PubMed

Pharmacokinetic and pharmacodynamic properties of taspoglutide, a once-weekly, human GLP-1 analogue, after single-dose administration in patients with Type 2 diabetes.

Kapitza C, Heise T, Birman P, Jallet K, Ramis J, Balena R.

Diabet Med. 2009 Nov;26(11):1156-64.PMID: 19929995 [PubMed - in process]

Plasma glucose and hypoglycaemia following exercise in people with Type 1 diabetes: a comparison of three basal insulins.

Arutchelvam V, Heise T, Dellweg S, Elbroend B, Minns I, Home PD.

Diabet Med. 2009 Oct;26(10):1027-32.PMID: 19900235 [PubMed - in process]Related articles

Biphasic insulin aspart 30/70: pharmacokinetics and pharmacodynamics compared with once-daily biphasic human insulin and Basal-bolus therapy.

Heise T, Heinemann L, Hövelmann U, Brauns B, Nosek L, Haahr HL, Olsen KJ.

Diabetes Care. 2009 Aug;32(8):1431-3. Epub 2009 Jun 1.PMID: 19487640 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients.

Heise T, Graefe-Mody EU, Hüttner S, Ring A, Trommeshauser D, Dugi KA.

Diabetes Obes Metab. 2009 Aug;11(8):786-94. Epub 2009 May 19.PMID: 19476474 [PubMed - in process]Related articles

PROMAXX inhaled insulin: safe and efficacious administration with a commercially available dry powder inhaler.

Heise T, Brugger A, Cook C, Eckers U, Hutchcraft A, Nosek L, Rave K, Troeger J, Valaitis P, White S, Heinemann L.

Diabetes Obes Metab. 2009 May;11(5):455-9. Epub 2009 Feb 19.PMID: 19236443 [PubMed - in process]Related articles

The rapid-acting properties of insulin aspart are preserved in elderly people with type 2 diabetes.

Krones R, Schütte C, Heise T.

Diabetes Obes Metab. 2009 Jan;11(1):41-4.PMID: 19120432 [PubMed - indexed for MEDLINE]Related articles

The pharmacokinetic and pharmacodynamic properties of different formulations of biphasic insulin aspart: a randomized, glucose clamp, crossover study.

Heise T, Eckers U, Kanc K, Nielsen JN, Nosek L.

Diabetes Technol Ther. 2008 Dec;10(6):479-85.PMID: 19049377 [PubMed - indexed for MEDLINE]Related articles

Primary rat hepatocytes as in vitro system for gene expression studies: comparison of sandwich, Matrigel and 2D cultures.

Schug M, Heise T, Bauer A, Storm D, Blaszkewicz M, Bedawy E, Brulport M, Geppert B, Hermes M, Föllmann W, Rapp K, Maccoux L, Schormann W, Appel KE, Oberemm A, Gundert-Remy U, Hengstler JG.

Arch Toxicol. 2008 Dec;82(12):923-31. Epub 2008 Nov 6.PMID: 18987846 [PubMed - indexed for MEDLINE]Related articles

Posttranscriptional control of HBV gene expression.

Sommer G, Heise T.

Front Biosci. 2008 May 1;13:5533-47. Review.PMID: 18508603 [PubMed - indexed for MEDLINE]Related articles

Clinical therapeutics. Realising the value of modern insulins: reaching further with rapid-acting insulin analogues. XIX World Diabetes Congress, Cape Town, South Africa, December 3, 2006. Forward.

Heise T.

Clin Ther. 2007;29 Suppl D:S133-4. No abstract available. PMID: 18504874 [PubMed - indexed for MEDLINE]Related articles

Getting closer to physiologic insulin secretion.

Heise T.

Clin Ther. 2007;29 Suppl D:S161-5.PMID: 18191068 [PubMed - indexed for MEDLINE]Related articles

Fluctuation and reproducibility of exposure and effect of insulin glargine in healthy subjects.

Becker RH, Frick AD, Teichert L, Nosek L, Heinemann L, Heise T, Rave K.

Diabetes Obes Metab. 2008 Nov;10(11):1105-13. Epub 2008 Mar 18.PMID: 18355326 [PubMed - indexed for MEDLINE]Related articles

Inhaled insulin: take a deep breath, but how?

