PubMed

Epac2: a molecular target for sulfonylurea-induced insulin release.

Hinke SA.

Sci Signal. 2009 Aug 25;2(85):pe54.PMID: 19706871 [PubMed]Related articles

Diamyd, an alum-formulated recombinant human GAD65 for the prevention of autoimmune diabetes.

Hinke SA.

Curr Opin Mol Ther. 2008 Oct;10(5):516-25. Review.PMID: 18830927 [PubMed - indexed for MEDLINE]Related articles

Finding GAD: early detection of beta-cell injury.

Hinke SA.

Endocrinology. 2007 Oct;148(10):4568-71. Review. No abstract available. PMID: 17876036 [PubMed - indexed for MEDLINE]Related articlesFree article

MyRIP anchors protein kinase A to the exocyst complex.

Goehring AS, Pedroja BS, Hinke SA, Langeberg LK, Scott JD.

J Biol Chem. 2007 Nov 9;282(45):33155-67. Epub 2007 Sep 7.PMID: 17827149 [PubMed - indexed for MEDLINE]Related articlesFree article

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

Hinke SA, Martens GA, Cai Y, Finsi J, Heimberg H, Pipeleers D, Van de Casteele M.

Br J Pharmacol. 2007 Apr;150(8):1031-43. Epub 2007 Mar 5.PMID: 17339833 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation.

Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, Van de Casteele M.

Free Radic Biol Med. 2007 Jan 1;42(1):64-78. Epub 2006 Sep 27.PMID: 17157194 [PubMed - indexed for MEDLINE]Related articles

Relative contribution of incretins to the glucose lowering effect of DP IV inhibitors in type 2 diabetes mellitus (T2DM).

Hinke SA, Pederson RA, McIntosh CH.

Adv Exp Med Biol. 2006;575:119-33. Review. No abstract available. PMID: 16700515 [PubMed - indexed for MEDLINE]Related articles

In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide.

Hinke SA, Manhart S, Speck M, Pederson RA, Demuth HU, McIntosh CH.

Life Sci. 2004 Aug 27;75(15):1857-70.PMID: 15302229 [PubMed - indexed for MEDLINE]Related articles

Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness.

Delmeire D, Flamez D, Moens K, Hinke SA, Van Schravendijk C, Pipeleers D, Schuit F.

Biochem Pharmacol. 2004 Jul 1;68(1):33-9.PMID: 15183115 [PubMed - indexed for MEDLINE]Related articles

Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal.

Hinke SA, Hellemans K, Schuit FC.

J Physiol. 2004 Jul 15;558(Pt 2):369-80. Epub 2004 Jun 4. Review.PMID: 15181163 [PubMed - indexed for MEDLINE]Related articlesFree article

Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.

Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F, Drucker DJ.

Diabetes. 2004 May;53(5):1326-35.PMID: 15111503 [PubMed - indexed for MEDLINE]Related articlesFree article

[Ser2]- and [SerP2] incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo.

Hinke SA, Manhart S, Kühn-Wache K, Nian C, Demuth HU, Pederson RA, McIntosh CH.

J Biol Chem. 2004 Feb 6;279(6):3998-4006. Epub 2003 Nov 10.PMID: 14610075 [PubMed - indexed for MEDLINE]Related articlesFree article

Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1.

Delmeire D, Flamez D, Hinke SA, Cali JJ, Pipeleers D, Schuit F.

Diabetologia. 2003 Oct;46(10):1383-93. Epub 2003 Sep 17.PMID: 13680124 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationships of glucose-dependent insulinotropic polypeptide (GIP).

Hinke SA, Gelling R, Manhart S, Lynn F, Pederson RA, Kühn-Wache K, Rosche F, Demuth HU, Coy D, McIntosh CH.

Biol Chem. 2003 Mar;384(3):403-7.PMID: 12715891 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential.

Hinke SA, Lynn F, Ehses J, Pamir N, Manhart S, Kühn-Wache K, Rosche F, Demuth HU, Pederson RA, McIntosh CH.

