PubMed

Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils.

Rosen H, Klebanoff SJ, Wang Y, Brot N, Heinecke JW, Fu X.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18686-91. Epub 2009 Oct 15.PMID: 19833874 [PubMed - in process]Related articles

Lipoproteomics: using mass spectrometry-based proteomics to explore the assembly, structure, and function of lipoproteins.

Hoofnagle AN, Heinecke JW.

J Lipid Res. 2009 Oct;50(10):1967-75.PMID: 19738003 [PubMed - in process]Related articles

Lipoproteomics: using mass spectrometry-based proteomics to explore the assembly, structures, and functions of lipoproteins.

Hoofnagle AF, Heinecke JW.

J Lipid Res. 2009 Jul 16. [Epub ahead of print]PMID: 19609005 [PubMed - as supplied by publisher]Related articlesFree article

Hypochlorous acid converts the gamma-glutamyl group of glutathione disulfide to 5-hydroxybutyrolactam, a potential marker for neutrophil activation.

Yuan W, Wang Y, Heinecke JW, Fu X.

J Biol Chem. 2009 Sep 25;284(39):26908-17. Epub 2009 Jul 7.PMID: 19584048 [PubMed - indexed for MEDLINE]Related articles

Mapping the lung proteome in cystic fibrosis.

Gharib SA, Vaisar T, Aitken ML, Park DR, Heinecke JW, Fu X.

J Proteome Res. 2009 Jun;8(6):3020-8.PMID: 19354268 [PubMed - indexed for MEDLINE]Related articles

Bioluminescence imaging of myeloperoxidase activity in vivo.

Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D.

Nat Med. 2009 Apr;15(4):455-61. Epub 2009 Mar 22.PMID: 19305414 [PubMed - indexed for MEDLINE]Related articles

Serum amyloid A3 does not contribute to circulating SAA levels.

Chiba T, Han CY, Vaisar T, Shimokado K, Kargi A, Chen MH, Wang S, McDonald TO, O'Brien KD, Heinecke JW, Chait A.

J Lipid Res. 2009 Jul;50(7):1353-62. Epub 2009 Mar 12.PMID: 19286646 [PubMed - in process]Related articles

A "new" thematic series: mass spectrometry-based proteomics of lipid biology.

Heinecke JW.

J Lipid Res. 2009 May;50(5):777-80. Epub 2009 Mar 2. No abstract available. PMID: 19258282 [PubMed - indexed for MEDLINE]Related articles

HDL, lipid peroxidation, and atherosclerosis.

Shao B, Heinecke JW.

J Lipid Res. 2009 Apr;50(4):599-601. Epub 2009 Jan 12. Review. No abstract available. PMID: 19141435 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet.

Posey KA, Clegg DJ, Printz RL, Byun J, Morton GJ, Vivekanandan-Giri A, Pennathur S, Baskin DG, Heinecke JW, Woods SC, Schwartz MW, Niswender KD.

Am J Physiol Endocrinol Metab. 2009 May;296(5):E1003-12. Epub 2008 Dec 30.PMID: 19116375 [PubMed - indexed for MEDLINE]Related articles

MMP-9 sheds the beta2 integrin subunit (CD18) from macrophages.

Vaisar T, Kassim SY, Gomez IG, Green PS, Hargarten S, Gough PJ, Parks WC, Wilson CL, Raines EW, Heinecke JW.

Mol Cell Proteomics. 2009 May;8(5):1044-60. Epub 2008 Dec 30.PMID: 19116209 [PubMed - indexed for MEDLINE]Related articles

The HDL proteome: a marker--and perhaps mediator--of coronary artery disease.

Heinecke JW.

J Lipid Res. 2009 Apr;50 Suppl:S167-71. Epub 2008 Dec 5.PMID: 19060251 [PubMed - indexed for MEDLINE]Related articles

A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL.

Wang XS, Shao B, Oda MN, Heinecke JW, Mahler S, Stocker R.

