PubMed

Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection.

Pechhold S, Stouffer M, Walker G, Martel R, Seligmann B, Hang Y, Stein R, Harlan DM, Pechhold K.

Nat Biotechnol. 2009 Nov;27(11):1038-42. Epub 2009 Oct 18.PMID: 19838197 [PubMed - in process]Related articles

Effects of Exenatide Alone and in Combination with Daclizumab on Beta Cell Function in Long-Standing Type 1 Diabetes Mellitus.

Rother KI, Spain LM, Wesley RA, Digon BJ 3rd, Baron A, Chen K, Nelson P, Dosch HM, Palmer J, Brooks-Worrell B, Ring M, Harlan DM.

Diabetes Care. 2009 Oct 6. [Epub ahead of print]PMID: 19808924 [PubMed - as supplied by publisher]Related articles

Current advances and travails in islet transplantation.

Harlan DM, Kenyon NS, Korsgren O, Roep BO; Immunology of Diabetes Society.

Diabetes. 2009 Oct;58(10):2175-84. Review. No abstract available. PMID: 19794074 [PubMed - indexed for MEDLINE]Related articles

Counterpoint: clinical islet transplantation: not ready for prime time.

Khan MH, Harlan DM.

Diabetes Care. 2009 Aug;32(8):1570-4. No abstract available. PMID: 19638528 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of ingested interferon-alpha on beta-cell function in children with new-onset type 1 diabetes.

Rother KI, Brown RJ, Morales MM, Wright E, Duan Z, Campbell C, Hardin DS, Popovic J, McEvoy RC, Harlan DM, Orlander PR, Brod SA.

Diabetes Care. 2009 Jul;32(7):1250-5. Erratum in: Diabetes Care. 2009 Sep;32(9):1751. PMID: 19564474 [PubMed - indexed for MEDLINE]Related articlesFree article

Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.

Craig AT, Gavrilova O, Dwyer NK, Jou W, Pack S, Liu E, Pechhold K, Schmidt M, McAlister VJ, Chiorini JA, Blanchette-Mackie EJ, Harlan DM, Owens RA.

Virol J. 2009 May 18;6:61.PMID: 19450275 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft.

Liu EH, Digon BJ 3rd, Hirshberg B, Chang R, Wood BJ, Neeman Z, Kam A, Wesley RA, Polly SM, Hofmann RM, Rother KI, Harlan DM.

Diabetologia. 2009 Jul;52(7):1369-80. Epub 2009 May 6.PMID: 19418039 [PubMed - indexed for MEDLINE]Related articles

Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations.

Shen HC, Adem A, Ylaya K, Wilson A, He M, Lorang D, Hewitt SM, Pechhold K, Harlan DM, Lubensky IA, Schmidt LS, Linehan WM, Libutti SK.

PLoS One. 2009;4(4):e4897. Epub 2009 Apr 2.PMID: 19340311 [PubMed - indexed for MEDLINE]Related articlesFree article

Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice.

Pechhold K, Koczwara K, Zhu X, Harrison VS, Walker G, Lee J, Harlan DM.

PLoS One. 2009;4(3):e4827. Epub 2009 Mar 16.PMID: 19287497 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function.

Lin HM, Lee JH, Yadav H, Kamaraju AK, Liu E, Zhigang D, Vieira A, Kim SJ, Collins H, Matschinsky F, Harlan DM, Roberts AB, Rane SG.

J Biol Chem. 2009 May 1;284(18):12246-57. Epub 2009 Mar 5.PMID: 19265200 [PubMed - indexed for MEDLINE]Related articles

Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes.

Pechhold K, Zhu X, Harrison VS, Lee J, Chakrabarty S, Koczwara K, Gavrilova O, Harlan DM.

Diabetes. 2009 May;58(5):1175-84. Epub 2009 Feb 19.PMID: 19228810 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytotoxic T cell-mediated diabetes in RIP-CD80 transgenic mice: autoantigen peptide sensitivity and fine specificity.

Pechhold K, Chakrabarty S, Harlan DM.

Ann N Y Acad Sci. 2007 Apr;1103:132-42. Epub 2007 Mar 21.PMID: 17376836 [PubMed - indexed for MEDLINE]Related articles

How much insulin is enough? A quantitative assessment of the transdifferentiaton potential of liver.

Perl S, Hirshberg B, Harlan DM, Tisdale JF.

Diabetologia. 2007 Mar;50(3):690-2. Epub 2007 Jan 13. No abstract available. PMID: 17221213 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.

Ren J, Jin P, Wang E, Liu E, Harlan DM, Li X, Stroncek DF.

J Transl Med. 2007 Jan 3;5:1.PMID: 17201925 [PubMed - in process]Related articlesFree article

T cell-directed therapies: lessons learned and future prospects.

Liu EH, Siegel RM, Harlan DM, O'Shea JJ.

Nat Immunol. 2007 Jan;8(1):25-30. Review.PMID: 17179969 [PubMed - indexed for MEDLINE]Related articles

Islet neogenesis associated protein transgenic mice are resistant to hyperglycemia induced by streptozotocin.

