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    Results: 1 to 50 of 551

    1.

    Expression of interleukin 15 in primary adult acute lymphoblastic leukemia.

    Wu S, Fischer L, Gökbuget N, Schwartz S, Burmeister T, Notter M, Hoelzer D, Fuchs H, Blau IW, Hofmann WK, Thiel E.

    Cancer. 2009 Nov 18. [Epub ahead of print]PMID: 19924795 [PubMed - as supplied by publisher]Related articles

    2.

    Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL.

    Giebel S, Stella-Holowiecka B, Krawczyk-Kulis M, Gökbuget N, Hoelzer D, Doubek M, Mayer J, Piatkowska-Jakubas B, Skotnicki AB, Dombret H, Ribera JM, Piccaluga PP, Czerw T, Kyrcz-Krzemien S, Holowiecki J.

    Bone Marrow Transplant. 2009 Oct 26. [Epub ahead of print]PMID: 19855438 [PubMed - as supplied by publisher]Related articles

    3.

    Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia.

    Baldus CD, Thibaut J, Goekbuget N, Stroux A, Schlee C, Mossner M, Burmeister T, Schwartz S, Bloomfield CD, Hoelzer D, Thiel E, Hofmann WK.

    Haematologica. 2009 Oct;94(10):1383-90.PMID: 19794083 [PubMed - in process]Related articlesFree article

    4.

    T-cell lymphoblastic lymphoma and T-cell acute lymphoblastic leukemia: a separate entity?

    Hoelzer D, Gökbuget N.

    Clin Lymphoma Myeloma. 2009;9 Suppl 3:S214-21.PMID: 19778844 [PubMed - in process]Related articles

    5.

    Outcomes of patients with burkitt lymphoma older than age 40 treated with intensive chemotherapeutic regimens.

    Kelly JL, Toothaker SR, Ciminello L, Hoelzer D, Holte H, LaCasce AS, Mead G, Thomas D, Van Imhoff GW, Kahl BS, Cheson BD, Magrath IT, Fisher RI, Friedberg JW.

    Clin Lymphoma Myeloma. 2009 Aug;9(4):307-10.PMID: 19717381 [PubMed - in process]Related articles

    6.

    Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia.

    Burmeister T, Gökbuget N, Schwartz S, Fischer L, Hubert D, Sindram A, Hoelzer D, Thiel E.

    Haematologica. 2009 Aug 27. [Epub ahead of print]PMID: 19713226 [PubMed - as supplied by publisher]Related articlesFree article

    7.

    Wilms' tumor gene 1 (WT1) expression in subtypes of acute lymphoblastic leukemia (ALL) of adults and impact on clinical outcome.

    Busse A, Gökbuget N, Siehl JM, Hoelzer D, Schwartz S, Rietz A, Thiel E, Keilholz U.

    Ann Hematol. 2009 Dec;88(12):1199-205. Epub 2009 Apr 29.PMID: 19404640 [PubMed - in process]Related articles

    8.

    [Role of multicenter study groups for clinical research in hematology and oncology]

    Gökbuget N, Hoelzer D.

    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2009 Apr;52(4):417-24. German. PMID: 19277471 [PubMed - indexed for MEDLINE]Related articles

    9.

    The homeobox gene CDX2 is aberrantly expressed and associated with an inferior prognosis in patients with acute lymphoblastic leukemia.

    Thoene S, Rawat VP, Heilmeier B, Hoster E, Metzeler KH, Herold T, Hiddemann W, Gökbuget N, Hoelzer D, Bohlander SK, Feuring-Buske M, Buske C.

    Leukemia. 2009 Apr;23(4):649-55. Epub 2009 Jan 22.PMID: 19158837 [PubMed - indexed for MEDLINE]Related articles

    10.

    The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.

    Burmeister T, Meyer C, Schwartz S, Hofmann J, Molkentin M, Kowarz E, Schneider B, Raff T, Reinhardt R, Gökbuget N, Hoelzer D, Thiel E, Marschalek R.