J Lipid Res. 2009 Mar;50(3):586-94. Epub 2008 Oct 2.PMID: 18832772 [PubMed - indexed for MEDLINE]Related articles

Quantification of thyroglobulin, a low-abundance serum protein, by immunoaffinity peptide enrichment and tandem mass spectrometry.

Hoofnagle AN, Becker JO, Wener MH, Heinecke JW.

Clin Chem. 2008 Nov;54(11):1796-804. Epub 2008 Sep 18.PMID: 18801935 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined statin and niacin therapy remodels the high-density lipoprotein proteome.

Green PS, Vaisar T, Pennathur S, Kulstad JJ, Moore AB, Marcovina S, Brunzell J, Knopp RH, Zhao XQ, Heinecke JW.

Circulation. 2008 Sep 16;118(12):1259-67. Epub 2008 Sep 2.PMID: 18765395 [PubMed - indexed for MEDLINE]Related articlesFree article

Methionine oxidation impairs reverse cholesterol transport by apolipoprotein A-I.

Shao B, Cavigiolio G, Brot N, Oda MN, Heinecke JW.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12224-9. Epub 2008 Aug 21.PMID: 18719109 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome.

Chang DW, Hayashi S, Gharib SA, Vaisar T, King ST, Tsuchiya M, Ruzinski JT, Park DR, Matute-Bello G, Wurfel MM, Bumgarner R, Heinecke JW, Martin TR.

Am J Respir Crit Care Med. 2008 Oct 1;178(7):701-9. Epub 2008 Jul 24.PMID: 18658106 [PubMed - indexed for MEDLINE]Related articlesFree article

When good cholesterol turns bad: the evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein.

Oram JF, Heinecke JW.

Curr Diab Rep. 2008 Jun;8(3):165-7. No abstract available. PMID: 18625111 [PubMed - indexed for MEDLINE]Related articles

Enhanced cellular uptake of remnant high-density lipoprotein particles: a mechanism for high-density lipoprotein lowering in insulin resistance and hypertriglyceridemia.

Xiao C, Watanabe T, Zhang Y, Trigatti B, Szeto L, Connelly PW, Marcovina S, Vaisar T, Heinecke JW, Lewis GF.

Circ Res. 2008 Jul 18;103(2):159-66. Epub 2008 Jun 12.PMID: 18556574 [PubMed - indexed for MEDLINE]Related articlesFree article

Using tandem mass spectrometry to quantify site-specific chlorination and nitration of proteins: model system studies with high-density lipoprotein oxidized by myeloperoxidase.

Shao B, Heinecke JW.

Methods Enzymol. 2008;440:33-63. Review.PMID: 18423210 [PubMed - indexed for MEDLINE]Related articles

When good cholesterol turns bad: the evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein.

Oram JF, Heinecke JW.

Curr Atheroscler Rep. 2007 Dec;9(6):425-7. No abstract available. PMID: 18377780 [PubMed - indexed for MEDLINE]Related articles

The interplay between size, morphology, stability, and functionality of high-density lipoprotein subclasses.

Cavigiolio G, Shao B, Geier EG, Ren G, Heinecke JW, Oda MN.

Biochemistry. 2008 Apr 22;47(16):4770-9. Epub 2008 Mar 27.PMID: 18366184 [PubMed - indexed for MEDLINE]Related articles

Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected].

Kirk EA, Sagawa ZK, McDonald TO, O'Brien KD, Heinecke JW.

Diabetes. 2008 May;57(5):1254-61. Epub 2008 Feb 11. Erratum in: Diabetes. 2008 Sep;57(9):2252. PMID: 18268047 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice.

Johansson F, Kramer F, Barnhart S, Kanter JE, Vaisar T, Merrill RD, Geng L, Oka K, Chan L, Chait A, Heinecke JW, Bornfeldt KE.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2082-7. Epub 2008 Feb 5.PMID: 18252823 [PubMed - indexed for MEDLINE]Related articlesFree article

Spectral index for assessment of differential protein expression in shotgun proteomics.

