PubMed

Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death.

Taylor SR, Gonzalez-Begne M, Dewhurst S, Chimini G, Higgins CF, Melvin JE, Elliott JI.

J Immunol. 2008 Jan 1;180(1):300-8.PMID: 18097031 [PubMed - indexed for MEDLINE]Related articlesFree article

Production of P-glycoprotein from the MDR1 upstream promoter is insufficient to affect the response to first-line chemotherapy in advanced breast cancer.

Raguz S, Randle RA, Sharpe ER, Foekens JA, Sieuwerts AM, Meijer-van Gelder ME, Melo JV, Higgins CF, Yagüe E.

Int J Cancer. 2008 Mar 1;122(5):1058-67.PMID: 17955490 [PubMed - indexed for MEDLINE]Related articles

Role of the highly structured 5'-end region of MDR1 mRNA in P-glycoprotein expression.

Randle RA, Raguz S, Higgins CF, Yagüe E.

Biochem J. 2007 Sep 15;406(3):445-55.PMID: 17573715 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple molecular mechanisms for multidrug resistance transporters.

Higgins CF.

Nature. 2007 Apr 12;446(7137):749-57. Review.PMID: 17429392 [PubMed - indexed for MEDLINE]Related articles

ClC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment.

Weylandt KH, Nebrig M, Jansen-Rosseck N, Amey JS, Carmena D, Wiedenmann B, Higgins CF, Sardini A.

Mol Cancer Ther. 2007 Mar;6(3):979-86. Erratum in: Mol Cancer Ther. 2008 Jul;7(7):2261. PMID: 17363491 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory T cells are resistant to apoptosis via TCR but not P2X7.

Taylor SR, Alexander DR, Cooper JC, Higgins CF, Elliott JI.

J Immunol. 2007 Mar 15;178(6):3474-82.PMID: 17339442 [PubMed - indexed for MEDLINE]Related articlesFree article

Ability to acquire drug resistance arises early during the tumorigenesis process.

Yagüe E, Arance A, Kubitza L, O'Hare M, Jat P, Ogilvie CM, Hart IR, Higgins CF, Raguz S.

Cancer Res. 2007 Feb 1;67(3):1130-7.PMID: 17283147 [PubMed - indexed for MEDLINE]Related articlesFree article

Twenty years of ATP-binding cassette (ABC) transporters.

Stieger B, Higgins CF.

Pflugers Arch. 2007 Feb;453(5):543. No abstract available. PMID: 17091310 [PubMed - indexed for MEDLINE]Related articles

The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus.

Okkenhaug H, Weylandt KH, Carmena D, Wells DJ, Higgins CF, Sardini A.

FASEB J. 2006 Nov;20(13):2390-2. Epub 2006 Oct 3.PMID: 17023393 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure and function of ABC transporters: the ATP switch provides flexible control.

Linton KJ, Higgins CF.

Pflugers Arch. 2007 Feb;453(5):555-67. Epub 2006 Aug 26. Review.PMID: 16937116 [PubMed - indexed for MEDLINE]Related articles

Phosphatidylserine exposure in B lymphocytes: a role for lipid packing.

Elliott JI, Sardini A, Cooper JC, Alexander DR, Davanture S, Chimini G, Higgins CF.

Blood. 2006 Sep 1;108(5):1611-7. Epub 2006 May 9.PMID: 16684961 [PubMed - indexed for MEDLINE]Related articlesFree article

Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA.

Bishop CL, Ramalho M, Nadkarni N, May Kong W, Higgins CF, Krauzewicz N.

Mol Cell Biol. 2006 Apr;26(7):2583-94. Erratum in: Mol Cell Biol. 2006 May;26(10):3997. PMID: 16537904 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes.

Elliott JI, Surprenant A, Marelli-Berg FM, Cooper JC, Cassady-Cain RL, Wooding C, Linton K, Alexander DR, Higgins CF.

Nat Cell Biol. 2005 Aug;7(8):808-16. Epub 2005 Jul 17.PMID: 16025105 [PubMed - indexed for MEDLINE]Related articles

Expression of RPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis.

Raguz S, De Bella MT, Slade MJ, Higgins CF, Coombes RC, Yagüe E.

Int J Cancer. 2005 Dec 20;117(6):934-41.PMID: 15986426 [PubMed - indexed for MEDLINE]Related articles

The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products.

Elliott JI, McVey JH, Higgins CF.

Arthritis Res Ther. 2005;7(3):R468-75. Epub 2005 Feb 21.PMID: 15899033 [PubMed - indexed for MEDLINE]Related articlesFree article

Accelerated exposure of phosphatidylserine on lymphocyte populations from patients with systemic lupus erythematosus or rheumatoid arthritis.

Albrecht C, Soumian S, Playford R, Higgins CF, Vyse T, Elliott J.

Thromb Haemost. 2005 May;93(5):989-92. No abstract available. PMID: 15886819 [PubMed - indexed for MEDLINE]Related articles

A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.

Albrecht C, McVey JH, Elliott JI, Sardini A, Kasza I, Mumford AD, Naoumova RP, Tuddenham EG, Szabo K, Higgins CF.