    Blood. 2009 Apr 23;113(17):4011-5. Epub 2009 Jan 14.PMID: 19144982 [PubMed - indexed for MEDLINE]Related articles

    11.

    CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy.

    Fischer L, Gökbuget N, Schwartz S, Burmeister T, Rieder H, Brüggemann M, Hoelzer D, Thiel E.

    Haematologica. 2009 Feb;94(2):224-9. Epub 2008 Dec 23.PMID: 19109214 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Treatment of adult acute lymphoblastic leukemia.

    Gökbuget N, Hoelzer D.

    Semin Hematol. 2009 Jan;46(1):64-75. Review.PMID: 19100369 [PubMed - indexed for MEDLINE]Related articles

    13.

    Aberrant promotor methylation in MDS hematopoietic cells during in vitro lineage specific differentiation is differently associated with DNMT isoforms.

    Hopfer O, Komor M, Koehler IS, Freitag C, Schulze M, Hoelzer D, Thiel E, Hofmann WK.

    Leuk Res. 2009 Mar;33(3):434-42. Epub 2008 Sep 30.PMID: 18829110 [PubMed - indexed for MEDLINE]Related articles

    14.

    Allogeneic SCT in refractory or relapsed adult ALL is effective without prior reinduction chemotherapy.

    Terwey TH, Massenkeil G, Tamm I, Hemmati PG, Neuburger S, Martus P, Dörken B, Hoelzer D, Arnold R.

    Bone Marrow Transplant. 2008 Dec;42(12):791-8. Epub 2008 Aug 18.PMID: 18711350 [PubMed - indexed for MEDLINE]Related articles

    15.

    Patients' age and BCR-ABL frequency in adult B-precursor ALL: a retrospective analysis from the GMALL study group.

    Burmeister T, Schwartz S, Bartram CR, Gökbuget N, Hoelzer D, Thiel E; GMALL study group.

    Blood. 2008 Aug 1;112(3):918-9. No abstract available. PMID: 18650471 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    High-dose chemotherapy and immunotherapy in adult Burkitt lymphoma: comparison of results in human immunodeficiency virus-infected and noninfected patients.

    Oriol A, Ribera JM, Bergua J, Giménez Mesa E, Grande C, Esteve J, Brunet S, Moreno MJ, Escoda L, Hernandez-Rivas JM, Hoelzer D.

    Cancer. 2008 Jul 1;113(1):117-25.PMID: 18457327 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group.

    Baak U, Gökbuget N, Orawa H, Schwartz S, Hoelzer D, Thiel E, Burmeister T; German Multicenter ALL Study Group.

    Leukemia. 2008 Jun;22(6):1154-60. Epub 2008 Mar 27.PMID: 18368072 [PubMed - indexed for MEDLINE]Related articles

    18.

    Purine nucleoside phosphorylase inhibition as a novel therapeutic approach for B-cell lymphoid malignancies.

    Furman RR, Hoelzer D.

    Semin Oncol. 2007 Dec;34(6 Suppl 5):S29-34. Review.PMID: 18086344 [PubMed - indexed for MEDLINE]Related articles

    19.

    Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia.

    Burmeister T, Schwartz S, Taubald A, Jost E, Lipp T, Schneller F, Diedrich H, Thomssen H, Mey UJ, Eucker J, Rieder H, Gökbuget N, Hoelzer D, Thiel E.

    Haematologica. 2007 Dec;92(12):1699-702.PMID: 18055996 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Impact of leukapheresis on early death rate in adult acute myeloid leukemia presenting with hyperleukocytosis.

    Bug G, Anargyrou K, Tonn T, Bialleck H, Seifried E, Hoelzer D, Ottmann OG.

    Transfusion. 2007 Oct;47(10):1843-50.PMID: 17880610 [PubMed - indexed for MEDLINE]Related articles

    21.

    Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells.

    Nowak D, Boehrer S, Hochmuth S, Trepohl B, Hofmann W, Hoelzer D, Hofmann WK, Mitrou PS, Ruthardt M, Chow KU.