Taylor-Fishwick DA, Bowman A, Hamblet N, Bernard P, Harlan DM, Vinik AI.

J Endocrinol. 2006 Sep;190(3):729-37.PMID: 17003274 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of islet function following islet and pancreas transplantation.

Dy EC, Harlan DM, Rother KI.

Curr Diab Rep. 2006 Aug;6(4):316-22. Review.PMID: 16879785 [PubMed - indexed for MEDLINE]Related articles

Immune intervention with anti-CD3 in diabetes.

Harlan DM, von Herrath M.

Nat Med. 2005 Jul;11(7):716-8. No abstract available. PMID: 16015359 [PubMed - indexed for MEDLINE]Related articles

Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance.

Bagenstose LM, Agarwal RK, Silver PB, Harlan DM, Hoffmann SC, Kampen RL, Chan CC, Caspi RR.

J Immunol. 2005 Jul 1;175(1):124-30.PMID: 15972638 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy.

Brissova M, Fowler MJ, Nicholson WE, Chu A, Hirshberg B, Harlan DM, Powers AC.

J Histochem Cytochem. 2005 Sep;53(9):1087-97. Epub 2005 May 27.PMID: 15923354 [PubMed - indexed for MEDLINE]Related articlesFree article

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.

Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA.

Diabetes. 2005 Jun;54(6):1763-9.PMID: 15919798 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging.

Fowler M, Virostko J, Chen Z, Poffenberger G, Radhika A, Brissova M, Shiota M, Nicholson WE, Shi Y, Hirshberg B, Harlan DM, Jansen ED, Powers AC.

Transplantation. 2005 Apr 15;79(7):768-76.PMID: 15818318 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islet transplantation.

Naftanel MA, Harlan DM.

PLoS Med. 2004 Dec;1(3):e58; quiz e75. Review. No abstract available. PMID: 15630467 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance.

Minn AH, Lan H, Rabaglia ME, Harlan DM, Peculis BA, Attie AD, Shalev A.

Mol Endocrinol. 2005 Mar;19(3):794-803. Epub 2004 Nov 18.PMID: 15550470 [PubMed - indexed for MEDLINE]Related articlesFree article

Pulmonary angiography for the diagnosis of thromboembolic events in the non-human primate.

Neeman Z, Hirshberg B, Tal MG, Wood BJ, Harlan DM.

Transplantation. 2004 Oct 15;78(7):1025-9.PMID: 15480169 [PubMed - indexed for MEDLINE]Related articlesFree article

Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus.

Rother KI, Harlan DM.

J Clin Invest. 2004 Oct;114(7):877-83.PMID: 15467822 [PubMed - indexed for MEDLINE]Related articlesFree article

The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge.

Ferrant JL, Benjamin CD, Cutler AH, Kalled SL, Hsu YM, Garber EA, Hess DM, Shapiro RI, Kenyon NS, Harlan DM, Kirk AD, Burkly LC, Taylor FR.

Int Immunol. 2004 Nov;16(11):1583-94. Epub 2004 Oct 5.PMID: 15466914 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet transplantation as a treatment for diabetes.

Harlan DM, Rother KI.

N Engl J Med. 2004 May 13;350(20):2104; author reply 2104. No abstract available. PMID: 15141057 [PubMed - indexed for MEDLINE]Related articles

Insulinomas and expression of an insulin splice variant.

Minn AH, Kayton M, Lorang D, Hoffmann SC, Harlan DM, Libutti SK, Shalev A.

Lancet. 2004 Jan 31;363(9406):363-7.PMID: 15070567 [PubMed - indexed for MEDLINE]Related articles

Resistin serum levels in type 1 diabetes pre- and post-islet transplantation.

Shalev A, Patterson NB, Hirshberg B, Rother KI, Harlan DM.

Metabolism. 2004 Apr;53(4):403-4.PMID: 15045683 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion in type 1 diabetes.

Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC.

Diabetes. 2004 Feb;53(2):426-33.PMID: 14747294 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene-altered islets for transplant: giant leap or small step?

Harlan DM.

Endocrinology. 2004 Feb;145(2):463-6. Review. No abstract available. PMID: 14739150 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of diabetes in nonhuman primates by means of temporary arterial embolization and selective arterial injection of streptozotocin.

Tal MG, Hirshberg B, Neeman Z, Bunnell D, Soleimanpour S, Bacher J, Patterson N, Chang R, Harlan DM.

Radiology. 2004 Jan;230(1):163-8.PMID: 14695391 [PubMed - indexed for MEDLINE]Related articlesFree article

Survival after pancreas transplantation in patients with diabetes and preserved kidney function.

Venstrom JM, McBride MA, Rother KI, Hirshberg B, Orchard TJ, Harlan DM.

JAMA. 2003 Dec 3;290(21):2817-23. Erratum in: JAMA. 2004 Apr 7;291(13):1566. PMID: 14657065 [PubMed - indexed for MEDLINE]Related articlesFree article

Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience.

