PubMed

Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, Engert JC, Fisher E, Francès F, Froguel P, Hebebrand J, Hegele RA, Hinney A, Hoehe MR, Hu FB, Hubacek JA, Humphries SE, Hunt SC, Illig T, Järvelin MR, Kaakinen M, Kollerits B, Krude H, Kumar J, Lange LA, Langer B, Li S, Luchner A, Lyon HN, Meyre D, Mohlke KL, Mooser V, Nebel A, Nguyen TT, Paulweber B, Perusse L, Qi L, Rankinen T, Rosskopf D, Schreiber S, Sengupta S, Sorice R, Suk A, Thorleifsson G, Thorsteinsdottir U, Völzke H, Vimaleswaran KS, Wareham NJ, Waterworth D, Yusuf S, Lindgren C, McCarthy MI, Lange C, Hirschhorn JN, Laird N, Wichmann HE.

PLoS Genet. 2009 Oct;5(10):e1000694. Epub 2009 Oct 23.PMID: 19851442 [PubMed - in process]Related articlesFree article

CYP19A1 genetic variation in relation to prostate cancer risk and circulating sex hormone concentrations in men from the Breast and Prostate Cancer Cohort Consortium.

Travis RC, Schumacher F, Hirschhorn JN, Kraft P, Allen NE, Albanes D, Berglund G, Berndt SI, Boeing H, Bueno-de-Mesquita HB, Calle EE, Chanock S, Dunning AM, Hayes R, Feigelson HS, Gaziano JM, Giovannucci E, Haiman CA, Henderson BE, Kaaks R, Kolonel LN, Ma J, Rodriguez L, Riboli E, Stampfer M, Stram DO, Thun MJ, Tjønneland A, Trichopoulos D, Vineis P, Virtamo J, Le Marchand L, Hunter DJ.

Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2734-44. Epub 2009 Sep 29.PMID: 19789370 [PubMed - in process]Related articles

Peroxisome proliferator-activated receptor-gamma (PPARgamma) Pro12Ala polymorphism and risk for pediatric obesity.

Dedoussis GV, Vidra N, Butler J, Papoutsakis C, Yannakoulia M, Hirschhorn JN, Lyon HN.

Clin Chem Lab Med. 2009;47(9):1047-50.PMID: 19634985 [PubMed - indexed for MEDLINE]Related articles

NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.

Heard-Costa NL, Zillikens MC, Monda KL, Johansson A, Harris TB, Fu M, Haritunians T, Feitosa MF, Aspelund T, Eiriksdottir G, Garcia M, Launer LJ, Smith AV, Mitchell BD, McArdle PF, Shuldiner AR, Bielinski SJ, Boerwinkle E, Brancati F, Demerath EW, Pankow JS, Arnold AM, Chen YD, Glazer NL, McKnight B, Psaty BM, Rotter JI, Amin N, Campbell H, Gyllensten U, Pattaro C, Pramstaller PP, Rudan I, Struchalin M, Vitart V, Gao X, Kraja A, Province MA, Zhang Q, Atwood LD, Dupuis J, Hirschhorn JN, Jaquish CE, O'Donnell CJ, Vasan RS, White CC, Aulchenko YS, Estrada K, Hofman A, Rivadeneira F, Uitterlinden AG, Witteman JC, Oostra BA, Kaplan RC, Gudnason V, O'Connell JR, Borecki IB, van Duijn CM, Cupples LA, Fox CS, North KE.

PLoS Genet. 2009 Jun;5(6):e1000539. Epub 2009 Jun 26.PMID: 19557197 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan J, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC, Zhao JH, Almgren P, Bandinelli S, Bennett AJ, Bergman RN, Bonnycastle LL, Bumpstead SJ, Chanock SJ, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney AS, Ebrahim S, Elliott P, Erdos MR, Estrada K, Ferrucci L, Fischer G, Forouhi NG, Gieger C, Grallert H, Groves CJ, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna AS, Hofman A, Holle R, Holloway JW, Illig T, Isomaa B, Jacobs LC, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop GM, Lawlor DA, Mangino M, McArdle WL, Meitinger T, Morken MA, Morris AP, Munroe P, Narisu N, Nordström A, Nordström P, Oostra BA, Palmer CN, Payne F, Peden JF, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu MS, Scott LJ, Scuteri A, Silander K, Song K, Yuan X, Stringham HM, Swift AJ, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters GB, Weedon MN; Wellcome Trust Case Control Consortium, Witteman JC, Zhang C, Zhang W, Caulfield MJ, Collins FS, Davey Smith G, Day IN, Franks PW, Hattersley AT, Hu FB, Jarvelin MR, Kong A, Kooner JS, Laakso M, Lakatta E, Mooser V, Morris AD, Peltonen L, Samani NJ, Spector TD, Strachan DP, Tanaka T, Tuomilehto J, Uitterlinden AG, van Duijn CM, Wareham NJ, Hugh Watkins; Procardis Consortia, Waterworth DM, Boehnke M, Deloukas P, Groop L, Hunter DJ, Thorsteinsdottir U, Schlessinger D, Wichmann HE, Frayling TM, Abecasis GR, Hirschhorn JN, Loos RJ, Stefansson K, Mohlke KL, Barroso I, McCarthy MI; Giant Consortium.