Heinemann L, Scheuch G, Heise T.

J Diabetes Sci Technol. 2008 Mar;2(2):297-9.PMID: 19885359 [PubMed - in process]Free article

Inhaled technosphere(r) insulin in comparison to subcutaneous regular human insulin: time action profile and variability in subjects with type 2 diabetes.

Rave K, Heise T, Heinemann L, Boss AH.

J Diabetes Sci Technol. 2008 Mar;2(2):205-12.PMID: 19885344 [PubMed - in process]Free article

La autoantigen suppresses IRES-dependent translation of the hepatitis A virus.

Cordes S, Kusov Y, Heise T, Gauss-Müller V.

Biochem Biophys Res Commun. 2008 Apr 18;368(4):1014-9. Epub 2008 Feb 20.PMID: 18282467 [PubMed - indexed for MEDLINE]Related articles

Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element.

Schwalbe M, Ohlenschläger O, Marchanka A, Ramachandran R, Häfner S, Heise T, Görlach M.

Nucleic Acids Res. 2008 Mar;36(5):1681-9. Epub 2008 Feb 7.PMID: 18263618 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhaled insulin.

Arnolds S, Heise T.

Best Pract Res Clin Endocrinol Metab. 2007 Dec;21(4):555-71. Review.PMID: 18054735 [PubMed - indexed for MEDLINE]Related articles

Sumoylation in axons triggers retrograde transport of the RNA-binding protein La.

van Niekerk EA, Willis DE, Chang JH, Reumann K, Heise T, Twiss JL.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12913-8. Epub 2007 Jul 23.PMID: 17646655 [PubMed - indexed for MEDLINE]Related articlesFree article

Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies.

Heise T, Pieber TR.

Diabetes Obes Metab. 2007 Sep;9(5):648-59. Epub 2007 Jul 21. Review.PMID: 17645556 [PubMed - indexed for MEDLINE]Related articles

Was insulin review biased, or simply a victim of bad timing?

Heise T.

J Fam Pract. 2007 May;56(5):E1-4; author reply E1-4. No abstract available. PMID: 17611994 [PubMed - indexed for MEDLINE]Related articles

Insulin glulisine: a faster onset of action compared with insulin lispro.

Heise T, Nosek L, Spitzer H, Heinemann L, Niemöller E, Frick AD, Becker RH.

Diabetes Obes Metab. 2007 Sep;9(5):746-53. Epub 2007 Jun 26.PMID: 17593235 [PubMed - indexed for MEDLINE]Related articles

Coverage of postprandial blood glucose excursions with inhaled technosphere insulin in comparison to subcutaneously injected regular human insulin in subjects with type 2 diabetes.

Rave K, Heise T, Pfützner A, Boss AH.

Diabetes Care. 2007 Sep;30(9):2307-8. Epub 2007 Jun 22. No abstract available. PMID: 17586744 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvement of insulin resistance after diet with a whole-grain based dietary product: results of a randomized, controlled cross-over study in obese subjects with elevated fasting blood glucose.

Rave K, Roggen K, Dellweg S, Heise T, tom Dieck H.

Br J Nutr. 2007 Nov;98(5):929-36. Epub 2007 Jun 12.PMID: 17562226 [PubMed - indexed for MEDLINE]Related articles

Albumin-bound basal insulin analogues (insulin detemir and NN344): comparable time-action profiles but less variability than insulin glargine in type 2 diabetes.

Klein O, Lynge J, Endahl L, Damholt B, Nosek L, Heise T.

Diabetes Obes Metab. 2007 May;9(3):290-9.PMID: 17391154 [PubMed - indexed for MEDLINE]Related articles

Murine leukemia virus regulates alternative splicing through sequences upstream of the 5' splice site.

Kraunus J, Zychlinski D, Heise T, Galla M, Bohne J, Baum C.

J Biol Chem. 2006 Dec 8;281(49):37381-90. Epub 2006 Oct 11.PMID: 17038324 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional analysis of complex hepatitis B virus variants associated with development of liver cirrhosis.

