PubMed

Predictive genetic testing for coronary artery disease.

Johansen CT, Hegele RA.

Crit Rev Clin Lab Sci. 2009;46(5-6):343-60.PMID: 19958218 [PubMed - in process]Related articles

Evolutionary concepts in biobanking - the BC BioLibrary.

Watson PH, Wilson-McManus JE, Barnes RO, Giesz SC, Png A, Hegele RG, Brinkman JN, Mackenzie IR, Huntsman DG, Junker A, Gilks B, Skarsgard E, Burgess M, Aparicio S, McManus BM.

J Transl Med. 2009 Nov 12;7:95.PMID: 19909513 [PubMed - in process]Related articlesFree article

Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, Engert JC, Fisher E, Francès F, Froguel P, Hebebrand J, Hegele RA, Hinney A, Hoehe MR, Hu FB, Hubacek JA, Humphries SE, Hunt SC, Illig T, Järvelin MR, Kaakinen M, Kollerits B, Krude H, Kumar J, Lange LA, Langer B, Li S, Luchner A, Lyon HN, Meyre D, Mohlke KL, Mooser V, Nebel A, Nguyen TT, Paulweber B, Perusse L, Qi L, Rankinen T, Rosskopf D, Schreiber S, Sengupta S, Sorice R, Suk A, Thorleifsson G, Thorsteinsdottir U, Völzke H, Vimaleswaran KS, Wareham NJ, Waterworth D, Yusuf S, Lindgren C, McCarthy MI, Lange C, Hirschhorn JN, Laird N, Wichmann HE.

PLoS Genet. 2009 Oct;5(10):e1000694. Epub 2009 Oct 23.PMID: 19851442 [PubMed - in process]Related articlesFree article

Triple X syndrome in a patient with partial lipodystrophy discovered using a high-density oligonucleotide microarray: a case report.

Lanktree MB, Fantus IG, Hegele RA.

J Med Case Reports. 2009 Aug 12;3:8867.PMID: 19830242 [PubMed - in process]Related articlesFree article

2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations.

Genest J, McPherson R, Frohlich J, Anderson T, Campbell N, Carpentier A, Couture P, Dufour R, Fodor G, Francis GA, Grover S, Gupta M, Hegele RA, Lau DC, Leiter L, Lewis GF, Lonn E, Mancini GB, Ng D, Pearson GJ, Sniderman A, Stone JA, Ur E.

Can J Cardiol. 2009 Oct;25(10):567-79. Review.PMID: 19812802 [PubMed - indexed for MEDLINE]Related articles

APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians.

Lahiry P, Cao H, Ban MR, Pollex RL, Mamakeesick M, Zinman B, Harris SB, Hanley AJ, Huff MW, Connelly PW, Hegele RA.

J Lipid Res. 2009 Oct 6. [Epub ahead of print]PMID: 19812053 [PubMed - as supplied by publisher]Related articlesFree article

Comparison of gadofluorine-M and Gd-DTPA for noninvasive staging of atherosclerotic plaque stability using MRI.

Ronald JA, Chen Y, Belisle AJ, Hamilton AM, Rogers KA, Hegele RA, Misselwitz B, Rutt BK.

Circ Cardiovasc Imaging. 2009 May;2(3):226-34. Epub 2009 Mar 24.PMID: 19808597 [PubMed - indexed for MEDLINE]Related articles

Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and Heart disease risk in the elderly.

Polisecki E, Peter I, Simon JS, Hegele RA, Robertson M, Ford I, Shepherd J, Packard C, Jukema JW, Decraen AJ, Westendorp RG, Buckley BM, Schaefer EJ.

J Lipid Res. 2009 Sep 14. [Epub ahead of print]PMID: 19752398 [PubMed - as supplied by publisher]Related articlesFree article

Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray.

Lanktree MB, Hegele RA, Yusuf S, Anand SS.

Stroke. 2009 Oct;40(10):3173-9. Epub 2009 Aug 13.PMID: 19679847 [PubMed - indexed for MEDLINE]Related articles

Alternate day dosing of rosuvastatin: potential usefulness in statin-intolerant patients.

Joy T, Hegele RA.

Can J Cardiol. 2009 Aug;25(8):453. No abstract available. PMID: 19678415 [PubMed - indexed for MEDLINE]Related articlesFree article

A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

Hegele RA, Ban MR, Hsueh N, Kennedy BA, Cao H, Zou GY, Anand S, Yusuf S, Huff MW, Wang J.