PLoS Genet. 2009 Jun;5(6):e1000508. Epub 2009 Jun 26. Erratum in: PLoS Genet. 2009 Jul;5(7). doi: 10.1371/annotation/b6e8f9f6-2496-4a40-b0e3-e1d1390c1928. PMID: 19557161 [PubMed - indexed for MEDLINE]Related articlesFree article

Common body mass index-associated variants confer risk of extreme obesity.

Cotsapas C, Speliotes EK, Hatoum IJ, Greenawalt DM, Dobrin R, Lum PY, Suver C, Chudin E, Kemp D, Reitman M, Voight BF, Neale BM, Schadt EE, Hirschhorn JN, Kaplan LM, Daly MJ; GIANT Consortium.

Hum Mol Genet. 2009 Sep 15;18(18):3502-7. Epub 2009 Jun 24.PMID: 19553259 [PubMed - in process]Related articles

Progress in genome-wide association studies of human height.

Hirschhorn JN, Lettre G.

Horm Res. 2009 Apr;71 Suppl 2:5-13. Epub 2009 Apr 29. Review.PMID: 19407491 [PubMed - indexed for MEDLINE]Related articles

Genomewide association studies--illuminating biologic pathways.

Hirschhorn JN.

N Engl J Med. 2009 Apr 23;360(17):1699-701. Epub 2009 Apr 15. No abstract available. PMID: 19369661 [PubMed - indexed for MEDLINE]Related articles

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure.

Newton-Cheh C, Larson MG, Vasan RS, Levy D, Bloch KD, Surti A, Guiducci C, Kathiresan S, Benjamin EJ, Struck J, Morgenthaler NG, Bergmann A, Blankenberg S, Kee F, Nilsson P, Yin X, Peltonen L, Vartiainen E, Salomaa V, Hirschhorn JN, Melander O, Wang TJ.

Nat Genet. 2009 Mar;41(3):348-53. Epub 2009 Feb 15.PMID: 19219041 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

Myocardial Infarction Genetics Consortium, Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Samani NJ, Schunkert H, Erdmann J, Reilly MP, Rader DJ, Morgan T, Spertus JA, Stoll M, Girelli D, McKeown PP, Patterson CC, Siscovick DS, O'Donnell CJ, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Melander O, Altshuler D, Ardissino D, Merlini PA, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, Celli P, Ferrario M, Fetiveau R, Marziliano N, Casari G, Galli M, Ribichini F, Rossi M, Bernardi F, Zonzin P, Piazza A, Mannucci PM, Schwartz SM, Siscovick DS, Yee J, Friedlander Y, Elosua R, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Kathiresan S, Meigs JB, Williams G, Nathan DM, MacRae CA, O'Donnell CJ, Salomaa V, Havulinna AS, Peltonen L, Melander O, Berglund G, Voight BF, Kathiresan S, Hirschhorn JN, Asselta R, Duga S, Spreafico M, Musunuru K, Daly MJ, Purcell S, Voight BF, Purcell S, Nemesh J, Korn JM, McCarroll SA, Schwartz SM, Yee J, Kathiresan S, Lucas G, Subirana I, Elosua R, Surti A, Guiducci C, Gianniny L, Mirel D, Parkin M, Burtt N, Gabriel SB, Samani NJ, Thompson JR, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Hall AS; Wellcome Trust Case Control Consortium, Schunkert H, Erdmann J, Linsel-Nitschke P, Lieb W, Ziegler A, König I, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Schunkert H, Samani NJ, Erdmann J, Ouwehand W, Hengstenberg C, Deloukas P, Scholz M, Cambien F, Reilly MP, Li M, Chen Z, Wilensky R, Matthai W, Qasim A, Hakonarson HH, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Epstein SE, Rader DJ, Scheffold T, Berger K, Stoll M, Huge A, Girelli D, Martinelli N, Olivieri O, Corrocher R, Morgan T, Spertus JA, McKeown P, Patterson CC, Schunkert H, Erdmann E, Linsel-Nitschke P, Lieb W, Ziegler A, König IR, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Hólm H, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Engert JC, Do R, Xie C, Anand S, Kathiresan S, Ardissino D, Mannucci PM, Siscovick D, O'Donnell CJ, Samani NJ, Melander O, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Altshuler D.

