PubMed

Has the time come to rethink the pathogenesis of asthma?

Holgate ST.

Curr Opin Allergy Clin Immunol. 2009 Nov 12. [Epub ahead of print]PMID: 19915457 [PubMed - as supplied by publisher]Related articles

Effect of omalizumab on peripheral blood eosinophilia in allergic asthma.

Massanari M, Holgate ST, Busse WW, Jimenez P, Kianifard F, Zeldin R.

Respir Med. 2009 Oct 19. [Epub ahead of print]PMID: 19846286 [PubMed - as supplied by publisher]Related articles

Rethinking the pathogenesis of asthma.

Holgate ST, Davies DE.

Immunity. 2009 Sep 18;31(3):362-7.PMID: 19766079 [PubMed - indexed for MEDLINE]Related articles

Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.

Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EJ, Xu J, Koning H, Bruinenberg M, Nolte IM, van Diemen CC, Boezen HM, Timens W, Whittaker PA, Stine OC, Barton SJ, Holloway JW, Holgate ST, Graves PE, Martinez FD, van Oosterhout AJ, Bleecker ER, Postma DS.

Am J Respir Crit Care Med. 2009 Nov 15;180(10):929-35. Epub 2009 Sep 3.PMID: 19729670 [PubMed - in process]Related articles

Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.

Haitchi HM, Bassett DJ, Bucchieri F, Gao X, Powell RM, Hanley NA, Wilson DI, Holgate ST, Davies DE.

J Allergy Clin Immunol. 2009 Sep;124(3):590-7, 597.e1-11. Epub 2009 Aug 8.PMID: 19665773 [PubMed - indexed for MEDLINE]Related articles

Adamalysins in biology and disease.

van Goor H, Melenhorst WB, Turner AJ, Holgate ST.

J Pathol. 2009 Nov;219(3):277-86.PMID: 19662664 [PubMed - in process]Related articles

Unmet needs in severe chronic upper airway disease (SCUAD).

Bousquet J, Bachert C, Canonica GW, Casale TB, Cruz AA, Lockey RJ, Zuberbier T; Extended Global Allergy and Asthma European Network, World Allergy Organization and Allergic Rhinitis and its Impact on Asthma Study Group.

J Allergy Clin Immunol. 2009 Sep;124(3):428-33. Epub 2009 Aug 5.PMID: 19660803 [PubMed - indexed for MEDLINE]Related articles

Genetic susceptibility to the respiratory effects of air pollution.

Yang IA, Fong KM, Zimmerman PV, Holgate ST, Holloway JW.

Postgrad Med J. 2009 Aug;85(1006):428-36.PMID: 19633009 [PubMed - in process]Related articles

Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways.

Knol AB, de Hartog JJ, Boogaard H, Slottje P, van der Sluijs JP, Lebret E, Cassee FR, Wardekker JA, Ayres JG, Borm PJ, Brunekreef B, Donaldson K, Forastiere F, Holgate ST, Kreyling WG, Nemery B, Pekkanen J, Stone V, Wichmann HE, Hoek G.

Part Fibre Toxicol. 2009 Jul 24;6:19.PMID: 19630955 [PubMed - in process]Related articlesFree article

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction.

Andrews AL, Nordgren IK, Kirby I, Holloway JW, Holgate ST, Davies DE, Tavassoli A.

Biochem Soc Trans. 2009 Aug;37(Pt 4):873-6. Review.PMID: 19614610 [PubMed - indexed for MEDLINE]Related articles

PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline.

Barton SJ, Koppelman GH, Vonk JM, Browning CA, Nolte IM, Stewart CE, Bainbridge S, Mutch S, Rose-Zerilli MJ, Postma DS, Maniatis N, Henry AP, Hall IP, Holgate ST, Tighe P, Holloway JW, Sayers I.

J Allergy Clin Immunol. 2009 Jun;123(6):1391-400.e17. Epub 2009 May 13.PMID: 19443020 [PubMed - indexed for MEDLINE]Related articles

Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.

