PubMed

2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.

Harris CM, Ericsson AM, Argiriadi MA, Barberis C, Borhani DW, Burchat A, Calderwood DJ, Cunha GA, Dixon RW, Frank KE, Johnson EF, Kamens J, Kwak S, Li B, Mullen KD, Perron DC, Wang L, Wishart N, Wu X, Zhang X, Zmetra TR, Talanian RV.

Bioorg Med Chem Lett. 2009 Oct 29. [Epub ahead of print]PMID: 19926477 [PubMed - as supplied by publisher]Related articles

2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.

Argiriadi MA, Ericsson AM, Harris CM, Banach DL, Borhani DW, Calderwood DJ, Demers MD, Dimauro J, Dixon RW, Hardman J, Kwak S, Li B, Mankovich JA, Marcotte D, Mullen KD, Ni B, Pietras M, Sadhukhan R, Sousa S, Tomlinson MJ, Wang L, Xiang T, Talanian RV.

Bioorg Med Chem Lett. 2009 Oct 29. [Epub ahead of print]PMID: 19919896 [PubMed - as supplied by publisher]Related articles

Differential base stacking interactions induced by trimethylene interstrand DNA cross-links in the 5'-CpG-3' and 5'-GpC-3' sequence contexts.

Huang H, Dooley PA, Harris CM, Harris TM, Stone MP.

Chem Res Toxicol. 2009 Nov;22(11):1810-6.PMID: 19916525 [PubMed - in process]Related articlesFree article

Structural perturbations induced by the alpha-anomer of the aflatoxin B(1) formamidopyrimidine adduct in duplex and single-strand DNA.

Brown KL, Voehler MW, Magee SM, Harris CM, Harris TM, Stone MP.

J Am Chem Soc. 2009 Nov 11;131(44):16096-107.PMID: 19831353 [PubMed - in process]Related articlesFree article

Lemierre's syndrome resulting from streptococcal induced otitis media and mastoiditis: a case report.

Harris CM, Johnikin M, Rhodes H, Fuller T, Rana SR, Nabhani H, Hussain D, Kurukumbi M, Jayam-Trouth A, Gajjala J, Farhat F, Mody V.

J Med Case Reports. 2009 Apr 3;3:6658.PMID: 19830121 [PubMed - in process]Related articlesFree article

Biomimetics of human movement: functional or aesthetic?

Harris CM.

Bioinspir Biomim. 2009 Sep;4(3):33001. Epub 2009 Jun 30.PMID: 19567935 [PubMed - indexed for MEDLINE]Related articles

Potentially inappropriate medication prescribing in outpatient practices: prevalence and patient characteristics based on electronic health records.

Buck MD, Atreja A, Brunker CP, Jain A, Suh TT, Palmer RM, Dorr DA, Harris CM, Wilcox AB.

Am J Geriatr Pharmacother. 2009 Apr;7(2):84-92.PMID: 19447361 [PubMed - indexed for MEDLINE]Related articles

Nonpigmented mycobacterial skin abscesses: a rare postoperative complication in a cancer patient.

Harris CM, Kim D, Ghali GE.

J Oral Maxillofac Surg. 2009 Feb;67(2):416-8. No abstract available. PMID: 19138620 [PubMed - indexed for MEDLINE]Related articles

Satisfaction with web-based training in an integrated healthcare delivery network: do age, education, computer skills and attitudes matter?

Atreja A, Mehta NB, Jain AK, Harris C, Ishwaran H, Avital M, Fishleder AJ.

BMC Med Educ. 2008 Oct 15;8:48.PMID: 18922178 [PubMed - indexed for MEDLINE]Related articlesFree article

Using technology to promote gastrointestinal outcomes research: a case for electronic health records.

Atreja A, Achkar JP, Jain AK, Harris CM, Lashner BA.

Am J Gastroenterol. 2008 Sep;103(9):2171-8. Review.PMID: 18844611 [PubMed - indexed for MEDLINE]Related articles

C. Martin Harris, M.D., MBA.

Harris CM.

Health Manag Technol. 2008 Jul;29(7):10. No abstract available. PMID: 18666516 [PubMed - indexed for MEDLINE]Related articles

Evaluating the influence of epidemiological parameters and host ecology on the spread of phocine distemper virus through populations of harbour seals.

Harris CM, Travis JM, Harwood J.

PLoS One. 2008 Jul 16;3(7):e2710.PMID: 18628992 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis of N2-substituted deoxyguanosine nucleosides from 2-fluoro-6-O-(trimethylsilylethyl)-2'-deoxyinosine.

