PubMed

Analysis of 23 Polycyclic Aromatic Hydrocarbons in Smokeless Tobacco by Gas Chromatography-Mass Spectrometry.

Stepanov I, Villalta PW, Knezevich A, Jensen J, Hatsukami D, Hecht SS.

Chem Res Toxicol. 2009 Oct 27. [Epub ahead of print]PMID: 19860436 [PubMed - as supplied by publisher]Related articles

Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense.

Kim YY, Von Weymarn L, Larsson O, Fan D, Underwood JM, Peterson MS, Hecht SS, Polunovsky VA, Bitterman PB.

Cancer Res. 2009 Nov 1;69(21):8455-62. Epub 2009 Oct 20.PMID: 19843855 [PubMed - in process]Related articles

Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products.

Stepanov I, Carmella SG, Briggs A, Hertsgaard L, Lindgren B, Hatsukami D, Hecht SS.

Cancer Res. 2009 Nov 1;69(21):8236-40. Epub 2009 Oct 20.PMID: 19843845 [PubMed - in process]Related articles

Formaldehyde and leukemia: Epidemiology, potential mechanisms, and implications for risk assessment.

Zhang L, Freeman LE, Nakamura J, Hecht SS, Vandenberg JJ, Smith MT, Sonawane BR.

Environ Mol Mutagen. 2009 Sep 29. [Epub ahead of print]PMID: 19790261 [PubMed - as supplied by publisher]Related articles

Mass spectrometric analysis of a cyclic 7,8-butanoguanine adduct of N-nitrosopyrrolidine: comparison to other N-nitrosopyrrolidine adducts in rat hepatic DNA.

Loureiro AP, Zhang W, Kassie F, Zhang S, Villalta PW, Wang M, Hecht SS.

Chem Res Toxicol. 2009 Oct;22(10):1728-35.PMID: 19761253 [PubMed - in process]Related articles

Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers.

Wang M, Cheng G, Balbo S, Carmella SG, Villalta PW, Hecht SS.

Cancer Res. 2009 Sep 15;69(18):7170-4. Epub 2009 Sep 8.PMID: 19738046 [PubMed - indexed for MEDLINE]Related articles

Inhibition of Vinyl Carbamate-Induced Pulmonary Adenocarcinoma by Indole-3-Carbinol and Myo-inositol in A/J Mice.

Kassie F, Kalscheuer S, Matise I, Ma L, Melkamu T, Upadhyaya P, Hecht SS.

Carcinogenesis. 2009 Jul 22. [Epub ahead of print]PMID: 19625346 [PubMed - as supplied by publisher]Related articles

The Influence of Repair Pathways on the Cytotoxicity and Mutagenicity Induced by the Pyridyloxobutylation Pathway of Tobacco-Specific Nitrosamines.

Li L, Perdigao J, Pegg AE, Lao Y, Hecht SS, Lindgren BR, Reardon JT, Sancar A, Wattenberg EV, Peterson LA.

Chem Res Toxicol. 2009 Jul 15. [Epub ahead of print]PMID: 19601657 [PubMed - as supplied by publisher]Related articles

Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer.

Derby KS, Cuthrell K, Caberto C, Carmella S, Murphy SE, Hecht SS, Le Marchand L.

Int J Cancer. 2009 Nov 15;125(10):2418-24.PMID: 19598261 [PubMed - indexed for MEDLINE]Related articles

Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers.

Hecht SS, Kassie F, Hatsukami DK.

Nat Rev Cancer. 2009 Jul;9(7):476-88. Review.PMID: 19550424 [PubMed - indexed for MEDLINE]Related articles

Medical coverage of gymnastics competitions.

Hecht SS, Burton MS.

Curr Sports Med Rep. 2009 May-Jun;8(3):113-8.PMID: 19436165 [PubMed - indexed for MEDLINE]Related articles

Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine.