Szczepankiewicz A, Rose-Zerilli MJ, Barton SJ, Holgate ST, Holloway JW.

Int Arch Allergy Immunol. 2009;149(4):343-9. Epub 2009 Mar 17.PMID: 19295238 [PubMed - indexed for MEDLINE]Related articles

Frmd7 expression in developing mouse brain.

Self J, Haitchi HM, Griffiths H, Holgate ST, Davies DE, Lotery A.

Eye (Lond). 2009 Mar 6. [Epub ahead of print]PMID: 19265863 [PubMed - as supplied by publisher]Related articles

Contribution of bronchial fibroblasts to the antiviral response in asthma.

Bedke N, Haitchi HM, Xatzipsalti M, Holgate ST, Davies DE.

J Immunol. 2009 Mar 15;182(6):3660-7.PMID: 19265144 [PubMed - indexed for MEDLINE]Related articles

Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development.

Haitchi HM, Yoshisue H, Ribbene A, Wilson SJ, Holloway JW, Bucchieri F, Hanley NA, Wilson DI, Zummo G, Holgate ST, Davies DE.

Eur Respir J. 2009 May;33(5):1095-104. Epub 2009 Feb 12.PMID: 19213785 [PubMed - indexed for MEDLINE]Related articles

Road ahead to respiratory health: experts chart future research directions.

Heffner JE, Holgate ST, Chung KF, Niederman MS, Daley CL, Jett JR, Stradling JR, Wells AU, Light RW, Tapson VF, Hansell DM, Provonost PJ, Lee YC.

Respirology. 2009 Jul;14(5):625-36. Epub 2009 Mar 11.PMID: 19207117 [PubMed - in process]Related articles

A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma.

Wenzel SE, Barnes PJ, Bleecker ER, Bousquet J, Busse W, Dahlén SE, Holgate ST, Meyers DA, Rabe KF, Antczak A, Baker J, Horvath I, Mark Z, Bernstein D, Kerwin E, Schlenker-Herceg R, Lo KH, Watt R, Barnathan ES, Chanez P; T03 Asthma Investigators.

Am J Respir Crit Care Med. 2009 Apr 1;179(7):549-58. Epub 2009 Jan 8.PMID: 19136369 [PubMed - indexed for MEDLINE]Related articles

Novel targets of therapy in asthma.

Holgate ST.

Curr Opin Pulm Med. 2009 Jan;15(1):63-71. Review.PMID: 19077708 [PubMed - indexed for MEDLINE]Related articles

A single-nucleotide polymorphism in intelectin 1 is associated with increased asthma risk.

Pemberton AD, Rose-Zerilli MJ, Holloway JW, Gray RD, Holgate ST.

J Allergy Clin Immunol. 2008 Nov;122(5):1033-4. No abstract available. PMID: 19000584 [PubMed - indexed for MEDLINE]Related articles

Are long-acting beta2-agonists safe in the treatment of asthma?

Holgate ST.

Pol Arch Med Wewn. 2008 Sep;118(9):460-1. No abstract available. PMID: 18846978 [PubMed - indexed for MEDLINE]Related articlesFree article

Developing consensus on national respiratory research priorities: key findings from the UK Respiratory Research Collaborative's e-Delphi exercise.

Sheikh A, Major P, Holgate ST.

Respir Med. 2008 Aug;102(8):1089-92. Epub 2008 Jun 24. No abstract available. PMID: 18573646 [PubMed - indexed for MEDLINE]Related articles

Cellular localization of interleukin 13 receptor alpha2 in human primary bronchial epithelial cells and fibroblasts.

Konstantinidis AK, Puddicombe SM, Mochizuki A, Sheth PD, Yang IA, Yoshisue H, Wilson SJ, Davies DE, Holgate ST, Holloway JW.

J Investig Allergol Clin Immunol. 2008;18(3):174-80.PMID: 18564628 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility.

Holloway JW, Barton SJ, Holgate ST, Rose-Zerilli MJ, Sayers I.

