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Adaptations in Mitochondrial Function Parallel, but Fail to Rescue, the Transition to Severe Hyperglycemia and Hyperinsulinemia: A Study in Zucker Diabetic Fatty Rats.

Lenaers E, De Feyter HM, Hoeks J, Schrauwen P, Schaart G, Nabben M, Nicolay K, Prompers JJ, Hesselink MK.

Obesity (Silver Spring). 2009 Oct 29. [Epub ahead of print]PMID: 19875988 [PubMed - as supplied by publisher]Related articles

Mitochondrial dysfunction and lipotoxicity.

Schrauwen P, Schrauwen-Hinderling V, Hoeks J, Hesselink MK.

Biochim Biophys Acta. 2009 Sep 24. [Epub ahead of print]PMID: 19782153 [PubMed - as supplied by publisher]Related articles

Modulation of myocellular fat stores: lipid droplet dynamics in health and disease.

Meex RC, Schrauwen P, Hesselink MK.

Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R913-24. Epub 2009 Aug 19. Review.PMID: 19692657 [PubMed - indexed for MEDLINE]Related articles

Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation.

Timmers S, de Vogel-van den Bosch J, Towler MC, Schaart G, Moonen-Kornips E, Mensink RP, Hesselink MK, Hardie DG, Schrauwen P.

J Lipid Res. 2009 Aug 18. [Epub ahead of print]PMID: 19690335 [PubMed - as supplied by publisher]Related articlesFree article

Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.

Minnaard R, Schrauwen P, Schaart G, Jorgensen JA, Lenaers E, Mensink M, Hesselink MK.

J Clin Endocrinol Metab. 2009 Oct;94(10):4077-85. Epub 2009 Jul 14.PMID: 19602560 [PubMed - indexed for MEDLINE]Related articles

Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss.

Rabøl R, Svendsen PF, Skovbro M, Boushel R, Haugaard SB, Schjerling P, Schrauwen P, Hesselink MK, Nilas L, Madsbad S, Dela F.

Metabolism. 2009 Aug;58(8):1145-52. Epub 2009 Jun 18.PMID: 19454354 [PubMed - indexed for MEDLINE]Related articles

Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids.

Kersten S, Lichtenstein L, Steenbergen E, Mudde K, Hendriks HF, Hesselink MK, Schrauwen P, Müller M.

Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):969-74. Epub 2009 Apr 2.PMID: 19342599 [PubMed - indexed for MEDLINE]Related articles

The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice.

Nabben M, Hoeks J, Briedé JJ, Glatz JF, Moonen-Kornips E, Hesselink MK, Schrauwen P.

FEBS Lett. 2008 Dec 24;582(30):4147-52. Epub 2008 Nov 27.PMID: 19041310 [PubMed - indexed for MEDLINE]Related articles

Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients.

Phielix E, Schrauwen-Hinderling VB, Mensink M, Lenaers E, Meex R, Hoeks J, Kooi ME, Moonen-Kornips E, Sels JP, Hesselink MK, Schrauwen P.

Diabetes. 2008 Nov;57(11):2943-9. Epub 2008 Aug 4.PMID: 18678616 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes.

De Feyter HM, Lenaers E, Houten SM, Schrauwen P, Hesselink MK, Wanders RJ, Nicolay K, Prompers JJ.

FASEB J. 2008 Nov;22(11):3947-55. Epub 2008 Jul 24.PMID: 18653763 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced tricarboxylic acid cycle flux in type 2 diabetes mellitus?

Schrauwen P, Hesselink MK.

Diabetologia. 2008 Sep;51(9):1694-7. Epub 2008 Jun 28.PMID: 18587560 [PubMed - indexed for MEDLINE]Related articlesFree article

Habitual physical activity in daily life correlates positively with markers for mitochondrial capacity.

den Hoed M, Hesselink MK, van Kranenburg GP, Westerterp KR.

J Appl Physiol. 2008 Aug;105(2):561-8. Epub 2008 May 29.PMID: 18511526 [PubMed - indexed for MEDLINE]Related articlesFree article

The insulin-sensitizing effect of rosiglitazone in type 2 diabetes mellitus patients does not require improved in vivo muscle mitochondrial function.

