEDLINE]Related articlesFree article

Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line.

Landa LR Jr, Harbeck M, Kaihara K, Chepurny O, Kitiphongspattana K, Graf O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW.

J Biol Chem. 2005 Sep 2;280(35):31294-302. Epub 2005 Jun 29.PMID: 15987680 [PubMed - indexed for MEDLINE]Related articlesFree article

A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells.

Kang G, Chepurny OG, Rindler MJ, Collis L, Chepurny Z, Li WH, Harbeck M, Roe MW, Holz GG.

J Physiol. 2005 Jul 1;566(Pt 1):173-88. Epub 2005 Apr 28.PMID: 15860526 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes outfoxed by GLP-1?

Holz GG, Chepurny OG.

Sci STKE. 2005 Jan 25;2005(268):pe2. Review.PMID: 15671479 [PubMed - indexed for MEDLINE]Related articles

New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic beta-cells.

Holz GG.

Horm Metab Res. 2004 Nov-Dec;36(11-12):787-94. Erratum in: Horm Metab Res. 2005 Feb;37(2):126. Holz, G [corrected to Holz, GG]. PMID: 15655710 [PubMed - indexed for MEDLINE]Related articles

Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell.

Holz GG.

Diabetes. 2004 Jan;53(1):5-13. Review.PMID: 14693691 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus.

Holz GG, Chepurny OG.

Curr Med Chem. 2003 Nov;10(22):2471-83. Review.PMID: 14529486 [PubMed - indexed for MEDLINE]Related articles

In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion.

Ianus A, Holz GG, Theise ND, Hussain MA.

J Clin Invest. 2003 Mar;111(6):843-50.PMID: 12639990 [PubMed - indexed for MEDLINE]Related articlesFree article

Amplification of exocytosis by Ca2+-induced Ca2+ release in INS-1 pancreatic beta cells.

Kang G, Holz GG.

J Physiol. 2003 Jan 1;546(Pt 1):175-89.PMID: 12509487 [PubMed - indexed for MEDLINE]Related articlesFree article

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

Kang G, Joseph JW, Chepurny OG, Monaco M, Wheeler MB, Bos JL, Schwede F, Genieser HG, Holz GG.

J Biol Chem. 2003 Mar 7;278(10):8279-85. Epub 2002 Dec 20.PMID: 12496249 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells.

Tsuboi T, da Silva Xavier G, Holz GG, Jouaville LS, Thomas AP, Rutter GA.

Biochem J. 2003 Jan 15;369(Pt 2):287-99.PMID: 12410638 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220.

Chepurny OG, Hussain MA, Holz GG.

Endocrinology. 2002 Jun;143(6):2303-13.PMID: 12021195 [PubMed - indexed for MEDLINE]Related articlesFree article

Syntaxin-3 and syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell lines.

Kang Y, Huang X, Pasyk EA, Ji J, Holz GG, Wheeler MB, Tsushima RG, Gaisano HY.

Diabetologia. 2002 Feb;45(2):231-41.PMID: 11935155 [PubMed - indexed for MEDLINE]Related articles

Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation.

Chepurny OG, Holz GG.

Cell Tissue Res. 2002 Feb;307(2):191-201. Epub 2002 Jan 8.PMID: 11845326 [PubMed - indexed for MEDLINE]Related articles

cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells.

Kang G, Chepurny OG, Holz GG.

J Physiol. 2001 Oct 15;536(Pt 2):375-85.PMID: 11600673 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells.

Holz GG, Leech CA, Habener JF.

Biochimie. 2000 Sep-Oct;82(9-10):915-26. Review.PMID: 11086221 [PubMed - indexed for MEDLINE]Related articles

Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells.

Leech CA, Holz GG, Chepurny O, Habener JF.

Biochem Biophys Res Commun. 2000 Nov 11;278(1):44-7.PMID: 11071853 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.

Skoglund G, Hussain MA, Holz GG.

Diabetes. 2000 Jul;49(7):1156-64.PMID: 10909973 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37).

Holz GG, Leech CA, Heller RS, Castonguay M, Habener JF.

J Biol Chem. 1999 May 14;274(20):14147-56.PMID: 10318832 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus.

Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, Habener JF.

J Clin Endocrinol Metab. 1999 Feb;84(2):670-6.PMID: 10022436 [PubMed - indexed for MEDLINE]Related articlesFree article

Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones.

Holz GG, Habener JF.

Comp Biochem Physiol B Biochem Mol Biol. 1998 Oct;121(2):177-84.PMID: 9972293 [PubMed - indexed for MEDLINE]Related articles

Pertussis toxin-sensitive GTP-binding proteins characterized in synaptosomal fractions of embryonic avian cerebral cortex.

Holz GG, Turner TJ.

Comp Biochem Physiol B Biochem Mol Biol. 1998 Jan;119(1):201-11.PMID: 9530821 [PubMed - indexed for MEDLINE]Related articles

Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells.

Kieffer TJ, Heller RS, Leech CA, Holz GG, Habener JF.

Diabetes. 1997 Jun;46(6):1087-93.PMID: 9166685 [PubMed - indexed for MEDLINE]Related articles

Signal transduction of PACAP and GLP-1 in pancreatic beta cells.

Leech CA, Holz GG, Habener JF.

Ann N Y Acad Sci. 1996 Dec 26;805:81-92; discussion 92-3. Review.PMID: 8993395 [PubMed - indexed for MEDLINE]Related articles

Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1.