Blood. 2005 Jul 15;106(2):542-9. Epub 2005 Mar 24.PMID: 15790791 [PubMed - indexed for MEDLINE]Related articlesFree article

ABCA1 expression in carotid atherosclerotic plaques.

Albrecht C, Soumian S, Amey JS, Sardini A, Higgins CF, Davies AH, Gibbs RG.

Stroke. 2004 Dec;35(12):2801-6. Epub 2004 Nov 4.PMID: 15528463 [PubMed - indexed for MEDLINE]Related articlesFree article

Multidrug transporter activity in lymphocytes.

Elliott JI, Raguz S, Higgins CF.

Br J Pharmacol. 2004 Dec;143(7):899-907. Epub 2004 Oct 18.PMID: 15492020 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.

Begley GS, Horvath AR, Taylor JC, Higgins CF.

Mol Immunol. 2005 Jan;42(1):137-41.PMID: 15488952 [PubMed - indexed for MEDLINE]Related articles

Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.

Rosenberg MF, Callaghan R, Modok S, Higgins CF, Ford RC.

J Biol Chem. 2005 Jan 28;280(4):2857-62. Epub 2004 Oct 13.PMID: 15485807 [PubMed - indexed for MEDLINE]Related articlesFree article

The ATP switch model for ABC transporters.

Higgins CF, Linton KJ.

Nat Struct Mol Biol. 2004 Oct;11(10):918-26. Review.PMID: 15452563 [PubMed - indexed for MEDLINE]Related articles

Extracellular acidification elicits a chloride current that shares characteristics with ICl(swell).

Nobles M, Higgins CF, Sardini A.

Am J Physiol Cell Physiol. 2004 Nov;287(5):C1426-35. Epub 2004 Aug 11.PMID: 15306547 [PubMed - indexed for MEDLINE]Related articlesFree article

Major histocompatibility complex class I shedding and programmed cell death stimulated through the proinflammatory P2X7 receptor: a candidate susceptibility gene for NOD diabetes.

Elliott JI, Higgins CF.

Diabetes. 2004 Aug;53(8):2012-7.PMID: 15277380 [PubMed - indexed for MEDLINE]Related articlesFree article

Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1.

Yagüe E, Higgins CF, Raguz S.

Gene Ther. 2004 Jul;11(14):1170-4.PMID: 15164094 [PubMed - indexed for MEDLINE]Related articles

Two novel missense mutations in ABCA1 result in altered trafficking and cause severe autosomal recessive HDL deficiency.

Albrecht C, Baynes K, Sardini A, Schepelmann S, Eden ER, Davies SW, Higgins CF, Feher MD, Owen JS, Soutar AK.

Biochim Biophys Acta. 2004 May 24;1689(1):47-57.PMID: 15158913 [PubMed - indexed for MEDLINE]Related articles

Activation of the MDR1 upstream promoter in breast carcinoma as a surrogate for metastatic invasion.

Raguz S, Tamburo De Bella M, Tripuraneni G, Slade MJ, Higgins CF, Coombes RC, Yagüe E.

Clin Cancer Res. 2004 Apr 15;10(8):2776-83.PMID: 15102684 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterisation of lymphocyte responses to Ca2+ in Scott syndrome.

Elliott JI, Mumford AD, Albrecht C, Collins PW, Giddings JC, Higgins CF, Tuddenham EG, McVey JH.

Thromb Haemost. 2004 Feb;91(2):412-5. Review. No abstract available. PMID: 14961172 [PubMed - indexed for MEDLINE]Related articles

Cell volume regulation and swelling-activated chloride channels.

Sardini A, Amey JS, Weylandt KH, Nobles M, Valverde MA, Higgins CF.

Biochim Biophys Acta. 2003 Dec 30;1618(2):153-62. Review.PMID: 14729152 [PubMed - indexed for MEDLINE]Related articles

Leukocyte ABCA1 gene expression is associated with fasting glucose concentration in normoglycemic men.

Albrecht C, Simon-Vermot I, Elliott JI, Higgins CF, Johnston DG, Valabhji J.

Metabolism. 2004 Jan;53(1):17-21.PMID: 14681836 [PubMed - indexed for MEDLINE]Related articles

P-glycoprotein in blood-brain barrier endothelial cells: interaction and oligomerization with caveolins.

Jodoin J, Demeule M, Fenart L, Cecchelli R, Farmer S, Linton KJ, Higgins CF, Béliveau R.

J Neurochem. 2003 Nov;87(4):1010-23.PMID: 14622130 [PubMed - indexed for MEDLINE]Related articles

An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulfide cross-linking and homology modeling.

Stenham DR, Campbell JD, Sansom MS, Higgins CF, Kerr ID, Linton KJ.

FASEB J. 2003 Dec;17(15):2287-9. Epub 2003 Oct 16.PMID: 14563687 [PubMed - indexed for MEDLINE]Related articlesFree article

Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein.

Kerr ID, Berridge G, Linton KJ, Higgins CF, Callaghan R.

Eur Biophys J. 2003 Nov;32(7):644-54. Epub 2003 Jun 26.PMID: 12830334 [PubMed - indexed for MEDLINE]Related articles

ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy.

