PubMed

Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity.

Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, Haynes WG, Patterson JT, Disse E, Pfluger PT, López M, Woods SC, DiMarchi R, Diéguez C, Rahmouni K, Rohner-Jeanrenaud F, Tschöp MH.

J Neurosci. 2009 May 6;29(18):5916-25.PMID: 19420258 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin.

Rahmouni K, Sigmund CD, Haynes WG, Mark AL.

Diabetes. 2009 Mar;58(3):536-42. Epub 2008 Dec 9.PMID: 19066310 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation between sympathetic nerve traffic and sympathetically mediated vascular tone in normotensive human obesity.

Agapitov AV, Correia ML, Sinkey CA, Haynes WG.

Hypertension. 2008 Oct;52(4):687-95. Epub 2008 Aug 11.PMID: 18695151 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder.

Fiedorowicz JG, Palagummi NM, Forman-Hoffman VL, Miller del D, Haynes WG.

Ann Clin Psychiatry. 2008 Jul-Sep;20(3):131-7.PMID: 18633739 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular smooth muscle function is associated with initiation and processing speed in patients with atherosclerotic vascular disease.

Moser DJ, Miller IN, Hoth KF, Correia M, Arndt S, Haynes WG.

J Int Neuropsychol Soc. 2008 Jul;14(4):535-41.PMID: 18577282 [PubMed - indexed for MEDLINE]Related articles

NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine.

Erondu N, Addy C, Lu K, Mallick M, Musser B, Gantz I, Proietto J, Astrup A, Toubro S, Rissannen AM, Tonstad S, Haynes WG, Gottesdiener KM, Kaufman KD, Amatruda JM, Heymsfield SB.

Obesity (Silver Spring). 2007 Aug;15(8):2027-42.PMID: 17712121 [PubMed - indexed for MEDLINE]Related articles

Arterial compliance and endothelial function.

Correia ML, Haynes WG.

Curr Diab Rep. 2007 Aug;7(4):269-75. Review.PMID: 17686402 [PubMed - indexed for MEDLINE]Related articles

Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease.

Dhaun N, Ferro CJ, Davenport AP, Haynes WG, Goddard J, Webb DJ.

Nephrol Dial Transplant. 2007 Nov;22(11):3228-34. Epub 2007 Jun 7.PMID: 17556408 [PubMed - indexed for MEDLINE]Related articlesFree article

LDL cholesteryl oleate: a biomarker for atherosclerosis?

Spector AA, Haynes WG.

Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1228-30. No abstract available. PMID: 17522395 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity impairs vascular relaxation in human subjects: hyperglycemia exaggerates adrenergic vasoconstriction arterial dysfunction in obesity and diabetes.

Sivitz WI, Wayson SM, Bayless ML, Sinkey CA, Haynes WG.

J Diabetes Complications. 2007 May-Jun;21(3):149-57.PMID: 17493547 [PubMed - indexed for MEDLINE]Related articles

Impairments in microvascular reactivity are related to organ failure in human sepsis.

Doerschug KC, Delsing AS, Schmidt GA, Haynes WG.

Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1065-71. Epub 2007 May 4.PMID: 17483235 [PubMed - indexed for MEDLINE]Related articlesFree article

Predictors of subjective cognitive difficulties in older adults with atherosclerotic vascular disease.

Humphreys CT, Moser DJ, Hynes SM, Reese RL, Haynes WG.

Am J Geriatr Psychiatry. 2007 Apr;15(4):328-34.PMID: 17384315 [PubMed - indexed for MEDLINE]Related articles

What is the most appropriate methodology for detection of conduit artery endothelial dysfunction?

Guthikonda S, Sinkey CA, Haynes WG.

Arterioscler Thromb Vasc Biol. 2007 May;27(5):1172-6. Epub 2007 Feb 15.PMID: 17303783 [PubMed - indexed for MEDLINE]Related articlesFree article

Lessons from Leptin's molecular biology: Potential therapeutic actions of recombinant leptin and leptin-related compounds.

Correia ML, Haynes WG.

Mini Rev Med Chem. 2007 Jan;7(1):31-8. Review.PMID: 17266635 [PubMed - indexed for MEDLINE]Related articles

Neuropsychological performance is associated with vascular function in patients with atherosclerotic vascular disease.

Moser DJ, Robinson RG, Hynes SM, Reese RL, Arndt S, Paulsen JS, Haynes WG.

Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):141-6. Epub 2006 Oct 26.PMID: 17068287 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity and insulin resistance but not hyperandrogenism mediates vascular dysfunction in women with polycystic ovary syndrome.

Dokras A, Jagasia DH, Maifeld M, Sinkey CA, VanVoorhis BJ, Haynes WG.

