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    Results: 1 to 50 of 81

    1.

    GOAT links dietary lipids with the endocrine control of energy balance.

    Kirchner H, Gutierrez JA, Solenberg PJ, Pfluger PT, Czyzyk TA, Willency JA, Schürmann A, Joost HG, Jandacek RJ, Hale JE, Heiman ML, Tschöp MH.

    Nat Med. 2009 Jul;15(7):741-5. Epub 2009 Jun 5. Erratum in: Nat Med. 2009 Sep;15(9):1093. PMID: 19503064 [PubMed - indexed for MEDLINE]Related articles

    2.

    Fat and water (1)h MRI to investigate effects of leptin in obese mice.

    James JR, Hertel JL, Babsky AM, Hekmatyar SK, Heiman ML, Jackson CV, Bansal N.

    Obesity (Silver Spring). 2009 Nov;17(11):2089-93. Epub 2009 Apr 30.PMID: 19407808 [PubMed - in process]Related articles

    3.

    Overview of rodent models for obesity research.

    Tschöp M, Heiman ML.

    Curr Protoc Neurosci. 2002 Feb;Chapter 9:Unit 9.10.PMID: 18428569 [PubMed - indexed for MEDLINE]Related articles

    4.

    Ghrelin in obesity.

    Heiman ML, Witcher DR.

    Metab Syndr Relat Disord. 2006 Spring;4(1):37-42.PMID: 18370769 [PubMed - in process]Related articles

    5.

    Preproghrelin-derived peptide, obestatin, fails to influence food intake in lean or obese rodents.

    Gourcerol G, Coskun T, Craft LS, Mayer JP, Heiman ML, Wang L, Million M, St-Pierre DH, Taché Y.

    Obesity (Silver Spring). 2007 Nov;15(11):2643-52.PMID: 18070755 [PubMed - indexed for MEDLINE]Related articles

    6.

    Potent oxindole based human beta3 adrenergic receptor agonists.

    Stevens FC, Bloomquist WE, Borel AG, Cohen ML, Droste CA, Heiman ML, Kriauciunas A, Sall DJ, Tinsley FC, Jesudason CD.

    Bioorg Med Chem Lett. 2007 Nov 15;17(22):6270-3. Epub 2007 Sep 7.PMID: 17911024 [PubMed - indexed for MEDLINE]Related articles

    7.

    Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists.

    Yan LZ, Hsiung HM, Heiman ML, Gadski RA, Emmerson PJ, Hertel J, Flora D, Edwards P, Smiley D, Zhang L, Husain S, Kahl SD, DiMarchi RD, Mayer JP.

    Curr Top Med Chem. 2007;7(11):1052-67. Review.PMID: 17584126 [PubMed - indexed for MEDLINE]Related articles

    8.

    Potent benzimidazolone based human beta(3)-adrenergic receptor agonists.

    Finley DR, Bell MG, Borel AG, Bloomquist WE, Cohen ML, Heiman ML, Kriauciunas A, Matthews DP, Miles T, Neel DA, Rito CJ, Sall DJ, Shuker AJ, Stephens TW, Tinsley FC, Winter MA, Jesudason CD.

    Bioorg Med Chem Lett. 2006 Nov 1;16(21):5691-4. Epub 2006 Aug 22.PMID: 16931005 [PubMed - indexed for MEDLINE]Related articles

    9.

    A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats.

    Hsiung HM, Hertel J, Zhang XY, Smith DP, Smiley DL, Heiman ML, Yang DD, Husain S, Mayer JP, Zhang L, Mo H, Yan LZ.

    Endocrinology. 2005 Dec;146(12):5257-66. Epub 2005 Sep 15.PMID: 16166226 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold.

    Yan LZ, Flora D, Edwards P, Smiley DL, Emmerson PJ, Hsiung HM, Gadski R, Hertel J, Heiman ML, Husain S, O'Brien TP, Kahl SD, Zhang L, Dimarchi RD, Mayer JP.

    Bioorg Med Chem Lett. 2005 Oct 15;15(20):4611-4.PMID: 16105738 [PubMed - indexed for MEDLINE]Related articles

    11.

    Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human beta-MSH(5-22) by dipeptidyl peptidase I and dipeptidyl peptidase IV.

    Hsiung HM, Smiley DL, Zhang XY, Zhang L, Yan LZ, Craft L, Heiman ML, Smith DP.