Allergy. 2008 Aug;63(8):1046-53. Epub 2008 Jun 10.PMID: 18547289 [PubMed - indexed for MEDLINE]Related articles

Genetic susceptibility to the respiratory effects of air pollution.

Yang IA, Fong KM, Zimmerman PV, Holgate ST, Holloway JW.

Thorax. 2008 Jun;63(6):555-63. Review.PMID: 18511640 [PubMed - indexed for MEDLINE]Related articles

Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study.

Hackett TL, Holloway R, Holgate ST, Warner JA.

Respir Res. 2008 May 29;9:47.PMID: 18510721 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathogenesis of asthma.

Holgate ST.

Clin Exp Allergy. 2008 Jun;38(6):872-97. Review.PMID: 18498538 [PubMed - indexed for MEDLINE]Related articles

Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Kerr JR, Petty R, Burke B, Gough J, Fear D, Sinclair LI, Mattey DL, Richards SC, Montgomery J, Baldwin DA, Kellam P, Harrison TJ, Griffin GE, Main J, Enlander D, Nutt DJ, Holgate ST.

J Infect Dis. 2008 Apr 15;197(8):1171-84.PMID: 18462164 [PubMed - indexed for MEDLINE]Related articles

Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium.

Pourazar J, Blomberg A, Kelly FJ, Davies DE, Wilson SJ, Holgate ST, Sandström T.

Part Fibre Toxicol. 2008 May 6;5:8.PMID: 18460189 [PubMed - in process]Related articlesFree article

Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells.

Yang Y, Haitchi HM, Cakebread J, Sammut D, Harvey A, Powell RM, Holloway JW, Howarth P, Holgate ST, Davies DE.

J Allergy Clin Immunol. 2008 Jun;121(6):1393-9, 1399.e1-14. Epub 2008 Apr 21.PMID: 18423563 [PubMed - indexed for MEDLINE]Related articles

The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma.

Puxeddu I, Pang YY, Harvey A, Haitchi HM, Nicholas B, Yoshisue H, Ribatti D, Clough G, Powell RM, Murphy G, Hanley NA, Wilson DI, Howarth PH, Holgate ST, Davies DE.

J Allergy Clin Immunol. 2008 Jun;121(6):1400-6, 1406.e1-4. Epub 2008 Apr 14.PMID: 18410963 [PubMed - indexed for MEDLINE]Related articles

Death rattle: its impact on staff and volunteers in palliative care.

Wee B, Coleman P, Hillier R, Holgate S.

Palliat Med. 2008 Mar;22(2):173-6.PMID: 18372381 [PubMed - indexed for MEDLINE]Related articles

Absence of respiratory effects with ivabradine in patients with asthma.

Babu KS, Gadzik F, Holgate ST.

Br J Clin Pharmacol. 2008 Jul;66(1):96-101. Epub 2008 Mar 13.PMID: 18341671 [PubMed - indexed for MEDLINE]Related articlesFree article

Interpatient variability in rates of asthma progression: can genetics provide an answer?

Holloway JW, Yang IA, Holgate ST.

J Allergy Clin Immunol. 2008 Mar;121(3):573-9. Review.PMID: 18328888 [PubMed - indexed for MEDLINE]Related articles

Treatment strategies for allergy and asthma.

Holgate ST, Polosa R.

Nat Rev Immunol. 2008 Mar;8(3):218-30. Epub 2008 Feb 15. Review.PMID: 18274559 [PubMed - indexed for MEDLINE]Related articles

The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial.

Morjaria JB, Chauhan AJ, Babu KS, Polosa R, Davies DE, Holgate ST.

Thorax. 2008 Jul;63(7):584-91. Epub 2008 Feb 1.PMID: 18245148 [PubMed - indexed for MEDLINE]Related articles

The airway epithelium is central to the pathogenesis of asthma.

Holgate ST.

Allergol Int. 2008 Mar;57(1):1-10. Epub 2008 Mar 1. Review.PMID: 18209502 [PubMed - indexed for MEDLINE]Related articlesFree article

Is artificial fluoride absorbed to the same extent as natural fluoride?

