PubMed

Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies.

Cernea S, Herold KC.

Clin Immunol. 2009 Oct 15. [Epub ahead of print]PMID: 19837003 [PubMed - as supplied by publisher]Related articles

Challenges in developing endpoints for type 1 diabetes intervention studies.

Cernea S, Raz I, Herold KC, Hirshberg B, Roep BO, Schatz DA, Fleming GA, Pozzilli P, Little R, Schloot NC, Leslie RD, Skyler JS, Palmer JP.

Diabetes Metab Res Rev. 2009 Nov;25(8):694-704.PMID: 19771545 [PubMed - in process]Related articles

Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes.

Herold KC, Brooks-Worrell B, Palmer J, Dosch HM, Peakman M, Gottlieb P, Reijonen H, Arif S, Spain LM, Thompson C, Lachin JM; Type 1 Diabetes TrialNet Research Group.

Diabetes. 2009 Nov;58(11):2588-95. Epub 2009 Aug 12.PMID: 19675135 [PubMed - in process]Related articles

Remission of type 1 diabetes after anti-CD3 antibody treatment and transplantation of embryonic pancreatic precursors.

Begum S, Chen W, Herold KC, Papaioannou VE.

Endocrinology. 2009 Oct;150(10):4512-20. Epub 2009 Jul 9.PMID: 19589867 [PubMed - indexed for MEDLINE]Related articles

Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice.

Lepus CM, Gibson TF, Gerber SA, Kawikova I, Szczepanik M, Hossain J, Ablamunits V, Kirkiles-Smith N, Herold KC, Donis RO, Bothwell AL, Pober JS, Harding MJ.

Hum Immunol. 2009 Oct;70(10):790-802. Epub 2009 Jun 12.PMID: 19524633 [PubMed - in process]Related articles

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years.

Herold KC, Gitelman S, Greenbaum C, Puck J, Hagopian W, Gottlieb P, Sayre P, Bianchine P, Wong E, Seyfert-Margolis V, Bourcier K, Bluestone JA; Immune Tolerance Network ITN007AI Study Group.

Clin Immunol. 2009 Aug;132(2):166-73. Epub 2009 May 14.PMID: 19443276 [PubMed - indexed for MEDLINE]Related articles

Advances in Type 1 diabetes therapeutics: immunomodulation and beta-cell salvage.

Waldron-Lynch F, Herold KC.

Endocrinol Metab Clin North Am. 2009 Jun;38(2):303-17, viii. Review.PMID: 19328413 [PubMed - indexed for MEDLINE]Related articles

Anti-CD3 mAbs for treatment of type 1 diabetes.

Kaufman A, Herold KC.

Diabetes Metab Res Rev. 2009 May;25(4):302-6. Review.PMID: 19319985 [PubMed - indexed for MEDLINE]Related articles

Towards a curative therapy in type 1 diabetes: remission of autoimmunity, maintenance and augmentation of beta cell mass.

Waldron-Lynch F, von Herrath M, Herold KC.

Novartis Found Symp. 2008;292:146-55; discussion 155-8, 202-3.PMID: 19203097 [PubMed - indexed for MEDLINE]Related articles

Human regulatory CD8 T cells.

Ablamunits V, Bisikirska BC, Herold KC.

Ann N Y Acad Sci. 2008 Dec;1150:234-8.PMID: 19120302 [PubMed - indexed for MEDLINE]Related articles

Continuous glucose monitoring: long live the revolution!

Waldron-Lynch F, Herold KC.

Nat Clin Pract Endocrinol Metab. 2009 Feb;5(2):82-3. Epub 2008 Dec 17. No abstract available. PMID: 19092785 [PubMed - indexed for MEDLINE]Related articles

Beta-cell mass and type 1 diabetes: going, going, gone?

Akirav E, Kushner JA, Herold KC.

Diabetes. 2008 Nov;57(11):2883-8. Review.PMID: 18971435 [PubMed - indexed for MEDLINE]Related articlesFree article

Promotion of beta-cell differentiation in pancreatic precursor cells by adult islet cells.

Chen W, Begum S, Opare-Addo L, Garyu J, Gibson TF, Bothwell AL, Papaioannou VE, Herold KC.

Endocrinology. 2009 Feb;150(2):570-9. Epub 2008 Oct 9.PMID: 18845629 [PubMed - indexed for MEDLINE]Related articles

Generation and function of human regulatory CD8+ T cells induced by a humanized OKT3 monoclonal antibody hOKT3gamma1 (Ala-Ala).

Ablamunits V, Herold KC.

Hum Immunol. 2008 Nov;69(11):732-6. Epub 2008 Sep 24. Review.PMID: 18817833 [PubMed - indexed for MEDLINE]Related articles

RAGE ligation affects T cell activation and controls T cell differentiation.

Chen Y, Akirav EM, Chen W, Henegariu O, Moser B, Desai D, Shen JM, Webster JC, Andrews RC, Mjalli AM, Rothlein R, Schmidt AM, Clynes R, Herold KC.

