PubMed

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.

Towler MC, Fogarty S, Hawley SA, Pan DA, Martin DM, Morrice NA, McCarthy A, Galardo MN, Meroni SB, Cigorraga SB, Ashworth A, Sakamoto K, Hardie DG.

Biochem J. 2008 Nov 15;416(1):1-14.PMID: 18774945 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice.

Mooney MH, Fogarty S, Stevenson C, Gallagher AM, Palit P, Hawley SA, Hardie DG, Coxon GD, Waigh RD, Tate RJ, Harvey AL, Furman BL.

Br J Pharmacol. 2008 Apr;153(8):1669-77. Epub 2008 Feb 25.PMID: 18297106 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K.

J Biol Chem. 2007 Nov 9;282(45):32549-60. Epub 2007 Sep 12.PMID: 17855357 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.

Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ, Liu ZX, Dong J, Mustard KJ, Hawley SA, Befroy D, Pypaert M, Hardie DG, Young LH, Shulman GI.

Cell Metab. 2007 Feb;5(2):151-6.PMID: 17276357 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

Tamás P, Hawley SA, Clarke RG, Mustard KJ, Green K, Hardie DG, Cantrell DA.

J Exp Med. 2006 Jul 10;203(7):1665-70. Epub 2006 Jul 3.PMID: 16818670 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase--development of the energy sensor concept.

Hardie DG, Hawley SA, Scott JW.

J Physiol. 2006 Jul 1;574(Pt 1):7-15. Epub 2006 Apr 27. Review.PMID: 16644800 [PubMed - indexed for MEDLINE]Related articlesFree article

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG.

Cell Metab. 2005 Jul;2(1):9-19.PMID: 16054095 [PubMed - indexed for MEDLINE]Related articles

Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.

Kola B, Hubina E, Tucci SA, Kirkham TC, Garcia EA, Mitchell SE, Williams LM, Hawley SA, Hardie DG, Grossman AB, Korbonits M.

J Biol Chem. 2005 Jul 1;280(26):25196-201. Epub 2005 May 16.PMID: 15899896 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.

Rencurel F, Stenhouse A, Hawley SA, Friedberg T, Hardie DG, Sutherland C, Wolf CR.

J Biol Chem. 2005 Feb 11;280(6):4367-73. Epub 2004 Nov 29.PMID: 15572372 [PubMed - indexed for MEDLINE]Related articlesFree article

AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus.

Gadalla AE, Pearson T, Currie AJ, Dale N, Hawley SA, Sheehan M, Hirst W, Michel AD, Randall A, Hardie DG, Frenguelli BG.

J Neurochem. 2004 Mar;88(5):1272-82.PMID: 15009683 [PubMed - indexed for MEDLINE]Related articles

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR.

EMBO J. 2004 Feb 25;23(4):833-43. Epub 2004 Feb 19.PMID: 14976552 [PubMed - indexed for MEDLINE]Related articlesFree article

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.

Scott JW, Hawley SA, Green KA, Anis M, Stewart G, Scullion GA, Norman DG, Hardie DG.

J Clin Invest. 2004 Jan;113(2):274-84.PMID: 14722619 [PubMed - indexed for MEDLINE]Related articlesFree article

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.

Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG.

J Biol. 2003;2(4):28. Epub 2003 Sep 24.PMID: 14511394 [PubMed - indexed for MEDLINE]Related articlesFree article

Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex.

Sutherland CM, Hawley SA, McCartney RR, Leech A, Stark MJ, Schmidt MC, Hardie DG.

Curr Biol. 2003 Aug 5;13(15):1299-305.PMID: 12906789 [PubMed - indexed for MEDLINE]Related articles

A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.

Hudson ER, Pan DA, James J, Lucocq JM, Hawley SA, Green KA, Baba O, Terashima T, Hardie DG.

Curr Biol. 2003 May 13;13(10):861-6.PMID: 12747836 [PubMed - indexed for MEDLINE]Related articles

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism.

Hawley SA, Gadalla AE, Olsen GS, Hardie DG.

Diabetes. 2002 Aug;51(8):2420-5.PMID: 12145153 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate.

Scott JW, Norman DG, Hawley SA, Kontogiannis L, Hardie DG.

J Mol Biol. 2002 Mar 22;317(2):309-23.PMID: 11902845 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase: the energy charge hypothesis revisited.

Hardie DG, Hawley SA.

Bioessays. 2001 Dec;23(12):1112-9. Review.PMID: 11746230 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.

Hardie DG, Salt IP, Hawley SA, Davies SP.

Biochem J. 1999 Mar 15;338 ( Pt 3):717-22.PMID: 10051444 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D, Hardie DG.

Biochem J. 1998 Aug 15;334 ( Pt 1):177-87.PMID: 9693118 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio.

Wilson WA, Hawley SA, Hardie DG.