    Peptides. 2005 Oct;26(10):1988-96.PMID: 15985311 [PubMed - indexed for MEDLINE]Related articles

    12.

    Discovery of a beta-MSH-derived MC-4R selective agonist.

    Mayer JP, Hsiung HM, Flora DB, Edwards P, Smith DP, Zhang XY, Gadski RA, Heiman ML, Hertel JL, Emmerson PJ, Husain S, O'brien TP, Kahl SD, Smiley DL, Zhang L, Dimarchi RD, Yan LZ.

    J Med Chem. 2005 May 5;48(9):3095-8.PMID: 15857110 [PubMed - indexed for MEDLINE]Related articles

    13.

    Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats.

    Lugar CW, Clay MP, Lindstrom TD, Woodson AL, Smiley D, Heiman ML, Dodge JA.

    Bioorg Med Chem Lett. 2004 Dec 6;14(23):5873-6.PMID: 15501059 [PubMed - indexed for MEDLINE]Related articles

    14.

    Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

    Tschöp M, Castañeda TR, Joost HG, Thöne-Reineke C, Ortmann S, Klaus S, Hagan MM, Chandler PC, Oswald KD, Benoit SC, Seeley RJ, Kinzig KP, Moran TH, Beck-sickinger AG, Koglin N, Rodgers RJ, Blundell JE, Ishii Y, Beattie AH, Holch P, Allison DB, Raun K, Madsen K, Wulff BS, Stidsen CE, Birringer M, Kreuzer OJ, Schindler M, Arndt K, Rudolf K, Mark M, Deng XY, Whitcomb DC, Halem H, Taylor J, Dong J, Datta R, Culler M, Craney S, Flora D, Smiley D, Heiman ML.

    Nature. 2004 Jul 8;430(6996):1 p following 165; discussion 2 p following 165. Erratum in: Nature. 2004 Sep 23;431(7007):1038. Withcomb, DC [corrected to Whitcomb, DC]. PMID: 15243972 [PubMed - indexed for MEDLINE]Related articles

    15.

    Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.

    van der Lely AJ, Tschöp M, Heiman ML, Ghigo E.

    Endocr Rev. 2004 Jun;25(3):426-57. Review. Erratum in: Endocr Rev. 2004 Oct;25(5):866. PMID: 15180951 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis.

    Tinsley FC, Taicher GZ, Heiman ML.

    Obes Res. 2004 Jan;12(1):150-60.PMID: 14742854 [PubMed - indexed for MEDLINE]Related articles

    17.

    Galanin-like peptide functions more like leptin than like galanin.

    Heiman ML, Statnick MA.

    Endocrinology. 2003 Nov;144(11):4707-8. Review. No abstract available. PMID: 14578222 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis.

    Taicher GZ, Tinsley FC, Reiderman A, Heiman ML.

    Anal Bioanal Chem. 2003 Nov;377(6):990-1002. Epub 2003 Sep 16.PMID: 13680051 [PubMed - indexed for MEDLINE]Related articles

    19.

    Peptides that regulate food intake: antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization.

    Statnick MA, Tinsley FC, Eastwood BJ, Suter TM, Mitch CH, Heiman ML.

    Am J Physiol Regul Integr Comp Physiol. 2003 Jun;284(6):R1399-408.PMID: 12736177 [PubMed - indexed for MEDLINE]Related articles

    20.

    Body composition of prolactin-, growth hormone, and thyrotropin-deficient Ames dwarf mice.

    Heiman ML, Tinsley FC, Mattison JA, Hauck S, Bartke A.

    Endocrine. 2003 Feb-Mar;20(1-2):149-54.PMID: 12668880 [PubMed - indexed for MEDLINE]Related articles

    21.

    The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

    Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL.

    Neuron. 2003 Feb 20;37(4):649-61.PMID: 12597862 [PubMed - indexed for MEDLINE]Related articles

    22.

    Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels.

    Pagotto U, Gambineri A, Vicennati V, Heiman ML, Tschöp M, Pasquali R.

    J Clin Endocrinol Metab. 2002 Dec;87(12):5625-9.PMID: 12466363 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome.

    DelParigi A, Tschöp M, Heiman ML, Salbe AD, Vozarova B, Sell SM, Bunt JC, Tataranni PA.

    J Clin Endocrinol Metab. 2002 Dec;87(12):5461-4.PMID: 12466337 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    Hypophysectomy prevents ghrelin-induced adiposity and increases gastric ghrelin secretion in rats.

