PubMed

Shortcomings of current models of glucose-induced insulin secretion.

Henquin JC, Nenquin M, Ravier MA, Szollosi A.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:168-79.PMID: 19817799 [PubMed - in process]Related articles

beta-Cell research - A decade of rapid growth.

Ahrén B, Accili D, Boitard C, Efendic S, Henquin JC, Seino S, Steiner DF, Cerasi E.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:iv-ix. No abstract available. PMID: 19817782 [PubMed - in process]Related articles

Regulation of insulin secretion: a matter of phase control and amplitude modulation.

Henquin JC.

Diabetologia. 2009 May;52(5):739-51. Epub 2009 Mar 14. Review.PMID: 19288076 [PubMed - indexed for MEDLINE]Related articles

Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells.

Quoix N, Cheng-Xue R, Mattart L, Zeinoun Z, Guiot Y, Beauvois MC, Henquin JC, Gilon P.

Diabetes. 2009 Feb;58(2):412-21. Epub 2008 Nov 13.PMID: 19008345 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta-cell mass in European subjects with type 2 diabetes.

Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:32-42.PMID: 18834431 [PubMed - indexed for MEDLINE]Related articles

Pancreatic beta-cell mass or beta-cell function? That is the question!

Henquin JC, Cerasi E, Efendic S, Steiner DF, Boitard C.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:1-4. No abstract available. PMID: 18834427 [PubMed - indexed for MEDLINE]Related articles

Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2.

Ravier MA, Nenquin M, Miki T, Seino S, Henquin JC.

Endocrinology. 2009 Jan;150(1):33-45. Epub 2008 Sep 11.PMID: 18787024 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.

Henquin JC, Nenquin M, Szollosi A, Kubosaki A, Notkins AL.

J Endocrinol. 2008 Mar;196(3):573-81.PMID: 18310453 [PubMed - indexed for MEDLINE]Related articlesFree article

Of mighty mice and diabetic men: animal models of islet dysfunction.

Efendic S, Boitard C, Ferrannini E, Henquin JC, Steiner DF, Cerasi E.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:1-4. No abstract available. PMID: 17919172 [PubMed - indexed for MEDLINE]Related articles

The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells.

Quoix N, Cheng-Xue R, Guiot Y, Herrera PL, Henquin JC, Gilon P.

FEBS Lett. 2007 Sep 4;581(22):4235-40. Epub 2007 Aug 7.PMID: 17706201 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced cytosolic pH changes in beta-cells and insulin secretion are not causally related: studies in islets lacking the Na+/H+ exchangeR NHE1.

Stiernet P, Nenquin M, Moulin P, Jonas JC, Henquin JC.

J Biol Chem. 2007 Aug 24;282(34):24538-46. Epub 2007 Jun 28.PMID: 17599909 [PubMed - indexed for MEDLINE]Related articlesFree article

Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas.

Guiot Y, Stevens M, Marhfour I, Stiernet P, Mikhailov M, Ashcroft SJ, Rahier J, Henquin JC, Sempoux C.

Diabetologia. 2007 Sep;50(9):1889-99. Epub 2007 Jun 26.PMID: 17593344 [PubMed - indexed for MEDLINE]Related articles

Nutrient control of insulin secretion in perifused adult pig islets.

Dufrane D, Nenquin M, Henquin JC.

Diabetes Metab. 2007 Dec;33(6):430-8. Epub 2007 Jun 20.PMID: 17584514 [PubMed - indexed for MEDLINE]Related articlesFree article

Overnight culture unmasks glucose-induced insulin secretion in mouse islets lacking ATP-sensitive K+ channels by improving the triggering Ca2+ signal.

Szollosi A, Nenquin M, Henquin JC.

J Biol Chem. 2007 May 18;282(20):14768-76. Epub 2007 Mar 27.PMID: 17389589 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and subcellular localization of the Na+/H+ exchanger and a novel related protein in the endocrine pancreas and adrenal medulla.

Moulin P, Guiot Y, Jonas JC, Rahier J, Devuyst O, Henquin JC.

J Mol Endocrinol. 2007 Mar;38(3):409-22.PMID: 17339404 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels.

Szollosi A, Nenquin M, Aguilar-Bryan L, Bryan J, Henquin JC.

J Biol Chem. 2007 Jan 19;282(3):1747-56. Epub 2006 Nov 30.PMID: 17138557 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutrient control of insulin secretion in isolated normal human islets.

Henquin JC, Dufrane D, Nenquin M.

Diabetes. 2006 Dec;55(12):3470-7.PMID: 17130494 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose acutely decreases pH of secretory granules in mouse pancreatic islets. Mechanisms and influence on insulin secretion.

Stiernet P, Guiot Y, Gilon P, Henquin JC.

J Biol Chem. 2006 Aug 4;281(31):22142-51. Epub 2006 Jun 7.PMID: 16760469 [PubMed - indexed for MEDLINE]Related articlesFree article

Antioxidants N-acetyl-L-cysteine and manganese(III)tetrakis (4-benzoic acid)porphyrin do not prevent beta-cell dysfunction in rat islets cultured in high glucose for 1 wk.

