PubMed

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.

Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A.

Cell. 2009 Aug 7;138(3):449-62.PMID: 19665969 [PubMed - indexed for MEDLINE]Related articles

Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro.

Baeyens L, Bonné S, Bos T, Rooman I, Peleman C, Lahoutte T, German M, Heimberg H, Bouwens L.

Gastroenterology. 2009 May;136(5):1750-60.e13. Epub 2009 Jan 27.PMID: 19208356 [PubMed - indexed for MEDLINE]Related articles

Boosting beta-cell numbers.

Heimberg H.

N Engl J Med. 2008 Dec 18;359(25):2723-4. No abstract available. PMID: 19092158 [PubMed - indexed for MEDLINE]Related articles

Retraction. Adult stem cells regenerate the endocrine pancreas and normalize hyperglycaemia and insulin production in diabetic mice. Verh Dtsch Ges Pathol (2005) 89: 184-190.

Xiao X, Heimberg H.

Pathologe. 2008 Nov;29 Suppl 2:289. English, German. No abstract available. PMID: 19039619 [PubMed - indexed for MEDLINE]Related articles

Beta cells within single human islets originate from multiple progenitors.

Scharfmann R, Xiao X, Heimberg H, Mallet J, Ravassard P.

PLoS One. 2008;3(10):e3559. Epub 2008 Oct 29.PMID: 18958289 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction.

Klein T, Heremans Y, Heimberg H, Pipeleers D, Madsen OD, Serup P, Heller RS.

Pancreas. 2009 Jan;38(1):36-48.PMID: 18665014 [PubMed - indexed for MEDLINE]Related articles

Glibenclamide activates translation in rat pancreatic beta cells through calcium-dependent mTOR, PKA and MEK signalling pathways.

Wang Q, Heimberg H, Pipeleers D, Ling Z.

Diabetologia. 2008 Jul;51(7):1202-12. Epub 2008 May 21.PMID: 18493739 [PubMed - indexed for MEDLINE]Related articles

Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters).

Vandenbroucke RE, De Geest BG, Bonné S, Vinken M, Van Haecke T, Heimberg H, Wagner E, Rogiers V, De Smedt SC, Demeester J, Sanders NN.

J Gene Med. 2008 Jul;10(7):783-94.PMID: 18470950 [PubMed - indexed for MEDLINE]Related articles

Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR.

Cai Y, Wang Q, Ling Z, Pipeleers D, McDermott P, Pende M, Heimberg H, Van de Casteele M.

Biochem Pharmacol. 2008 May 15;75(10):1981-93. Epub 2008 Feb 26.PMID: 18377870 [PubMed - indexed for MEDLINE]Related articles

Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas.

Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H.

Cell. 2008 Jan 25;132(2):197-207.PMID: 18243096 [PubMed - indexed for MEDLINE]Related articles

[Adult stem cells regenerate the endocrine pankreas and normalize hyperglycaemia and insulin production in diabetic mice]

Huss R, Xiangwei X, Heimberg H.

Verh Dtsch Ges Pathol. 2005;89:184-90. German. Retraction in: Xiao X, Heimberg H. Pathologe. 2008 Nov;29 Suppl 2:289. PMID: 18035689 [PubMed - indexed for MEDLINE]Related articles

The genetic programme of pancreatic beta-cells: basic science for the development of beta-cell therapy. Workshop on programming pancreatic beta-cells.

Grapin-Botton A, Heimberg H, Lemaigre F.

EMBO Rep. 2007 Apr;8(4):322-6. Epub 2007 Mar 16. No abstract available. PMID: 17363969 [PubMed - indexed for MEDLINE]Related articlesFree article

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

Hinke SA, Martens GA, Cai Y, Finsi J, Heimberg H, Pipeleers D, Van de Casteele M.

Br J Pharmacol. 2007 Apr;150(8):1031-43. Epub 2007 Mar 5.PMID: 17339833 [PubMed - indexed for MEDLINE]Related articlesFree article

Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development.

Mfopou JK, De Groote V, Xu X, Heimberg H, Bouwens L.

Stem Cells. 2007 May;25(5):1156-65. Epub 2007 Feb 1.PMID: 17272496 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation.

Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, Van de Casteele M.

Free Radic Biol Med. 2007 Jan 1;42(1):64-78. Epub 2006 Sep 27.PMID: 17157194 [PubMed - indexed for MEDLINE]Related articles

Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas.

Rooman I, De Medts N, Baeyens L, Lardon J, De Breuck S, Heimberg H, Bouwens L.