Zhang S, Wang M, Villalta PW, Lindgren BR, Lao Y, Hecht SS.

Chem Res Toxicol. 2009 May;22(5):949-56.PMID: 19405515 [PubMed - indexed for MEDLINE]Related articles

Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Zhang S, Wang M, Villalta PW, Lindgren BR, Upadhyaya P, Lao Y, Hecht SS.

Chem Res Toxicol. 2009 May;22(5):926-36.PMID: 19358518 [PubMed - indexed for MEDLINE]Related articles

Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Upadhyaya P, Lindgren BR, Hecht SS.

Drug Metab Dispos. 2009 Jun;37(6):1147-51. Epub 2009 Mar 26.PMID: 19324941 [PubMed - indexed for MEDLINE]Related articles

Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers.

Yuan JM, Koh WP, Murphy SE, Fan Y, Wang R, Carmella SG, Han S, Wickham K, Gao YT, Yu MC, Hecht SS.

Cancer Res. 2009 Apr 1;69(7):2990-5. Epub 2009 Mar 24.PMID: 19318550 [PubMed - indexed for MEDLINE]Related articles

Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers.

Carmella SG, Chen M, Han S, Briggs A, Jensen J, Hatsukami DK, Hecht SS.

Chem Res Toxicol. 2009 Apr;22(4):734-41.PMID: 19317515 [PubMed - indexed for MEDLINE]Related articles

Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users.

Stepanov I, Carmella SG, Han S, Pinto A, Strasser AA, Lerman C, Hecht SS.

Nicotine Tob Res. 2009 Jan;11(1):99-105. Epub 2009 Jan 27.PMID: 19246447 [PubMed - indexed for MEDLINE]Related articles

Preferential glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of phenanthrene in human hepatocytes: relevance to molecular epidemiology studies of glutathione-s-transferase polymorphisms and cancer.

Hecht SS, Berg JZ, Hochalter JB.

Chem Res Toxicol. 2009 Mar;22(3):426-32.PMID: 19187038 [PubMed - in process]Related articles

Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Stepanov I, Hecht SS.

Chem Res Toxicol. 2009 Feb;22(2):406-14.PMID: 19166332 [PubMed - indexed for MEDLINE]Related articles

Anthocyanins in black raspberries prevent esophageal tumors in rats.

Wang LS, Hecht SS, Carmella SG, Yu N, Larue B, Henry C, McIntyre C, Rocha C, Lechner JF, Stoner GD.

Cancer Prev Res (Phila Pa). 2009 Jan;2(1):84-93.PMID: 19139022 [PubMed - indexed for MEDLINE]Related articles

Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol.

Kassie F, Matise I, Negia M, Upadhyaya P, Hecht SS.

Cancer Prev Res (Phila Pa). 2008 Dec;1(7):568-76.PMID: 19139007 [PubMed - indexed for MEDLINE]Related articles

Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice.

Johnson TE, Kassie F, O'Sullivan MG, Negia M, Hanson TE, Upadhyaya P, Ruvolo PP, Hecht SS, Xing C.

Cancer Prev Res (Phila Pa). 2008 Nov;1(6):430-8.PMID: 19138990 [PubMed - indexed for MEDLINE]Related articles

Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice.

Kassie F, Matise I, Negia M, Lahti D, Pan Y, Scherber R, Upadhyaya P, Hecht SS.

Cancer Prev Res (Phila Pa). 2008 Sep;1(4):285-97.PMID: 19138972 [PubMed - indexed for MEDLINE]Related articles

A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers.

Church TR, Anderson KE, Caporaso NE, Geisser MS, Le CT, Zhang Y, Benoit AR, Carmella SG, Hecht SS.

Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):260-6.PMID: 19124507 [PubMed - indexed for MEDLINE]Related articles

Exposure to a tobacco-specific lung carcinogen in adolescent versus adult smokers.