Sheldon T, Holgate ST.

J Dent Res. 2008 Jan;87(1):8; author reply 8. No abstract available. PMID: 18096887 [PubMed - indexed for MEDLINE]Related articles

Epithelium dysfunction in asthma.

Holgate ST.

J Allergy Clin Immunol. 2007 Dec;120(6):1233-44; quiz 1245-6. Review.PMID: 18073119 [PubMed - indexed for MEDLINE]Related articles

The future of lung research in the UK.

Holgate ST.

Thorax. 2007 Dec;62(12):1028-32. No abstract available. PMID: 18025137 [PubMed - indexed for MEDLINE]Related articles

Fluoridation: Interpreting the Newcastle fluoride bioavailability study.

Holgate ST, Sheldon TA.

BMJ. 2007 Oct 27;335(7625):840-1. No abstract available. PMID: 17962249 [PubMed - indexed for MEDLINE]Related articles

A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects.

Lakind JS, Holgate ST, Ownby DR, Mansur AH, Helms PJ, Pyatt D, Hays SM.

Biomarkers. 2007 Sep-Oct;12(5):445-67. Review.PMID: 17701745 [PubMed - indexed for MEDLINE]Related articles

Replacing animal experiments: choices, chances and challenges.

Langley G, Evans T, Holgate ST, Jones A.

Bioessays. 2007 Sep;29(9):918-26.PMID: 17688239 [PubMed - indexed for MEDLINE]Related articles

IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations.

Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, Zummo G, Holgate ST, Attia J, Thakkinstian A, Davies DE.

J Allergy Clin Immunol. 2007 Sep;120(3):586-93. Epub 2007 Jul 12.PMID: 17628646 [PubMed - indexed for MEDLINE]Related articles

Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q.

Andrews AL, Bucchieri F, Arima K, Izuhara K, Holgate ST, Davies DE, Holloway JW.

J Allergy Clin Immunol. 2007 Jul;120(1):91-7. Epub 2007 Jun 8.PMID: 17560640 [PubMed - indexed for MEDLINE]Related articles

Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4.

Jame AJ, Lackie PM, Cazaly AM, Sayers I, Penrose JF, Holgate ST, Sampson AP.

Clin Exp Allergy. 2007 Jun;37(6):880-92.PMID: 17517102 [PubMed - indexed for MEDLINE]Related articles

The epithelium takes centre stage in asthma and atopic dermatitis.

Holgate ST.

Trends Immunol. 2007 Jun;28(6):248-51. Epub 2007 Apr 27. Review.PMID: 17466594 [PubMed - indexed for MEDLINE]Related articles

Factors associated with mortality after an asthma admission: a national United Kingdom database analysis.

Watson L, Turk F, James P, Holgate ST.

Respir Med. 2007 Aug;101(8):1659-64. Epub 2007 Apr 25.PMID: 17462875 [PubMed - indexed for MEDLINE]Related articles

Severe asthma in adults: what are the important questions?

Chanez P, Wenzel SE, Anderson GP, Anto JM, Bel EH, Boulet LP, Brightling CE, Busse WW, Castro M, Dahlen B, Dahlen SE, Fabbri LM, Holgate ST, Humbert M, Gaga M, Joos GF, Levy B, Rabe KF, Sterk PJ, Wilson SJ, Vachier I.

J Allergy Clin Immunol. 2007 Jun;119(6):1337-48. Epub 2007 Apr 9.PMID: 17416409 [PubMed - indexed for MEDLINE]Related articles

Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms.

Holgate ST, Davies DE, Powell RM, Howarth PH, Haitchi HM, Holloway JW.

Eur Respir J. 2007 Apr;29(4):793-803. Review.PMID: 17400878 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy.

Konstantinidis AK, Barton SJ, Sayers I, Yang IA, Lordan JL, Rorke S, Clough JB, Holgate ST, Holloway JW.

Eur Respir J. 2007 Jul;30(1):40-7. Epub 2007 Mar 28.PMID: 17392323 [PubMed - indexed for MEDLINE]Related articlesFree article