Märschenz S, Endres AS, Brinckmann A, Heise T, Kristiansen G, Nürnberg P, Krüger DH, Günther S, Meisel H.

Gastroenterology. 2006 Sep;131(3):765-80.PMID: 16952546 [PubMed - indexed for MEDLINE]Related articles

Inhaled insulin as adjunctive therapy in subjects with type 2 diabetes failing oral agents: a controlled proof-of-concept study.

Hausmann M, Dellweg S, Osborn C, Heinemann L, Buchwald A, Rosskamp R, Genova P, Heise T.

Diabetes Obes Metab. 2006 Sep;8(5):574-80.PMID: 16918593 [PubMed - indexed for MEDLINE]Related articles

Time-action profile of insulin detemir and NPH insulin in patients with type 2 diabetes from different ethnic groups.

Hompesch M, Troupin B, Heise T, Elbroend B, Endahl L, Haahr H, Heinemann L.

Diabetes Obes Metab. 2006 Sep;8(5):568-73.PMID: 16918592 [PubMed - indexed for MEDLINE]Related articles

Influence of nebivolol and enalapril on metabolic parameters and arterial stiffness in hypertensive type 2 diabetic patients.

Kaiser T, Heise T, Nosek L, Eckers U, Sawicki PT.

J Hypertens. 2006 Jul;24(7):1397-403.PMID: 16794490 [PubMed - indexed for MEDLINE]Related articles

Insulin detemir under steady-state conditions: no accumulation and constant metabolic effect over time with twice daily administration in subjects with Type 1 diabetes.

Bott S, Tusek C, Jacobsen LV, Endahl L, Draeger E, Kapitza C, Heise T.

Diabet Med. 2006 May;23(5):522-8.PMID: 16681561 [PubMed - indexed for MEDLINE]Related articles

Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes--results of a hyperglycaemic glucose clamp study.

Rave K, Nosek L, Posner J, Heise T, Roggen K, van Hoogdalem EJ.

Nephrol Dial Transplant. 2006 Aug;21(8):2166-71. Epub 2006 Apr 20.PMID: 16627603 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a domain in Yersinia virulence factor YadA that is crucial for extracellular matrix-specific cell adhesion and uptake.

Heise T, Dersch P.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3375-80. Epub 2006 Feb 17.PMID: 16488979 [PubMed - indexed for MEDLINE]Related articlesFree article

The hepatitis B virus PRE contains a splicing regulatory element.

Heise T, Sommer G, Reumann K, Meyer I, Will H, Schaal H.

Nucleic Acids Res. 2006 Jan 12;34(1):353-63. Print 2006.PMID: 16410615 [PubMed - indexed for MEDLINE]Related articlesFree article

The pharmacokinetic and pharmacodynamic properties of biphasic insulin Aspart 70 (BIAsp 70) are significantly different from those of biphasic insulin Aspart 30 (BIAsp 30).

Bott S, Tusek C, Heinemann L, Friberg HH, Heise T.

Exp Clin Endocrinol Diabetes. 2005 Oct;113(9):545-50.PMID: 16235159 [PubMed - indexed for MEDLINE]Related articles

The effect of insulin antibodies on the metabolic action of inhaled and subcutaneous insulin: a prospective randomized pharmacodynamic study.

Heise T, Bott S, Tusek C, Stephan JA, Kawabata T, Finco-Kent D, Liu C, Krasner A.

Diabetes Care. 2005 Sep;28(9):2161-9.PMID: 16123484 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetics, prandial glucose control, and safety of insulin glulisine in children and adolescents with type 1 diabetes.

Danne T, Becker RH, Heise T, Bittner C, Frick AD, Rave K.

Diabetes Care. 2005 Sep;28(9):2100-5.PMID: 16123473 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of smoking on the metabolic action of subcutaneous regular insulin in type 2 diabetic patients.

Bott S, Shafagoj YA, Sawicki PT, Heise T.

Horm Metab Res. 2005 Jul;37(7):445-9.PMID: 16034718 [PubMed - indexed for MEDLINE]Related articles

Enhancement of blood glucose lowering effect of a sulfonylurea when coadministered with an ACE inhibitor: results of a glucose-clamp study.

