PubMed

Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivo.

Klieverik LP, Coomans CP, Endert E, Sauerwein HP, Havekes LM, Voshol PJ, Rensen PC, Romijn JA, Kalsbeek A, Fliers E.

Endocrinology. 2009 Dec;150(12):5639-48. Epub 2009 Oct 23.PMID: 19854865 [PubMed - in process]Related articles

Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice.

Boesten LS, Zadelaar AS, van Nieuwkoop A, Hu L, Teunisse AF, Jochemsen AG, Evers B, van de Water B, Gijbels MJ, van Vlijmen BJ, Havekes LM, de Winther MP.

Atherosclerosis. 2009 Jun 18. [Epub ahead of print]PMID: 19608184 [PubMed - as supplied by publisher]Related articles

CETP does not affect triglyceride production or clearance in APOE*3-leiden mice.

Bijland S, van den Berg SA, Voshol PJ, van den Hoek AM, Princen HM, Havekes LM, Rensen PC, Willems van Dijk K.

J Lipid Res. 2009 Jun 29. [Epub ahead of print]PMID: 19564641 [PubMed - as supplied by publisher]Related articlesFree article

Improved cholesterol phenotype analysis by a model relating lipoprotein lifecycle processes to particle size.

van Schalkwijk DB, de Graaf AA, van Ommen B, van Bochove K, Rensen PC, Havekes LM, van de Pas NC, Hoefsloot HC, van der Greef J, Freidig AP.

J Lipid Res. 2009 Jun 10. [Epub ahead of print]PMID: 19515990 [PubMed - as supplied by publisher]Related articlesFree article

Human CETP aggravates atherosclerosis by increasing VLDL-cholesterol rather than by decreasing HDL-cholesterol in APOE*3-Leiden mice.

de Vries-van der Weij J, Zadelaar S, Toet K, Havekes LM, Kooistra T, Rensen PC.

Atherosclerosis. 2009 Sep;206(1):153-8. Epub 2009 Mar 19.PMID: 19345354 [PubMed - in process]Related articles

The dual PPARalpha/gamma agonist tesaglitazar blocks progression of pre-existing atherosclerosis in APOE*3Leiden.CETP transgenic mice.

van der Hoorn JW, Jukema JW, Havekes LM, Lundholm E, Camejo G, Rensen PC, Princen HM.

Br J Pharmacol. 2009 Apr;156(7):1067-75. Epub 2009 Feb 13.PMID: 19220285 [PubMed - indexed for MEDLINE]Related articles

Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models.

Voshol PJ, Rensen PC, van Dijk KW, Romijn JA, Havekes LM.

Biochim Biophys Acta. 2009 Jun;1791(6):479-85. Epub 2009 Jan 8. Review.PMID: 19168150 [PubMed - indexed for MEDLINE]Related articles

PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice.

de Haan W, de Vries-van der Weij J, Mol IM, Hoekstra M, Romijn JA, Jukema JW, Havekes LM, Princen HM, Rensen PC.

Biochim Biophys Acta. 2009 Mar;1791(3):191-7. Epub 2008 Dec 25.PMID: 19150509 [PubMed - indexed for MEDLINE]Related articles

Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein.

de Vries-van der Weij J, de Haan W, Hu L, Kuif M, Oei HL, van der Hoorn JW, Havekes LM, Princen HM, Romijn JA, Smit JW, Rensen PC.

Endocrinology. 2009 May;150(5):2368-75. Epub 2009 Jan 15.PMID: 19147676 [PubMed - indexed for MEDLINE]Related articles

The expression of type III hyperlipoproteinemia: involvement of lipolysis genes.

Henneman P, van der Sman-de Beer F, Moghaddam PH, Huijts P, Stalenhoef AF, Kastelein JJ, van Duijn CM, Havekes LM, Frants RR, van Dijk KW, Smelt AH.

Eur J Hum Genet. 2009 May;17(5):620-8. Epub 2008 Nov 26.PMID: 19034316 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo.

de Haan W, Out R, Berbée JF, van der Hoogt CC, van Dijk KW, van Berkel TJ, Romijn JA, Jukema JW, Havekes LM, Rensen PC.

Biochem Biophys Res Commun. 2008 Dec 26;377(4):1294-8. Epub 2008 Nov 6.PMID: 18992221 [PubMed - indexed for MEDLINE]Related articles

CNTO736, a novel glucagon-like peptide-1 receptor agonist, ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice.