Holz GG 4th, Leech CA, Habener JF.

J Biol Chem. 1995 Jul 28;270(30):17749-57.PMID: 7543091 [PubMed - indexed for MEDLINE]Related articlesFree article

Pituitary adenylate cyclase-activating polypeptide induces the voltage-independent activation of inward membrane currents and elevation of intracellular calcium in HIT-T15 insulinoma cells.

Leech CA, Holz GG, Habener JF.

Endocrinology. 1995 Apr;136(4):1530-6.PMID: 7895663 [PubMed - indexed for MEDLINE]Related articles

Voltage-independent calcium channels mediate slow oscillations of cytosolic calcium that are glucose dependent in pancreatic beta-cells.

Leech CA, Holz GG 4th, Habener JF.

Endocrinology. 1994 Jul;135(1):365-72.PMID: 8013370 [PubMed - indexed for MEDLINE]Related articles

Application of patch clamp methods to the study of calcium currents and calcium channels.

Leech CA, Holz GG 4th.

Methods Cell Biol. 1994;40:135-51. Review. No abstract available. PMID: 8201974 [PubMed - indexed for MEDLINE]Related articles

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).

Holz GG 4th, Kühtreiber WM, Habener JF.

Nature. 1993 Jan 28;361(6410):362-5.PMID: 8381211 [PubMed - indexed for MEDLINE]Related articles

Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept.

Holz GG, Habener JF.

Trends Biochem Sci. 1992 Oct;17(10):388-93. Review.PMID: 1455507 [PubMed - indexed for MEDLINE]Related articles

Phospholipid metabolism of cultured Trichomonas vaginalis and Tritrichomonas foetus.

Beach DH, Holz GG Jr, Singh BN, Lindmark DG.

Mol Biochem Parasitol. 1991 Jan;44(1):97-108.PMID: 2011157 [PubMed - indexed for MEDLINE]Related articles

Characterization of glycosyl phosphatidylinositol lipids of parasitic protozoans: Leishmania mexicana mexicana promastigotes, Trypanosoma cruzi Peru epimastigotes and Tritrichomonas foetus.

Singh BN, Costello CE, Beach DH, Holz GG Jr.

Indian J Biochem Biophys. 1990 Dec;27(6):411-5.PMID: 2102485 [PubMed - indexed for MEDLINE]Related articles

Fatty acid and sterol metabolism of cultured Trichomonas vaginalis and Tritrichomonas foetus.

Beach DH, Holz GG Jr, Singh BN, Lindmark DG.

Mol Biochem Parasitol. 1990 Jan 15;38(2):175-90.PMID: 2325705 [PubMed - indexed for MEDLINE]Related articles

Effects of thiastearic acids on growth and on dihydrosterculic acid and other phospholipid fatty acyl groups of Leishmania promastigotes.

Beach DH, Pascal RA Jr, Holz GG Jr.

Mol Biochem Parasitol. 1989 Jun 1;35(1):57-66.PMID: 2761573 [PubMed - indexed for MEDLINE]Related articles

Sufentanil, morphine, met-enkephalin, and kappa-agonist (U-50,488H) inhibit substance P release from primary sensory neurons: a model for presynaptic spinal opioid actions.

Chang HM, Berde CB, Holz GG 4th, Steward GF, Kream RM.

Anesthesiology. 1989 Apr;70(4):672-7.PMID: 2467589 [PubMed - indexed for MEDLINE]Related articlesFree article

G proteins couple alpha-adrenergic and GABAb receptors to inhibition of peptide secretion from peripheral sensory neurons.

Holz GG 4th, Kream RM, Spiegel A, Dunlap K.

J Neurosci. 1989 Feb;9(2):657-66.PMID: 2465394 [PubMed - indexed for MEDLINE]Related articlesFree article

The activity of ketoconazole and other azoles against Trypanosoma cruzi: biochemistry and chemotherapeutic action in vitro.

Goad LJ, Berens RL, Marr JJ, Beach DH, Holz GG Jr.

Mol Biochem Parasitol. 1989 Jan 15;32(2-3):179-89.PMID: 2494453 [PubMed - indexed for MEDLINE]Related articles

Calcium channels that regulate neurosecretion.

Dunlap K, Holz GG, Lindgren CA, Moore JW.

Soc Gen Physiol Ser. 1989;44:239-50. No abstract available. PMID: 2476855 [PubMed - indexed for MEDLINE]Related articles

Di-O-alkylglycerol, mono-O-alkylglycerol and ceramide inositol phosphates of Leishmania mexicana mexicana promastigotes.

Singh BN, Costello CE, Beach DH, Holz GG Jr.

Biochem Biophys Res Commun. 1988 Dec 30;157(3):1239-46.PMID: 3207423 [PubMed - indexed for MEDLINE]Related articles

Effects of antimycotic azoles on growth and sterol biosynthesis of Leishmania promastigotes.

Beach DH, Goad LJ, Holz GG Jr.

Mol Biochem Parasitol. 1988 Nov;31(2):149-62.PMID: 2847043 [PubMed - indexed for MEDLINE]Related articles

Characterization of the electrically evoked release of substance P from dorsal root ganglion neurons: methods and dihydropyridine sensitivity.

Holz GG 4th, Dunlap K, Kream RM.

J Neurosci. 1988 Feb;8(2):463-71.PMID: 2448433 [PubMed - indexed for MEDLINE]Related articlesFree article