Harris TM, Harris CM.

Curr Protoc Nucleic Acid Chem. 2001 May;Chapter 1:Unit 1.3.PMID: 18428818 [PubMed - indexed for MEDLINE]Related articles

Physicians' perceptions of an electronic health record-based clinical trial alert approach to subject recruitment: a survey.

Embi PJ, Jain A, Harris CM.

BMC Med Inform Decis Mak. 2008 Apr 2;8:13.PMID: 18384682 [PubMed - indexed for MEDLINE]Related articlesFree article

Electronic medical record-assisted design of a cluster-randomized trial to improve diabetes care and outcomes.

Love TE, Cebul RD, Einstadter D, Jain AK, Miller H, Harris CM, Greco PJ, Husak SS, Dawson NV; DIG-IT Investigators.

J Gen Intern Med. 2008 Apr;23(4):383-91.PMID: 18373134 [PubMed - indexed for MEDLINE]Related articlesFree article

3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.

Ji Z, Ahmed AA, Albert DH, Bouska JJ, Bousquet PF, Cunha GA, Diaz G, Glaser KB, Guo J, Harris CM, Li J, Marcotte PA, Moskey MD, Oie T, Pease L, Soni NB, Stewart KD, Davidsen SK, Michaelides MR.

J Med Chem. 2008 Mar 13;51(5):1231-41. Epub 2008 Feb 9.PMID: 18260617 [PubMed - indexed for MEDLINE]Related articles

Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure.

Tang WH, Tong W, Jain A, Francis GS, Harris CM, Young JB.

J Am Coll Cardiol. 2008 Feb 5;51(5):569-76.PMID: 18237687 [PubMed - indexed for MEDLINE]Related articles

Cosmetic surgery considerations in the female patient.

Ghali GE, Harris CM.

Oral Maxillofac Surg Clin North Am. 2007 May;19(2):235-44, vii. Review.PMID: 18088881 [PubMed - indexed for MEDLINE]Related articles

Perioperative management of maxillofacial tumor and reconstruction patients.

Harris CM, Nierzwicki BL, Blanchaert RH Jr.

Oral Maxillofac Surg Clin North Am. 2006 May;18(2):227-39.PMID: 18088826 [PubMed - in process]Related articles

Allelic variation of the FRMD7 gene in congenital idiopathic nystagmus.

Self JE, Shawkat F, Malpas CT, Thomas NS, Harris CM, Hodgkins PR, Chen X, Trump D, Lotery AJ.

Arch Ophthalmol. 2007 Sep;125(9):1255-63.PMID: 17846367 [PubMed - indexed for MEDLINE]Related articlesFree article

The importance of correct phenotyping in Gaucher disease.

Harris CM, Campbell P.

J Child Neurol. 2007 Aug;22(8):1056-7. No abstract available. PMID: 17761664 [PubMed - indexed for MEDLINE]Related articles

Infantile nystagmus adapts to visual demand.

Wiggins D, Woodhouse JM, Margrain TH, Harris CM, Erichsen JT.

Invest Ophthalmol Vis Sci. 2007 May;48(5):2089-94.PMID: 17460265 [PubMed - indexed for MEDLINE]Related articlesFree article

1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.

Dinges J, Albert DH, Arnold LD, Ashworth KL, Akritopoulou-Zanze I, Bousquet PF, Bouska JJ, Cunha GA, Davidsen SK, Diaz GJ, Djuric SW, Gasiecki AF, Gintant GA, Gracias VJ, Harris CM, Houseman KA, Hutchins CW, Johnson EF, Li H, Marcotte PA, Martin RL, Michaelides MR, Nyein M, Sowin TJ, Su Z, Tapang PH, Xia Z, Zhang HQ.

J Med Chem. 2007 May 3;50(9):2011-29. Epub 2007 Apr 11.PMID: 17425296 [PubMed - indexed for MEDLINE]Related articles

Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors.

Akritopoulou-Zanze I, Albert DH, Bousquet PF, Cunha GA, Harris CM, Moskey M, Dinges J, Stewart KD, Sowin TJ.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3136-40. Epub 2007 Mar 15.PMID: 17391959 [PubMed - indexed for MEDLINE]Related articles

Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.