Fu X, Gharib SA, Green PS, Aitken ML, Frazer DA, Park DR, Vaisar T, Heinecke JW.

J Proteome Res. 2008 Mar;7(3):845-54. Epub 2008 Jan 17.PMID: 18198819 [PubMed - indexed for MEDLINE]Related articles

The role of myeloperoxidase in HDL oxidation and atherogenesis.

Heinecke JW.

Curr Atheroscler Rep. 2007 Oct;9(4):249-51. Review. No abstract available. PMID: 18173946 [PubMed - indexed for MEDLINE]Related articles

A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages.

Shepherd J, Hilderbrand SA, Waterman P, Heinecke JW, Weissleder R, Libby P.

Chem Biol. 2007 Nov;14(11):1221-31.PMID: 18022561 [PubMed - indexed for MEDLINE]Related articles

Myeloperoxidase and inflammatory proteins: pathways for generating dysfunctional high-density lipoprotein in humans.

Vaisar T, Shao B, Green PS, Oda MN, Oram JF, Heinecke JW.

Curr Atheroscler Rep. 2007 Nov;9(5):417-24.PMID: 18001626 [PubMed - indexed for MEDLINE]Related articles

Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation.

Wang Y, Rosen H, Madtes DK, Shao B, Martin TR, Heinecke JW, Fu X.

J Biol Chem. 2007 Nov 2;282(44):31826-34. Epub 2007 Aug 28.PMID: 17726014 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation and silencing of matrix metalloproteinases.

Fu X, Parks WC, Heinecke JW.

Semin Cell Dev Biol. 2008 Feb;19(1):2-13. Epub 2007 Jul 6. Review. Retraction in: Semin Cell Dev Biol. 2009 May;20(3):375. PMID: 17689277 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress and endothelial dysfunction in vascular disease.

Pennathur S, Heinecke JW.

Curr Diab Rep. 2007 Aug;7(4):257-64. Review.PMID: 17686400 [PubMed - indexed for MEDLINE]Related articles

Mechanisms for oxidative stress in diabetic cardiovascular disease.

Pennathur S, Heinecke JW.

Antioxid Redox Signal. 2007 Jul;9(7):955-69. Review.PMID: 17508917 [PubMed - indexed for MEDLINE]Related articles

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL.

Vaisar T, Pennathur S, Green PS, Gharib SA, Hoofnagle AN, Cheung MC, Byun J, Vuletic S, Kassim S, Singh P, Chea H, Knopp RH, Brunzell J, Geary R, Chait A, Zhao XQ, Elkon K, Marcovina S, Ridker P, Oram JF, Heinecke JW.

J Clin Invest. 2007 Mar;117(3):746-56.PMID: 17332893 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathways for oxidation of high-density lipoprotein in human cardiovascular disease.

Shao B, Oda MN, Vaisar T, Oram JF, Heinecke JW.

Curr Opin Mol Ther. 2006 Jun;8(3):198-205. Review.PMID: 16774039 [PubMed - indexed for MEDLINE]Related articles

Myeloperoxidase: an inflammatory enzyme for generating dysfunctional high density lipoprotein.

Shao B, Oda MN, Oram JF, Heinecke JW.

Curr Opin Cardiol. 2006 Jul;21(4):322-8. Review.PMID: 16755201 [PubMed - indexed for MEDLINE]Related articles

Chemical knockout of C-reactive protein in cardiovascular disease.

Heinecke JW.

Nat Chem Biol. 2006 Jun;2(6):300-1. No abstract available. PMID: 16710337 [PubMed - indexed for MEDLINE]Related articles

Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation.

Gaut JP, Belaaouaj A, Byun J, Roberts LJ 2nd, Maeda N, Frei B, Heinecke JW.

Free Radic Biol Med. 2006 May 1;40(9):1494-501. Epub 2006 Jan 6.PMID: 16632110 [PubMed - indexed for MEDLINE]Related articles

Lipoprotein oxidation in cardiovascular disease: chief culprit or innocent bystander?