Nat Genet. 2009 Mar;41(3):334-41. Epub 2009 Feb 8.PMID: 19198609 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of weighted reference panels based on empirical estimates of ancestry for capturing untyped variation.

Egyud MR, Gajdos ZK, Butler JL, Tischfield S, Le Marchand L, Kolonel LN, Haiman CA, Henderson BE, Hirschhorn JN.

Hum Genet. 2009 Apr;125(3):295-303. Epub 2009 Jan 28.PMID: 19184111 [PubMed - indexed for MEDLINE]Related articles

What controls the timing of puberty? An update on progress from genetic investigation.

Gajdos ZK, Hirschhorn JN, Palmert MR.

Curr Opin Endocrinol Diabetes Obes. 2009 Feb;16(1):16-24. Review.PMID: 19104234 [PubMed - indexed for MEDLINE]Related articles

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of ANthropometric Traits Consortium.

Nat Genet. 2009 Jan;41(1):25-34. Epub 2008 Dec 14.PMID: 19079261 [PubMed - indexed for MEDLINE]Related articlesFree article

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH.

Science. 2008 Dec 19;322(5909):1839-42. Epub 2008 Dec 4.PMID: 19056937 [PubMed - indexed for MEDLINE]Related articlesFree article

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.

Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, Li M, Derohannessian S, de Bakker PI, Bailey SD, Montpetit A, Edmondson AC, Taylor K, Gai X, Wang SS, Fornage M, Shaikh T, Groop L, Boehnke M, Hall AS, Hattersley AT, Frackelton E, Patterson N, Chiang CW, Kim CE, Fabsitz RR, Ouwehand W, Price AL, Munroe P, Caulfield M, Drake T, Boerwinkle E, Reich D, Whitehead AS, Cappola TP, Samani NJ, Lusis AJ, Schadt E, Wilson JG, Koenig W, McCarthy MI, Kathiresan S, Gabriel SB, Hakonarson H, Anand SS, Reilly M, Engert JC, Nickerson DA, Rader DJ, Hirschhorn JN, Fitzgerald GA.

PLoS One. 2008;3(10):e3583. Epub 2008 Oct 31.PMID: 18974833 [PubMed - indexed for MEDLINE]Related articlesFree article

Ultraconserved elements: analyses of dosage sensitivity, motifs and boundaries.

Chiang CW, Derti A, Schwartz D, Chou MF, Hirschhorn JN, Wu CT.

Genetics. 2008 Dec;180(4):2277-93. Epub 2008 Oct 28.PMID: 18957701 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide association studies: potential next steps on a genetic journey.

McCarthy MI, Hirschhorn JN.

Hum Mol Genet. 2008 Oct 15;17(R2):R156-65. Review.PMID: 18852205 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide association studies: past, present and future.

McCarthy MI, Hirschhorn JN.

Hum Mol Genet. 2008 Oct 15;17(R2):R100-1. No abstract available. PMID: 18852196 [PubMed - indexed for MEDLINE]Related articlesFree article

Association studies of common variants in 10 hypogonadotropic hypogonadism genes with age at menarche.

Gajdos ZK, Butler JL, Henderson KD, He C, Supelak PJ, Egyud M, Price A, Reich D, Clayton PE, Le Marchand L, Hunter DJ, Henderson BE, Palmert MR, Hirschhorn JN.

J Clin Endocrinol Metab. 2008 Nov;93(11):4290-8. Epub 2008 Aug 26.PMID: 18728166 [PubMed - indexed for MEDLINE]Related articlesFree article

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.