Parlevliet ET, Schröder-van der Elst JP, Corssmit EP, Picha K, O'Neil K, Stojanovic-Susulic V, Ort T, Havekes LM, Romijn JA, Pijl H.

J Pharmacol Exp Ther. 2009 Jan;328(1):240-8. Epub 2008 Oct 10.PMID: 18849357 [PubMed - indexed for MEDLINE]Related articles

Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice.

van der Hoorn JW, de Haan W, Berbée JF, Havekes LM, Jukema JW, Rensen PC, Princen HM.

Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2016-22. Epub 2008 Jul 31.PMID: 18669886 [PubMed - indexed for MEDLINE]Related articlesFree article

Maternal transmission of risk for atherosclerosis.

DeRuiter MC, Alkemade FE, Gittenberger-de Groot AC, Poelmann RE, Havekes LM, van Dijk KW.

Curr Opin Lipidol. 2008 Aug;19(4):333-7. Review.PMID: 18607178 [PubMed - indexed for MEDLINE]Related articles

Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation.

van den Hoek AM, van Heijningen C, Schröder-van der Elst JP, Ouwens DM, Havekes LM, Romijn JA, Kalsbeek A, Pijl H.

Diabetes. 2008 Sep;57(9):2304-10. Epub 2008 Jun 10.PMID: 18544708 [PubMed - indexed for MEDLINE]Related articlesFree article

Gut-brain axis.

Romijn JA, Corssmit EP, Havekes LM, Pijl H.

Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):518-21. Review.PMID: 18542016 [PubMed - indexed for MEDLINE]Related articles

Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin.

de Haan W, de Vries-van der Weij J, van der Hoorn JW, Gautier T, van der Hoogt CC, Westerterp M, Romijn JA, Jukema JW, Havekes LM, Princen HM, Rensen PC.

Circulation. 2008 May 13;117(19):2515-22. Epub 2008 May 5.PMID: 18458167 [PubMed - indexed for MEDLINE]Related articlesFree article

Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery.

Schippers EF, Berbée JF, van Disseldorp IM, Versteegh MI, Havekes LM, Rensen PC, van Dissel JT.

Intensive Care Med. 2008 Aug;34(8):1492-7. Epub 2008 Apr 12.PMID: 18408916 [PubMed - indexed for MEDLINE]Related articlesFree article

The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI.

Hu L, van der Hoogt CC, Espirito Santo SM, Out R, Kypreos KE, van Vlijmen BJ, Van Berkel TJ, Romijn JA, Havekes LM, van Dijk KW, Rensen PC.

J Lipid Res. 2008 Jul;49(7):1553-61. Epub 2008 Mar 26.PMID: 18367731 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma apolipoprotein CI protects against mortality from infection in old age.

Berbée JF, Mooijaart SP, de Craen AJ, Havekes LM, van Heemst D, Rensen PC, Westendorp RG.

J Gerontol A Biol Sci Med Sci. 2008 Feb;63(2):122-6.PMID: 18314445 [PubMed - indexed for MEDLINE]Related articles

ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency.

Gerritsen G, van der Hoogt CC, Schaap FG, Voshol PJ, Kypreos KE, Maeda N, Groen AK, Havekes LM, Rensen PC, van Dijk KW.

J Lipid Res. 2008 May;49(5):1048-55. Epub 2008 Feb 10.PMID: 18263930 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis.

Berbée JF, van der Hoogt CC, de Haas CJ, van Kessel KP, Dallinga-Thie GM, Romijn JA, Havekes LM, van Leeuwen HJ, Rensen PC.

Intensive Care Med. 2008 May;34(5):907-11. Epub 2008 Jan 30.PMID: 18231776 [PubMed - indexed for MEDLINE]Related articles

Human apolipoprotein C-I expression in mice impairs learning and memory functions.

Abildayeva K, Berbée JF, Blokland A, Jansen PJ, Hoek FJ, Meijer O, Lütjohann D, Gautier T, Pillot T, De Vente J, Havekes LM, Ramaekers FC, Kuipers F, Rensen PC, Mulder M.

J Lipid Res. 2008 Apr;49(4):856-69. Epub 2007 Dec 26.PMID: 18160739 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male mice.

Korsheninnikova E, Voshol PJ, Baan B, van der Zon GC, Havekes LM, Romijn JA, Maassen JA, Ouwens DM.