Rave K, Flesch S, Kühn-Velten WN, Hompesch BC, Heinemann L, Heise T.

Diabetes Metab Res Rev. 2005 Sep-Oct;21(5):459-64.PMID: 15915547 [PubMed - indexed for MEDLINE]Related articles

Time-action profile of inhaled insulin in comparison with subcutaneously injected insulin lispro and regular human insulin.

Rave K, Bott S, Heinemann L, Sha S, Becker RH, Willavize SA, Heise T.

Diabetes Care. 2005 May;28(5):1077-82.PMID: 15855570 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell invasion and IL-8 production pathways initiated by YadA of Yersinia pseudotuberculosis require common signalling molecules (FAK, c-Src, Ras) and distinct cell factors.

Eitel J, Heise T, Thiesen U, Dersch P.

Cell Microbiol. 2005 Jan;7(1):63-77.PMID: 15617524 [PubMed - indexed for MEDLINE]Related articles

The La motif and the RNA recognition motifs of human La autoantigen contribute individually to RNA recognition and subcellular localization.

Horke S, Reumann K, Schulze C, Grosse F, Heise T.

J Biol Chem. 2004 Nov 26;279(48):50302-9. Epub 2004 Sep 15.PMID: 15371415 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of pramlintide on symptom, catecholamine, and glucagon responses to hypoglycemia in healthy subjects.

Heise T, Heinemann L, Heller S, Weyer C, Wang Y, Strobel S, Kolterman O, Maggs D.

Metabolism. 2004 Sep;53(9):1227-32.PMID: 15334389 [PubMed - indexed for MEDLINE]Related articles

Intrasubject variability of inhaled insulin in type 1 diabetes: a comparison with subcutaneous insulin.

Kapitza C, Hompesch M, Scharling B, Heise T.

Diabetes Technol Ther. 2004 Aug;6(4):466-72.PMID: 15321001 [PubMed - indexed for MEDLINE]Related articles

Functional characterization of the interaction between human La and hepatitis B virus RNA.

Ehlers I, Horke S, Reumann K, Rang A, Grosse F, Will H, Heise T.

J Biol Chem. 2004 Oct 15;279(42):43437-47. Epub 2004 Aug 9.PMID: 15302879 [PubMed - indexed for MEDLINE]Related articlesFree article

Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes.

Heise T, Nosek L, Rønn BB, Endahl L, Heinemann L, Kapitza C, Draeger E.

Diabetes. 2004 Jun;53(6):1614-20.PMID: 15161770 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of particle size and aerosolization time on the metabolic effect of an inhaled insulin aerosol.

Kapitza C, Heise T, Fishman RS, Shapiro DA, Gopalakrishnan V, Rave K, Bott S, Perera AD, Heinemann L.

Diabetes Technol Ther. 2004 Apr;6(2):119-27.PMID: 15117578 [PubMed - indexed for MEDLINE]Related articles

Reduced postprandial glycaemic excursion with biphasic insulin Aspart 30 injected immediately before a meal.

Kapitza C, Rave K, Ostrowski K, Heise T, Heinemann L.

Diabet Med. 2004 May;21(5):500-1. No abstract available. PMID: 15089801 [PubMed - indexed for MEDLINE]Related articles

Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA.

Horke S, Reumann K, Schweizer M, Will H, Heise T.

J Biol Chem. 2004 Jun 18;279(25):26563-70. Epub 2004 Apr 1.PMID: 15060081 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoglycemia warning signal and glucose sensors: requirements and concepts.

Heise T, Koschinsky T, Heinemann L, Lodwig V; Glucose Monitoring Study Group.

Diabetes Technol Ther. 2003;5(4):563-71. Review.PMID: 14511411 [PubMed - indexed for MEDLINE]Related articles

Absorption and metabolic effect of inhaled insulin: intrapatient variability after inhalation via the Aerodose insulin inhaler in patients with type 2 diabetes.

Perera AD, Kapitza C, Nosek L, Fishman RS, Shapiro DA, Heise T, Heinemann L.

Diabetes Care. 2002 Dec;25(12):2276-81.PMID: 12453973 [PubMed - indexed for MEDLINE]Related articlesFree article