PubMed

5T4 as a target for immunotherapy in renal cell carcinoma.

Elkord E, Shablak A, Stern PL, Hawkins RE.

Expert Rev Anticancer Ther. 2009 Dec;9(12):1705-9. No abstract available. PMID: 19954280 [PubMed - in process]Related articles

T cell-based immunotherapy of metastatic renal cell carcinoma: modest success and future perspective.

Shablak A, Hawkins RE, Rothwell DG, Elkord E.

Clin Cancer Res. 2009 Nov 1;15(21):6503-10. Epub 2009 Oct 20.PMID: 19843660 [PubMed - in process]Related articles

The second cellular therapy of cancer symposium, 27-29 March 2009, Milan, Italy.

Bridgeman JS, Gilham DE, Hawkins RE, Cheadle EJ.

Cancer Immunol Immunother. 2009 Aug 8. [Epub ahead of print] No abstract available. PMID: 19669146 [PubMed - as supplied by publisher]Related articles

Toward meeting the challenge of physician competence assessment: the University of California, San Diego Physician Assessment and Clinical Education (PACE) Program.

Norcross WA, Henzel TR, Freeman K, Milner-Mares J, Hawkins RE.

Acad Med. 2009 Aug;84(8):1008-14.PMID: 19638764 [PubMed - indexed for MEDLINE]Related articles

Assessment of medical professionalism: who, what, when, where, how, and ... why?

Hawkins RE, Katsufrakis PJ, Holtman MC, Clauser BE.

Med Teach. 2009 Apr;31(4):348-61.PMID: 19404894 [PubMed - indexed for MEDLINE]Related articles

Vaccination of patients with metastatic renal cancer with modified vaccinia Ankara encoding the tumor antigen 5T4 (TroVax) given alongside interferon-alpha.

Hawkins RE, Macdermott C, Shablak A, Hamer C, Thistlethwaite F, Drury NL, Chikoti P, Shingler W, Naylor S, Harrop R.

J Immunother. 2009 May;32(4):424-9.PMID: 19342962 [PubMed - indexed for MEDLINE]Related articles

Eradication of established B-cell lymphoma by CD19-specific murine T cells is dependent on host lymphopenic environment and can be mediated by CD4+ and CD8+ T cells.

Cheadle EJ, Hawkins RE, Batha H, Rothwell DG, Ashton G, Gilham DE.

J Immunother. 2009 Apr;32(3):207-18.PMID: 19242379 [PubMed - indexed for MEDLINE]Related articles

The association of faculty and residents' gender on faculty evaluations of internal medicine residents in 16 residencies.

Holmboe ES, Huot SJ, Brienza RS, Hawkins RE.

Acad Med. 2009 Mar;84(3):381-4.PMID: 19240452 [PubMed - indexed for MEDLINE]Related articles

Developing an in-training examination for fellows: the experience of the American Society of Clinical Oncology.

Collichio FA, Kayoumi KM, Hande KR, Hawkins RE, Hawley JL, Adelstein DJ, D'Angelo JM, Stewart JA.

J Clin Oncol. 2009 Apr 1;27(10):1706-11. Epub 2009 Feb 17.PMID: 19224843 [PubMed - indexed for MEDLINE]Related articles

Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4).

Elkord E, Dangoor A, Burt DJ, Southgate TD, Daayana S, Harrop R, Drijfhout JW, Sherlock D, Hawkins RE, Stern PL.

Cancer Immunol Immunother. 2009 Oct;58(10):1657-67. Epub 2009 Feb 17.PMID: 19221742 [PubMed - indexed for MEDLINE]Related articles

A postcode lottery still exists for cancer patients with 'exceptional circumstances'.

Clarke R, Waddell T, Gallagher J, Lee K, Radhakrishna G, Cavet J, Hawkins RE, Saunders MP.

Clin Oncol (R Coll Radiol). 2008 Dec;20(10):771-2. Epub 2008 Oct 29. No abstract available. PMID: 18973994 [PubMed - indexed for MEDLINE]Related articles

An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases.

Elkord E, Dangoor A, Drury NL, Harrop R, Burt DJ, Drijfhout JW, Hamer C, Andrews D, Naylor S, Sherlock D, Hawkins RE, Stern PL.

J Immunother. 2008 Nov-Dec;31(9):820-9.PMID: 18833005 [PubMed - indexed for MEDLINE]Related articles

The combination of cyclophosphamide and human T cells genetically engineered to target CD19 can eradicate established B-cell lymphoma.