    Tschöp M, Flora DB, Mayer JP, Heiman ML.

    Obes Res. 2002 Oct;10(10):991-9.PMID: 12376579 [PubMed - indexed for MEDLINE]Related articles

    25.

    Vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating peptide receptor 2 deficiency in mice results in growth retardation and increased basal metabolic rate.

    Asnicar MA, Köster A, Heiman ML, Tinsley F, Smith DP, Galbreath E, Fox N, Ma YL, Blum WF, Hsiung HM.

    Endocrinology. 2002 Oct;143(10):3994-4006.PMID: 12239111 [PubMed - indexed for MEDLINE]Related articlesFree article

    26.

    Role of ghrelin polymorphisms in obesity based on three different studies.

    Ukkola O, Ravussin E, Jacobson P, Pérusse L, Rankinen T, Tschöp M, Heiman ML, Leon AS, Rao DC, Skinner JS, Wilmore JH, Sjöström L, Bouchard C.

    Obes Res. 2002 Aug;10(8):782-91.PMID: 12181387 [PubMed - indexed for MEDLINE]Related articles

    27.

    Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure.

    Banks WA, Tschöp M, Robinson SM, Heiman ML.

    J Pharmacol Exp Ther. 2002 Aug;302(2):822-7.PMID: 12130749 [PubMed - indexed for MEDLINE]Related articlesFree article

    28.

    Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity.

    Chen Y, Hu C, Hsu CK, Zhang Q, Bi C, Asnicar M, Hsiung HM, Fox N, Slieker LJ, Yang DD, Heiman ML, Shi Y.

    Endocrinology. 2002 Jul;143(7):2469-77.PMID: 12072376 [PubMed - indexed for MEDLINE]Related articlesFree article

    29.

    Chronic central infusion of cocaine- and amphetamine-regulated transcript (CART 55-102): effects on body weight homeostasis in lean and high-fat-fed obese rats.

    Rohner-Jeanrenaud F, Craft LS, Bridwell J, Suter TM, Tinsley FC, Smiley DL, Burkhart DR, Statnick MA, Heiman ML, Ravussin E, Caro JF.

    Int J Obes Relat Metab Disord. 2002 Feb;26(2):143-9.PMID: 11850744 [PubMed - indexed for MEDLINE]Related articlesFree article

    30.

    GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein.

    Tschöp M, Statnick MA, Suter TM, Heiman ML.

    Endocrinology. 2002 Feb;143(2):558-68.PMID: 11796511 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa.

    Otto B, Cuntz U, Fruehauf E, Wawarta R, Folwaczny C, Riepl RL, Heiman ML, Lehnert P, Fichter M, Tschöp M.

    Eur J Endocrinol. 2001 Nov;145(5):669-73.PMID: 11720888 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    Rodent obesity models: an overview.

    Tschöp M, Heiman ML.

    Exp Clin Endocrinol Diabetes. 2001;109(6):307-19. Review.PMID: 11571668 [PubMed - indexed for MEDLINE]Related articles

    33.

    Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet.

    Asnicar MA, Smith DP, Yang DD, Heiman ML, Fox N, Chen YF, Hsiung HM, Köster A.

    Endocrinology. 2001 Oct;142(10):4394-400.PMID: 11564703 [PubMed - indexed for MEDLINE]Related articlesFree article

    34.

    Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins.

    Ravussin E, Tschöp M, Morales S, Bouchard C, Heiman ML.

    J Clin Endocrinol Metab. 2001 Sep;86(9):4547-51. Erratum in: J Clin Endocrinol Metab 2001 Dec;86(12):5972. PMID: 11549706 [PubMed - indexed for MEDLINE]Related articlesFree article

    35.

    Harnessing the power of the group for latency-aged sexual abuse victims.

    Heiman ML, Ettin MF.

    Int J Group Psychother. 2001 Apr;51(2):265-82.PMID: 11321904 [PubMed - indexed for MEDLINE]Related articles

    36.

    Circulating ghrelin levels are decreased in human obesity.

    Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML.

    Diabetes. 2001 Apr;50(4):707-9.PMID: 11289032 [PubMed - indexed for MEDLINE]Related articlesFree article

    37.

    Increased weight gain after ovariectomy is not a consequence of leptin resistance.

    Chen Y, Heiman ML.