Hum Mol Genet. 2009 Nov 1;18(21):4189-94. Epub 2009 Aug 5.PMID: 19656773 [PubMed - in process]Related articlesFree article

Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques.

Ronald JA, Chen JW, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK.

Circulation. 2009 Aug 18;120(7):592-9. Epub 2009 Aug 3.PMID: 19652086 [PubMed - indexed for MEDLINE]Related articlesFree article

Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance.

Mulvihill EE, Allister EM, Sutherland BG, Telford DE, Sawyez CG, Edwards JY, Markle JM, Hegele RA, Huff MW.

Diabetes. 2009 Oct;58(10):2198-210. Epub 2009 Jul 10.PMID: 19592617 [PubMed - indexed for MEDLINE]Related articles

Narrative review: statin-related myopathy.

Joy TR, Hegele RA.

Ann Intern Med. 2009 Jun 16;150(12):858-68. Review.PMID: 19528564 [PubMed - indexed for MEDLINE]Related articlesFree article

The end of the road for CETP inhibitors after torcetrapib?

Joy T, Hegele RA.

Curr Opin Cardiol. 2009 Jul;24(4):364-71. Review.PMID: 19522058 [PubMed - in process]Related articles

Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies.

Kraus JP, Hasek J, Kozich V, Collard R, Venezia S, Janosíková B, Wang J, Stabler SP, Allen RH, Jakobs C, Finn CT, Chien YH, Hwu WL, Hegele RA, Mudd SH.

Mol Genet Metab. 2009 Aug;97(4):250-9. Epub 2009 Apr 9.PMID: 19428278 [PubMed - indexed for MEDLINE]Related articles

The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2--therapy.

Khan NA, Hemmelgarn B, Herman RJ, Bell CM, Mahon JL, Leiter LA, Rabkin SW, Hill MD, Padwal R, Touyz RM, Larochelle P, Feldman RD, Schiffrin EL, Campbell NR, Moe G, Prasad R, Arnold MO, Campbell TS, Milot A, Stone JA, Jones C, Ogilvie RI, Hamet P, Fodor G, Carruthers G, Burns KD, Ruzicka M, DeChamplain J, Pylypchuk G, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, McFarlane P, Vallée M, Howlett J, Bacon SL, Lindsay P, Gilbert RE, Lewanczuk RZ, Tobe S; Canadian Hypertension Education Program.

Can J Cardiol. 2009 May;25(5):287-98. Review.PMID: 19417859 [PubMed - indexed for MEDLINE]Related articles

Predicting abdominal adipose tissue among women with familial partial lipodystrophy.

Joy T, Kennedy BA, Al-Attar S, Rutt BK, Hegele RA.

Metabolism. 2009 Jun;58(6):828-34.PMID: 19375764 [PubMed - indexed for MEDLINE]Related articles

Update on the genetics of stroke and cerebrovascular disease 2008.

Dichgans M, Hegele RA.

Stroke. 2009 May;40(5):e289-91. Epub 2009 Apr 9. Review. No abstract available. PMID: 19359634 [PubMed - indexed for MEDLINE]Related articles

Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease.

Lanktree MB, Hegele RA.

Genome Med. 2009 Feb 26;1(2):28. [Epub ahead of print]PMID: 19341499 [PubMed - as supplied by publisher]Related articlesFree article

Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.

Lanktree MB, Anand SS, Yusuf S, Hegele RA; SHARE Investigators.

J Lipid Res. 2009 Jul;50(7):1487-96. Epub 2009 Mar 18.PMID: 19299407 [PubMed - indexed for MEDLINE]Related articles

Novel LPL mutations associated with lipoprotein lipase deficiency: two case reports and a literature review.

Rahalkar AR, Giffen F, Har B, Ho J, Morrison KM, Hill J, Wang J, Hegele RA, Joy T.

Can J Physiol Pharmacol. 2009 Mar;87(3):151-60. Review.PMID: 19295657 [PubMed - indexed for MEDLINE]Related articles

Clinical field-strength MRI of amyloid plaques induced by low-level cholesterol feeding in rabbits.

Ronald JA, Chen Y, Bernas L, Kitzler HH, Rogers KA, Hegele RA, Rutt BK.

Brain. 2009 May;132(Pt 5):1346-54. Epub 2009 Mar 17.PMID: 19293239 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community.

Ley SH, Harris SB, Mamakeesick M, Noon T, Fiddler E, Gittelsohn J, Wolever TM, Connelly PW, Hegele RA, Zinman B, Hanley AJ.

CMAJ. 2009 Mar 17;180(6):617-24.PMID: 19289805 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans.

