PubMed

Primary prevention of cardiovascular disease: time to get more or less personal?

Hingorani AD, Psaty BM.

JAMA. 2009 Nov 18;302(19):2144-5. No abstract available. PMID: 19920239 [PubMed - in process]Related articles

Inhaled tiotropium bromide and risk of stroke.

Grosso A, Douglas I, Hingorani AD, MacAllister R, Hubbard R, Smeeth L.

Br J Clin Pharmacol. 2009 Nov;68(5):731-6.PMID: 19916997 [PubMed - in process]Related articles

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD; ASCOT investigators; NORDIL investigators; BRIGHT Consortium.

Am J Hum Genet. 2009 Nov;85(5):628-42.PMID: 19913121 [PubMed - in process]Related articles

Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach.

Welsh P, Polisecki E, Robertson M, Jahn S, Buckley BM, de Craen AJ, Ford I, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Hingorani AD, Smith GD, Schaefer E, Sattar N.

J Clin Endocrinol Metab. 2009 Nov 11. [Epub ahead of print]PMID: 19906786 [PubMed - as supplied by publisher]Related articles

Evaluating the causal relevance of diverse risk markers: horizontal systematic review.

Kuper H, Nicholson A, Kivimaki M, Aitsi-Selmi A, Cavalleri G, Deanfield JE, Heuschmann P, Jouven X, Malyutina S, Mayosi BM, Sans S, Thomsen T, Witteman JC, Hingorani AD, Lawlor DA, Hemingway H.

BMJ. 2009 Nov 5;339:b4265. doi: 10.1136/bmj.b4265.PMID: 19892791 [PubMed - in process]Related articlesFree article

Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis.

Bellamy L, Casas JP, Hingorani AD, Williams D.

Lancet. 2009 May 23;373(9677):1773-9.PMID: 19465232 [PubMed - indexed for MEDLINE]Related articles

Multilocus Bayesian meta-analysis of gene-disease associations.

Newcombe PJ, Verzilli C, Casas JP, Hingorani AD, Smeeth L, Whittaker JC.

Am J Hum Genet. 2009 May;84(5):567-80. Epub 2009 Apr 30.PMID: 19409523 [PubMed - indexed for MEDLINE]Related articlesFree article

C-reactive protein and prognosis in diabetes: getting to the heart of the matter.

Sattar N, Hingorani AD.

Diabetes. 2009 Apr;58(4):798-9. No abstract available. PMID: 19336689 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

Drenos F, Talmud PJ, Casas JP, Smeeth L, Palmen J, Humphries SE, Hingorani AD.

Hum Mol Genet. 2009 Jun 15;18(12):2305-16. Epub 2009 Mar 31.PMID: 19336475 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of a strategy based on calculated risk scores in managing cardiovascular risk factors in a large British cohort of patients with systemic lupus erythematosus.

O'Neill SG, Pego-Reigosa JM, Hingorani AD, Bessant R, Isenberg DA, Rahman A.

Rheumatology (Oxford). 2009 May;48(5):573-5. Epub 2009 Mar 9.PMID: 19273540 [PubMed - indexed for MEDLINE]Related articles

C-reactive protein and coronary heart disease: predictive test or therapeutic target?

Hingorani AD, Shah T, Casas JP, Humphries SE, Talmud PJ.

Clin Chem. 2009 Feb;55(2):239-55. Epub 2008 Dec 29. Review.PMID: 19114670 [PubMed - indexed for MEDLINE]Related articles

Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts.

Shah T, Casas JP, Cooper JA, Tzoulaki I, Sofat R, McCormack V, Smeeth L, Deanfield JE, Lowe GD, Rumley A, Fowkes FG, Humphries SE, Hingorani AD.

Int J Epidemiol. 2009 Feb;38(1):217-31. Epub 2008 Oct 17. Review. Erratum in: Int J Epidemiol. 2009 Jun;38(3):890. PMID: 18930961 [PubMed - indexed for MEDLINE]Related articles

C-reactive protein and coronary heart disease: a critical review.