Orho-Melander M, Melander O, Guiducci C, Perez-Martinez P, Corella D, Roos C, Tewhey R, Rieder MJ, Hall J, Abecasis G, Tai ES, Welch C, Arnett DK, Lyssenko V, Lindholm E, Saxena R, de Bakker PI, Burtt N, Voight BF, Hirschhorn JN, Tucker KL, Hedner T, Tuomi T, Isomaa B, Eriksson KF, Taskinen MR, Wahlstrand B, Hughes TE, Parnell LD, Lai CQ, Berglund G, Peltonen L, Vartiainen E, Jousilahti P, Havulinna AS, Salomaa V, Nilsson P, Groop L, Altshuler D, Ordovas JM, Kathiresan S.

Diabetes. 2008 Nov;57(11):3112-21. Epub 2008 Aug 4.PMID: 18678614 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.

Lettre G, Sankaran VG, Bezerra MA, Araújo AS, Uda M, Sanna S, Cao A, Schlessinger D, Costa FF, Hirschhorn JN, Orkin SH.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11869-74. Epub 2008 Jul 30.PMID: 18667698 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver fat is reproducibly measured using computed tomography in the Framingham Heart Study.

Speliotes EK, Massaro JM, Hoffmann U, Foster MC, Sahani DV, Hirschhorn JN, O'Donnell CJ, Fox CS.

J Gastroenterol Hepatol. 2008 Jun;23(6):894-9.PMID: 18565021 [PubMed - indexed for MEDLINE]Related articles

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium, Willer CJ; FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL.

Nat Genet. 2008 Jun;40(6):768-75. Epub 2008 May 4.PMID: 18454148 [PubMed - indexed for MEDLINE]Related articlesFree article

Bona fide genetic associations with bone mineral density.

Hirschhorn JN, Gennari L.

N Engl J Med. 2008 May 29;358(22):2403-5. Epub 2008 Apr 29. No abstract available. PMID: 18445778 [PubMed - indexed for MEDLINE]Related articles

Genome-wide association studies for complex traits: consensus, uncertainty and challenges.

McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN.

Nat Rev Genet. 2008 May;9(5):356-69. Review.PMID: 18398418 [PubMed - indexed for MEDLINE]Related articles

Identification of ten loci associated with height highlights new biological pathways in human growth.

Lettre G, Jackson AU, Gieger C, Schumacher FR, Berndt SI, Sanna S, Eyheramendy S, Voight BF, Butler JL, Guiducci C, Illig T, Hackett R, Heid IM, Jacobs KB, Lyssenko V, Uda M; Diabetes Genetics Initiative; FUSION; KORA; Prostate, Lung Colorectal and Ovarian Cancer Screening Trial; Nurses' Health Study; SardiNIA, Boehnke M, Chanock SJ, Groop LC, Hu FB, Isomaa B, Kraft P, Peltonen L, Salomaa V, Schlessinger D, Hunter DJ, Hayes RB, Abecasis GR, Wichmann HE, Mohlke KL, Hirschhorn JN.

Nat Genet. 2008 May;40(5):584-91. Epub 2008 Apr 6.PMID: 18391950 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms associated with cholesterol and risk of cardiovascular events.

Kathiresan S, Melander O, Anevski D, Guiducci C, Burtt NP, Roos C, Hirschhorn JN, Berglund G, Hedblad B, Groop L, Altshuler DM, Newton-Cheh C, Orho-Melander M.

N Engl J Med. 2008 Mar 20;358(12):1240-9.PMID: 18354102 [PubMed - indexed for MEDLINE]Related articles

Comprehensive evaluation of ESR2 variation and ovarian cancer risk.

Leigh Pearce C, Near AM, Butler JL, Van Den Berg D, Bretsky P, Conti DV, Stram DO, Pike MC, Hirschhorn JN, Wu AH.

Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):393-6.PMID: 18268123 [PubMed - indexed for MEDLINE]Related articlesFree article

A survey of allelic imbalance in F1 mice.

Campbell CD, Kirby A, Nemesh J, Daly MJ, Hirschhorn JN.

Genome Res. 2008 Apr;18(4):555-63. Epub 2008 Feb 6.PMID: 18256236 [PubMed - indexed for MEDLINE]Related articlesFree article

Lactose and lactase--who is lactose intolerant and why?

Montgomery RK, Krasinski SD, Hirschhorn JN, Grand RJ.