    Am J Physiol Endocrinol Metab. 2001 Feb;280(2):E315-22.PMID: 11158936 [PubMed - indexed for MEDLINE]Related articlesFree article

    38.

    Ghrelin induces adiposity in rodents.

    Tschöp M, Smiley DL, Heiman ML.

    Nature. 2000 Oct 19;407(6806):908-13.PMID: 11057670 [PubMed - indexed for MEDLINE]Related articles

    39.

    Chronic leptin administration promotes lipid utilization until fat mass is greatly reduced and preserves lean mass of normal female rats.

    Chen Y, Heiman ML.

    Regul Pept. 2000 Aug 25;92(1-3):113-9.PMID: 11024573 [PubMed - indexed for MEDLINE]Related articles

    40.

    Pharmacological characterization of (125)I-1229U91 binding to Y1 and Y4 neuropeptide Y/Peptide YY receptors.

    Schober DA, Gackenheimer SL, Heiman ML, Gehlert DR.

    J Pharmacol Exp Ther. 2000 Apr;293(1):275-80.PMID: 10734179 [PubMed - indexed for MEDLINE]Related articlesFree article

    41.

    Changes in leptin expression are not associated with corresponding changes in CCAAT/enhancer binding protein-alpha.

    Sloop KW, Surface PL, Heiman ML, Slieker LJ.

    Biochem Biophys Res Commun. 1998 Oct 9;251(1):142-7.PMID: 9790921 [PubMed - indexed for MEDLINE]Related articles

    42.

    The effect of exercise on leptin concentration in healthy men and in type 1 diabetic patients.

    Koistinen HA, Tuominen JA, Ebeling P, Heiman ML, Stephens TW, Koivisto VA.

    Med Sci Sports Exerc. 1998 Jun;30(6):805-10.PMID: 9624635 [PubMed - indexed for MEDLINE]Related articles

    43.

    A comparative survey of beliefs about "normal" childhood sexual behaviors.

    Heiman ML, Leiblum S, Cohen Esquilin S, Melendez Pallitto L.

    Child Abuse Negl. 1998 Apr;22(4):289-304.PMID: 9589180 [PubMed - indexed for MEDLINE]Related articles

    44.

    Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans.

    Landt M, Gingerich RL, Havel PJ, Mueller WM, Schoner B, Hale JE, Heiman ML.

    Clin Chem. 1998 Mar;44(3):565-70.PMID: 9510863 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    Leptin inhibits in vitro hypothalamic somatostatin secretion and somatostatin mRNA levels.

    Quintela M, Señaris R, Heiman ML, Casanueva FF, Dieguez C.

    Endocrinology. 1997 Dec;138(12):5641-4.PMID: 9389553 [PubMed - indexed for MEDLINE]Related articlesFree article

    46.

    Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone.

    Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Müller J, Skakkebaek NE, Heiman ML, Birkett M, Attanasio AM, Kiess W, Rascher W.

    J Clin Endocrinol Metab. 1997 Sep;82(9):2904-10.PMID: 9284717 [PubMed - indexed for MEDLINE]Related articlesFree article

    47.

    Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress.

    Heiman ML, Ahima RS, Craft LS, Schoner B, Stephens TW, Flier JS.

    Endocrinology. 1997 Sep;138(9):3859-63.PMID: 9275075 [PubMed - indexed for MEDLINE]Related articlesFree article

    48.

    Leptin and thermogenesis in humans.

    Tuominen JA, Ebeling P, Heiman ML, Stephens T, Koivisto VA.

    Acta Physiol Scand. 1997 May;160(1):83-7.PMID: 9179315 [PubMed - indexed for MEDLINE]Related articles

    49.

    Serum leptin concentration and fuel homeostasis in healthy man.

    Tuominen JA, Ebeling P, Laquier FW, Heiman ML, Stephens T, Koivisto VA.

    Eur J Clin Invest. 1997 Mar;27(3):206-11.PMID: 9088856 [PubMed - indexed for MEDLINE]Related articles

    50.

    Leptin synthesis is resistant to acute effects of insulin in insulin-dependent diabetes mellitus patients.

    Tuominen JA, Ebeling P, Stenman UH, Heiman ML, Stephens TW, Koivisto VA.

    J Clin Endocrinol Metab. 1997 Feb;82(2):381-2.PMID: 9024222 [PubMed - indexed for MEDLINE]Related articlesFree article

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