Edmondson AC, Brown RJ, Kathiresan S, Cupples LA, Demissie S, Manning AK, Jensen MK, Rimm EB, Wang J, Rodrigues A, Bamba V, Khetarpal SA, Wolfe ML, Derohannessian S, Li M, Reilly MP, Aberle J, Evans D, Hegele RA, Rader DJ.

J Clin Invest. 2009 Apr;119(4):1042-50. doi: 10.1172/JCI37176. Epub 2009 Mar 16.PMID: 19287092 [PubMed - indexed for MEDLINE]Related articlesFree article

ERK MAP kinase-activated Arf6 trafficking directs coxsackievirus type B3 into an unproductive compartment during virus host-cell entry.

Marchant D, Sall A, Si X, Abraham T, Wu W, Luo Z, Petersen T, Hegele RG, McManus BM.

J Gen Virol. 2009 Apr;90(Pt 4):854-62. Epub 2009 Mar 4.PMID: 19264606 [PubMed - indexed for MEDLINE]Related articles

Hoofbeats, zebras, and insights into insulin resistance.

Hegele RA, Reue K.

J Clin Invest. 2009 Feb;119(2):249-51.PMID: 19244606 [PubMed - indexed for MEDLINE]Related articles

Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis.

Marchant D, Dou Y, Luo H, Garmaroudi FS, McDonough JE, Si X, Walker E, Luo Z, Arner A, Hegele RG, Laher I, McManus BM.

Circ Res. 2009 Mar 27;104(6):813-21. Epub 2009 Feb 12.PMID: 19213955 [PubMed - indexed for MEDLINE]Related articles

A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems.

Lahiry P, Wang J, Robinson JF, Turowec JP, Litchfield DW, Lanktree MB, Gloor GB, Puffenberger EG, Strauss KA, Martens MB, Ramsay DA, Rupar CA, Siu V, Hegele RA.

Am J Hum Genet. 2009 Feb;84(2):134-47. Epub 2009 Jan 29. Erratum in: Am J Hum Genet. 2009 Jun;84(6):822. PMID: 19185282 [PubMed - indexed for MEDLINE]Related articlesFree article

Carnitine palmitoyltransferase IA polymorphism P479L is common in Greenland Inuit and is associated with elevated plasma apolipoprotein A-I.

Rajakumar C, Ban MR, Cao H, Young TK, Bjerregaard P, Hegele RA.

J Lipid Res. 2009 Jun;50(6):1223-8. Epub 2009 Jan 29.PMID: 19181627 [PubMed - indexed for MEDLINE]Related articles

Prevalence of reproductive abnormalities among women with familial partial lipodystrophy.

Joy TR, Hegele RA.

Endocr Pract. 2008 Dec;14(9):1126-32.PMID: 19158052 [PubMed - indexed for MEDLINE]Related articles

Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes.

Connelly PW, Zinman B, Maguire GF, Mamakeesick M, Harris SB, Hegele RA, Retnakaran R, Hanley AJ.

J Lipid Res. 2009 Jun;50(6):1216-22. Epub 2009 Jan 18.PMID: 19151417 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma lipoproteins: genetic influences and clinical implications.

Hegele RA.

Nat Rev Genet. 2009 Feb;10(2):109-21. Epub 2009 Jan 13. Review.PMID: 19139765 [PubMed - indexed for MEDLINE]Related articles

Hypertriglyceridemia: phenomics and genomics.

Hegele RA, Pollex RL.

Mol Cell Biochem. 2009 Jun;326(1-2):35-43. Epub 2009 Jan 7.PMID: 19130180 [PubMed - indexed for MEDLINE]Related articles

Predictors of mammographic density: insights gained from a novel regression analysis of a twin study.

Dite GS, Gurrin LC, Byrnes GB, Stone J, Gunasekara A, McCredie MR, English DR, Giles GG, Cawson J, Hegele RA, Chiarelli AM, Yaffe MJ, Boyd NF, Hopper JL.

Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3474-81.PMID: 19064564 [PubMed - indexed for MEDLINE]Related articlesFree article

Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR.

Lanktree MB, Rajakumar C, Brunt JH, Koschinsky ML, Connelly PW, Hegele RA.

J Lipid Res. 2009 Apr;50(4):768-72. Epub 2008 Dec 5.PMID: 19060253 [PubMed - indexed for MEDLINE]Related articles

Genetic testing for atherosclerosis risk: inevitability or pipe dream?

Lanktree M, Oh J, Hegele RA.