J Pediatr Gastroenterol Nutr. 2007 Dec;45 Suppl 2:S131-7. Review.PMID: 18185074 [PubMed - indexed for MEDLINE]Related articles

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, Crisponi L, Naitza S, Asunis I, Deiana M, Nagaraja R, Perseu L, Satta S, Cipollina MD, Sollaino C, Moi P, Hirschhorn JN, Orkin SH, Abecasis GR, Schlessinger D, Cao A.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1620-5. Epub 2008 Feb 1.PMID: 18245381 [PubMed - indexed for MEDLINE]Related articlesFree article

Discerning the ancestry of European Americans in genetic association studies.

Price AL, Butler J, Patterson N, Capelli C, Pascali VL, Scarnicci F, Ruiz-Linares A, Groop L, Saetta AA, Korkolopoulou P, Seligsohn U, Waliszewska A, Schirmer C, Ardlie K, Ramos A, Nemesh J, Arbeitman L, Goldstein DB, Reich D, Hirschhorn JN.

PLoS Genet. 2008 Jan;4(1):e236. Epub 2007 Nov 19.PMID: 18208327 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants in the GDF5-UQCC region are associated with variation in human height.

Sanna S, Jackson AU, Nagaraja R, Willer CJ, Chen WM, Bonnycastle LL, Shen H, Timpson N, Lettre G, Usala G, Chines PS, Stringham HM, Scott LJ, Dei M, Lai S, Albai G, Crisponi L, Naitza S, Doheny KF, Pugh EW, Ben-Shlomo Y, Ebrahim S, Lawlor DA, Bergman RN, Watanabe RM, Uda M, Tuomilehto J, Coresh J, Hirschhorn JN, Shuldiner AR, Schlessinger D, Collins FS, Davey Smith G, Boerwinkle E, Cao A, Boehnke M, Abecasis GR, Mohlke KL.

Nat Genet. 2008 Feb;40(2):198-203. Epub 2008 Jan 13.PMID: 18193045 [PubMed - indexed for MEDLINE]Related articles

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.

McAteer JB, Prudente S, Bacci S, Lyon HN, Hirschhorn JN, Trischitta V, Florez JC; ENPP1 Consortium.

Diabetes. 2008 Apr;57(4):1125-30. Epub 2007 Dec 10.PMID: 18071025 [PubMed - indexed for MEDLINE]Related articlesFree article

A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort.

Lee SA, Haiman CA, Burtt NP, Pooler LC, Cheng I, Kolonel LN, Pike MC, Altshuler D, Hirschhorn JN, Henderson BE, Stram DO.

BMC Med Genet. 2007 Dec 1;8:72.PMID: 18053149 [PubMed - indexed for MEDLINE]Related articlesFree article

A common variant of HMGA2 is associated with adult and childhood height in the general population.

Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V; Diabetes Genetics Initiative; Wellcome Trust Case Control Consortium, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM.

Nat Genet. 2007 Oct;39(10):1245-50. Epub 2007 Sep 2.PMID: 17767157 [PubMed - indexed for MEDLINE]Related articles

Common genetic variation in KCNH2 is associated with QT interval duration: the Framingham Heart Study.

Newton-Cheh C, Guo CY, Larson MG, Musone SL, Surti A, Camargo AL, Drake JA, Benjamin EJ, Levy D, D'Agostino RB Sr, Hirschhorn JN, O'donnell CJ.

Circulation. 2007 Sep 4;116(10):1128-36. Epub 2007 Aug 20. Erratum in: Circulation. 2008 Jan 1/8;117(1):e9. PMID: 17709632 [PubMed - indexed for MEDLINE]Related articlesFree article

Replicating genotype-phenotype associations.

NCI-NHGRI Working Group on Replication in Association Studies, Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni JF Jr, Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, Rotimi C, Tucker MA, Vogan KJ, Wacholder S, Wijsman EM, Winn DM, Collins FS.

Nature. 2007 Jun 7;447(7145):655-60. No abstract available. PMID: 17554299 [PubMed - indexed for MEDLINE]Related articles

Heritability, linkage, and genetic associations of exercise treadmill test responses.

Ingelsson E, Larson MG, Vasan RS, O'Donnell CJ, Yin X, Hirschhorn JN, Newton-Cheh C, Drake JA, Musone SL, Heard-Costa NL, Benjamin EJ, Levy D, Atwood LD, Wang TJ, Kathiresan S.

Circulation. 2007 Jun 12;115(23):2917-24. Epub 2007 Jun 4.PMID: 17548724 [PubMed - indexed for MEDLINE]Related articlesFree article

Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation.

Lettre G, Butler JL, Ardlie KG, Hirschhorn JN.