J Immunol. 2008 Sep 15;181(6):4272-8.PMID: 18768885 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of type 1 diabetes: the time has come.

Sherr J, Sosenko J, Skyler JS, Herold KC.

Nat Clin Pract Endocrinol Metab. 2008 Jun;4(6):334-43. Epub 2008 Apr 29. Review.PMID: 18446141 [PubMed - indexed for MEDLINE]Related articles

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL.

Clin Immunol. 2008 Mar;126(3):303-14. Epub 2007 Dec 21.PMID: 18096436 [PubMed - indexed for MEDLINE]Related articles

A patient with type B insulin resistance syndrome, responsive to immune therapy.

Page KA, Dejardin S, Kahn CR, Kulkarni RN, Herold KC, Inzucchi SE.

Nat Clin Pract Endocrinol Metab. 2007 Dec;3(12):835-40.PMID: 18026162 [PubMed - indexed for MEDLINE]Related articles

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.

Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC.

Endocrinology. 2007 Nov;148(11):5136-44. Epub 2007 Aug 2.PMID: 17673522 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough.

Ablamunits V, Sherry NA, Kushner JA, Herold KC.

Ann N Y Acad Sci. 2007 Apr;1103:19-32. Epub 2007 Mar 21. Review.PMID: 17376841 [PubMed - indexed for MEDLINE]Related articles

Blockade of RAGE suppresses alloimmune reactions in vitro and delays allograft rejection in murine heart transplantation.

Moser B, Szabolcs MJ, Ankersmit HJ, Lu Y, Qu W, Weinberg A, Herold KC, Schmidt AM.

Am J Transplant. 2007 Feb;7(2):293-302. Erratum in: Am J Transplant. 2007 May;7(5):1318. PMID: 17241110 [PubMed - indexed for MEDLINE]Related articles

Increasing the accuracy of oral glucose tolerance testing and extending its application to individuals with normal glucose tolerance for the prediction of type 1 diabetes: the Diabetes Prevention Trial-Type 1.

Sosenko JM, Palmer JP, Greenbaum CJ, Mahon J, Cowie C, Krischer JP, Chase HP, White NH, Buckingham B, Herold KC, Cuthbertson D, Skyler JS; Diabetes Prevention Trial-Type 1 Study Group.

Diabetes Care. 2007 Jan;30(1):38-42.PMID: 17192330 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet transplantation for type 1 diabetes--where should we go?

Witkowski P, Herold KC.

Nat Clin Pract Endocrinol Metab. 2007 Jan;3(1):2-3. No abstract available. PMID: 17179921 [PubMed - indexed for MEDLINE]Related articles

Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes.

Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, Herold KC.

Diabetes. 2006 Dec;55(12):3238-45.PMID: 17130466 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study.

Seyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, Eisenbarth GS, Palmer JP, Greenbaum CJ, Gitelman SE, Nepom GT, Bluestone JA, Herold KC.

Diabetes. 2006 Sep;55(9):2588-94.PMID: 16936208 [PubMed - indexed for MEDLINE]Related articlesFree article

Drug insight: New immunomodulatory therapies in type 1 diabetes.

Cernea S, Herold KC.

Nat Clin Pract Endocrinol Metab. 2006 Feb;2(2):89-98. Review.PMID: 16932263 [PubMed - indexed for MEDLINE]Related articles

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs.

Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von Herrath M.

J Clin Invest. 2006 May;116(5):1371-81. Epub 2006 Apr 20.PMID: 16628253 [PubMed - indexed for MEDLINE]Related articlesFree article

Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1.

Sosenko JM, Palmer JP, Greenbaum CJ, Mahon J, Cowie C, Krischer JP, Chase HP, White NH, Buckingham B, Herold KC, Cuthbertson D, Skyler JS.

Diabetes Care. 2006 Mar;29(3):643-9.PMID: 16505520 [PubMed - indexed for MEDLINE]Related articlesFree article

RAGE: a journey from the complications of diabetes to disorders of the nervous system - striking a fine balance between injury and repair.

Rong LL, Gooch C, Szabolcs M, Herold KC, Lalla E, Hays AP, Yan SF, Yan SS, Schmidt AM.

Restor Neurol Neurosci. 2005;23(5-6):355-65. Review.PMID: 16477098 [PubMed - indexed for MEDLINE]Related articles

The rise and fall of insulin secretion in type 1 diabetes mellitus.

Tsai EB, Sherry NA, Palmer JP, Herold KC.

Diabetologia. 2006 Feb;49(2):261-70. Epub 2006 Jan 11. Review.PMID: 16404554 [PubMed - indexed for MEDLINE]Related articles

Receptor for advanced glycation end products and its ligands: initiators or amplifiers of joint inflammation--a bit of both?

Moser B, Herold KC, Schmidt AM.

