PubMed

Regulation of Neph3 gene in podocytes--key roles of transcription factors NF-kappaB and Sp1.

Ristola M, Arpiainen S, Saleem MA, Mathieson PW, Welsh GI, Lehtonen S, Holthöfer H.

BMC Mol Biol. 2009 Aug 24;10:83.PMID: 19703278 [PubMed - indexed for MEDLINE]Related articlesFree article

Epigenetic and microRNA-mediated regulation in diabetes.

Muhonen P, Holthofer H.

Nephrol Dial Transplant. 2009 Apr;24(4):1088-96. Epub 2009 Jan 14. No abstract available. PMID: 19145005 [PubMed - indexed for MEDLINE]Related articlesFree article

The MIF receptor CD74 in diabetic podocyte injury.

Sanchez-Niño MD, Sanz AB, Ihalmo P, Lassila M, Holthofer H, Mezzano S, Aros C, Groop PH, Saleem MA, Mathieson PW, Langham R, Kretzler M, Nair V, Lemley KV, Nelson RG, Mervaala E, Mattinzoli D, Rastaldi MP, Ruiz-Ortega M, Martin-Ventura JL, Egido J, Ortiz A.

J Am Soc Nephrol. 2009 Feb;20(2):353-62. Epub 2008 Oct 8.PMID: 18842989 [PubMed - indexed for MEDLINE]Related articles

A slit in podocyte death.

Moreno JA, Sanchez-Niño MD, Sanz AB, Lassila M, Holthofer H, Blanco-Colio LM, Egido J, Ruiz-Ortega M, Ortiz A.

Curr Med Chem. 2008;15(16):1645-54. Review.PMID: 18673230 [PubMed - indexed for MEDLINE]Related articles

Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy.

Ihalmo P, Wessman M, Kaunisto MA, Kilpikari R, Parkkonen M, Forsblom C, Holthöfer H, Groop PH; FinnDiane Study Group.

Diabetologia. 2008 Jan;51(1):86-90. Epub 2007 Oct 30.PMID: 17968527 [PubMed - indexed for MEDLINE]Related articles

The nephrin-based slit diaphragm: new insight into the signalling platform identifies targets for therapy.

Aaltonen P, Holthöfer H.

Nephrol Dial Transplant. 2007 Dec;22(12):3408-10. Epub 2007 Sep 24. Review. No abstract available. PMID: 17893108 [PubMed - indexed for MEDLINE]Related articles

Densin and beta-catenin form a complex and co-localize in cultured podocyte cell junctions.

Heikkilä E, Ristola M, Endlich K, Lehtonen S, Lassila M, Havana M, Endlich N, Holthöfer H; Addnet Consortium.

Mol Cell Biochem. 2007 Nov;305(1-2):9-18. Epub 2007 Jun 21.PMID: 17581699 [PubMed - indexed for MEDLINE]Related articles

Molecular architecture of the glomerular slit diaphragm: lessons learnt for a better understanding of disease pathogenesis.

Holthöfer H.

Nephrol Dial Transplant. 2007 Aug;22(8):2124-8. Epub 2007 Jun 5. Review. No abstract available. Erratum in: Nephrol Dial Transplant. 2007 Dec;22(12):3691. PMID: 17550922 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of filtrin in human glomerular diseases.

Ihalmo P, Schmid H, Rastaldi MP, Mattinzoli D, Langham RG, Luimula P, Kilpikari R, Lassila M, Gilbert RE, Kerjaschki D, Kretzler M, Holthöfer H.

Nephrol Dial Transplant. 2007 Jul;22(7):1903-9. Epub 2007 Apr 18.PMID: 17442742 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular basis of the glomerular filtration: nephrin and the emerging protein complex at the podocyte slit diaphragm.

Pätäri-Sampo A, Ihalmo P, Holthöfer H.

Ann Med. 2006;38(7):483-92. Review.PMID: 17101539 [PubMed - indexed for MEDLINE]Related articles

Densin is a novel cell membrane protein of Sertoli cells in the testis.

Lassila M, Juhila J, Heikkilä E, Holthöfer H.

Mol Reprod Dev. 2007 May;74(5):641-5.PMID: 17039495 [PubMed - indexed for MEDLINE]Related articles

Circulating antibodies to nephrin in patients with type 1 diabetes.