Can J Cardiol. 2008 Nov;24(11):851-4. Review.PMID: 18987759 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the FABP2 T54 variant with plasma triglycerides and insulin resistance in a multiethnic population.

de Koning L, Merchant AT, Hegele RA, Xie C, Vuksan V, Teo K, Yusuf S, Anand SS; Study of Health Assessment and Risk in Ethnic Groups investigators.

Clin Chem. 2008 Oct;54(10):1742-4. No abstract available. PMID: 18824579 [PubMed - indexed for MEDLINE]Related articlesFree article

APOA5 genetic variants are markers for classic hyperlipoproteinemia phenotypes and hypertriglyceridemia.

Wang J, Ban MR, Kennedy BA, Anand S, Yusuf S, Huff MW, Pollex RL, Hegele RA.

Nat Clin Pract Cardiovasc Med. 2008 Nov;5(11):730-7. Epub 2008 Sep 9.PMID: 18779834 [PubMed - indexed for MEDLINE]Related articles

Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada.

Burman D, Mente A, Hegele RA, Islam S, Yusuf S, Anand SS.

Atherosclerosis. 2009 Mar;203(1):192-200. Epub 2008 Jun 20.PMID: 18656198 [PubMed - indexed for MEDLINE]Related articles

Abetalipoproteinemia: two case reports and literature review.

Zamel R, Khan R, Pollex RL, Hegele RA.

Orphanet J Rare Dis. 2008 Jul 8;3:19. Review.PMID: 18611256 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoprotein(a) is associated differentially with carotid stenosis, occlusion, and total plaque area.

Klein JH, Hegele RA, Hackam DG, Koschinsky ML, Huff MW, Spence JD.

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1851-6. Epub 2008 Jul 3.PMID: 18599799 [PubMed - indexed for MEDLINE]Related articlesFree article

Polygenic determinants of severe hypertriglyceridemia.

Wang J, Ban MR, Zou GY, Cao H, Lin T, Kennedy BA, Anand S, Yusuf S, Huff MW, Pollex RL, Hegele RA.

Hum Mol Genet. 2008 Sep 15;17(18):2894-9. Epub 2008 Jul 1.PMID: 18596051 [PubMed - indexed for MEDLINE]Related articlesFree article

The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy.

Khan NA, Hemmelgarn B, Herman RJ, Rabkin SW, McAlister FA, Bell CM, Touyz RM, Padwal R, Leiter LA, Mahon JL, Hill MD, Larochelle P, Feldman RD, Schiffrin EL, Campbell NR, Arnold MO, Moe G, Campbell TS, Milot A, Stone JA, Jones C, Ogilvie RI, Hamet P, Fodor G, Carruthers G, Burns KD, Ruzicka M, dechamplain J, Pylypchuk G, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, McFarlane P, Vallée M, Howlett J, Katzmarzyk P, Tobe S, Lewanczuk RZ; Canadian Hypertension Education Program.

Can J Cardiol. 2008 Jun;24(6):465-75. Review.PMID: 18548143 [PubMed - indexed for MEDLINE]Related articlesFree article

Emerging antidyslipidemic drugs.

Pollex RL, Joy TR, Hegele RA.

Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81. Review.PMID: 18537526 [PubMed - indexed for MEDLINE]Related articles

The failure of torcetrapib: what have we learned?

Joy TR, Hegele RA.

Br J Pharmacol. 2008 Aug;154(7):1379-81. Epub 2008 Jun 9.PMID: 18536741 [PubMed - indexed for MEDLINE]Related articlesFree article

A Glimpse at HDL-based Therapy for Atherosclerosis.

Hegele RA.

Clin Biochem Rev. 2004 Feb;25(1):3-6.PMID: 18516205 [PubMed - in process]Related articlesFree article

Microsomal triglyceride transfer protein inhibition-friend or foe?

Joy TR, Hegele RA.

Nat Clin Pract Cardiovasc Med. 2008 Aug;5(8):506-8. Epub 2008 May 27. Review.PMID: 18506153 [PubMed - indexed for MEDLINE]Related articles

Genetics of metabolic syndrome: is there a role for phenomics?

Joy T, Hegele RA.

Curr Atheroscler Rep. 2008 Jun;10(3):201-8. Review.PMID: 18489847 [PubMed - indexed for MEDLINE]Related articles

Genetics of metabolic syndrome.

Joy T, Lahiry P, Pollex RL, Hegele RA.

Curr Diab Rep. 2008 Apr;8(2):141-8. Review.PMID: 18445357 [PubMed - indexed for MEDLINE]Related articles