Casas JP, Shah T, Hingorani AD, Danesh J, Pepys MB.

J Intern Med. 2008 Oct;264(4):295-314. Review.PMID: 18823504 [PubMed - indexed for MEDLINE]Related articles

Maternal endothelial function and serum concentrations of placental growth factor and soluble endoglin in women with abnormal placentation.

Savvidou MD, Noori M, Anderson JM, Hingorani AD, Nicolaides KH.

Ultrasound Obstet Gynecol. 2008 Dec;32(7):871-6.PMID: 18814185 [PubMed - indexed for MEDLINE]Related articles

Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study.

Kivimäki M, Lawlor DA, Smith GD, Kumari M, Donald A, Britton A, Casas JP, Shah T, Brunner E, Timpson NJ, Halcox JP, Miller MA, Humphries SE, Deanfield J, Marmot MG, Hingorani AD.

PLoS One. 2008 Aug 20;3(8):e3013.PMID: 18714381 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream.

Brunner EJ, Kivimäki M, Witte DR, Lawlor DA, Davey Smith G, Cooper JA, Miller M, Lowe GD, Rumley A, Casas JP, Shah T, Humphries SE, Hingorani AD, Marmot MG, Timpson NJ, Kumari M.

PLoS Med. 2008 Aug 12;5(8):e155.PMID: 18700811 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the metabolic syndrome with severe periodontitis in a large U.S. population-based survey.

D'Aiuto F, Sabbah W, Netuveli G, Donos N, Hingorani AD, Deanfield J, Tsakos G.

J Clin Endocrinol Metab. 2008 Oct;93(10):3989-94. Epub 2008 Aug 5.PMID: 18682518 [PubMed - indexed for MEDLINE]Related articlesFree article

Bayesian meta-analysis of genetic association studies with different sets of markers.

Verzilli C, Shah T, Casas JP, Chapman J, Sandhu M, Debenham SL, Boekholdt MS, Khaw KT, Wareham NJ, Judson R, Benjamin EJ, Kathiresan S, Larson MG, Rong J, Sofat R, Humphries SE, Smeeth L, Cavalleri G, Whittaker JC, Hingorani AD.

Am J Hum Genet. 2008 Apr;82(4):859-72.PMID: 18394581 [PubMed - indexed for MEDLINE]Related articlesFree article

Biomarkers of inflammation predict both vascular and non-vascular mortality in older men.

Clarke R, Emberson JR, Breeze E, Casas JP, Parish S, Hingorani AD, Fletcher A, Collins R, Smeeth L.

Eur Heart J. 2008 Mar;29(6):800-9. Epub 2008 Feb 25.PMID: 18303034 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic inflammation, periodontitis and cardiovascular diseases.

Hingorani AD, D'Aiuto F.

Oral Dis. 2008 Mar;14(2):102-4. No abstract available. PMID: 18302670 [PubMed - indexed for MEDLINE]Related articles

Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men.

Talmud PJ, Cooper JA, Palmen J, Lovering R, Drenos F, Hingorani AD, Humphries SE.

Clin Chem. 2008 Mar;54(3):467-74. Epub 2008 Feb 4.PMID: 18250146 [PubMed - indexed for MEDLINE]Related articlesFree article

Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis.

Bellamy L, Casas JP, Hingorani AD, Williams DJ.

BMJ. 2007 Nov 10;335(7627):974. Epub 2007 Nov 1. Review.PMID: 17975258 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of infection in cardiovascular disease: more support but many questions remain.

Smeeth L, Casas JP, Hingorani AD.

Eur Heart J. 2007 May;28(10):1178-9. Epub 2007 Apr 30. No abstract available. PMID: 17470675 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetics of ischaemic stroke among persons of non-European descent: a meta-analysis of eight genes involving approximately 32,500 individuals.

Ariyaratnam R, Casas JP, Whittaker J, Smeeth L, Hingorani AD, Sharma P.