Dai Y, Hartandi K, Ji Z, Ahmed AA, Albert DH, Bauch JL, Bouska JJ, Bousquet PF, Cunha GA, Glaser KB, Harris CM, Hickman D, Guo J, Li J, Marcotte PA, Marsh KC, Moskey MD, Martin RL, Olson AM, Osterling DJ, Pease LJ, Soni NB, Stewart KD, Stoll VS, Tapang P, Reuter DR, Davidsen SK, Michaelides MR.

J Med Chem. 2007 Apr 5;50(7):1584-97. Epub 2007 Mar 8.PMID: 17343372 [PubMed - indexed for MEDLINE]Related articles

Structure of the 1,4-Bis(2'-deoxyadenosin-N(6)-yl)-2S,3S-butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence.

Xu W, Merritt WK, Nechev LV, Harris TM, Harris CM, Lloyd RS, Stone MP.

Chem Res Toxicol. 2007 Feb;20(2):187-98. Epub 2007 Jan 27.PMID: 17256975 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific and efficient binding of xeroderma pigmentosum complementation group A to double-strand/single-strand DNA junctions with 3'- and/or 5'-ssDNA branches.

Yang Z, Roginskaya M, Colis LC, Basu AK, Shell SM, Liu Y, Musich PR, Harris CM, Harris TM, Zou Y.

Biochemistry. 2006 Dec 26;45(51):15921-30. Epub 2006 Dec 19.PMID: 17176115 [PubMed - indexed for MEDLINE]Related articlesFree article

Unraveling the aflatoxin-FAPY conundrum: structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1.

Brown KL, Deng JZ, Iyer RS, Iyer LG, Voehler MW, Stone MP, Harris CM, Harris TM.

J Am Chem Soc. 2006 Nov 29;128(47):15188-99.PMID: 17117870 [PubMed - indexed for MEDLINE]Related articlesFree article

Fine mapping of the X-linked recessive congenital idiopathic nystagmus locus at Xq24-q26.3.

Self JE, Ennis S, Collins A, Shawkat F, Harris CM, Mackey DA, Hodgkins PR, Temple IK, Chen X, Lotery AJ.

Mol Vis. 2006 Oct 18;12:1211-6.PMID: 17102799 [PubMed - indexed for MEDLINE]Related articlesFree article

Infant saccades are not slow.

Garbutt S, Harwood MR, Harris CM.

Dev Med Child Neurol. 2006 Aug;48(8):662-7.PMID: 16836778 [PubMed - indexed for MEDLINE]Related articles

Physician perceptions of an Electronic Health Record-based Clinical Trial Alert system: a survey of study participants.

Embi PJ, Jain A, Harris CM.

AMIA Annu Symp Proc. 2005:949.PMID: 16779236 [PubMed - indexed for MEDLINE]Related articlesFree article

Drug-age alerting for outpatient geriatric prescriptions: a joint study using interoperable drug standards.

Atreja A, Buck M, Jain A, Brunker C, Suh TT, Harris CM, Palmer R, Wilcox A.

AMIA Annu Symp Proc. 2005:886.PMID: 16779173 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of an electronic health record-based Clinical Trial Alert system to enhance recruitment at the point of care.

Embi PJ, Jain A, Clark J, Harris CM.

AMIA Annu Symp Proc. 2005:231-5.PMID: 16779036 [PubMed - indexed for MEDLINE]Related articlesFree article

One size does not fit all: using qualitative methods to inform the development of an Internet portal for multiple sclerosis patients.

Atreja A, Mehta N, Miller D, Moore S, Nichols K, Miller H, Harris CM.

AMIA Annu Symp Proc. 2005:16-20.PMID: 16778993 [PubMed - indexed for MEDLINE]Related articlesFree article

The main sequence of saccades optimizes speed-accuracy trade-off.

Harris CM, Wolpert DM.

Biol Cybern. 2006 Jul;95(1):21-9. Epub 2006 Mar 23.PMID: 16555070 [PubMed - indexed for MEDLINE]Related articlesFree article

Bilateral recurrent laryngeal nerve palsy resulting from treatment with vincristine.

Harris CM, Blanchaert RH.

J Oral Maxillofac Surg. 2006 Apr;64(4):738-9. No abstract available. PMID: 16546662 [PubMed - indexed for MEDLINE]Related articles

How should we advise patients about the contraceptive patch, given the FDA warning?

Thacker HL, Falcone T, Atreja A, Jain A, Harris CM.

Cleve Clin J Med. 2006 Jan;73(1):45-7. No abstract available. PMID: 16444915 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for Escherichia coli polymerase II mutagenic bypass of intrastrand DNA crosslinks.