Schrauwen-Hinderling VB, Mensink M, Hesselink MK, Sels JP, Kooi ME, Schrauwen P.

J Clin Endocrinol Metab. 2008 Jul;93(7):2917-21. Epub 2008 May 6.PMID: 18460571 [PubMed - indexed for MEDLINE]Related articlesFree article

Shift in metabolic fuel in acylation-stimulating protein-deficient mice following a high-fat diet.

Roy C, Paglialunga S, Fisette A, Schrauwen P, Moonen-Kornips E, St-Onge J, Hesselink MK, Richard D, Joanisse DR, Cianflone K.

Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1051-9. Epub 2008 Apr 8.PMID: 18398012 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle fiber-type distribution and habitual physical activity in daily life.

den Hoed M, Hesselink MK, Westerterp KR.

Scand J Med Sci Sports. 2009 Jun;19(3):373-80. Epub 2009 Mar 31.PMID: 18384492 [PubMed - in process]Related articles

Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake.

De Bock K, Derave W, Eijnde BO, Hesselink MK, Koninckx E, Rose AJ, Schrauwen P, Bonen A, Richter EA, Hespel P.

J Appl Physiol. 2008 Apr;104(4):1045-55. Epub 2008 Feb 14.PMID: 18276898 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding.

Hoeks J, Briedé JJ, de Vogel J, Schaart G, Nabben M, Moonen-Kornips E, Hesselink MK, Schrauwen P.

FEBS Lett. 2008 Feb 20;582(4):510-6. Epub 2008 Jan 28.PMID: 18230360 [PubMed - indexed for MEDLINE]Related articles

Muscular mitochondrial dysfunction and type 2 diabetes mellitus.

Schrauwen-Hinderling VB, Roden M, Kooi ME, Hesselink MK, Schrauwen P.

Curr Opin Clin Nutr Metab Care. 2007 Nov;10(6):698-703. Review.PMID: 18089950 [PubMed - indexed for MEDLINE]Related articles

Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients.

Jazet IM, Schaart G, Gastaldelli A, Ferrannini E, Hesselink MK, Schrauwen P, Romijn JA, Maassen JA, Pijl H, Ouwens DM, Meinders AE.

Diabetologia. 2008 Feb;51(2):309-19. Epub 2007 Dec 14.PMID: 18080107 [PubMed - indexed for MEDLINE]Related articles

Reduced adipose tissue triglyceride synthesis and increased muscle fatty acid oxidation in C5L2 knockout mice.

Paglialunga S, Schrauwen P, Roy C, Moonen-Kornips E, Lu H, Hesselink MK, Deshaies Y, Richard D, Cianflone K.

J Endocrinol. 2007 Aug;194(2):293-304.PMID: 17641279 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle uncoupling protein-3 restores upon intervention in the prediabetic and diabetic state: implications for diabetes pathogenesis?

Mensink M, Hesselink MK, Borghouts LB, Keizer H, Moonen-Kornips E, Schaart G, Blaak EE, Schrauwen P.

Diabetes Obes Metab. 2007 Jul;9(4):594-6.PMID: 17587402 [PubMed - indexed for MEDLINE]Related articles

Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD.

Gosker HR, Hesselink MK, Duimel H, Ward KA, Schols AM.

Eur Respir J. 2007 Jul;30(1):73-9. Epub 2007 Apr 11. Erratum in: Eur Respir J. 2007 Oct;30(4):817. PMID: 17428811 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus.

Mensink M, Hesselink MK, Russell AP, Schaart G, Sels JP, Schrauwen P.

Int J Obes (Lond). 2007 Aug;31(8):1302-10. Epub 2007 Feb 20.PMID: 17310221 [PubMed - indexed for MEDLINE]Related articles

Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects.

Schrauwen-Hinderling VB, Kooi ME, Hesselink MK, Jeneson JA, Backes WH, van Echteld CJ, van Engelshoven JM, Mensink M, Schrauwen P.

Diabetologia. 2007 Jan;50(1):113-20. Epub 2006 Nov 9.PMID: 17093944 [PubMed - indexed for MEDLINE]Related articles

Eat the meat or feed the meat: protein turnover in remodeling muscle.