Cheadle EJ, Gilham DE, Hawkins RE.

Br J Haematol. 2008 Jul;142(1):65-8. Epub 2008 May 8.PMID: 18477047 [PubMed - indexed for MEDLINE]Related articles

Making self-assessment more effective.

Galbraith RM, Hawkins RE, Holmboe ES.

J Contin Educ Health Prof. 2008 Winter;28(1):20-4.PMID: 18366125 [PubMed - indexed for MEDLINE]Related articles

Immunotherapy for gastrointestinal cancer: current status and strategies for improving efficacy.

Elkord E, Hawkins RE, Stern PL.

Expert Opin Biol Ther. 2008 Apr;8(4):385-95. Review.PMID: 18352844 [PubMed - indexed for MEDLINE]Related articles

Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses.

Harrop R, Drury N, Shingler W, Chikoti P, Redchenko I, Carroll MW, Kingsman SM, Naylor S, Griffiths R, Steven N, Hawkins RE.

Cancer Immunol Immunother. 2008 Jul;57(7):977-86.PMID: 18060404 [PubMed - indexed for MEDLINE]Related articles

CD4+ T-cell recognition of human 5T4 oncofoetal antigen: implications for initial depletion of CD25+ T cells.

Elkord E, Burt DJ, Drijfhout JW, Hawkins RE, Stern PL.

Cancer Immunol Immunother. 2008 Jun;57(6):833-47. Epub 2007 Nov 15.PMID: 18004564 [PubMed - indexed for MEDLINE]Related articles

Eotaxin-2 and colorectal cancer: a potential target for immune therapy.

Cheadle EJ, Riyad K, Subar D, Rothwell DG, Ashton G, Batha H, Sherlock DJ, Hawkins RE, Gilham DE.

Clin Cancer Res. 2007 Oct 1;13(19):5719-28.PMID: 17908961 [PubMed - indexed for MEDLINE]Related articlesFree article

Adoptive transfer of T(reg) depleted autologous T cells in advanced renal cell carcinoma.

Thistlethwaite FC, Elkord E, Griffiths RW, Burt DJ, Shablak AM, Campbell JD, Gilham DE, Austin EB, Stern PL, Hawkins RE.

Cancer Immunol Immunother. 2008 May;57(5):623-34. Epub 2007 Sep 27.PMID: 17899077 [PubMed - indexed for MEDLINE]Related articles

Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival.

Griffiths RW, Elkord E, Gilham DE, Ramani V, Clarke N, Stern PL, Hawkins RE.

Cancer Immunol Immunother. 2007 Nov;56(11):1743-53. Epub 2007 May 9.PMID: 17487490 [PubMed - indexed for MEDLINE]Related articles

A phase II open-label study of DHA-paclitaxel (Taxoprexin) by 2-h intravenous infusion in previously untreated patients with locally advanced or metastatic gastric or oesophageal adenocarcinoma.

Jones RJ, Hawkins RE, Eatock MM, Ferry DR, Eskens FA, Wilke H, Evans TR.

Cancer Chemother Pharmacol. 2008 Mar;61(3):435-41. Epub 2007 Apr 18.PMID: 17440725 [PubMed - indexed for MEDLINE]Related articles

Cellular therapy of cancer symposium December 2nd-3rd 2006 Manchester, UK.

Thistlethwaite FC, Gilham DE, Hawkins RE.

Cancer Immunol Immunother. 2007 Jun;56(6):939-42. Epub 2007 Feb 27. No abstract available. PMID: 17333180 [PubMed - indexed for MEDLINE]Related articles

Patients with pancreatic cancer participating in clinical trials: are targets being met, and if not, why?

Board RE, Thorley D, Hawkins RE, Valle JW.

Pancreas. 2007 Mar;34(2):269-70. No abstract available. PMID: 17312469 [PubMed - indexed for MEDLINE]Related articles

A phase II study of a 5T4 oncofoetal antigen tumour-targeted superantigen (ABR-214936) therapy in patients with advanced renal cell carcinoma.

Shaw DM, Connolly NB, Patel PM, Kilany S, Hedlund G, Nordle O, Forsberg G, Zweit J, Stern PL, Hawkins RE.

Br J Cancer. 2007 Feb 26;96(4):567-74. Epub 2007 Feb 6.PMID: 17285137 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-angiogenic therapy in the treatment of advanced renal cell cancer.