Adv Exp Med Biol. 2003;524:293-301. No abstract available. PMID: 12675251 [PubMed - indexed for MEDLINE]Related articles

Structure-function analysis of a series of novel GIP analogues containing different helical length linkers.

Manhart S, Hinke SA, McIntosh CH, Pederson RA, Demuth HU.

Biochemistry. 2003 Mar 18;42(10):3081-8.PMID: 12627975 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.

Pamir N, Lynn FC, Buchan AM, Ehses J, Hinke SA, Pospisilik JA, Miyawaki K, Yamada Y, Seino Y, McIntosh CH, Pederson RA.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E931-9. Epub 2003 Jan 21.PMID: 12540373 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells.

Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, McIntosh CH, Pederson RA.

FASEB J. 2003 Jan;17(1):91-3. Epub 2002 Nov 15.PMID: 12475913 [PubMed - indexed for MEDLINE]Related articlesFree article

Rebuttal to Deacon and Holst: "Metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1" versus "Dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective".

Demuth HU, Hinke SA, Pederson RA, McIntosh CH.

Biochem Biophys Res Commun. 2002 Aug 16;296(2):229-32. No abstract available. PMID: 12163006 [PubMed - indexed for MEDLINE]Related articles

On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors.

Hinke SA, McIntosh CH, Hoffmann T, Kühn-Wache K, Wagner L, Bär J, Manhart S, Wermann M, Pederson RA, Demuth HU.

Diabetes Care. 2002 Aug;25(8):1490-1; author reply 1491-2. No abstract available. PMID: 12145269 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1.

Hinke SA, Kühn-Wache K, Hoffmann T, Pederson RA, McIntosh CH, Demuth HU.

Biochem Biophys Res Commun. 2002 Mar 15;291(5):1302-8.PMID: 11883961 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats.

Hinke SA, Gelling RW, Pederson RA, Manhart S, Nian C, Demuth HU, McIntosh CH.

Diabetes. 2002 Mar;51(3):652-61.PMID: 11872663 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP).

Hinke SA, Manhart S, Pamir N, Demuth H, W Gelling R, Pederson RA, McIntosh CH.

Biochim Biophys Acta. 2001 May 5;1547(1):143-55.PMID: 11343800 [PubMed - indexed for MEDLINE]Related articles

Metabolism of glucagon by dipeptidyl peptidase IV (CD26).

Pospisilik JA, Hinke SA, Pederson RA, Hoffmann T, Rosche F, Schlenzig D, Glund K, Heiser U, McIntosh CH, Demuth H.

Regul Pept. 2001 Jan 12;96(3):133-41.PMID: 11111019 [PubMed - indexed for MEDLINE]Related articles

Analogs of glucose-dependent insulinotropic polypeptide with increased dipeptidyl peptidase IV resistance.

Kühn-Wache K, Manhart S, Hoffmann T, Hinke SA, Gelling R, Pederson RA, McIntosh CH, Demuth HU.

Adv Exp Med Biol. 2000;477:187-95. No abstract available. PMID: 10849746 [PubMed - indexed for MEDLINE]Related articles

Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide.

Hinke SA, Pauly RP, Ehses J, Kerridge P, Demuth HU, McIntosh CH, Pederson RA.

J Endocrinol. 2000 May;165(2):281-91.PMID: 10810292 [PubMed - indexed for MEDLINE]Related articlesFree article

Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs.

Hinke SA, Pospisilik JA, Demuth HU, Mannhart S, Kühn-Wache K, Hoffmann T, Nishimura E, Pederson RA, McIntosh CH.

J Biol Chem. 2000 Feb 11;275(6):3827-34.PMID: 10660533 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization.

Wheeler MB, Gelling RW, Hinke SA, Tu B, Pederson RA, Lynn F, Ehses J, McIntosh CH.

J Biol Chem. 1999 Aug 27;274(35):24593-601.PMID: 10455124 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin.

McIntosh CH, Bremsak I, Lynn FC, Gill R, Hinke SA, Gelling R, Nian C, McKnight G, Jaspers S, Pederson RA.

Endocrinology. 1999 Jan;140(1):398-404.PMID: 9886851 [PubMed - indexed for MEDLINE]Related articlesFree article