Hertsgaard LA, Hanson K, Hecht SS, Lindgren BR, Luo X, Carmella SG, Riley WT, Zylla EB, Murphy SE, Hatsukami DK.

Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3337-43.PMID: 19064548 [PubMed - indexed for MEDLINE]Related articles

Nicotine metabolism in three ethnic/racial groups with different risks of lung cancer.

Derby KS, Cuthrell K, Caberto C, Carmella SG, Franke AA, Hecht SS, Murphy SE, Le Marchand L.

Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3526-35. Epub 2008 Nov 24.PMID: 19029401 [PubMed - indexed for MEDLINE]Related articles

New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels.

Stepanov I, Jensen J, Hatsukami D, Hecht SS.

Nicotine Tob Res. 2008 Dec;10(12):1773-82.PMID: 19023828 [PubMed - indexed for MEDLINE]Related articles

Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine.

Le Marchand L, Derby KS, Murphy SE, Hecht SS, Hatsukami D, Carmella SG, Tiirikainen M, Wang H.

Cancer Res. 2008 Nov 15;68(22):9137-40.PMID: 19010884 [PubMed - indexed for MEDLINE]Related articlesFree article

N2-ethyldeoxyguanosine as a potential biomarker for assessing effects of alcohol consumption on DNA.

Balbo S, Hashibe M, Gundy S, Brennan P, Canova C, Simonato L, Merletti F, Richiardi L, Agudo A, Castellsagué X, Znaor A, Talamini R, Bencko V, Holcátová I, Wang M, Hecht SS, Boffetta P.

Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3026-32.PMID: 18990745 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of adducts formed in the reactions of 5'-acetoxy-N'-nitrosonornicotine with deoxyadenosine, thymidine, and DNA.

Upadhyaya P, Hecht SS.

Chem Res Toxicol. 2008 Nov;21(11):2164-71.PMID: 18821782 [PubMed - indexed for MEDLINE]Related articlesFree article

Developing the science base for reducing tobacco harm.

Hatsukami DK, Joseph AM, Lesage M, Jensen J, Murphy SE, Pentel PR, Kotlyar M, Borgida E, Le C, Hecht SS.

Nicotine Tob Res. 2007 Nov;9 Suppl 4:S537-53. Review.PMID: 18067031 [PubMed - indexed for MEDLINE]Related articles

Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers.

Stepanov I, Upadhyaya P, Carmella SG, Feuer R, Jensen J, Hatsukami DK, Hecht SS.

Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1764-73.PMID: 18628430 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Upadhyaya P, Kalscheuer S, Hochalter JB, Villalta PW, Hecht SS.

Chem Res Toxicol. 2008 Jul;21(7):1468-76. Epub 2008 Jun 21.PMID: 18570389 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of phenanthrene diol epoxide mercapturic acid detoxification products in human urine: relevance to molecular epidemiology studies of glutathione S-transferase polymorphisms.

Hecht SS, Villalta PW, Hochalter JB.

Carcinogenesis. 2008 May;29(5):937-43. Epub 2008 May 13.PMID: 18477646 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection and quantitation of N'-nitrosonornicotine in human toenails by liquid chromatography-electrospray ionization-tandem mass spectrometry.

Stepanov I, Hecht SS.

Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):945-8.PMID: 18398035 [PubMed - indexed for MEDLINE]Related articlesFree article

Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobacco.

Hecht SS, Carmella SG, Edmonds A, Murphy SE, Stepanov I, Luo X, Hatsukami DK.

Tob Control. 2008 Apr;17(2):128-31.PMID: 18375734 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users.

Hecht SS, Carmella SG, Stepanov I, Jensen J, Anderson A, Hatsukami DK.

Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):732-5.PMID: 18349296 [PubMed - indexed for MEDLINE]Related articlesFree article

Smoking reduction fails to improve clinical and biological markers of cardiac disease: a randomized controlled trial.

Joseph AM, Hecht SS, Murphy SE, Lando H, Carmella SG, Gross M, Bliss R, Le CT, Hatsukami DK.