PLoS Med. 2007 Apr;4(4):e131.PMID: 17455988 [PubMed - indexed for MEDLINE]Related articlesFree article

(6R)-5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm.

Mayahi L, Heales S, Owen D, Casas JP, Harris J, MacAllister RJ, Hingorani AD.

Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1334-9. Epub 2007 Apr 5.PMID: 17413035 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of periodontitis and endothelial function.

Tonetti MS, D'Aiuto F, Nibali L, Donald A, Storry C, Parkar M, Suvan J, Hingorani AD, Vallance P, Deanfield J.

N Engl J Med. 2007 Mar 1;356(9):911-20.PMID: 17329698 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: evidence of small-study bias.

Serrano NC, Díaz LA, Páez MC, Mesa CM, Cifuentes R, Monterrosa A, González A, Smeeth L, Hingorani AD, Casas JP.

PLoS Med. 2006 Dec;3(12):e520.PMID: 17194198 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review.

Casas JP, Cavalleri GL, Bautista LE, Smeeth L, Humphries SE, Hingorani AD.

Am J Epidemiol. 2006 Nov 15;164(10):921-35. Epub 2006 Oct 3. Review.PMID: 17018701 [PubMed - indexed for MEDLINE]Related articlesFree article

Linking observational and genetic approaches to determine the role of C-reactive protein in heart disease risk.

Hingorani AD, Shah T, Casas JP.

Eur Heart J. 2006 Jun;27(11):1261-3. Epub 2006 May 9. No abstract available. PMID: 16684780 [PubMed - indexed for MEDLINE]Related articlesFree article

Maternal serum concentration of soluble fms-like tyrosine kinase 1 and vascular endothelial growth factor in women with abnormal uterine artery Doppler and in those with fetal growth restriction.

Savvidou MD, Yu CK, Harland LC, Hingorani AD, Nicolaides KH.

Am J Obstet Gynecol. 2006 Dec;195(6):1668-73. Epub 2006 Apr 27.PMID: 16643817 [PubMed - indexed for MEDLINE]Related articles

Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies.

Casas JP, Cooper J, Miller GJ, Hingorani AD, Humphries SE.

Ann Hum Genet. 2006 Mar;70(Pt 2):145-69.PMID: 16626327 [PubMed - indexed for MEDLINE]Related articles

Estimation of bias in nongenetic observational studies using "mendelian triangulation".

Bautista LE, Smeeth L, Hingorani AD, Casas JP.

Ann Epidemiol. 2006 Sep;16(9):675-80. Epub 2006 Apr 18.PMID: 16621596 [PubMed - indexed for MEDLINE]Related articles

Insight into the nature of the CRP-coronary event association using Mendelian randomization.

Casas JP, Shah T, Cooper J, Hawe E, McMahon AD, Gaffney D, Packard CJ, O'Reilly DS, Juhan-Vague I, Yudkin JS, Tremoli E, Margaglione M, Di Minno G, Hamsten A, Kooistra T, Stephens JW, Hurel SJ, Livingstone S, Colhoun HM, Miller GJ, Bautista LE, Meade T, Sattar N, Humphries SE, Hingorani AD.

Int J Epidemiol. 2006 Aug;35(4):922-31. Epub 2006 Mar 24.PMID: 16565153 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis.

Yu CK, Casas JP, Savvidou MD, Sahemey MK, Nicolaides KH, Hingorani AD.

BMC Pregnancy Childbirth. 2006 Mar 16;6:7.PMID: 16542455 [PubMed]Related articlesFree article

Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis.

Casas JP, Chua W, Loukogeorgakis S, Vallance P, Smeeth L, Hingorani AD, MacAllister RJ.

Lancet. 2005 Dec 10;366(9502):2026-33. Review.PMID: 16338452 [PubMed - indexed for MEDLINE]Related articles

Genetic regulation of endothelial function.

Jones LC, Hingorani AD.

Heart. 2005 Oct;91(10):1275-7. Review. No abstract available. PMID: 16162616 [PubMed - indexed for MEDLINE]Related articlesFree article

Human monoclonal IgG anticardiolipin antibodies induce nitric oxide synthase expression.