Khaldi MZ, Elouil H, Guiot Y, Henquin JC, Jonas JC.

Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E137-46. Epub 2006 Feb 7.PMID: 16464909 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo and in vitro glucose-induced biphasic insulin secretion in the mouse: pattern and role of cytoplasmic Ca2+ and amplification signals in beta-cells.

Henquin JC, Nenquin M, Stiernet P, Ahren B.

Diabetes. 2006 Feb;55(2):441-51.PMID: 16443779 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced mixed [Ca2+]c oscillations in mouse beta-cells are controlled by the membrane potential and the SERCA3 Ca2+-ATPase of the endoplasmic reticulum.

Beauvois MC, Merezak C, Jonas JC, Ravier MA, Henquin JC, Gilon P.

Am J Physiol Cell Physiol. 2006 Jun;290(6):C1503-11. Epub 2005 Dec 28.PMID: 16381799 [PubMed - indexed for MEDLINE]Related articlesFree article

A tale of two cousins: type 1 and type 2 diabetes.

Boitard C, Efendic S, Ferrannini E, Henquin JC, Steiner DF, Cerasi E.

Diabetes. 2005 Dec;54 Suppl 2:S1-3. No abstract available. PMID: 16306326 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual mechanism of the potentiation by glucose of insulin secretion induced by arginine and tolbutamide in mouse islets.

Ishiyama N, Ravier MA, Henquin JC.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E540-9. Epub 2005 Oct 25.PMID: 16249257 [PubMed - indexed for MEDLINE]Related articlesFree article

Congenital hyperinsulinism and mosaic abnormalities of the ploidy.

Giurgea I, Sanlaville D, Fournet JC, Sempoux C, Bellanné-Chantelot C, Touati G, Hubert L, Groos MS, Brunelle F, Rahier J, Henquin JC, Dunne MJ, Jaubert F, Robert JJ, Nihoul-Fékété C, Vekemans M, Junien C, de Lonlay P.

J Med Genet. 2006 Mar;43(3):248-54. Epub 2005 Jul 20.PMID: 16033916 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.

Ravier MA, Güldenagel M, Charollais A, Gjinovci A, Caille D, Söhl G, Wollheim CB, Willecke K, Henquin JC, Meda P.

Diabetes. 2005 Jun;54(6):1798-807.PMID: 15919802 [PubMed - indexed for MEDLINE]Related articlesFree article

A simple method using a polymethylpenten chamber for isolation of human pancreatic islets.

Dufrane D, Goebbels RM, Guiot Y, Squifflet JP, Henquin JC, Gianello P.

Pancreas. 2005 Apr;30(3):e51-9.PMID: 15782089 [PubMed - indexed for MEDLINE]Related articles

High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB.

Elouil H, Cardozo AK, Eizirik DL, Henquin JC, Jonas JC.

Diabetologia. 2005 Mar;48(3):496-505. Epub 2005 Mar 1. Erratum in: Diabetologia. 2005 Dec;48(12):2693. PMID: 15739117 [PubMed - indexed for MEDLINE]Related articles

Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin secretagogues.

Henquin JC.

Diabetes. 2004 Dec;53 Suppl 3:S48-58.PMID: 15561921 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of treatment on islet function in type 2 diabetes.

Henquin JC, Boitard C, Cerasi E, Ferrannini E, Steiner DF, Efendic S.

Diabetes. 2004 Dec;53 Suppl 3:S1-5. No abstract available. PMID: 15561896 [PubMed - indexed for MEDLINE]Related articlesFree article

Atypical Ca2+-induced Ca2+ release from a sarco-endoplasmic reticulum Ca2+-ATPase 3-dependent Ca2+ pool in mouse pancreatic beta-cells.

Beauvois MC, Arredouani A, Jonas JC, Rolland JF, Schuit F, Henquin JC, Gilon P.

J Physiol. 2004 Aug 15;559(Pt 1):141-56. Epub 2004 Jun 24.PMID: 15218077 [PubMed - indexed for MEDLINE]Related articlesFree article

Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells.

Nenquin M, Szollosi A, Aguilar-Bryan L, Bryan J, Henquin JC.

J Biol Chem. 2004 Jul 30;279(31):32316-24. Epub 2004 Jun 1.PMID: 15175349 [PubMed - indexed for MEDLINE]Related articlesFree article

Synchronization and entrainment of cytoplasmic Ca2+ oscillations in cell clusters prepared from single or multiple mouse pancreatic islets.

Zarkovic M, Henquin JC.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E340-7. Epub 2004 May 4.PMID: 15126238 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular mechanisms of insulin secretion.

Henquin JC.

Ann Endocrinol (Paris). 2004 Feb;65(1):8. No abstract available. PMID: 15122085 [PubMed - indexed for MEDLINE]Related articles

Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose.