Kanuri M, Nechev LV, Kiehna SE, Tamura PJ, Harris CM, Harris TM, Lloyd RS.

DNA Repair (Amst). 2005 Dec 8;4(12):1374-80. Epub 2005 Oct 27.PMID: 16257273 [PubMed - indexed for MEDLINE]Related articles

Effect of a clinical trial alert system on physician participation in trial recruitment.

Embi PJ, Jain A, Clark J, Bizjack S, Hornung R, Harris CM.

Arch Intern Med. 2005 Oct 24;165(19):2272-7.PMID: 16246994 [PubMed - indexed for MEDLINE]Related articlesFree article

Microvascular free bone flaps.

Blanchaert RH Jr, Harris CM.

Atlas Oral Maxillofac Surg Clin North Am. 2005 Sep;13(2):151-71. No abstract available. PMID: 16139761 [PubMed - indexed for MEDLINE]Related articles

Structure of the 1,4-bis(2'-deoxyadenosin-N6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide.

Merritt WK, Nechev LV, Scholdberg TA, Dean SM, Kiehna SE, Chang JC, Harris TM, Harris CM, Lloyd RS, Stone MP.

Biochemistry. 2005 Aug 2;44(30):10081-92.PMID: 16042385 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual roles of glycosyl torsion angle conformation and stereochemical configuration in butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adducts: a structural perspective.

Merritt WK, Kowalczyk A, Scholdberg TA, Dean SM, Harris TM, Harris CM, Lloyd RS, Stone MP.

Chem Res Toxicol. 2005 Jul;18(7):1098-107.PMID: 16022502 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence.

Scholdberg TA, Merritt WK, Dean SM, Kowalcyzk A, Harris CM, Harris TM, Rizzo CJ, Lloyd RS, Stone MP.

Biochemistry. 2005 Mar 8;44(9):3327-37.PMID: 15736943 [PubMed - indexed for MEDLINE]Related articles

Mispairing of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA Adduct of butadiene diol epoxide with deoxyguanosine: formation of a dA(anti).dG(anti) pairing interaction.

Scholdberg TA, Nechev LV, Merritt WK, Harris TM, Harris CM, Lloyd RS, Stone MP.

Chem Res Toxicol. 2005 Feb;18(2):145-53.PMID: 15720118 [PubMed - indexed for MEDLINE]Related articles

Responding to the rofecoxib withdrawal crisis: a new model for notifying patients at risk and their health care providers.

Jain A, Atreja A, Harris CM, Lehmann M, Burns J, Young J.

Ann Intern Med. 2005 Feb 1;142(3):182-6.PMID: 15684206 [PubMed - indexed for MEDLINE]Related articlesFree article

Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.

Dormer RL, Harris CM, Clark Z, Pereira MM, Doull IJ, Norez C, Becq F, McPherson MA.

Thorax. 2005 Jan;60(1):55-9.PMID: 15618584 [PubMed - indexed for MEDLINE]Related articlesFree article

Joubert syndrome: long-term follow-up.

Hodgkins PR, Harris CM, Shawkat FS, Thompson DA, Chong K, Timms C, Russell-Eggitt I, Taylor DS, Kriss A.

Dev Med Child Neurol. 2004 Oct;46(10):694-9.PMID: 15473174 [PubMed - indexed for MEDLINE]Related articles

Assessment of CFTR localisation in native airway epithelial cells obtained by nasal brushing.

Harris CM, Mendes F, Dragomir A, Doull IJ, Carvalho-Oliveira I, Bebok Z, Clancy JP, Eubanks V, Sorscher EJ, Roomans GM, Amaral MD, McPherson MA, Penque D, Dormer RL.

J Cyst Fibros. 2004 Aug;3 Suppl 2:43-8. Review.PMID: 15463924 [PubMed - indexed for MEDLINE]Related articles

Stereospecific structural perturbations arising from adenine N(6) butadiene triol adducts in duplex DNA.

Merritt WK, Scholdberg TA, Nechev LV, Harris TM, Harris CM, Lloyd RS, Stone MP.

Chem Res Toxicol. 2004 Aug;17(8):1007-19.PMID: 15310233 [PubMed - indexed for MEDLINE]Related articles

Deterioration of the auditory brainstem response in children with type 3 Gaucher disease.

Campbell PE, Harris CM, Vellodi A.

Neurology. 2004 Jul 27;63(2):385-7.PMID: 15277647 [PubMed - indexed for MEDLINE]Related articles