    Anticancer Drugs. 2007 Oct;18(9):981-95.PMID: 17704648 [PubMed - indexed for MEDLINE]Related articles

    22.

    Nonsecretory primary plasma cell leukemia with good response to thalidomide-based treatment.

    Brück P, Mousset S, Bühme A, Hoelzer D, Atta J.

    Int J Hematol. 2007 Jul;86(1):66-8.PMID: 17675269 [PubMed - indexed for MEDLINE]Related articles

    23.

    Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome.

    Baldus CD, Martus P, Burmeister T, Schwartz S, Gökbuget N, Bloomfield CD, Hoelzer D, Thiel E, Hofmann WK.

    J Clin Oncol. 2007 Aug 20;25(24):3739-45. Epub 2007 Jul 23.PMID: 17646667 [PubMed - indexed for MEDLINE]Related articles

    24.

    The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines.

    Chow KU, Nowak D, Trepohl B, Hochmuth S, Schneider B, Hoelzer D, Mitrou PS, Bergmann L, Ottmann OG, Boehrer S.

    Leuk Lymphoma. 2007 Jul;48(7):1379-88.PMID: 17613767 [PubMed - indexed for MEDLINE]Related articles

    25.

    Genomic imprinting of insulin-like growth factor 2 (IGF-2) in chronic synovitis.

    Möller B, Kerschbaumer G, Komor M, Kerschbaumer F, Ottmann OG, Hoelzer D, Hofmann WK.

    Growth Horm IGF Res. 2007 Dec;17(6):500-5. Epub 2007 Jun 21.PMID: 17590364 [PubMed - indexed for MEDLINE]Related articles

    26.

    Advances in the treatment of Chronic Granulomatous Disease by gene therapy.

    Ott MG, Seger R, Stein S, Siler U, Hoelzer D, Grez M.

    Curr Gene Ther. 2007 Jun;7(3):155-61. Review.PMID: 17584034 [PubMed - indexed for MEDLINE]Related articles

    27.

    DNA methylation profiling of myelodysplastic syndrome hematopoietic progenitor cells during in vitro lineage-specific differentiation.

    Hopfer O, Komor M, Koehler IS, Schulze M, Hoelzer D, Thiel E, Hofmann WK.

    Exp Hematol. 2007 May;35(5):712-23.PMID: 17577921 [PubMed - indexed for MEDLINE]Related articles

    28.

    Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.

    Bug G, Schwarz K, Schoch C, Kampfmann M, Henschler R, Hoelzer D, Ottmann OG, Ruthardt M.

    Haematologica. 2007 Apr;92(4):542-5.PMID: 17488665 [PubMed - indexed for MEDLINE]Related articlesFree article

    29.

    Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL).

    Ottmann OG, Wassmann B, Pfeifer H, Giagounidis A, Stelljes M, Dührsen U, Schmalzing M, Wunderle L, Binckebanck A, Hoelzer D; GMALL Study Group.

    Cancer. 2007 May 15;109(10):2068-76.PMID: 17429836 [PubMed - indexed for MEDLINE]Related articlesFree article

    30.

    Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).

    Pfeifer H, Wassmann B, Pavlova A, Wunderle L, Oldenburg J, Binckebanck A, Lange T, Hochhaus A, Wystub S, Brück P, Hoelzer D, Ottmann OG.

    Blood. 2007 Jul 15;110(2):727-34. Epub 2007 Apr 3.PMID: 17405907 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells.

    Zheng X, Seshire A, Rüster B, Bug G, Beissert T, Puccetti E, Hoelzer D, Henschler R, Ruthardt M.

    Haematologica. 2007 Mar;92(3):323-31.PMID: 17339181 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    Dexa-BEAM as salvage therapy in patients with primary refractory aggressive non-Hodgkin lymphoma.

    Atta J, Chow KU, Weidmann E, Mitrou PS, Hoelzer D, Martin H.