Hesselink MK, Minnaard R, Schrauwen P.

Curr Opin Clin Nutr Metab Care. 2006 Nov;9(6):672-6. Review.PMID: 17053418 [PubMed - indexed for MEDLINE]Related articles

UCP3 in muscle wasting, a role in modulating lipotoxicity?

Minnaard R, Schrauwen P, Schaart G, Hesselink MK.

FEBS Lett. 2006 Oct 2;580(22):5172-6. Epub 2006 Sep 5.PMID: 16962595 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids.

Hoeks J, Hesselink MK, Russell AP, Mensink M, Saris WH, Mensink RP, Schrauwen P.

Diabetologia. 2006 Oct;49(10):2419-26. Epub 2006 Aug 1.PMID: 16896940 [PubMed - indexed for MEDLINE]Related articles

Regional variations in intramyocellular lipid concentration correlate with muscle fiber type distribution in rat tibialis anterior muscle.

De Feyter HM, Schaart G, Hesselink MK, Schrauwen P, Nicolay K, Prompers JJ.

Magn Reson Med. 2006 Jul;56(1):19-25.PMID: 16767761 [PubMed - indexed for MEDLINE]Related articles

Intramyocellular lipid content in human skeletal muscle.

Schrauwen-Hinderling VB, Hesselink MK, Schrauwen P, Kooi ME.

Obesity (Silver Spring). 2006 Mar;14(3):357-67. Review.PMID: 16648604 [PubMed - indexed for MEDLINE]Related articles

Short-term training is accompanied by a down regulation of ACC2 mRNA in skeletal muscle.

Schrauwen-Hinderling VB, Hesselink MK, Moonen-Kornips E, Schaart G, Kooi ME, Saris WH, Schrauwen P.

Int J Sports Med. 2006 Oct;27(10):786-91. Epub 2006 Feb 1.PMID: 16586331 [PubMed - indexed for MEDLINE]Related articles

Involvement of UCP3 in mild uncoupling and lipotoxicity.

Hoeks J, Hesselink MK, Schrauwen P.

Exp Gerontol. 2006 Jul;41(7):658-62. Epub 2006 Mar 27. Review.PMID: 16564663 [PubMed - indexed for MEDLINE]Related articles

The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice.

Hoeks J, Hesselink MK, Sluiter W, Schaart G, Willems J, Morrisson A, Clapham JC, Saris WH, Schrauwen P.

FEBS Lett. 2006 Feb 20;580(5):1371-5. Epub 2006 Jan 26.PMID: 16455084 [PubMed - indexed for MEDLINE]Related articles

Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet.

Schrauwen-Hinderling VB, Kooi ME, Hesselink MK, Moonen-Kornips E, Schaart G, Mustard KJ, Hardie DG, Saris WH, Nicolay K, Schrauwen P.

Obes Res. 2005 Dec;13(12):2088-94.PMID: 16421342 [PubMed - indexed for MEDLINE]Related articles

Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment.

Schrauwen P, Mensink M, Schaart G, Moonen-Kornips E, Sels JP, Blaak EE, Russell AP, Hesselink MK.

J Clin Endocrinol Metab. 2006 Apr;91(4):1520-5. Epub 2005 Dec 29.PMID: 16384852 [PubMed - indexed for MEDLINE]Related articlesFree article

Putative function and physiological relevance of the mitochondrial uncoupling protein-3: involvement in fatty acid metabolism?

Schrauwen P, Hoeks J, Hesselink MK.

Prog Lipid Res. 2006 Jan;45(1):17-41. Epub 2005 Dec 9. Review.PMID: 16384603 [PubMed - indexed for MEDLINE]Related articles

Exercise training restores uncoupling protein-3 content in limb muscles of patients with chronic obstructive pulmonary disease.

Gosker HR, Schrauwen P, Broekhuizen R, Hesselink MK, Moonen-Kornips E, Ward KA, Franssen FM, Wouters EF, Schols AM.

Am J Physiol Endocrinol Metab. 2006 May;290(5):E976-81. Epub 2005 Dec 13.PMID: 16352674 [PubMed - indexed for MEDLINE]Related articlesFree article

Towards comprehension of the physiological role of UCP3.

