PubMed

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development.

Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1832-7. Epub 2009 Jan 30.PMID: 19181853 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma.

Lin W, Kunkler PE, Harding HP, Ron D, Kraig RP, Popko B.

Am J Pathol. 2008 Nov;173(5):1508-17. Epub 2008 Sep 25.PMID: 18818381 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward the discovery of new antifungal agents: the design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p.

Lackey JG, Ron D, Damha MJ, Harding HP.

Nucleic Acids Symp Ser (Oxf). 2008;(52):475-6.PMID: 18776460 [PubMed - in process]Related articlesFree article

Novel function of PERK as a mediator of force-induced apoptosis.

Mak BC, Wang Q, Laschinger C, Lee W, Ron D, Harding HP, Kaufman RJ, Scheuner D, Austin RC, McCulloch CA.

J Biol Chem. 2008 Aug 22;283(34):23462-72. Epub 2008 Jun 11.PMID: 18550523 [PubMed - indexed for MEDLINE]Related articlesFree article

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice.

Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D.

Cell Metab. 2008 Jun;7(6):520-32.PMID: 18522833 [PubMed - indexed for MEDLINE]Related articlesFree article

An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation.

Harding HP, Lackey JG, Hsu HC, Zhang Y, Deng J, Xu RM, Damha MJ, Ron D.

RNA. 2008 Feb;14(2):225-32. Epub 2007 Dec 19.PMID: 18094117 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation.

Su Q, Wang S, Gao HQ, Kazemi S, Harding HP, Ron D, Koromilas AE.

J Biol Chem. 2008 Jan 4;283(1):469-75. Epub 2007 Nov 12.PMID: 17998206 [PubMed - indexed for MEDLINE]Related articlesFree article

Recurrent concussion and risk of depression in retired professional football players.

Guskiewicz KM, Marshall SW, Bailes J, McCrea M, Harding HP Jr, Matthews A, Mihalik JR, Cantu RC.

Med Sci Sports Exerc. 2007 Jun;39(6):903-9.PMID: 17545878 [PubMed - indexed for MEDLINE]Related articles

Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux.

Shang J, Gao N, Kaufman RJ, Ron D, Harding HP, Lehrman MA.

J Cell Biol. 2007 Feb 26;176(5):605-16.PMID: 17325203 [PubMed - indexed for MEDLINE]Related articlesFree article

The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage.

Lin W, Bailey SL, Ho H, Harding HP, Ron D, Miller SD, Popko B.

J Clin Invest. 2007 Feb;117(2):448-56.PMID: 17273557 [PubMed - indexed for MEDLINE]Related articlesFree article

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress.

Blais JD, Addison CL, Edge R, Falls T, Zhao H, Wary K, Koumenis C, Harding HP, Ron D, Holcik M, Bell JC.

Mol Cell Biol. 2006 Dec;26(24):9517-32. Epub 2006 Oct 9.PMID: 17030613 [PubMed - indexed for MEDLINE]Related articlesFree article

Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload.

Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D.

Cell. 2006 Aug 25;126(4):727-39. Erratum in: Cell. 2006 Dec 16;127(6):1284. PMID: 16923392 [PubMed - indexed for MEDLINE]Related articles

Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response.

Benedetti C, Haynes CM, Yang Y, Harding HP, Ron D.

Genetics. 2006 Sep;174(1):229-39. Epub 2006 Jul 2.PMID: 16816413 [PubMed - indexed for MEDLINE]Related articlesFree article

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses.

Berlanga JJ, Ventoso I, Harding HP, Deng J, Ron D, Sonenberg N, Carrasco L, de Haro C.

EMBO J. 2006 Apr 19;25(8):1730-40. Epub 2006 Apr 6.PMID: 16601681 [PubMed - indexed for MEDLINE]Related articlesFree article

Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress.

Lin W, Kemper A, Dupree JL, Harding HP, Ron D, Popko B.

Brain. 2006 May;129(Pt 5):1306-18. Epub 2006 Feb 27.PMID: 16504972 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.

Marciniak SJ, Garcia-Bonilla L, Hu J, Harding HP, Ron D.

J Cell Biol. 2006 Jan 16;172(2):201-9.PMID: 16418533 [PubMed - indexed for MEDLINE]Related articlesFree article

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.

Huang G, Yao J, Zeng W, Mizuno Y, Kamm KE, Stull JT, Harding HP, Ron D, Muallem S.

J Cell Sci. 2006 Jan 1;119(Pt 1):153-61. Epub 2005 Dec 13.PMID: 16352659 [PubMed - indexed for MEDLINE]Related articlesFree article

Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression.

Harding HP, Zhang Y, Khersonsky S, Marciniak S, Scheuner D, Kaufman RJ, Javitt N, Chang YT, Ron D.

Cell Metab. 2005 Dec;2(6):361-71.PMID: 16330322 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate.