Aaltonen P, Rinta-Valkama J, Pätäri A, Tossavainen P, Palmén T, Kulmala P, Knip M, Holthöfer H.

Nephrol Dial Transplant. 2007 Jan;22(1):146-53. Epub 2006 Sep 8.PMID: 16963480 [PubMed - indexed for MEDLINE]Related articlesFree article

Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo.

Menne J, Meier M, Park JK, Boehne M, Kirsch T, Lindschau C, Ociepka R, Leitges M, Rinta-Valkama J, Holthofer H, Haller H.

Kidney Int. 2006 Oct;70(8):1456-62. Epub 2006 Sep 6.PMID: 16955103 [PubMed - indexed for MEDLINE]Related articles

Podocyte-associated proteins FAT, alpha-actinin-4 and filtrin are expressed in Langerhans islets of the pancreas.

Rinta-Valkama J, Palmén T, Lassila M, Holthöfer H.

Mol Cell Biochem. 2007 Jan;294(1-2):117-25. Epub 2006 Jul 14.PMID: 16841182 [PubMed - indexed for MEDLINE]Related articles

Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes.

Rinta-Valkama J, Aaltonen P, Lassila M, Palmén T, Tossavainen P, Knip M, Holthöfer H.

Diabetes Metab Res Rev. 2007 Feb;23(2):119-26.PMID: 16741999 [PubMed - indexed for MEDLINE]Related articles

Glomerular podocytes contain neuron-like functional synaptic vesicles.

Rastaldi MP, Armelloni S, Berra S, Calvaresi N, Corbelli A, Giardino LA, Li M, Wang GQ, Fornasieri A, Villa A, Heikkila E, Soliymani R, Boucherot A, Cohen CD, Kretzler M, Nitsche A, Ripamonti M, Malgaroli A, Pesaresi M, Forloni GL, Schlöndorff D, Holthofer H, D'Amico G.

FASEB J. 2006 May;20(7):976-8. Epub 2006 Apr 3.PMID: 16585060 [PubMed - indexed for MEDLINE]Related articlesFree article

Podocyte cell-specific expression of doxycycline inducible Cre recombinase in mice.

Juhila J, Roozendaal R, Lassila M, Verbeek SJ, Holthofer H.

J Am Soc Nephrol. 2006 Mar;17(3):648-54. Epub 2006 Feb 8.PMID: 16467448 [PubMed - indexed for MEDLINE]Related articlesFree article

Nephrin in human lymphoid tissues.

Aström E, Rinta-Valkama J, Gylling M, Ahola H, Miettinen A, Timonen T, Holthöfer H.

Cell Mol Life Sci. 2006 Feb;63(4):498-504.PMID: 16456616 [PubMed - indexed for MEDLINE]Related articles

A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients.

Pätäri A, Karhapää P, Taipale H, Salmenniemi U, Ruotsalainen E, Vanninen P, Holthöfer H, Laakso M.

Diabetologia. 2005 Sep;48(9):1844-50. Epub 2005 Jul 8.PMID: 16003531 [PubMed - indexed for MEDLINE]Related articles

High calcium diet down-regulates kidney angiotensin-converting enzyme in experimental renal failure.

Pörsti I, Fan M, Kööbi P, Jolma P, Kalliovalkama J, Vehmas TI, Helin H, Holthöfer H, Mervaala E, Nyman T, Tikkanen I.

Kidney Int. 2004 Dec;66(6):2155-66.PMID: 15569305 [PubMed - indexed for MEDLINE]Related articles

Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin.

Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG.

Am J Pathol. 2004 Sep;165(3):923-36.PMID: 15331416 [PubMed - indexed for MEDLINE]Related articlesFree article

Stable expression of nephrin and localization to cell-cell contacts in novel murine podocyte cell lines.

Schiwek D, Endlich N, Holzman L, Holthöfer H, Kriz W, Endlich K.

Kidney Int. 2004 Jul;66(1):91-101.PMID: 15200416 [PubMed - indexed for MEDLINE]Related articles

Molecular cloning and characterization of an endogenous antisense transcript of Nphs1.

Ihalmo P, Rinta-Valkama J, Mai P, Aström E, Palmén T, Pham TT, Floss T, Holthöfer H.

Genomics. 2004 Jun;83(6):1134-40.PMID: 15177566 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II-induced proteinuria and expression of the podocyte slit pore membrane protein, nephrin.