Arthritis Rheum. 2006 Jan;54(1):14-8. Review. No abstract available. PMID: 16385492 [PubMed - indexed for MEDLINE]Related articlesFree article

Achieving antigen-specific tolerance in diabetes: regulating specifically.

Chen W, Bluestone JA, Herold KC.

Int Rev Immunol. 2005 Sep-Dec;24(5-6):287-305. Review. Erratum in: Int Rev Immunol. 2006 Jan-Apr;25(1-2):49. PMID: 16318983 [PubMed - indexed for MEDLINE]Related articles

Natural history of beta-cell function in type 1 diabetes.

Sherry NA, Tsai EB, Herold KC.

Diabetes. 2005 Dec;54 Suppl 2:S32-9. Review.PMID: 16306337 [PubMed - indexed for MEDLINE]Related articlesFree article

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs.

Bisikirska B, Colgan J, Luban J, Bluestone JA, Herold KC.

J Clin Invest. 2005 Oct;115(10):2904-13. Epub 2005 Sep 15.PMID: 16167085 [PubMed - indexed for MEDLINE]Related articlesFree article

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.

Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA.

Diabetes. 2005 Jun;54(6):1763-9.PMID: 15919798 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory T cells and type 1 diabetes.

Bisikirska BC, Herold KC.

Curr Diab Rep. 2005 Apr;5(2):104-9. Review.PMID: 15794912 [PubMed - indexed for MEDLINE]Related articles

Use of anti-CD3 monoclonal antibody to induce immune regulation in type 1 diabetes.

Bisikirska BC, Herold KC.

Ann N Y Acad Sci. 2004 Dec;1037:1-9. Review.PMID: 15699486 [PubMed - indexed for MEDLINE]Related articles

Continuous subcutaneous insulin infusion in older patients with type 1 diabetes.

Siegel-Czarkowski L, Herold KC, Goland RS.

Diabetes Care. 2004 Dec;27(12):3022-3. No abstract available. PMID: 15562235 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of type 1 diabetes with anti-T-cell agents: from T-cell depletion to T-cell regulation.

Glandt M, Herold KC.

Curr Diab Rep. 2004 Aug;4(4):291-7. Review.PMID: 15265472 [PubMed - indexed for MEDLINE]Related articles

Blockade of late stages of autoimmune diabetes by inhibition of the receptor for advanced glycation end products.

Chen Y, Yan SS, Colgan J, Zhang HP, Luban J, Schmidt AM, Stern D, Herold KC.

J Immunol. 2004 Jul 15;173(2):1399-405.PMID: 15240736 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of type 1 diabetes mellitus to preserve insulin secretion.

Herold KC.

Endocrinol Metab Clin North Am. 2004 Mar;33(1):93-111, ix. Review. No abstract available. PMID: 15053897 [PubMed - indexed for MEDLINE]Related articles

Achieving antigen-specific immune regulation.

Herold KC.

J Clin Invest. 2004 Feb;113(3):346-9. Review.PMID: 14755329 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion in type 1 diabetes.

Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC.

Diabetes. 2004 Feb;53(2):426-33.PMID: 14747294 [PubMed - indexed for MEDLINE]Related articlesFree article

C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.

Palmer JP, Fleming GA, Greenbaum CJ, Herold KC, Jansa LD, Kolb H, Lachin JM, Polonsky KS, Pozzilli P, Skyler JS, Steffes MW.

Diabetes. 2004 Jan;53(1):250-64. Erratum in: Diabetes. 2004 Jul;53(7):1934. PMID: 14693724 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of type 1 diabetes with anti-CD3 monoclonal antibody.

Glandt M, Hagopian W, Herold KC.

Rev Endocr Metab Disord. 2003 Dec;4(4):361-8. Review. No abstract available. PMID: 14618021 [PubMed - indexed for MEDLINE]Related articles

Treatment of Type 1 diabetes with anti-CD3 monoclonal antibody: induction of immune regulation?

Herold KC, Taylor L.

Immunol Res. 2003;28(2):141-50. Review.PMID: 14610290 [PubMed - indexed for MEDLINE]Related articles

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

Herold KC, Burton JB, Francois F, Poumian-Ruiz E, Glandt M, Bluestone JA.

J Clin Invest. 2003 Feb;111(3):409-18.PMID: 12569167 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic islets activate portal vein endothelial cells in vitro.

Fontaine MJ, Blanchard J, Rastellini C, Lazda V, Herold KC, Pollak R.

Ann Clin Lab Sci. 2002 Fall;32(4):352-61.PMID: 12458886 [PubMed - indexed for MEDLINE]Related articles

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus.

Herold KC, Hagopian W, Auger JA, Poumian-Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA.

N Engl J Med. 2002 May 30;346(22):1692-8.PMID: 12037148 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatitis C virus infection.

Herold KC.

N Engl J Med. 2001 Nov 8;345(19):1426; author reply 1427-8. No abstract available. PMID: 11794187 [PubMed - indexed for MEDLINE]Related articles