Hirshberg B, Rother KI, Digon BJ 3rd, Lee J, Gaglia JL, Hines K, Read EJ, Chang R, Wood BJ, Harlan DM.

Diabetes Care. 2003 Dec;26(12):3288-95.PMID: 14633816 [PubMed - indexed for MEDLINE]Related articlesFree article

State of the art: islet transplantation for the cure of type 1 diabetes mellitus.

Hirshberg B, Rother KI, Digon III BJ, Venstrom J, Harlan DM.

Rev Endocr Metab Disord. 2003 Dec;4(4):381-9. Review. No abstract available. PMID: 14618023 [PubMed - indexed for MEDLINE]Related articles

Sirolimus-induced interstitial pneumonitis in an islet transplant recipient.

Digon BJ 3rd, Rother KI, Hirshberg B, Harlan DM.

Diabetes Care. 2003 Nov;26(11):3191. No abstract available. PMID: 14578266 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of combined treatment with CD25- and CD154-specific monoclonal antibodies in non-human primate allotransplantation.

Xu H, Elster EA, Blair PJ, Burkly LC, Tadaki DK, Harlan DM, Kirk AD.

Am J Transplant. 2003 Nov;3(11):1350-4.PMID: 14525594 [PubMed - indexed for MEDLINE]Related articles

Resistin is expressed in pancreatic islets.

Minn AH, Patterson NB, Pack S, Hoffmann SC, Gavrilova O, Vinson C, Harlan DM, Shalev A.

Biochem Biophys Res Commun. 2003 Oct 17;310(2):641-5.PMID: 14521959 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.

Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, Perfetti R.

Endocrinology. 2003 Dec;144(12):5149-58. Epub 2003 Aug 28.PMID: 12960095 [PubMed - indexed for MEDLINE]Related articlesFree article

Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H).

Kirk AD, Hale DA, Mannon RB, Kleiner DE, Hoffmann SC, Kampen RL, Cendales LK, Tadaki DK, Harlan DM, Swanson SJ.

Transplantation. 2003 Jul 15;76(1):120-9.PMID: 12865797 [PubMed - indexed for MEDLINE]Related articles

Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model.

Hirshberg B, Preston EH, Xu H, Tal MG, Neeman Z, Bunnell D, Soleimanpour S, Hale DA, Kirk AD, Harlan DM.

Transplantation. 2003 Jul 15;76(1):55-60.PMID: 12865786 [PubMed - indexed for MEDLINE]Related articles

Islet transplantation: where do we stand now?

Hirshberg B, Rother KI, Harlan DM.

Diabetes Metab Res Rev. 2003 May-Jun;19(3):175-8; discussion 175. Review.PMID: 12789649 [PubMed - indexed for MEDLINE]Related articles

Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation.

Tadaki DK, Williams A, Lee KP, Kirk AD, Harlan DM.

Xenotransplantation. 2003 May;10(3):252-8.PMID: 12694545 [PubMed - indexed for MEDLINE]Related articles

Beta cell-specific CD80 (B7-1) expression disrupts tissue protection from autoantigen-specific CTL-mediated diabetes.

Pechhold K, Karges W, Blum C, Boehm BO, Harlan DM.

J Autoimmun. 2003 Feb;20(1):1-13.PMID: 12604308 [PubMed - indexed for MEDLINE]Related articles

Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation.

Xu H, Montgomery SP, Preston EH, Tadaki DK, Hale DA, Harlan DM, Kirk AD.

J Immunol. 2003 Mar 1;170(5):2776-82.PMID: 12594309 [PubMed - indexed for MEDLINE]Related articlesFree article

Histopathological study of intrahepatic islets transplanted in the nonhuman primate model using edmonton protocol immunosuppression.

Hirshberg B, Mog S, Patterson N, Leconte J, Harlan DM.

J Clin Endocrinol Metab. 2002 Dec;87(12):5424-9.PMID: 12466330 [PubMed - indexed for MEDLINE]Related articlesFree article

Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy.

Swanson SJ, Hale DA, Mannon RB, Kleiner DE, Cendales LC, Chamberlain CE, Polly SM, Harlan DM, Kirk AD.

Lancet. 2002 Nov 23;360(9346):1662-4.PMID: 12457792 [PubMed - indexed for MEDLINE]Related articles

Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation.

Montgomery SP, Xu H, Tadaki DK, Celniker A, Burkly LC, Berning JD, Cruzata F, Elster EA, Gray G, Kampen RL, Swanson SJ, Harlan DM, Kirk AD.

Transplantation. 2002 Nov 27;74(10):1365-9.PMID: 12451232 [PubMed - indexed for MEDLINE]Related articles

Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates.

Xu H, Tadaki DK, Elster EA, Burkly LC, Berning JD, Cruzata F, Kampen RL, Montgomery SP, Patterson NB, Harlan DM, Kirk AD.

Transplantation. 2002 Oct 15;74(7):940-3.PMID: 12394834 [PubMed - indexed for MEDLINE]Related articles