Langham RG, Kelly DJ, Cox AJ, Gow RM, Holthofer H, Gilbert RE.

Nephrol Dial Transplant. 2004 Jan;19(1):262-3. No abstract available. PMID: 14671077 [PubMed - indexed for MEDLINE]Related articlesFree article

Nephrinuria in diabetic nephropathy of type 1 diabetes.

Pätäri A, Forsblom C, Havana M, Taipale H, Groop PH, Holthöfer H.

Diabetes. 2003 Dec;52(12):2969-74.PMID: 14633858 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel protein, densin, expressed by glomerular podocytes.

Ahola H, Heikkilä E, Aström E, Inagaki M, Izawa I, Pavenstädt H, Kerjaschki D, Holthöfer H.

J Am Soc Nephrol. 2003 Jul;14(7):1731-7.PMID: 12819232 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes.

Huwiler A, Ren S, Holthöfer H, Pavenstädt H, Pfeilschifter J.

Biochem Biophys Res Commun. 2003 May 23;305(1):136-42.PMID: 12732207 [PubMed - indexed for MEDLINE]Related articles

Filtrin is a novel member of nephrin-like proteins.

Ihalmo P, Palmén T, Ahola H, Valtonen E, Holthöfer H.

Biochem Biophys Res Commun. 2003 Jan 10;300(2):364-70.PMID: 12504092 [PubMed - indexed for MEDLINE]Related articles

Hypercholesterolemia is a prerequisite for puromycin inducible damage in mouse kidney.

Cheng ZZ, Pätäri A, Aalto-Setälä K, Novikov D, Schlöndorff D, Holthöfer H.

Kidney Int. 2003 Jan;63(1):107-12.PMID: 12472773 [PubMed - indexed for MEDLINE]Related articles

High rate of monoclonal gammopathy among immunocompetent subjects with primary cytomegalovirus infection.

Bühler S, Laitinen K, Holthöfer H, Järvinen A, Schauman KO, Hedman K.

Clin Infect Dis. 2002 Dec 1;35(11):1430-3. Epub 2002 Nov 11.PMID: 12439809 [PubMed - indexed for MEDLINE]Related articles

Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition.

Langham RG, Kelly DJ, Cox AJ, Thomson NM, Holthöfer H, Zaoui P, Pinel N, Cordonnier DJ, Gilbert RE.

Diabetologia. 2002 Nov;45(11):1572-6. Epub 2002 Sep 25.PMID: 12436341 [PubMed - indexed for MEDLINE]Related articles

Expression of the slit-diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of anti-proteinuric therapies.

Kelly DJ, Aaltonen P, Cox AJ, Rumble JR, Langham R, Panagiotopoulos S, Jerums G, Holthöfer H, Gilbert RE.

Nephrol Dial Transplant. 2002 Jul;17(7):1327-32.PMID: 12105259 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of endogenous nephrin and CD2-associated protein in mouse epithelial M-1 cell line.

Palmén T, Lehtonen S, Ora A, Kerjaschki D, Antignac C, Lehtonen E, Holthöfer H.

J Am Soc Nephrol. 2002 Jul;13(7):1766-72.PMID: 12089372 [PubMed - indexed for MEDLINE]Related articlesFree article

Podocyte-associated molecules in puromycin aminonucleoside nephrosis of the rat.

Luimula P, Sandström N, Novikov D, Holthöfer H.

Lab Invest. 2002 Jun;82(6):713-8.PMID: 12065681 [PubMed - indexed for MEDLINE]Related articles

Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.

Rantanen M, Palmén T, Pätäri A, Ahola H, Lehtonen S, Aström E, Floss T, Vauti F, Wurst W, Ruiz P, Kerjaschki D, Holthöfer H.

J Am Soc Nephrol. 2002 Jun;13(6):1586-94.PMID: 12039988 [PubMed - indexed for MEDLINE]Related articlesFree article

Patterns of nephrin and a new proteinuria-associated protein expression in human renal diseases.

Wang SX, Rastaldi MP, Pätäri A, Ahola H, Heikkilä E, Holthöfer H.

Kidney Int. 2002 Jan;61(1):141-7.PMID: 11786094 [PubMed - indexed for MEDLINE]Related articlesFree article

Nephrin is expressed in the pancreatic beta cells.

Palmén T, Ahola H, Palgi J, Aaltonen P, Luimula P, Wang S, Jaakkola I, Knip M, Otonkoski T, Holthöfer H.