Board RE, Thistlethwaite FC, Hawkins RE.

Cancer Treat Rev. 2007 Feb;33(1):1-8. Epub 2006 Oct 27. Review.PMID: 17071006 [PubMed - indexed for MEDLINE]Related articles

Use of the mini-clinical evaluation exercise to rate examinee performance on a multiple-station clinical skills examination: a validity study.

Margolis MJ, Clauser BE, Cuddy MM, Ciccone A, Mee J, Harik P, Hawkins RE.

Acad Med. 2006 Oct;81(10 Suppl):S56-60.PMID: 17001137 [PubMed - indexed for MEDLINE]Related articles

Combination of vaccination and chimeric receptor expressing T cells provides improved active therapy of tumors.

Jiang HR, Gilham DE, Mulryan K, Kirillova N, Hawkins RE, Stern PL.

J Immunol. 2006 Oct 1;177(7):4288-98.PMID: 16982863 [PubMed - indexed for MEDLINE]Related articlesFree article

Checklist content on a standardized patient assessment: an ex post facto review.

Boulet JR, van Zanten M, de Champlain A, Hawkins RE, Peitzman SJ.

Adv Health Sci Educ Theory Pract. 2008 Mar;13(1):59-69. Epub 2006 Jul 27.PMID: 16871427 [PubMed - indexed for MEDLINE]Related articles

Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: a phase I/II trial.

Harrop R, Connolly N, Redchenko I, Valle J, Saunders M, Ryan MG, Myers KA, Drury N, Kingsman SM, Hawkins RE, Carroll MW.

Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3416-24.PMID: 16740766 [PubMed - indexed for MEDLINE]Related articlesFree article

CD8 T-cell recognition of human 5T4 oncofetal antigen.

Smyth LJ, Elkord E, Taher TE, Jiang HR, Burt DJ, Clayton A, van Veelen PA, de Ru A, Ossendorp F, Melief CJ, Drijfhout JW, Dermime S, Hawkins RE, Stern PL.

Int J Cancer. 2006 Oct 1;119(7):1638-47.PMID: 16646078 [PubMed - indexed for MEDLINE]Related articles

Identification of a major histocompatibility complex class I-restricted T-cell epitope in the tumour-associated antigen, 5T4.

Redchenko I, Harrop R, Ryan MG, Hawkins RE, Carroll MW.

Immunology. 2006 May;118(1):50-7.PMID: 16630022 [PubMed - indexed for MEDLINE]Related articlesFree article

A phase II study of weekly cisplatin and gemcitabine in patients with advanced pancreatic cancer: is this a strategy still worth pursuing?

Clayton AJ, Mansoor AW, Jones ET, Hawkins RE, Saunders MP, Swindell R, Valle JW.

Pancreas. 2006 Jan;32(1):51-7.PMID: 16340744 [PubMed - indexed for MEDLINE]Related articles

Engineering T cells for cancer therapy.

Mansoor W, Gilham DE, Thistlethwaite FC, Hawkins RE.

Br J Cancer. 2005 Nov 14;93(10):1085-91. Review.PMID: 16251873 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of laparotomy and liver resection on the peritoneal concentrations of fibroblast growth factor 2, vascular endothelial growth factor and hepatocyte growth factor.

Whitworth MK, Sheen A, Rosa DD, Duff SE, Ryder D, Burumdayal A, Wiener K, Hawkins RE, Saunders M, Valle JW, Sherlock D, Jayson GC.

J Cancer Res Clin Oncol. 2006 Jan;132(1):41-4. Epub 2005 Oct 26.PMID: 16249905 [PubMed - indexed for MEDLINE]Related articles

Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T-cell-based immunotherapy.

Griffiths RW, Gilham DE, Dangoor A, Ramani V, Clarke NW, Stern PL, Hawkins RE.

Br J Cancer. 2005 Sep 19;93(6):670-7.PMID: 16222313 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward personalized immunotherapy for non-Hodgkin lymphoma: targeting the idiotypic immunoglobulin.

Armstrong AC, Cheadle EJ, Hawkins RE.

BioDrugs. 2005;19(5):289-97. Review.PMID: 16207070 [PubMed - indexed for MEDLINE]Related articles

Safety and tolerability of PCK3145, a synthetic peptide derived from prostate secretory protein 94 (PSP94) in metastatic hormone-refractory prostate cancer.