Müllenbach R, Linton KJ, Wiltshire S, Weerasekera N, Chambers J, Elias E, Higgins CF, Johnston DG, McCarthy MI, Williamson C.

J Med Genet. 2003 May;40(5):e70. No abstract available. PMID: 12746424 [PubMed - indexed for MEDLINE]Related articlesFree article

IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosis.

Elliott JI, Higgins CF.

EMBO Rep. 2003 Feb;4(2):189-94.PMID: 12612610 [PubMed - indexed for MEDLINE]Related articlesFree article

P-glycoprotein (MDR1) expression in leukemic cells is regulated at two distinct steps, mRNA stabilization and translational initiation.

Yague E, Armesilla AL, Harrison G, Elliott J, Sardini A, Higgins CF, Raguz S.

J Biol Chem. 2003 Mar 21;278(12):10344-52. Epub 2003 Jan 13.PMID: 12525496 [PubMed - indexed for MEDLINE]Related articlesFree article

Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding.

Rosenberg MF, Kamis AB, Callaghan R, Higgins CF, Ford RC.

J Biol Chem. 2003 Mar 7;278(10):8294-9. Epub 2002 Dec 25.PMID: 12501241 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional analysis of candidate ABC transporter proteins for sitosterol transport.

Albrecht C, Elliott JI, Sardini A, Litman T, Stieger B, Meier PJ, Higgins CF.

Biochim Biophys Acta. 2002 Dec 23;1567(1-2):133-42.PMID: 12488046 [PubMed - indexed for MEDLINE]Related articles

Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: application to single virus-like particle entry into a cell.

Gorelik J, Shevchuk A, Ramalho M, Elliott M, Lei C, Higgins CF, Lab MJ, Klenerman D, Krauzewicz N, Korchev Y.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16018-23. Epub 2002 Dec 4.PMID: 12466501 [PubMed - indexed for MEDLINE]Related articlesFree article

H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein.

Esposito D, Petrovic A, Harris R, Ono S, Eccleston JF, Mbabaali A, Haq I, Higgins CF, Hinton JC, Driscoll PC, Ladbury JE.

J Mol Biol. 2002 Dec 6;324(4):841-50.PMID: 12460581 [PubMed - indexed for MEDLINE]Related articles

The human bile salt export pump: characterization of substrate specificity and identification of inhibitors.

Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ.

Gastroenterology. 2002 Nov;123(5):1649-58.PMID: 12404239 [PubMed - indexed for MEDLINE]Related articles

P-glycoprotein misfolds in Escherichia coli: evidence against alternating-topology models of the transport cycle.

Linton KJ, Higgins CF.

Mol Membr Biol. 2002 Jan-Mar;19(1):51-8.PMID: 11989822 [PubMed - indexed for MEDLINE]Related articles

The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein.

Martin C, Higgins CF, Callaghan R.

Biochemistry. 2001 Dec 25;40(51):15733-42.PMID: 11747450 [PubMed - indexed for MEDLINE]Related articles

Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein.

Taylor AM, Storm J, Soceneantu L, Linton KJ, Gabriel M, Martin C, Woodhouse J, Blott E, Higgins CF, Callaghan R.

Br J Pharmacol. 2001 Dec;134(8):1609-18.PMID: 11739236 [PubMed - indexed for MEDLINE]Related articlesFree article

The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence.

Rothnie A, Theron D, Soceneantu L, Martin C, Traikia M, Berridge G, Higgins CF, Devaux PF, Callaghan R.

Eur Biophys J. 2001 Oct;30(6):430-42.PMID: 11718296 [PubMed - indexed for MEDLINE]Related articles

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.

Gill DR, Smyth SE, Goddard CA, Pringle IA, Higgins CF, Colledge WH, Hyde SC.

Gene Ther. 2001 Oct;8(20):1539-46.PMID: 11704814 [PubMed - indexed for MEDLINE]Related articlesFree article

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle.

Rosenberg MF, Velarde G, Ford RC, Martin C, Berridge G, Kerr ID, Callaghan R, Schmidlin A, Wooding C, Linton KJ, Higgins CF.

EMBO J. 2001 Oct 15;20(20):5615-25.PMID: 11598005 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural biology. The xyz of ABC transporters.

Higgins CF, Linton KJ.

Science. 2001 Sep 7;293(5536):1782-4. No abstract available. PMID: 11546861 [PubMed - indexed for MEDLINE]Related articles

The multidrug resistance P-glycoprotein. Oligomeric state and intramolecular interactions.

Taylor JC, Horvath AR, Higgins CF, Begley GS.

J Biol Chem. 2001 Sep 28;276(39):36075-8. Epub 2001 Aug 8.PMID: 11495894 [PubMed - indexed for MEDLINE]Related articlesFree article

Multidrug transport by ATP binding cassette transporters: a proposed two-cylinder engine mechanism.

van Veen HW, Higgins CF, Konings WN.

Res Microbiol. 2001 Apr-May;152(3-4):365-74. Review.PMID: 11421284 [PubMed - indexed for MEDLINE]Related articles