Khaldi MZ, Guiot Y, Gilon P, Henquin JC, Jonas JC.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E207-17. Epub 2004 Apr 20.PMID: 15100093 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel factors in the regulation of beta-cell function.

Boitard C, Cerasi E, Efendic S, Henquin JC, Steiner DF, Ferrannini E.

Diabetes. 2004 Feb;53 Suppl 1:S1-3. No abstract available. PMID: 14749258 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.

Van de Casteele M, Kefas BA, Cai Y, Heimberg H, Scott DK, Henquin JC, Pipeleers D, Jonas JC.

Biochem Biophys Res Commun. 2003 Dec 26;312(4):937-44.PMID: 14651961 [PubMed - indexed for MEDLINE]Related articles

Hierarchy of the beta-cell signals controlling insulin secretion.

Henquin JC, Ravier MA, Nenquin M, Jonas JC, Gilon P.

Eur J Clin Invest. 2003 Sep;33(9):742-50. Review. No abstract available. PMID: 12925032 [PubMed - indexed for MEDLINE]Related articles

Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP.

Jonas JC, Guiot Y, Rahier J, Henquin JC.

Diabetologia. 2003 Sep;46(9):1234-44. Epub 2003 Jul 24. Erratum in: Diabetologia.2004 Apr;47(4):765. PMID: 12898011 [PubMed - indexed for MEDLINE]Related articles

SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells.

Arredouani A, Guiot Y, Jonas JC, Liu LH, Nenquin M, Pertusa JA, Rahier J, Rolland JF, Shull GE, Stevens M, Wuytack F, Henquin JC, Gilon P.

Diabetes. 2002 Nov;51(11):3245-53.PMID: 12401716 [PubMed - indexed for MEDLINE]Related articlesFree article

Time and amplitude regulation of pulsatile insulin secretion by triggering and amplifying pathways in mouse islets.

Ravier MA, Henquin JC.

FEBS Lett. 2002 Oct 23;530(1-3):215-9.PMID: 12387895 [PubMed - indexed for MEDLINE]Related articles

Disorganization of cytoplasmic Ca(2+) oscillations and pulsatile insulin secretion in islets from ob/ obmice.

Ravier MA, Sehlin J, Henquin JC.

Diabetologia. 2002 Aug;45(8):1154-63. Epub 2002 Jul 4.PMID: 12189446 [PubMed - indexed for MEDLINE]Related articles

G protein-independent activation of an inward Na(+) current by muscarinic receptors in mouse pancreatic beta-cells.

Rolland JF, Henquin JC, Gilon P.

J Biol Chem. 2002 Oct 11;277(41):38373-80. Epub 2002 Aug 2.PMID: 12161432 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes.

Pertusa JA, Nesher R, Kaiser N, Cerasi E, Henquin JC, Jonas JC.

Diabetes. 2002 Aug;51(8):2552-60.PMID: 12145170 [PubMed - indexed for MEDLINE]Related articlesFree article

The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related.

Bertrand G, Ishiyama N, Nenquin M, Ravier MA, Henquin JC.

J Biol Chem. 2002 Sep 6;277(36):32883-91. Epub 2002 Jun 26.PMID: 12087106 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of the endoplasmic reticulum to the glucose-induced [Ca(2+)](c) response in mouse pancreatic islets.

Arredouani A, Henquin JC, Gilon P.

Am J Physiol Endocrinol Metab. 2002 May;282(5):E982-91.PMID: 11934662 [PubMed - indexed for MEDLINE]Related articlesFree article

Do oscillations of insulin secretion occur in the absence of cytoplasmic Ca2+ oscillations in beta-cells?

Kjems LL, Ravier MA, Jonas JC, Henquin JC.

Diabetes. 2002 Feb;51 Suppl 1:S177-82.PMID: 11815478 [PubMed - indexed for MEDLINE]Related articlesFree article

Control mechanisms of the oscillations of insulin secretion in vitro and in vivo.

Gilon P, Ravier MA, Jonas JC, Henquin JC.

Diabetes. 2002 Feb;51 Suppl 1:S144-51. Review.PMID: 11815474 [PubMed - indexed for MEDLINE]Related articlesFree article

Signals and pools underlying biphasic insulin secretion.

Henquin JC, Ishiyama N, Nenquin M, Ravier MA, Jonas JC.

Diabetes. 2002 Feb;51 Suppl 1:S60-7. Review.PMID: 11815460 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion: movement at all levels.

Henquin JC, Boitard C, Efendic S, Ferrannini E, Steiner DF, Cerasi E.

Diabetes. 2002 Feb;51 Suppl 1:S1-2. No abstract available. PMID: 11815449 [PubMed - indexed for MEDLINE]Related articlesFree article

Feedback control of the ATP-sensitive K(+) current by cytosolic Ca(2+) contributes to oscillations of the membrane potential in pancreatic beta-cells.

Rolland JF, Henquin JC, Gilon P.

Diabetes. 2002 Feb;51(2):376-84.PMID: 11812744 [PubMed - indexed for MEDLINE]Related articlesFree article