Arch Physiol Biochem. 2007 Oct-Dec;113(4-5):173-85.PMID: 18158643 [PubMed - indexed for MEDLINE]Related articles

Leptin deficiency per se dictates body composition and insulin action in ob/ob mice.

van den Hoek AM, Teusink B, Voshol PJ, Havekes LM, Romijn JA, Pijl H.

J Neuroendocrinol. 2008 Jan;20(1):120-7.PMID: 18081560 [PubMed - indexed for MEDLINE]Related articles

Development of atopic dermatitis in mice transgenic for human apolipoprotein C1.

Nagelkerken L, Verzaal P, Lagerweij T, Persoon-Deen C, Berbee JF, Prens EP, Havekes LM, Oranje AP.

J Invest Dermatol. 2008 May;128(5):1165-72. Epub 2007 Nov 29.PMID: 18049452 [PubMed - indexed for MEDLINE]Related articlesFree article

Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice.

van der Hoorn JW, Kleemann R, Havekes LM, Kooistra T, Princen HM, Jukema JW.

J Hypertens. 2007 Dec;25(12):2454-62.PMID: 17984667 [PubMed - indexed for MEDLINE]Related articles

Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet.

Parlevliet ET, Heijboer AC, Schröder-van der Elst JP, Havekes LM, Romijn JA, Pijl H, Corssmit EP.

Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E142-7. Epub 2007 Oct 30.PMID: 17971509 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice.

Westerterp M, Berbée JF, Pires NM, van Mierlo GJ, Kleemann R, Romijn JA, Havekes LM, Rensen PC.

Circulation. 2007 Nov 6;116(19):2173-81. Epub 2007 Oct 22.PMID: 17967778 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma plasminogen activator inhibitor-1 level is not regulated by the hepatic low-density lipoprotein receptor-related protein.

Hu L, Bovenschen N, Havekes LM, van Vlijmen BJ, Tamsma JT.

J Thromb Haemost. 2007 Nov;5(11):2301-4. No abstract available. PMID: 17958748 [PubMed - indexed for MEDLINE]Related articles

Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice.

de Haan W, van der Hoogt CC, Westerterp M, Hoekstra M, Dallinga-Thie GM, Princen HM, Romijn JA, Jukema JW, Havekes LM, Rensen PC.

Atherosclerosis. 2008 Mar;197(1):57-63. Epub 2007 Sep 14.PMID: 17868678 [PubMed - indexed for MEDLINE]Related articles

LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus.

Mulder M, Koopmans G, Wassink G, Al Mansouri G, Simard ML, Havekes LM, Prickaerts J, Blokland A.

Neurosci Res. 2007 Nov;59(3):251-6. Epub 2007 Jul 17.PMID: 17720268 [PubMed - indexed for MEDLINE]Related articles

Intrauterine exposure to maternal atherosclerotic risk factors increases the susceptibility to atherosclerosis in adult life.

Alkemade FE, Gittenberger-de Groot AC, Schiel AE, VanMunsteren JC, Hogers B, van Vliet LS, Poelmann RE, Havekes LM, Willems van Dijk K, DeRuiter MC.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2228-35. Epub 2007 Jul 26.PMID: 17656671 [PubMed - indexed for MEDLINE]Related articlesFree article

The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides.

Moen CJ, Tholens AP, Voshol PJ, de Haan W, Havekes LM, Gargalovic P, Lusis AJ, van Dyk KW, Frants RR, Hofker MH, Rensen PC.

J Lipid Res. 2007 Oct;48(10):2182-92. Epub 2007 Jul 3.PMID: 17609525 [PubMed - indexed for MEDLINE]Related articlesFree article

Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression.

van der Hoogt CC, de Haan W, Westerterp M, Hoekstra M, Dallinga-Thie GM, Romijn JA, Princen HM, Jukema JW, Havekes LM, Rensen PC.

J Lipid Res. 2007 Aug;48(8):1763-71. Epub 2007 May 24.PMID: 17525476 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification.

Westerterp M, Berbée JF, Delsing DJ, Jong MC, Gijbels MJ, Dahlmans VE, Offerman EH, Romijn JA, Havekes LM, Rensen PC.

J Lipid Res. 2007 Jun;48(6):1353-61. Epub 2007 Mar 5.PMID: 17339654 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein CI aggravates atherosclerosis development in ApoE-knockout mice despite mediating cholesterol efflux from macrophages.