Curr Biol. 1996 Nov 1;6(11):1426-34.PMID: 8939604 [PubMed - indexed for MEDLINE]Related articles

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase.

Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, Hardie DG.

J Biol Chem. 1996 Nov 1;271(44):27879-87.PMID: 8910387 [PubMed - indexed for MEDLINE]Related articlesFree article

5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms.

Hawley SA, Selbert MA, Goldstein EG, Edelman AM, Carling D, Hardie DG.

J Biol Chem. 1995 Nov 10;270(45):27186-91.PMID: 7592975 [PubMed - indexed for MEDLINE]Related articlesFree article

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

Corton JM, Gillespie JG, Hawley SA, Hardie DG.

Eur J Biochem. 1995 Apr 15;229(2):558-65.PMID: 7744080 [PubMed - indexed for MEDLINE]Related articlesFree article

The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA.

Verhoeven AJ, Woods A, Brennan CH, Hawley SA, Hardie DG, Scott J, Beri RK, Carling D.

Eur J Biochem. 1995 Mar 1;228(2):236-43.PMID: 7705334 [PubMed - indexed for MEDLINE]Related articlesFree article

Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.

Davies SP, Hawley SA, Woods A, Carling D, Haystead TA, Hardie DG.

Eur J Biochem. 1994 Jul 15;223(2):351-7.PMID: 8055903 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues.

Weekes J, Hawley SA, Corton J, Shugar D, Hardie DG.

Eur J Biochem. 1994 Feb 1;219(3):751-7.PMID: 8112325 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular analysis of cis-regulatory sequences at the alpha-amylase locus in Drosophila melanogaster.

Hawley SA, Doane WW, Norman RA.

Biochem Genet. 1992 Jun;30(5-6):257-77.PMID: 1616481 [PubMed - indexed for MEDLINE]Related articles

Amylase gene expression in intraspecific and interspecific somatic transformants of Drosophila.

Hawley SA, Norman RA, Brown CJ, Doane WW, Anderson WW, Hickey DA.

Genome. 1990 Aug;33(4):501-8.PMID: 1699842 [PubMed - indexed for MEDLINE]Related articles

Molecular genetics of a three-gene cluster in the Amy region of Drosophila.

Doane WW, Thompson DB, Norman RA, Hawley SA.

Prog Clin Biol Res. 1990;344:19-48. Review.PMID: 1697417 [PubMed - indexed for MEDLINE]Related articles

Structural organization of the alpha-amylase gene locus in Drosophila melanogaster and Drosophila miranda.

Doane WW, Gemmill RM, Schwartz PE, Hawley SA, Norman RA.

Isozymes Curr Top Biol Med Res. 1987;14:229-66. Review.PMID: 3110097 [PubMed - indexed for MEDLINE]Related articles

Genetic mechanism for tissue-specific control of alpha-amylase expression in Drosophila melanogaster.

Doane WW, Treat-Clemons LG, Gemmill RM, Levy JN, Hawley SA, Buchberg AM, Paigen K.

Isozymes Curr Top Biol Med Res. 1983;9:63-90. No abstract available. PMID: 6413453 [PubMed - indexed for MEDLINE]Related articles

High-pressure techniques.

Hawley SA.

Methods Enzymol. 1978;49:14-24. No abstract available. PMID: 651660 [PubMed - indexed for MEDLINE]Related articles

The effect of base composition on the pressure stability of DNA in neutral salt solution.

Hawley SA, Macleod RM.

Biopolymers. 1977 Aug;16(8):1833-5. No abstract available. PMID: 19108 [PubMed - indexed for MEDLINE]Related articles

Electrophoretic separation of molecular species associated with the thermal transition of chymotrypsinogen A.

Hawley SA, Macleod RM.

J Mol Biol. 1976 May 25;103(3):655-7. No abstract available. PMID: 940159 [PubMed - indexed for MEDLINE]Related articles

An electrophoretic study of reversible protein denaturation: chymotrypsinogen at high pressures.

Hawley SA, Mitchell RM.

Biochemistry. 1975 Jul 15;14(14):3257-64.PMID: 238588 [PubMed - indexed for MEDLINE]Related articles

Pressure-temperature stability of DNA in neutral salt solutions.

Hawley SA, MacLeod RM.

Biopolymers. 1974;13(7):1417-26. No abstract available. PMID: 4415191 [PubMed - indexed for MEDLINE]Related articles

Reversible pressure--temperature denaturation of chymotrypsinogen.

Hawley SA.

Biochemistry. 1971 Jun 22;10(13):2436-42. No abstract available. PMID: 5557794 [PubMed - indexed for MEDLINE]Related articles

Ultrasonic absorption in aqueous solutions of high-molecular-weight polysaccharides.

Hawley SA, Kessler LW, Dunn F.

J Acoust Soc Am. 1965 Oct;38(4):521-3. No abstract available. PMID: 5831008 [PubMed - indexed for MEDLINE]Related articles