Alves JD, Clapp BR, Stidwill R, Chen PP, Hingorani AD, Singer M, Isenberg DA.

Atherosclerosis. 2006 Apr;185(2):246-53. Epub 2005 Aug 25.PMID: 16125710 [PubMed - indexed for MEDLINE]Related articles

Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability.

Clapp BR, Hirschfield GM, Storry C, Gallimore JR, Stidwill RP, Singer M, Deanfield JE, MacAllister RJ, Pepys MB, Vallance P, Hingorani AD.

Circulation. 2005 Mar 29;111(12):1530-6.PMID: 15795363 [PubMed - indexed for MEDLINE]Related articlesFree article

C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus.

D'Aiuto F, Casas JP, Shah T, Humphries SE, Hingorani AD, Tonetti MS.

Atherosclerosis. 2005 Apr;179(2):413-7. Epub 2004 Dec 18.PMID: 15777561 [PubMed - indexed for MEDLINE]Related articles

Homocysteine and stroke: evidence on a causal link from mendelian randomisation.

Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD.

Lancet. 2005 Jan 15-21;365(9455):224-32.PMID: 15652605 [PubMed - indexed for MEDLINE]Related articles

Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.

Casas JP, Hingorani AD, Bautista LE, Sharma P.

Arch Neurol. 2004 Nov;61(11):1652-61.PMID: 15534175 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study.

Serrano NC, Casas JP, Díaz LA, Páez C, Mesa CM, Cifuentes R, Monterrosa A, Bautista A, Hawe E, Hingorani AD, Vallance P, López-Jaramillo P.

Hypertension. 2004 Nov;44(5):702-7. Epub 2004 Sep 13.PMID: 15364897 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress.

Clapp BR, Hingorani AD, Kharbanda RK, Mohamed-Ali V, Stephens JW, Vallance P, MacAllister RJ.

Cardiovasc Res. 2004 Oct 1;64(1):172-8.PMID: 15364625 [PubMed - indexed for MEDLINE]Related articlesFree article

Tau gene and Parkinson's disease: a case-control study and meta-analysis.

Healy DG, Abou-Sleiman PM, Lees AJ, Casas JP, Quinn N, Bhatia K, Hingorani AD, Wood NW.

J Neurol Neurosurg Psychiatry. 2004 Jul;75(7):962-5.PMID: 15201350 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects.

Casas JP, Bautista LE, Humphries SE, Hingorani AD.

Circulation. 2004 Mar 23;109(11):1359-65. Epub 2004 Mar 8.PMID: 15007011 [PubMed - indexed for MEDLINE]Related articlesFree article

Ximelagatran or warfarin in atrial fibrillation?

MacAllister R, Hingorani AD, Casas JP.

Lancet. 2004 Feb 28;363(9410):735-6; author reply 736. No abstract available. PMID: 15001337 [PubMed - indexed for MEDLINE]Related articles

Diet, the endothelium and atherosclerosis.

Hingorani AD.

Clin Sci (Lond). 2004 May;106(5):447-8. Review.PMID: 14741041 [PubMed - indexed for MEDLINE]Related articles

Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells.

Jones LC, Tran CT, Leiper JM, Hingorani AD, Vallance P.

Biochem Biophys Res Commun. 2003 Oct 24;310(3):836-43.PMID: 14550280 [PubMed - indexed for MEDLINE]Related articles

Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease.

Brull DJ, Serrano N, Zito F, Jones L, Montgomery HE, Rumley A, Sharma P, Lowe GD, World MJ, Humphries SE, Hingorani AD.

Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2063-9. Epub 2003 Jul 3. Erratum in: Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1328. PMID: 12842840 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia.

Savvidou MD, Hingorani AD, Tsikas D, Frölich JC, Vallance P, Nicolaides KH.

Lancet. 2003 May 3;361(9368):1511-7.PMID: 12737861 [PubMed - indexed for MEDLINE]Related articles