Hesselink MK, Schrauwen P.

Horm Metab Res. 2005 Sep;37(9):550-4. Review.PMID: 16175492 [PubMed - indexed for MEDLINE]Related articles

Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes.

Civitarese AE, Hesselink MK, Russell AP, Ravussin E, Schrauwen P.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1023-9. Epub 2005 Jul 19.PMID: 16030063 [PubMed - indexed for MEDLINE]Related articlesFree article

Ubiquitin-proteasome-dependent proteolytic activity remains elevated after zymosan-induced sepsis in rats while muscle mass recovers.

Minnaard R, Wagenmakers AJ, Combaret L, Attaix D, Drost MR, van Kranenburg GP, Schaart G, Hesselink MK.

Int J Biochem Cell Biol. 2005 Oct;37(10):2217-25.PMID: 15955721 [PubMed - indexed for MEDLINE]Related articles

Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise.

Russell AP, Hesselink MK, Lo SK, Schrauwen P.

FASEB J. 2005 Jun;19(8):986-8. Epub 2005 Apr 6.PMID: 15814608 [PubMed - indexed for MEDLINE]Related articlesFree article

Acylation-stimulating protein: effect of acute exercise and endurance training.

Schrauwen P, Hesselink MK, Jain M, Cianflone K.

Int J Obes (Lond). 2005 Jun;29(6):632-8.PMID: 15809665 [PubMed - indexed for MEDLINE]Related articles

Skeletal Muscle wasting and contractile performance in septic rats.

Minnaard R, Drost MR, Wagenmakers AJ, van Kranenburg GP, Kuipers H, Hesselink MK.

Muscle Nerve. 2005 Mar;31(3):339-48.PMID: 15751123 [PubMed - indexed for MEDLINE]Related articles

Effect of 2 weeks of endurance training on uncoupling protein 3 content in untrained human subjects.

Schrauwen P, Russell AP, Moonen-Kornips E, Boon N, Hesselink MK.

Acta Physiol Scand. 2005 Mar;183(3):273-80.PMID: 15743387 [PubMed - indexed for MEDLINE]Related articles

Uncoupling proteins in the failing human heart: friend or foe?

Hesselink MK, Schrauwen P.

Lancet. 2005 Jan 29-Feb 4;365(9457):385-6. No abstract available. PMID: 15680450 [PubMed - indexed for MEDLINE]Related articles

DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content.

Roorda BD, Hesselink MK, Schaart G, Moonen-Kornips E, Martínez-Martínez P, Losen M, De Baets MH, Mensink RP, Schrauwen P.

J Lipid Res. 2005 Feb;46(2):230-6. Epub 2004 Dec 1.PMID: 15576838 [PubMed - indexed for MEDLINE]Related articlesFree article

A modified PAS stain combined with immunofluorescence for quantitative analyses of glycogen in muscle sections.

Schaart G, Hesselink RP, Keizer HA, van Kranenburg G, Drost MR, Hesselink MK.

Histochem Cell Biol. 2004 Aug;122(2):161-9. Epub 2004 Aug 3.PMID: 15322861 [PubMed - indexed for MEDLINE]Related articles

The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity?

Schrauwen P, Hesselink MK.

Proc Nutr Soc. 2004 May;63(2):287-92. Review.PMID: 15294045 [PubMed - indexed for MEDLINE]Related articles

Physical activity and health, novel concepts and new targets: report from the 12th Conference of the International Research Group on the Biochemistry of Exercise.

Hesselink MK, van Baak MA.

Proc Nutr Soc. 2004 May;63(2):189-97. Review.PMID: 15294029 [PubMed - indexed for MEDLINE]Related articles

Intramyocellular lipids and insulin sensitivity: does size really matter?

Hesselink MK, Mensink M, Schrauwen P.

Obes Res. 2004 May;12(5):741-2. No abstract available. PMID: 15166292 [PubMed - indexed for MEDLINE]Related articles

Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes.

Schrauwen P, Hesselink MK.

Diabetes. 2004 Jun;53(6):1412-7. Review.PMID: 15161742 [PubMed - indexed for MEDLINE]Related articlesFree article