Fertil Steril. 2006 Dec;86(6):1702-9. Epub 2006 Oct 24.PMID: 17067587 [PubMed - indexed for MEDLINE]Related articles

A role for plasminogen activator inhibitor-1 in obesity: from pie to PAI?

Correia ML, Haynes WG.

Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2183-5. Review. No abstract available. PMID: 16990563 [PubMed - indexed for MEDLINE]Related articlesFree article

Antecedent hypoglycemia, catecholamine depletion, and subsequent sympathetic neural responses.

Herlein JA, Morgan DA, Phillips BG, Haynes WG, Sivitz WI.

Endocrinology. 2006 Jun;147(6):2781-8. Epub 2006 Mar 9.PMID: 16527844 [PubMed - indexed for MEDLINE]Related articlesFree article

Homocysteine: role and implications in atherosclerosis.

Guthikonda S, Haynes WG.

Curr Atheroscler Rep. 2006 Mar;8(2):100-6. Review.PMID: 16510043 [PubMed - indexed for MEDLINE]Related articles

Role of leptin in obesity-related hypertension.

Haynes WG.

Exp Physiol. 2005 Sep;90(5):683-8. Epub 2005 Aug 16. Review.PMID: 16105937 [PubMed - indexed for MEDLINE]Related articlesFree article

Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines.

Correia ML, Haynes WG.

Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. Review.PMID: 16083333 [PubMed - indexed for MEDLINE]Related articles

Dietary and medical therapy of obesity.

Stumbo P, Hemingway D, Haynes WG.

Surg Clin North Am. 2005 Aug;85(4):703-23, vi. Review.PMID: 16061081 [PubMed - indexed for MEDLINE]Related articles

Lack of dilator effect of leptin in the hindlimb vascular bed of conscious rats.

Rahmouni K, Jalali A, Morgan DA, Haynes WG.

Eur J Pharmacol. 2005 Aug 22;518(2-3):175-81.PMID: 16054621 [PubMed - indexed for MEDLINE]Related articles

Effects of aging and atherosclerosis on endothelial and vascular smooth muscle function in humans.

Al-Shaer MH, Choueiri NE, Correia ML, Sinkey CA, Barenz TA, Haynes WG.

Int J Cardiol. 2006 May 10;109(2):201-6. Epub 2005 Jul 27.PMID: 16054252 [PubMed - indexed for MEDLINE]Related articles

Endothelial effects of leptin: implications in health and diseases.

Rahmouni K, Haynes WG.

Curr Diab Rep. 2005 Aug;5(4):260-6. Review.PMID: 16033675 [PubMed - indexed for MEDLINE]Related articles

Role of selective leptin resistance in diet-induced obesity hypertension.

Rahmouni K, Morgan DA, Morgan GM, Mark AL, Haynes WG.

Diabetes. 2005 Jul;54(7):2012-8.PMID: 15983201 [PubMed - indexed for MEDLINE]Related articlesFree article

Sibutramine and the sympathetic nervous system in obese humans.

Haynes WG, Egri Z.

Clin Auton Res. 2005 Jun;15(3):189-92. No abstract available. PMID: 15944867 [PubMed - indexed for MEDLINE]Related articles

Loss of leptin actions in obesity: two concepts with cardiovascular implications.

Mark AL, Correia ML, Rahmouni K, Haynes WG.

Clin Exp Hypertens. 2004 Oct-Nov;26(7-8):629-36. Review.PMID: 15702617 [PubMed - indexed for MEDLINE]Related articles

Effect of hyperhomocysteinemia induced by methionine administration on flow-mediated dilatation of the brachial artery in healthy subjects.

Al-Shaer MH, Raghuveer G, Browning R, Sinkey CA, Chenard C, Stumbo P, Haynes WG.

Am J Cardiol. 2005 Feb 1;95(3):428-30.PMID: 15670563 [PubMed - indexed for MEDLINE]Related articles

Obesity-associated hypertension: new insights into mechanisms.

Rahmouni K, Correia ML, Haynes WG, Mark AL.

Hypertension. 2005 Jan;45(1):9-14. Epub 2004 Dec 6. Review.PMID: 15583075 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin and C-reactive protein in obesity, type 2 diabetes, and monodrug therapy.

Putz DM, Goldner WS, Bar RS, Haynes WG, Sivitz WI.

Metabolism. 2004 Nov;53(11):1454-61.PMID: 15536601 [PubMed - indexed for MEDLINE]Related articles

Homocysteine: is it a clinically important cardiovascular risk factor?

Lentz SR, Haynes WG.

Cleve Clin J Med. 2004 Sep;71(9):729-34. Review.PMID: 15478704 [PubMed - indexed for MEDLINE]Related articlesFree article

Blood vessel function and cognition in elderly patients with atherosclerosis.