    Leuk Lymphoma. 2007 Feb;48(2):349-56.PMID: 17325896 [PubMed - indexed for MEDLINE]Related articles

    33.

    No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms.

    Burmeister T, Schwartz S, Hummel M, Hoelzer D, Thiel E.

    Retrovirology. 2007 Feb 7;4:11.PMID: 17284327 [PubMed - indexed for MEDLINE]Related articlesFree article

    34.

    Advances in the management of Ph-positive ALL.

    Hoelzer D.

    Clin Adv Hematol Oncol. 2006 Nov;4(11):804-5. Review. No abstract available. PMID: 17143248 [PubMed - indexed for MEDLINE]Related articles

    35.

    Treatment of adult acute lymphoblastic leukemia.

    Gökbuget N, Hoelzer D.

    Hematology Am Soc Hematol Educ Program. 2006:133-41. Review.PMID: 17124052 [PubMed - indexed for MEDLINE]Related articlesFree article

    36.

    AIDS-associated Burkitt or Burkitt-like lymphoma: short intensive polychemotherapy is feasible and effective.

    Hoffmann C, Wolf E, Wyen C, Fätkenheuer G, Van Lunzen J, Stellbrink HJ, Stoehr A, Plettenberg A, Jaeger H, Noppeney R, Hentrich M, Goekbuget N, Hoelzer D, Horst HA.

    Leuk Lymphoma. 2006 Sep;47(9):1872-80.PMID: 17065000 [PubMed - indexed for MEDLINE]Related articles

    37.

    [Clinical research at the European LeukemiaNet]

    Saussele S, Adam K, Hochhaus A, Béné MC, Büchner T, Burnett A, Finazzi G, Fonatsch C, Gluckman E, Gökbuget N, Grimwade DJ, Haferlach T, Hallek M, Hasford J, Hoelzer D, Ljungman P, Niederwieser D, Serve H, Simonsson B, de Witte TJ, Hehlmann R; European LeukemiaNet.

    Dtsch Med Wochenschr. 2006 Oct 27;131(43):2423-6. German. No abstract available. PMID: 17054061 [PubMed - indexed for MEDLINE]Related articles

    38.

    Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trials.

    Raff T, Gökbuget N, Lüschen S, Reutzel R, Ritgen M, Irmer S, Böttcher S, Horst HA, Kneba M, Hoelzer D, Brüggemann M; GMALL Study Group.

    Blood. 2007 Feb 1;109(3):910-5. Epub 2006 Oct 5.PMID: 17023577 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Novel antibody-based therapy for acute lymphoblastic leukaemia.

    Gökbuget N, Hoelzer D.

    Best Pract Res Clin Haematol. 2006;19(4):701-13. Review.PMID: 16997178 [PubMed - indexed for MEDLINE]Related articles

    40.

    High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults.

    Baldus CD, Burmeister T, Martus P, Schwartz S, Gökbuget N, Bloomfield CD, Hoelzer D, Thiel E, Hofmann WK.

    J Clin Oncol. 2006 Oct 10;24(29):4714-20. Epub 2006 Sep 5.PMID: 16954520 [PubMed - indexed for MEDLINE]Related articles

    41.

    The molecular biology of TRAIL-mediated signaling and its potential therapeutic exploitation in hematopoietic malignancies.

    Boehrer S, Nowak D, Hoelzer D, Mitrou PS, Chow KU.

    Curr Med Chem. 2006;13(18):2091-100. Review.PMID: 16918339 [PubMed - indexed for MEDLINE]Related articles

    42.

    NUP214-ABL1 in adult T-ALL: the GMALL study group experience.

    Burmeister T, Gökbuget N, Reinhardt R, Rieder H, Hoelzer D, Schwartz S.

    Blood. 2006 Nov 15;108(10):3556-9. Epub 2006 Jul 27.PMID: 16873673 [PubMed - indexed for MEDLINE]Related articlesFree article

    43.