Hum Genet. 2007 Sep;122(2):129-39. Epub 2007 Jun 2.PMID: 17546465 [PubMed - indexed for MEDLINE]Related articles

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.

Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, Walters GB, Thorsteinsdottir U, Kong A, Gulcher J, Nguyen TT, Scherag A, Pfeufer A, Meitinger T, Brönner G, Rief W, Soto-Quiros ME, Avila L, Klanderman B, Raby BA, Silverman EK, Weiss ST, Laird N, Ding X, Groop L, Tuomi T, Isomaa B, Bengtsson K, Butler JL, Cooper RS, Fox CS, O'Donnell CJ, Vollmert C, Celedón JC, Wichmann HE, Hebebrand J, Stefansson K, Lange C, Hirschhorn JN.

PLoS Genet. 2007 Apr 27;3(4):e61. Epub 2007 Mar 7.PMID: 17465681 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Boström K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Råstam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjögren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S.

Science. 2007 Jun 1;316(5829):1331-6. Epub 2007 Apr 26.PMID: 17463246 [PubMed - indexed for MEDLINE]Related articlesFree article

Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.

Florez JC, Sjögren M, Agapakis CM, Burtt NP, Almgren P, Lindblad U, Berglund G, Tuomi T, Gaudet D, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, Groop L.

Diabetologia. 2007 Jun;50(6):1209-17. Epub 2007 Apr 19.PMID: 17443311 [PubMed - indexed for MEDLINE]Related articles

Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study.

Mitchell GF, Guo CY, Kathiresan S, Vasan RS, Larson MG, Vita JA, Keyes MJ, Vyas M, Newton-Cheh C, Musone SL, Camargo AL, Drake JA, Levy D, O'Donnell CJ, Hirschhorn JN, Benjamin EJ.

Hypertension. 2007 Jun;49(6):1285-90. Epub 2007 Apr 2.PMID: 17404185 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic model testing and statistical power in population-based association studies of quantitative traits.

Lettre G, Lange C, Hirschhorn JN.

Genet Epidemiol. 2007 May;31(4):358-62.PMID: 17352422 [PubMed - indexed for MEDLINE]Related articles

Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.

Winckler W, Weedon MN, Graham RR, McCarroll SA, Purcell S, Almgren P, Tuomi T, Gaudet D, Boström KB, Walker M, Hitman G, Hattersley AT, McCarthy MI, Ardlie KG, Hirschhorn JN, Daly MJ, Frayling TM, Groop L, Altshuler D.

Diabetes. 2007 Mar;56(3):685-93.PMID: 17327436 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations.

Gallagher CJ, Keene KL, Mychaleckyj JC, Langefeld CD, Hirschhorn JN, Henderson BE, Gordon CJ, Freedman BI, Rich SS, Bowden DW, Sale MM.

Diabetes. 2007 Mar;56(3):675-84.PMID: 17327435 [PubMed - indexed for MEDLINE]Related articlesFree article

Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men.

Campbell CD, Lyon HN, Nemesh J, Drake JA, Tuomi T, Gaudet D, Zhu X, Cooper RS, Ardlie KG, Groop LC, Hirschhorn JN.

Diabetes. 2007 May;56(5):1460-7. Epub 2007 Feb 26.PMID: 17325259 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.

Haiman CA, Dossus L, Setiawan VW, Stram DO, Dunning AM, Thomas G, Thun MJ, Albanes D, Altshuler D, Ardanaz E, Boeing H, Buring J, Burtt N, Calle EE, Chanock S, Clavel-Chapelon F, Colditz GA, Cox DG, Feigelson HS, Hankinson SE, Hayes RB, Henderson BE, Hirschhorn JN, Hoover R, Hunter DJ, Kaaks R, Kolonel LN, Le Marchand L, Lenner P, Lund E, Panico S, Peeters PH, Pike MC, Riboli E, Tjonneland A, Travis R, Trichopoulos D, Wacholder S, Ziegler RG.

Cancer Res. 2007 Mar 1;67(5):1893-7. Epub 2007 Feb 26.PMID: 17325027 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample.

Newton-Cheh C, Guo CY, Gona P, Larson MG, Benjamin EJ, Wang TJ, Kathiresan S, O'Donnell CJ, Musone SL, Camargo AL, Drake JA, Levy D, Hirschhorn JN, Vasan RS.

Hypertension. 2007 Apr;49(4):846-56. Epub 2007 Feb 12.PMID: 17296870 [PubMed - indexed for MEDLINE]Related articlesFree article