Moser DJ, Hoth KF, Robinson RG, Paulsen JS, Sinkey CA, Benjamin ML, Schultz SK, Haynes WG.

Stroke. 2004 Nov;35(11):e369-72. Epub 2004 Oct 7.PMID: 15472091 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin.

Rahmouni K, Morgan DA, Morgan GM, Liu X, Sigmund CD, Mark AL, Haynes WG.

J Clin Invest. 2004 Sep;114(5):652-8.PMID: 15343383 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin, obesity and cardiovascular disease.

Correia ML, Haynes WG.

Curr Opin Nephrol Hypertens. 2004 Mar;13(2):215-23. Review.PMID: 15202616 [PubMed - indexed for MEDLINE]Related articles

Obesity-related hypertension: is there a role for selective leptin resistance?

Correia ML, Haynes WG.

Curr Hypertens Rep. 2004 Jun;6(3):230-5. Review.PMID: 15128477 [PubMed - indexed for MEDLINE]Related articles

Role of xanthine oxidase in conduit artery endothelial dysfunction in cigarette smokers.

Guthikonda S, Woods K, Sinkey CA, Haynes WG.

Am J Cardiol. 2004 Mar 1;93(5):664-8.PMID: 14996607 [PubMed - indexed for MEDLINE]Related articles

Leptin and the cardiovascular system.

Rahmouni K, Haynes WG.

Recent Prog Horm Res. 2004;59:225-44. Review.PMID: 14749504 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity.

Rahmouni K, Mark AL, Haynes WG, Sigmund CD.

Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E891-5. Epub 2004 Jan 28.PMID: 14749209 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin administration to normal rats does not alter catecholamine responsiveness to insulin-induced hypoglycemia.

Herlein JA, Fink BD, Morgan DA, Phillips BG, Haynes WG, Sivitz WI.

Metabolism. 2003 Nov;52(11):1484-90.PMID: 14624411 [PubMed - indexed for MEDLINE]Related articles

Periodontal disease and atherosclerosis: from dental to arterial plaque.

Haynes WG, Stanford C.

Arterioscler Thromb Vasc Biol. 2003 Aug 1;23(8):1309-11. Review. No abstract available. PMID: 12909566 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin.

Rahmouni K, Haynes WG, Morgan DA, Mark AL.

J Neurosci. 2003 Jul 9;23(14):5998-6004.PMID: 12853417 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute neuropsychological functioning following cardiosurgical interventions associated with the production of intraoperative cerebral microemboli.

Browndyke JN, Moser DJ, Cohen RA, O'Brien DJ, Algina JJ, Haynes WG, Staples ED, Alexander J, Davies LK, Bauer RM.

Clin Neuropsychol. 2002 Dec;16(4):463-71.PMID: 12822055 [PubMed - indexed for MEDLINE]Related articles

Leptin and body fat in type 2 diabetes and monodrug therapy.

Sivitz WI, Wayson SM, Bayless ML, Larson LF, Sinkey C, Bar RS, Haynes WG.

J Clin Endocrinol Metab. 2003 Apr;88(4):1543-53.PMID: 12679437 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperhomocysteinemia, vascular function and atherosclerosis: effects of vitamins.

Haynes WG.

Cardiovasc Drugs Ther. 2002 Sep;16(5):391-9. Review.PMID: 12652108 [PubMed - indexed for MEDLINE]Related articles

Medical management of obesity: a clinical imperative?

Haynes WG.

Curr Diab Rep. 2003 Feb;3(1):1-3. Review. No abstract available. PMID: 12643140 [PubMed - indexed for MEDLINE]Related articles

Intracellular mechanisms involved in leptin regulation of sympathetic outflow.

Rahmouni K, Haynes WG, Morgan DA, Mark AL.

Hypertension. 2003 Mar;41(3 Pt 2):763-7. Epub 2002 Dec 16.PMID: 12623993 [PubMed - indexed for MEDLINE]Related articlesFree article

A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat.

Mark AL, Rahmouni K, Correia M, Haynes WG.

Acta Physiol Scand. 2003 Mar;177(3):345-9. Review.PMID: 12609005 [PubMed - indexed for MEDLINE]Related articles

Triglyceride-rich lipoproteins and vascular function.

Haynes WG.

Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):153-5. Review. No abstract available. PMID: 12588751 [PubMed - indexed for MEDLINE]Related articlesFree article

Xanthine oxidase inhibition reverses endothelial dysfunction in heavy smokers.

Guthikonda S, Sinkey C, Barenz T, Haynes WG.

Circulation. 2003 Jan 28;107(3):416-21.PMID: 12551865 [PubMed - indexed for MEDLINE]Related articlesFree article