Heinecke JW.

J Exp Med. 2006 Apr 17;203(4):813-6. Epub 2006 Apr 10. Review.PMID: 16606677 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific sequence motifs direct the oxygenation and chlorination of tryptophan by myeloperoxidase.

Fu X, Wang Y, Kao J, Irwin A, d'Avignon A, Mecham RP, Parks WC, Heinecke JW.

Biochemistry. 2006 Mar 28;45(12):3961-71.PMID: 16548523 [PubMed - indexed for MEDLINE]Related articlesFree article

Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I.

Shao B, Oda MN, Bergt C, Fu X, Green PS, Brot N, Oram JF, Heinecke JW.

J Biol Chem. 2006 Apr 7;281(14):9001-4. Epub 2006 Feb 22.PMID: 16497665 [PubMed - indexed for MEDLINE]Related articlesFree article

Misincorporation of free m-tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids.

Gurer-Orhan H, Ercal N, Mare S, Pennathur S, Orhan H, Heinecke JW.

Biochem J. 2006 Apr 15;395(2):277-84.PMID: 16363993 [PubMed - indexed for MEDLINE]Related articlesFree article

Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages.

Takeshita J, Byun J, Nhan TQ, Pritchard DK, Pennathur S, Schwartz SM, Chait A, Heinecke JW.

J Biol Chem. 2006 Feb 10;281(6):3096-104. Epub 2005 Dec 1.PMID: 16326702 [PubMed - indexed for MEDLINE]Related articlesFree article

Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction.

Vasilyev N, Williams T, Brennan ML, Unzek S, Zhou X, Heinecke JW, Spitz DR, Topol EJ, Hazen SL, Penn MS.

Circulation. 2005 Nov 1;112(18):2812-20.PMID: 16267254 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease.

Oram JF, Heinecke JW.

Physiol Rev. 2005 Oct;85(4):1343-72. Review.PMID: 16183915 [PubMed - indexed for MEDLINE]Related articlesFree article

Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I.

Shao B, Fu X, McDonald TO, Green PS, Uchida K, O'Brien KD, Oram JF, Heinecke JW.

J Biol Chem. 2005 Oct 28;280(43):36386-96. Epub 2005 Aug 25.PMID: 16126721 [PubMed - indexed for MEDLINE]Related articlesFree article

Acrolein modifies apolipoprotein A-I in the human artery wall.

Shao B, O'brien KD, McDonald TO, Fu X, Oram JF, Uchida K, Heinecke JW.

Ann N Y Acad Sci. 2005 Jun;1043:396-403.PMID: 16037261 [PubMed - indexed for MEDLINE]Related articles

Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.

Choi DK, Pennathur S, Perier C, Tieu K, Teismann P, Wu DC, Jackson-Lewis V, Vila M, Vonsattel JP, Heinecke JW, Przedborski S.

J Neurosci. 2005 Jul 13;25(28):6594-600.PMID: 16014720 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells.

Passarelli M, Tang C, McDonald TO, O'Brien KD, Gerrity RG, Heinecke JW, Oram JF.

Diabetes. 2005 Jul;54(7):2198-205.PMID: 15983222 [PubMed - indexed for MEDLINE]Related articlesFree article

NADPH oxidase restrains the matrix metalloproteinase activity of macrophages.

Kassim SY, Fu X, Liles WC, Shapiro SD, Parks WC, Heinecke JW.

J Biol Chem. 2005 Aug 26;280(34):30201-5. Epub 2005 Jun 27.PMID: 15983040 [PubMed - indexed for MEDLINE]Related articlesFree article

Methionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase.

Shao B, Belaaouaj A, Verlinde CL, Fu X, Heinecke JW.

J Biol Chem. 2005 Aug 12;280(32):29311-21. Epub 2005 Jun 20.PMID: 15967795 [PubMed - indexed for MEDLINE]Related articlesFree article