Hawkins RE, Daigneault L, Cowan R, Griffiths R, Panchal C, Armstrong A, Fenemore J, Irvine A, Sereda K, Dulude H.

Clin Prostate Cancer. 2005 Sep;4(2):91-9.PMID: 16197609 [PubMed - indexed for MEDLINE]Related articles

Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer.

Rao S, Cunningham D, Hawkins RE, Hill ME, Smith D, Daniel F, Ross PJ, Oates J, Norman AR.

Br J Cancer. 2005 May 9;92(9):1650-4.PMID: 15856037 [PubMed - indexed for MEDLINE]Related articlesFree article

Killing of non-Hodgkin lymphoma cells by autologous CD19 engineered T cells.

Cheadle EJ, Gilham DE, Thistlethwaite FC, Radford JA, Hawkins RE.

Br J Haematol. 2005 May;129(3):322-32.PMID: 15842655 [PubMed - indexed for MEDLINE]Related articles

The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens.

Guest RD, Hawkins RE, Kirillova N, Cheadle EJ, Arnold J, O'Neill A, Irlam J, Chester KA, Kemshead JT, Shaw DM, Embleton MJ, Stern PL, Gilham DE.

J Immunother. 2005 May-Jun;28(3):203-11.PMID: 15838376 [PubMed - indexed for MEDLINE]Related articles

Engineering T-cells with antibody-based chimeric receptors for effective cancer therapy.

Thistlethwaite F, Mansoor W, Gilham DE, Hawkins RE.

Curr Opin Mol Ther. 2005 Feb;7(1):48-55. Review.PMID: 15732529 [PubMed - indexed for MEDLINE]Related articles

Phase II study of troxacitabine in chemotherapy-naive patients with advanced cancer of the pancreas: gastrointestinal tumors.

Lapointe R, Létourneau R, Steward W, Hawkins RE, Batist G, Vincent M, Whittom R, Eatock M, Jolivet J, Moore M.

Ann Oncol. 2005 Feb;16(2):289-93.PMID: 15668286 [PubMed - indexed for MEDLINE]Related articlesFree article

Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes.

Tew SR, Li Y, Pothacharoen P, Tweats LM, Hawkins RE, Hardingham TE.

Osteoarthritis Cartilage. 2005 Jan;13(1):80-9.PMID: 15639641 [PubMed - indexed for MEDLINE]Related articles

Simulations in the United States Medical Licensing Examination (USMLE).

Dillon GF, Boulet JR, Hawkins RE, Swanson DB.

Qual Saf Health Care. 2004 Oct;13 Suppl 1:i41-5. Review.PMID: 15465954 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of adenoviruses encoding CD40L or IL-2 against B cell lymphoma.

Meziane el K, Bhattacharyya T, Armstrong AC, Qian C, Hawkins RE, Stern PL, Dermime S.

Int J Cancer. 2004 Oct 10;111(6):910-20.PMID: 15300803 [PubMed - indexed for MEDLINE]Related articles

Vaccine and antibody-directed T cell tumour immunotherapy.

Dermime S, Gilham DE, Shaw DM, Davidson EJ, Meziane el-K, Armstrong A, Hawkins RE, Stern PL.

Biochim Biophys Acta. 2004 Jul 6;1704(1):11-35. Review.PMID: 15238242 [PubMed - indexed for MEDLINE]Related articles

Effects of training in direct observation of medical residents' clinical competence: a randomized trial.

Holmboe ES, Hawkins RE, Huot SJ.

Ann Intern Med. 2004 Jun 1;140(11):874-81.PMID: 15172901 [PubMed - indexed for MEDLINE]Related articlesFree article

Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9.

Li Y, Tew SR, Russell AM, Gonzalez KR, Hardingham TE, Hawkins RE.

Tissue Eng. 2004 Mar-Apr;10(3-4):575-84.PMID: 15165474 [PubMed - indexed for MEDLINE]Related articles

Adoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma.

Armstrong AC, Dermime S, Mulryan K, Stern PL, Bhattacharyya T, Hawkins RE.

J Immunother. 2004 May-Jun;27(3):227-31.PMID: 15076140 [PubMed - indexed for MEDLINE]Related articles

Antibody-directed enzyme-prodrug therapy.

Pedley RB, Sharma SK, Hawkins RE, Chester KA.

Methods Mol Med. 2004;90:491-514. No abstract available. PMID: 14657581 [PubMed - indexed for MEDLINE]Related articles