PubMed

Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates.

Bruss MD, Khambatta CF, Ruby MA, Aggarwal I, Hellerstein MK.

Am J Physiol Endocrinol Metab. 2009 Nov 3. [Epub ahead of print]PMID: 19887594 [PubMed - as supplied by publisher]Related articles

Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: Validation of a simplified method suitable for multi-center clinical studies.

Hayes GM, Busch R, Voogt J, Siah IM, Gee TA, Hellerstein MK, Chiorazzi N, Rai KR, Murphy EJ.

Leuk Res. 2009 Oct 23. [Epub ahead of print]PMID: 19854509 [PubMed - as supplied by publisher]Related articles

In vivo intra- and inter-clonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia.

Calissano C, Damle RN, Hayes G, Murphy EJ, Hellerstein MK, Moreno C, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Chiorazzi N.

Blood. 2009 Sep 29. [Epub ahead of print]PMID: 19789386 [PubMed - as supplied by publisher]Related articles

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.

Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ.

J Clin Invest. 2009 May;119(5):1322-34. doi: 10.1172/JCI37385. Epub 2009 Apr 20.PMID: 19381015 [PubMed - indexed for MEDLINE]Related articlesFree article

Modified alternate-day fasting and cardioprotection: relation to adipose tissue dynamics and dietary fat intake.

Varady KA, Hudak CS, Hellerstein MK.

Metabolism. 2009 Jun;58(6):803-11.PMID: 19375762 [PubMed - indexed for MEDLINE]Related articles

A stable isotope method for the simultaneous measurement of matrix synthesis and cell proliferation in articular cartilage in vivo.

Li KW, Siraj SA, Cheng EW, Awada M, Hellerstein MK, Turner SM.

Osteoarthritis Cartilage. 2009 Jul;17(7):923-32. Epub 2009 Feb 7.PMID: 19230856 [PubMed - indexed for MEDLINE]Related articles

Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction.

Varady KA, Allister CA, Roohk DJ, Hellerstein MK.

J Nutr Biochem. 2009 Feb 4. [Epub ahead of print]PMID: 19195863 [PubMed - as supplied by publisher]Related articles

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.

Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS.

Nat Med. 2009 Feb;15(2):159-68. Epub 2009 Jan 11.PMID: 19136964 [PubMed - indexed for MEDLINE]Related articles

Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity.

Ahmadian M, Duncan RE, Varady KA, Frasson D, Hellerstein MK, Birkenfeld AL, Samuel VT, Shulman GI, Wang Y, Kang C, Sul HS.

Diabetes. 2009 Apr;58(4):855-66. Epub 2009 Jan 9.PMID: 19136649 [PubMed - indexed for MEDLINE]Related articlesFree article

Alternate-day fasting reduces global cell proliferation rates independently of dietary fat content in mice.

Varady KA, Roohk DJ, Bruss M, Hellerstein MK.

Nutrition. 2009 Apr;25(4):486-91. Epub 2008 Dec 11.PMID: 19084375 [PubMed - indexed for MEDLINE]Related articles

Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis.

Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D.

Cancer Res. 2008 Aug 15;68(16):6831-9. Erratum in: Cancer Res. 2008 Sep 15;68(18):7692. PMID: 18701509 [PubMed - indexed for MEDLINE]Related articlesFree article

A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes.

Beysen C, Murphy EJ, Nagaraja H, Decaris M, Riiff T, Fong A, Hellerstein MK, Boyle PJ.

J Lipid Res. 2008 Dec;49(12):2657-63. Epub 2008 Jul 18.PMID: 18641372 [PubMed - indexed for MEDLINE]Related articlesFree article

Heavy water labeling of DNA for measurement of cell proliferation and recruitment during primary murine lymph node responses against model antigens.

Busch R, Siah IM, Gee TA, Hellerstein MK.

J Immunol Methods. 2008 Aug 20;337(1):24-34. Epub 2008 Jun 13.PMID: 18590913 [PubMed - indexed for MEDLINE]Related articles

Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.