Westerterp M, Van Eck M, de Haan W, Offerman EH, Van Berkel TJ, Havekes LM, Rensen PC.

Atherosclerosis. 2007 Nov;195(1):e9-16. Epub 2007 Feb 23.PMID: 17320883 [PubMed - indexed for MEDLINE]Related articles

Inhibition of neointima formation by local delivery of estrogen receptor alpha and beta specific agonists.

Krom YD, Pires NM, Jukema JW, de Vries MR, Frants RR, Havekes LM, van Dijk KW, Quax PH.

Cardiovasc Res. 2007 Jan 1;73(1):217-26. Epub 2006 Nov 10.PMID: 17141206 [PubMed - indexed for MEDLINE]Related articlesFree article

Gut-brain axis: regulation of glucose metabolism.

Heijboer AC, Pijl H, Van den Hoek AM, Havekes LM, Romijn JA, Corssmit EP.

J Neuroendocrinol. 2006 Dec;18(12):883-94. Review.PMID: 17076764 [PubMed - indexed for MEDLINE]Related articles

Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein.

Gautier T, Tietge UJ, Boverhof R, Perton FG, Le Guern N, Masson D, Rensen PC, Havekes LM, Lagrost L, Kuipers F.

J Lipid Res. 2007 Jan;48(1):30-40. Epub 2006 Oct 19.PMID: 17053273 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice.

Hu L, Boesten LS, May P, Herz J, Bovenschen N, Huisman MV, Berbée JF, Havekes LM, van Vlijmen BJ, Tamsma JT.

Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2710-5. Epub 2006 Oct 12.PMID: 17038633 [PubMed - indexed for MEDLINE]Related articlesFree article

Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice.

Korsheninnikova E, van der Zon GC, Voshol PJ, Janssen GM, Havekes LM, Grefhorst A, Kuipers F, Reijngoud DJ, Romijn JA, Ouwens DM, Maassen JA.

Diabetologia. 2006 Dec;49(12):3049-57. Epub 2006 Sep 28.PMID: 17006666 [PubMed - indexed for MEDLINE]Related articles

Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice.

Westerterp M, van der Hoogt CC, de Haan W, Offerman EH, Dallinga-Thie GM, Jukema JW, Havekes LM, Rensen PC.

Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2552-9. Epub 2006 Aug 31.PMID: 16946130 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice.

van den Hoek AM, Heijboer AC, Voshol PJ, Havekes LM, Romijn JA, Corssmit EP, Pijl H.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E238-45. Epub 2006 Aug 29.PMID: 16940471 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation.

Ferreira V, van Dijk KW, Groen AK, Vos RM, van der Kaa J, Gijbels MJ, Havekes LM, Pannekoek H.

Atherosclerosis. 2007 Jun;192(2):283-90. Epub 2006 Aug 30.PMID: 16938301 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsis.

Berbée JF, van der Hoogt CC, Kleemann R, Schippers EF, Kitchens RL, van Dissel JT, Bakker-Woudenberg IA, Havekes LM, Rensen PC.

FASEB J. 2006 Oct;20(12):2162-4. Epub 2006 Aug 25.PMID: 16935938 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual PPARalpha/gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice.

Zadelaar AS, Boesten LS, Jukema JW, van Vlijmen BJ, Kooistra T, Emeis JJ, Lundholm E, Camejo G, Havekes LM.

Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2560-6. Epub 2006 Aug 24.PMID: 16931788 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice.

Duivenvoorden I, Voshol PJ, Rensen PC, van Duyvenvoorde W, Romijn JA, Emeis JJ, Havekes LM, Nieuwenhuizen WF.

Am J Clin Nutr. 2006 Aug;84(2):312-21.PMID: 16895877 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic glucose production is more sensitive to insulin-mediated inhibition than hepatic VLDL-triglyceride production.

den Boer MA, Voshol PJ, Kuipers F, Romijn JA, Havekes LM.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1360-4. Epub 2006 Jul 18.PMID: 16849628 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism.

Henneman P, Schaap FG, Havekes LM, Rensen PC, Frants RR, van Tol A, Hattori H, Smelt AH, van Dijk KW.

Atherosclerosis. 2007 Jul;193(1):129-34. Epub 2006 Jun 13.PMID: 16777114 [PubMed - indexed for MEDLINE]Related articles