Diabetologia. 2001 Oct;44(10):1274-80.PMID: 11692176 [PubMed - indexed for MEDLINE]Related articles

Changes in the expression of nephrin gene and protein in experimental diabetic nephropathy.

Aaltonen P, Luimula P, Aström E, Palmen T, Grönholm T, Palojoki E, Jaakkola I, Ahola H, Tikkanen I, Holthöfer H.

Lab Invest. 2001 Sep;81(9):1185-90.PMID: 11555666 [PubMed - indexed for MEDLINE]Related articles

Recurrence of nephrotic syndrome after transplantation in CNF is due to autoantibodies to nephrin.

Wang SX, Ahola H, Palmen T, Solin ML, Luimula P, Holthöfer H.

Exp Nephrol. 2001;9(5):327-31.PMID: 11549850 [PubMed - indexed for MEDLINE]Related articles

Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm.

Simons M, Schwarz K, Kriz W, Miettinen A, Reiser J, Mundel P, Holthöfer H.

Am J Pathol. 2001 Sep;159(3):1069-77.PMID: 11549599 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrin-linked kinase as a candidate downstream effector in proteinuria.

Kretzler M, Teixeira VP, Unschuld PG, Cohen CD, Wanke R, Edenhofer I, Mundel P, Schlöndorff D, Holthöfer H.

FASEB J. 2001 Aug;15(10):1843-5. No abstract available. PMID: 11481249 [PubMed - indexed for MEDLINE]Related articlesFree article

Nephrin mRNA regulation by protein kinase C.

Wang SX, Menè P, Holthöfer H.

J Nephrol. 2001 Mar-Apr;14(2):98-103.PMID: 11411021 [PubMed - indexed for MEDLINE]Related articles

Lipid peroxidation in human proteinuric disease.

Solin ML, Ahola H, Haltia A, Ursini F, Montine T, Roveri A, Kerjaschki D, Holthöfer H.

Kidney Int. 2001 Feb;59(2):481-7.PMID: 11168930 [PubMed - indexed for MEDLINE]Related articlesFree article

Alternatively spliced nephrin in experimental glomerular disease of the rat.

Luimula P, Aaltonen P, Ahola H, Palmen T, Holthöfer H.

Pediatr Res. 2000 Dec;48(6):759-62.PMID: 11102543 [PubMed - indexed for MEDLINE]Related articles

Interactions between mitochondrial proteins and lipid peroxidation products in the maintenance of the glomerular filtration barrier in the in vitro perfused kidney.

Wang S, Solin M, Ahola H, Luimula P, Holthöfer H.

Exp Nephrol. 2001;9(1):14-20.PMID: 11053976 [PubMed - indexed for MEDLINE]Related articles

Nephrin in experimental glomerular disease.

Luimula P, Ahola H, Wang SX, Solin ML, Aaltonen P, Tikkanen I, Kerjaschki D, Holthöfer H.

Kidney Int. 2000 Oct;58(4):1461-8.PMID: 11012881 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial dysfunction in congenital nephrotic syndrome.

Solin ML, Pitkänen S, Taanman JW, Holthöfer H.

Lab Invest. 2000 Aug;80(8):1227-32.PMID: 10950113 [PubMed - indexed for MEDLINE]Related articles

Puromycin-induced lipid peroxidation in the cochlea of ApoE knockout mice.

Aarnisalo AA, Aalto-Setälä K, Holthöfer H, Ylikoski J.

Acta Otolaryngol Suppl. 2000;543:102-4.PMID: 10908992 [PubMed - indexed for MEDLINE]Related articles

Chemokine and chemokine receptor expression in a novel human mesangial cell line.

Banas B, Luckow B, Möller M, Klier C, Nelson PJ, Schadde E, Brigl M, Halevy D, Holthöfer H, Reinhart B, Schlöndorff D.

J Am Soc Nephrol. 1999 Nov;10(11):2314-22.PMID: 10541290 [PubMed - indexed for MEDLINE]Related articlesFree article

Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney.

Holthöfer H, Ahola H, Solin ML, Wang S, Palmen T, Luimula P, Miettinen A, Kerjaschki D.

Am J Pathol. 1999 Nov;155(5):1681-7.PMID: 10550324 [PubMed - indexed for MEDLINE]Related articlesFree article