Ladell K, Hellerstein MK, Cesar D, Busch R, Boban D, McCune JM.

J Immunol. 2008 Jun 15;180(12):7907-18.PMID: 18523254 [PubMed - indexed for MEDLINE]Related articlesFree article

Do calorie restriction or alternate-day fasting regimens modulate adipose tissue physiology in a way that reduces chronic disease risk?

Varady KA, Hellerstein MK.

Nutr Rev. 2008 Jun;66(6):333-42. Review.PMID: 18522622 [PubMed - indexed for MEDLINE]Related articles

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.

Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV Jr, Horton JD, Preitner F, Thorens B, Tappy L.

J Lipid Res. 2008 Sep;49(9):2038-44. Epub 2008 Jun 1.PMID: 18515909 [PubMed - indexed for MEDLINE]Related articlesFree article

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility.

Keller MP, Choi Y, Wang P, Davis DB, Rabaglia ME, Oler AT, Stapleton DS, Argmann C, Schueler KL, Edwards S, Steinberg HA, Chaibub Neto E, Kleinhanz R, Turner S, Hellerstein MK, Schadt EE, Yandell BS, Kendziorski C, Attie AD.

Genome Res. 2008 May;18(5):706-16. Epub 2008 Mar 17.PMID: 18347327 [PubMed - indexed for MEDLINE]Related articlesFree article

Exploiting complexity and the robustness of network architecture for drug discovery.

Hellerstein MK.

J Pharmacol Exp Ther. 2008 Apr;325(1):1-9. Epub 2008 Jan 17. Review.PMID: 18202293 [PubMed - indexed for MEDLINE]Related articlesFree article

Modified alternate-day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice.

Varady KA, Roohk DJ, McEvoy-Hein BK, Gaylinn BD, Thorner MO, Hellerstein MK.

FASEB J. 2008 Jun;22(6):2090-6. Epub 2008 Jan 9.PMID: 18184721 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurement of very low rates of cell proliferation by heavy water labeling of DNA and gas chromatography/pyrolysis/isotope ratio-mass spectrometric analysis.

Voogt JN, Awada M, Murphy EJ, Hayes GM, Busch R, Hellerstein MK.

Nat Protoc. 2007;2(12):3058-62.PMID: 18079704 [PubMed - indexed for MEDLINE]Related articles

Measurement of cell proliferation by heavy water labeling.

Busch R, Neese RA, Awada M, Hayes GM, Hellerstein MK.

Nat Protoc. 2007;2(12):3045-57.PMID: 18079703 [PubMed - indexed for MEDLINE]Related articles

A critique of the molecular target-based drug discovery paradigm based on principles of metabolic control: advantages of pathway-based discovery.

Hellerstein MK.

Metab Eng. 2008 Jan;10(1):1-9. Epub 2007 Sep 20. Review.PMID: 17962055 [PubMed - indexed for MEDLINE]Related articles

Measurement of pancreatic islet cell proliferation by heavy water labeling.

Chen S, Turner S, Tsang E, Stark J, Turner H, Mahsut A, Keifer K, Goldfinger M, Hellerstein MK.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1459-64. Epub 2007 Aug 28.PMID: 17726142 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects.

Hudgins LC, Baday A, Hellerstein MK, Parker TS, Levine DM, Seidman CE, Neese RA, Tremaroli JD, Hirsch J.

J Nutr Biochem. 2008 Apr;19(4):237-45. Epub 2007 Jul 6.PMID: 17618104 [PubMed - indexed for MEDLINE]Related articlesFree article

Alternate-day fasting and chronic disease prevention: a review of human and animal trials.

Varady KA, Hellerstein MK.

Am J Clin Nutr. 2007 Jul;86(1):7-13. Review.PMID: 17616757 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice.

Varady KA, Roohk DJ, Loe YC, McEvoy-Hein BK, Hellerstein MK.