Nicotine Tob Res. 2008 Mar;10(3):471-81.PMID: 18324566 [PubMed - indexed for MEDLINE]Related articles

Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA).

Cheng G, Wang M, Upadhyaya P, Villalta PW, Hecht SS.

Chem Res Toxicol. 2008 Mar;21(3):746-51. Epub 2008 Jan 19.PMID: 18205321 [PubMed - indexed for MEDLINE]Related articles

Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.

Kassie F, Anderson LB, Higgins L, Pan Y, Matise I, Negia M, Upadhyaya P, Wang M, Hecht SS.

Carcinogenesis. 2008 Mar;29(3):610-9. Epub 2008 Jan 12.PMID: 18192687 [PubMed - indexed for MEDLINE]Related articlesFree article

Smokeless tobacco reduction: preliminary study of tobacco-free snuff versus no snuff.

Hatsukami DK, Ebbert JO, Edmonds A, Li C, Lin H, Le C, Hecht SS.

Nicotine Tob Res. 2008 Jan;10(1):77-85.PMID: 18188748 [PubMed - indexed for MEDLINE]Related articles

Pilot study on lower nitrosamine smokeless tobacco products compared with medicinal nicotine.

Mendoza-Baumgart MI, Tulunay OE, Hecht SS, Zhang Y, Murphy S, Le C, Jensen J, Hatsukami DK.

Nicotine Tob Res. 2007 Dec;9(12):1309-23.PMID: 18058349 [PubMed - indexed for MEDLINE]Related articles

Progress and challenges in selected areas of tobacco carcinogenesis.

Hecht SS.

Chem Res Toxicol. 2008 Jan;21(1):160-71. Epub 2007 Dec 4. Review.PMID: 18052103 [PubMed - indexed for MEDLINE]Related articlesFree article

Changing smokeless tobacco products new tobacco-delivery systems.

Hatsukami DK, Ebbert JO, Feuer RM, Stepanov I, Hecht SS.

Am J Prev Med. 2007 Dec;33(6 Suppl):S368-78. Review.PMID: 18021912 [PubMed - indexed for MEDLINE]Related articles

Deoxygenated phosphorothioate inositol phosphate analogs: synthesis, phosphatase stability, and binding affinity.

Liu X, Moody EC, Hecht SS, Sturla SJ.

Bioorg Med Chem. 2008 Mar 15;16(6):3419-27. Epub 2007 Oct 14.PMID: 17981044 [PubMed - indexed for MEDLINE]Related articles

Liquid chromatography-electrospray ionization tandem mass spectrometry analysis of 7-ethylguanine in human liver DNA.

Chen L, Wang M, Villalta PW, Hecht SS.

Chem Res Toxicol. 2007 Oct;20(10):1498-502. Epub 2007 Sep 22.PMID: 17887725 [PubMed - indexed for MEDLINE]Related articles

Detection of cotinine in newborn dried blood spots.

Spector LG, Hecht SS, Ognjanovic S, Carmella SG, Ross JA.

Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1902-5.PMID: 17855712 [PubMed - indexed for MEDLINE]Related articlesFree article

The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics.

Lubin JH, Caporaso N, Hatsukami DK, Joseph AM, Hecht SS.

Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1852-7.PMID: 17855705 [PubMed - indexed for MEDLINE]Related articlesFree article

Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers.

Hecht SS, Carmella SG, Murphy SE, Riley WT, Le C, Luo X, Mooney M, Hatsukami DK.

Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1567-72.PMID: 17684130 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Wang M, Cheng G, Villalta PW, Hecht SS.

Chem Res Toxicol. 2007 Aug;20(8):1141-8. Epub 2007 Aug 4. Erratum in: Chem Res Toxicol. 2008 Feb;21(2):555. PMID: 17676814 [PubMed - indexed for MEDLINE]Related articles