    Multicenter phase II trial of immunotherapy with the humanized anti-CD22 antibody, epratuzumab, in combination with rituximab, in refractory or recurrent non-Hodgkin's lymphoma.

    Strauss SJ, Morschhauser F, Rech J, Repp R, Solal-Celigny P, Zinzani PL, Engert A, Coiffier B, Hoelzer DF, Wegener WA, Teoh NK, Goldenberg DM, Lister TA.

    J Clin Oncol. 2006 Aug 20;24(24):3880-6. Epub 2006 Jul 24.PMID: 16864854 [PubMed - indexed for MEDLINE]Related articles

    44.

    Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL.

    Kantarjian H, Giles F, Wunderle L, Bhalla K, O'Brien S, Wassmann B, Tanaka C, Manley P, Rae P, Mietlowski W, Bochinski K, Hochhaus A, Griffin JD, Hoelzer D, Albitar M, Dugan M, Cortes J, Alland L, Ottmann OG.

    N Engl J Med. 2006 Jun 15;354(24):2542-51.PMID: 16775235 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    [Clinical research within the German competence net "acute and chronic leukemias"]

    Saussele S, Berger U, Aul C, Büchner T, Döhner H, Ehninger G, Ganser A, Gökbuget N, Hoelzer D, Uberla K, Hehlmann R.

    Med Klin (Munich). 2006 May 15;101(5):414-20. German. PMID: 16685489 [PubMed - indexed for MEDLINE]Related articles

    46.

    Comparative analysis of hypermethylation of cell cycle control and DNA-mismatch repair genes in low-density and CD34+ bone marrow cells from patients with myelodysplastic syndrome.

    Hofmann WK, Takeuchi S, Takeuchi N, Thiel E, Hoelzer D, Koeffler HP.

    Leuk Res. 2006 Nov;30(11):1347-53. Epub 2006 May 8.PMID: 16682076 [PubMed - indexed for MEDLINE]Related articles

    47.

    Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).

    Wassmann B, Pfeifer H, Goekbuget N, Beelen DW, Beck J, Stelljes M, Bornhäuser M, Reichle A, Perz J, Haas R, Ganser A, Schmid M, Kanz L, Lenz G, Kaufmann M, Binckebanck A, Brück P, Reutzel R, Gschaidmeier H, Schwartz S, Hoelzer D, Ottmann OG.

    Blood. 2006 Sep 1;108(5):1469-77. Epub 2006 Apr 25.PMID: 16638934 [PubMed - indexed for MEDLINE]Related articlesFree article

    48.

    Inhibition of phosphotyrosine phosphatase 1B causes resistance in BCR-ABL-positive leukemia cells to the ABL kinase inhibitor STI571.

    Koyama N, Koschmieder S, Tyagi S, Portero-Robles I, Chromic J, Myloch S, Nürnberger H, Rossmanith T, Hofmann WK, Hoelzer D, Ottmann OG.

    Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2025-31.PMID: 16609011 [PubMed - indexed for MEDLINE]Related articlesFree article

    49.

    Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

    Ott MG, Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U, Glimm H, Kühlcke K, Schilz A, Kunkel H, Naundorf S, Brinkmann A, Deichmann A, Fischer M, Ball C, Pilz I, Dunbar C, Du Y, Jenkins NA, Copeland NG, Lüthi U, Hassan M, Thrasher AJ, Hoelzer D, von Kalle C, Seger R, Grez M.

    Nat Med. 2006 Apr;12(4):401-9. Epub 2006 Apr 2.PMID: 16582916 [PubMed - indexed for MEDLINE]Related articles

    50.

    Prostate-apoptosis-response-gene-4 increases sensitivity to TRAIL-induced apoptosis.

    Boehrer S, Nowak D, Puccetti E, Ruthardt M, Sattler N, Trepohl B, Schneider B, Hoelzer D, Mitrou PS, Chow KU.

    Leuk Res. 2006 May;30(5):597-605. Epub 2006 Mar 2.PMID: 16513168 [PubMed - indexed for MEDLINE]Related articles

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