J Lipid Res. 2007 Oct;48(10):2212-9. Epub 2007 Jul 2.PMID: 17607017 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological doses of dietary curcumin increase colon epithelial cell proliferation in vivo in rats.

Kim SJ, Hellerstein MK.

Phytother Res. 2007 Oct;21(10):995-8.PMID: 17582595 [PubMed - indexed for MEDLINE]Related articles

Stabilization of hyperdynamic microtubules is neuroprotective in amyotrophic lateral sclerosis.

Fanara P, Banerjee J, Hueck RV, Harper MR, Awada M, Turner H, Husted KH, Brandt R, Hellerstein MK.

J Biol Chem. 2007 Aug 10;282(32):23465-72. Epub 2007 Jun 13.PMID: 17567579 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurement of brain microglial proliferation rates in vivo in response to neuroinflammatory stimuli: application to drug discovery.

Shankaran M, Marino ME, Busch R, Keim C, King C, Lee J, Killion S, Awada M, Hellerstein MK.

J Neurosci Res. 2007 Aug 15;85(11):2374-84.PMID: 17551981 [PubMed - indexed for MEDLINE]Related articles

Dose effects of modified alternate-day fasting regimens on in vivo cell proliferation and plasma insulin-like growth factor-1 in mice.

Varady KA, Roohk DJ, Hellerstein MK.

J Appl Physiol. 2007 Aug;103(2):547-51. Epub 2007 May 10.PMID: 17495119 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions.

Gardner JL, Turner SM, Bautista A, Lindwall G, Awada M, Hellerstein MK.

Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1695-705. Epub 2007 Mar 8.PMID: 17347453 [PubMed - indexed for MEDLINE]Related articlesFree article

Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivo.

Beysen C, Murphy EJ, McLaughlin T, Riiff T, Lamendola C, Turner HC, Awada M, Turner SM, Reaven G, Hellerstein MK.

Diabetes Care. 2007 May;30(5):1143-9. Epub 2007 Jan 26.PMID: 17259480 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice.

Turner SM, Roy S, Sul HS, Neese RA, Murphy EJ, Samandi W, Roohk DJ, Hellerstein MK.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1101-9. Epub 2006 Dec 12.PMID: 17164440 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery of novel hippocampal neurogenic agents by using an in vivo stable isotope labeling technique.

Shankaran M, King C, Lee J, Busch R, Wolff M, Hellerstein MK.

J Pharmacol Exp Ther. 2006 Dec;319(3):1172-81. Epub 2006 Sep 14.PMID: 16973885 [PubMed - indexed for MEDLINE]Related articlesFree article

Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans.

Vedala A, Wang W, Neese RA, Christiansen MP, Hellerstein MK.

J Lipid Res. 2006 Nov;47(11):2562-74. Epub 2006 Aug 23.PMID: 16929033 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurement of mouse vascular smooth muscle and atheroma cell proliferation by 2H2O incorporation into DNA.

Chu A, Ordonez ET, Hellerstein MK.

Am J Physiol Cell Physiol. 2006 Nov;291(5):C1014-21. Epub 2006 Jun 14.PMID: 16774990 [PubMed - indexed for MEDLINE]Related articlesFree article

Thematic review series: patient-oriented research. Recent advances in liver triacylglycerol and fatty acid metabolism using stable isotope labeling techniques.

Parks EJ, Hellerstein MK.

J Lipid Res. 2006 Aug;47(8):1651-60. Epub 2006 Jun 1. Review.PMID: 16741290 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurement of protein turnover rates by heavy water labeling of nonessential amino acids.

Busch R, Kim YK, Neese RA, Schade-Serin V, Collins M, Awada M, Gardner JL, Beysen C, Marino ME, Misell LM, Hellerstein MK.

Biochim Biophys Acta. 2006 May;1760(5):730-44. Epub 2006 Jan 24.PMID: 16567052 [PubMed - indexed for MEDLINE]Related articles

Heavy water labeling of keratin as a non-invasive biomarker of skin turnover in vivo in rodents and humans.