Am J Pathol. 2006 Oct;169(4):1206-14.PMID: 17003479 [PubMed - indexed for MEDLINE]Related articlesFree article

Ectopic expression of neurogenin 3 in neonatal pig pancreatic precursor cells induces (trans)differentiation to functional alpha cells.

Harb G, Heremans Y, Heimberg H, Korbutt GS.

Diabetologia. 2006 Aug;49(8):1855-63. Epub 2006 May 31.PMID: 16736130 [PubMed - indexed for MEDLINE]Related articles

Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway.

Baeyens L, Bonné S, German MS, Ravassard P, Heimberg H, Bouwens L.

Cell Death Differ. 2006 Nov;13(11):1892-9. Epub 2006 Mar 3.PMID: 16514419 [PubMed - indexed for MEDLINE]Related articlesFree article

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.

Mellitzer G, Bonné S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G, Heimberg H.

EMBO J. 2006 Mar 22;25(6):1344-52. Epub 2006 Mar 2.PMID: 16511571 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells.

Huypens P, Moens K, Heimberg H, Ling Z, Pipeleers D, Van de Casteele M.

Life Sci. 2005 Jul 29;77(11):1273-82.PMID: 15893773 [PubMed - indexed for MEDLINE]Related articles

EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade.

Rescan C, Le Bras S, Lefebvre VH, Frandsen U, Klein T, Foschi M, Pipeleers DG, Scharfmann R, Madsen OD, Heimberg H.

Lab Invest. 2005 Jan;85(1):65-74.PMID: 15543206 [PubMed - indexed for MEDLINE]Related articlesFree article

[Reprogramming of adult human pancreatic duct cells as functional beta cells]

Heimberg H.

Verh K Acad Geneeskd Belg. 2004;66(3):183-96. Review. German. PMID: 15315119 [PubMed - indexed for MEDLINE]Related articles

Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis.

Kefas BA, Cai Y, Kerckhofs K, Ling Z, Martens G, Heimberg H, Pipeleers D, Van de Casteele M.

Biochem Pharmacol. 2004 Aug 1;68(3):409-16.PMID: 15242807 [PubMed - indexed for MEDLINE]Related articles

Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas.

Heller RS, Klein T, Ling Z, Heimberg H, Katoh M, Madsen OD, Serup P.

Gene Expr. 2003;11(3-4):141-7.PMID: 14686787 [PubMed - indexed for MEDLINE]Related articles

Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.

Van de Casteele M, Kefas BA, Cai Y, Heimberg H, Scott DK, Henquin JC, Pipeleers D, Jonas JC.

Biochem Biophys Res Commun. 2003 Dec 26;312(4):937-44.PMID: 14651961 [PubMed - indexed for MEDLINE]Related articles

Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling.

Ling Z, Van de Casteele M, Dong J, Heimberg H, Haefliger JA, Waeber G, Schuit F, Pipeleers D.

Diabetes. 2003 Oct;52(10):2497-502.PMID: 14514632 [PubMed - indexed for MEDLINE]Related articlesFree article

Nestin is expressed in vascular endothelial cells in the adult human pancreas.

Klein T, Ling Z, Heimberg H, Madsen OD, Heller RS, Serup P.

J Histochem Cytochem. 2003 Jun;51(6):697-706.PMID: 12754281 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase.

Kefas BA, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D, Van de Casteele M.

J Mol Endocrinol. 2003 Apr;30(2):151-61.PMID: 12683939 [PubMed - indexed for MEDLINE]Related articlesFree article

AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase.

Kefas BA, Heimberg H, Vaulont S, Meisse D, Hue L, Pipeleers D, Van de Casteele M.

Diabetologia. 2003 Feb;46(2):250-4. Epub 2003 Feb 8.PMID: 12627324 [PubMed - indexed for MEDLINE]Related articles

Purification of rat pancreatic B-cells by fluorescence-activated cell sorting.

Stangé G, Van De Casteele M, Heimberg H.

Methods Mol Med. 2003;83:15-22. No abstract available. PMID: 12619712 [PubMed - indexed for MEDLINE]Related articles

Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.

Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H.

J Cell Biol. 2002 Oct 28;159(2):303-12. Epub 2002 Oct 28.PMID: 12403815 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis.

Van de Casteele M, Kefas BA, Ling Z, Heimberg H, Pipeleers DG.

Endocrinology. 2002 Jan;143(1):320-6.PMID: 11751624 [PubMed - indexed for MEDLINE]Related articlesFree article

A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells.

Cardozo AK, Heimberg H, Heremans Y, Leeman R, Kutlu B, Kruhøffer M, Ørntoft T, Eizirik DL.

J Biol Chem. 2001 Dec 28;276(52):48879-86. Epub 2001 Oct 30.PMID: 11687580 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis.

Heimberg H, Heremans Y, Jobin C, Leemans R, Cardozo AK, Darville M, Eizirik DL.

Diabetes. 2001 Oct;50(10):2219-24.PMID: 11574401 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus.

Schuit FC, Huypens P, Heimberg H, Pipeleers DG.

Diabetes. 2001 Jan;50(1):1-11. Review.PMID: 11147773 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro.

Rooman I, Heremans Y, Heimberg H, Bouwens L.

Diabetologia. 2000 Jul;43(7):907-14.PMID: 10952464 [PubMed - indexed for MEDLINE]Related articles

Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1.

Heimberg H, Bouwens L, Heremans Y, Van De Casteele M, Lefebvre V, Pipeleers D.

Diabetes. 2000 Apr;49(4):571-9.PMID: 10871194 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.

Rochlitz H, Voigt A, Lankat-Buttgereit B, Göke B, Heimberg H, Nauck MA, Schiemann U, Schatz H, Pfeiffer AF.

Diabetologia. 2000 Apr;43(4):465-73.PMID: 10819240 [PubMed - indexed for MEDLINE]Related articles

Cellular origin of hexokinase in pancreatic islets.

Schuit F, Moens K, Heimberg H, Pipeleers D.

J Biol Chem. 1999 Nov 12;274(46):32803-9.PMID: 10551841 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factors in developing endocrine pancreas.

Heimberg H.

Ann Endocrinol (Paris). 1999 Sep;60(3):249-50. No abstract available. PMID: 10520418 [PubMed - indexed for MEDLINE]Related articles

Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP.

Hresko RC, Heimberg H, Chi MM, Mueckler M.

J Biol Chem. 1998 Aug 7;273(32):20658-68.PMID: 9685425 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcellular distribution and differential expression of endogenous ADP-ribosylation factor 6 in mammalian cells.

Yang CZ, Heimberg H, D'Souza-Schorey C, Mueckler MM, Stahl PD.

J Biol Chem. 1998 Feb 13;273(7):4006-11.PMID: 9461590 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential expression of rat insulin I and II messenger ribonucleic acid after prolonged exposure of islet beta-cells to elevated glucose levels.

Ling Z, Heimberg H, Foriers A, Schuit F, Pipeleers D.

Endocrinology. 1998 Feb;139(2):491-5.PMID: 9449616 [PubMed - indexed for MEDLINE]Related articlesFree article

Surrogate beta cells.

Ferber S, Heimberg H, Brownlee M, Colton C.

Diabetologia. 1997 Oct;40 Suppl 3:B39-43. No abstract available. PMID: 9345644 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced B-cell recruitment and the expression of hexokinase isoenzymes.

Schuit FC, De Vos A, Moens K, Quartier E, Heimberg H.

Adv Exp Med Biol. 1997;426:259-66. Review. No abstract available. PMID: 9544283 [PubMed - indexed for MEDLINE]Related articles

The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.

Heimberg H, De Vos A, Moens K, Quartier E, Bouwens L, Pipeleers D, Van Schaftingen E, Madsen O, Schuit F.

Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7036-41.PMID: 8692940 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells.

Moens K, Heimberg H, Flamez D, Huypens P, Quartier E, Ling Z, Pipeleers D, Gremlich S, Thorens B, Schuit F.

Diabetes. 1996 Feb;45(2):257-61.PMID: 8549871 [PubMed - indexed for MEDLINE]Related articles

Further definition of the sequence and position requirements of the arginine control element that mediates repression and induction by arginine in Saccharomyces cerevisiae.

Crabeel M, de Rijcke M, Seneca S, Heimberg H, Pfeiffer I, Matisova A.

Yeast. 1995 Nov;11(14):1367-80.PMID: 8585320 [PubMed - indexed for MEDLINE]Related articles

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

De Vos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, Schuit F.

J Clin Invest. 1995 Nov;96(5):2489-95.PMID: 7593639 [PubMed - indexed for MEDLINE]Related articlesFree article

DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.

Van der Auwera B, Van Waeyenberge C, Schuit F, Heimberg H, Vandewalle C, Gorus F, Flament J.

Diabetes. 1995 May;44(5):527-30.PMID: 7729610 [PubMed - indexed for MEDLINE]Related articles