Lindwall G, Hsieh EA, Misell LM, Chai CM, Turner SM, Hellerstein MK.

J Invest Dermatol. 2006 Apr;126(4):841-8.PMID: 16470175 [PubMed - indexed for MEDLINE]Related articlesFree article

A stable isotope-mass spectrometric method for measuring human spermatogenesis kinetics in vivo.

Misell LM, Holochwost D, Boban D, Santi N, Shefi S, Hellerstein MK, Turek PJ.

J Urol. 2006 Jan;175(1):242-6; discussion 246.PMID: 16406920 [PubMed - indexed for MEDLINE]Related articles

Sources of plasma glucose and liver glycogen in fasted ob/ob mice.

Turner SM, Linfoot PA, Neese RA, Hellerstein MK.

Acta Diabetol. 2005 Dec;42(4):187-93.PMID: 16382307 [PubMed - indexed for MEDLINE]Related articles

Physiologic and pharmacologic factors influencing glyceroneogenic contribution to triacylglyceride glycerol measured by mass isotopomer distribution analysis.

Chen JL, Peacock E, Samady W, Turner SM, Neese RA, Hellerstein MK, Murphy EJ.

J Biol Chem. 2005 Jul 8;280(27):25396-402. Epub 2005 May 11.PMID: 15888453 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo measurement of DNA synthesis rates of colon epithelial cells in carcinogenesis.

Kim SJ, Turner S, Killion S, Hellerstein MK.

Biochem Biophys Res Commun. 2005 May 27;331(1):203-9.PMID: 15845379 [PubMed - indexed for MEDLINE]Related articles

Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans.

Misell LM, Hwang ES, Au A, Esserman L, Hellerstein MK.

Breast Cancer Res Treat. 2005 Feb;89(3):257-64.PMID: 15754124 [PubMed - indexed for MEDLINE]Related articles

In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells.

Messmer BT, Messmer D, Allen SL, Kolitz JE, Kudalkar P, Cesar D, Murphy EJ, Koduru P, Ferrarini M, Zupo S, Cutrona G, Damle RN, Wasil T, Rai KR, Hellerstein MK, Chiorazzi N.

J Clin Invest. 2005 Mar;115(3):755-64.PMID: 15711642 [PubMed - indexed for MEDLINE]Related articlesFree article

Emerging applications of kinetic biomarkers in preclinical and clinical drug development.

Turner SM, Hellerstein MK.

Curr Opin Drug Discov Devel. 2005 Jan;8(1):115-26. Review.PMID: 15679179 [PubMed - indexed for MEDLINE]Related articles

Effects of caloric restriction on cell proliferation in several tissues in mice: role of intermittent feeding.

Hsieh EA, Chai CM, Hellerstein MK.

Am J Physiol Endocrinol Metab. 2005 May;288(5):E965-72. Epub 2004 Dec 21.PMID: 15613681 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water. Effect of taxanes.

Fanara P, Turner S, Busch R, Killion S, Awada M, Turner H, Mahsut A, Laprade KL, Stark JM, Hellerstein MK.

J Biol Chem. 2004 Nov 26;279(48):49940-7. Epub 2004 Sep 21.PMID: 15385549 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of nucleoside reverse transcriptase inhibitors on mitochondrial DNA synthesis in rats and humans.

Collins ML, Sondel N, Cesar D, Hellerstein MK.

J Acquir Immune Defic Syndr. 2004 Sep 1;37(1):1132-9.PMID: 15319672 [PubMed - indexed for MEDLINE]Related articles

Dynamics of keratinocytes in vivo using HO labeling: a sensitive marker of epidermal proliferation state.

Hsieh EA, Chai CM, de Lumen BO, Neese RA, Hellerstein MK.

J Invest Dermatol. 2004 Sep;123(3):530-6.PMID: 15304093 [PubMed - indexed for MEDLINE]Related articlesFree article