Skalet AH, Isler JA, King LB, Harding HP, Ron D, Monroe JG.

J Biol Chem. 2005 Dec 2;280(48):39762-71. Epub 2005 Sep 27.PMID: 16188879 [PubMed - indexed for MEDLINE]Related articlesFree article

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores.

Maurin AC, Jousse C, Averous J, Parry L, Bruhat A, Cherasse Y, Zeng H, Zhang Y, Harding HP, Ron D, Fafournoux P.

Cell Metab. 2005 Apr;1(4):273-7.PMID: 16054071 [PubMed - indexed for MEDLINE]Related articles

Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients.

Kantor L, Harding HP, Ron D, Schiffmann R, Kaneski CR, Kimball SR, Elroy-Stein O.

Hum Genet. 2005 Oct;118(1):99-106. Epub 2005 Oct 28.PMID: 16041584 [PubMed - indexed for MEDLINE]Related articles

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma.

Lin W, Harding HP, Ron D, Popko B.

J Cell Biol. 2005 May 23;169(4):603-12.PMID: 15911877 [PubMed - indexed for MEDLINE]Related articlesFree article

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

Munn DH, Sharma MD, Baban B, Harding HP, Zhang Y, Ron D, Mellor AL.

Immunity. 2005 May;22(5):633-42.PMID: 15894280 [PubMed - indexed for MEDLINE]Related articles

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.

Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J.

Science. 2005 Feb 11;307(5711):935-9.PMID: 15705855 [PubMed - indexed for MEDLINE]Related articlesFree article

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum.

Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D.

Genes Dev. 2004 Dec 15;18(24):3066-77.PMID: 15601821 [PubMed - indexed for MEDLINE]Related articlesFree article

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2.

Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D.

Mol Cell Biol. 2004 Dec;24(23):10161-8.PMID: 15542827 [PubMed - indexed for MEDLINE]Related articlesFree article

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response.

Lu PD, Harding HP, Ron D.

J Cell Biol. 2004 Oct 11;167(1):27-33.PMID: 15479734 [PubMed - indexed for MEDLINE]Related articlesFree article

Activating transcription factor 4 is translationally regulated by hypoxic stress.

Blais JD, Filipenko V, Bi M, Harding HP, Ron D, Koumenis C, Wouters BG, Bell JC.

Mol Cell Biol. 2004 Sep;24(17):7469-82.PMID: 15314157 [PubMed - indexed for MEDLINE]Related articlesFree article

Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones.

Yoneda T, Benedetti C, Urano F, Clark SG, Harding HP, Ron D.

J Cell Sci. 2004 Aug 15;117(Pt 18):4055-66. Epub 2004 Jul 27.PMID: 15280428 [PubMed - indexed for MEDLINE]Related articlesFree article

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.

Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC.

Mol Cell Biol. 2004 Feb;24(3):1365-77.PMID: 14729979 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2.

Lu PD, Jousse C, Marciniak SJ, Zhang Y, Novoa I, Scheuner D, Kaufman RJ, Ron D, Harding HP.

EMBO J. 2004 Jan 14;23(1):169-79. Epub 2004 Jan 8.PMID: 14713949 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells.

Jousse C, Oyadomari S, Novoa I, Lu P, Zhang Y, Harding HP, Ron D.

J Cell Biol. 2003 Nov 24;163(4):767-75.PMID: 14638860 [PubMed - indexed for MEDLINE]Related articlesFree article

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages.

Feng B, Yao PM, Li Y, Devlin CM, Zhang D, Harding HP, Sweeney M, Rong JX, Kuriakose G, Fisher EA, Marks AR, Ron D, Tabas I.

Nat Cell Biol. 2003 Sep;5(9):781-92. Epub 2003 Aug 10.PMID: 12907943 [PubMed - indexed for MEDLINE]Related articles

Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum.

Harding HP, Novoa I, Bertolotti A, Zeng H, Zhang Y, Urano F, Jousse C, Ron D.

Cold Spring Harb Symp Quant Biol. 2001;66:499-508. Review. No abstract available. PMID: 12762052 [PubMed - indexed for MEDLINE]Related articles

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.

Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D.

Mol Cell. 2003 Mar;11(3):619-33.PMID: 12667446 [PubMed - indexed for MEDLINE]Related articles

Stress-induced gene expression requires programmed recovery from translational repression.

Novoa I, Zhang Y, Zeng H, Jungreis R, Harding HP, Ron D.

EMBO J. 2003 Mar 3;22(5):1180-7. Erratum in: EMBO J. 2003 May 1;22(9):2307. PMID: 12606582 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.

Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, Greene LA.

J Neurosci. 2002 Dec 15;22(24):10690-8.PMID: 12486162 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum stress and the development of diabetes: a review.

Harding HP, Ron D.

Diabetes. 2002 Dec;51 Suppl 3:S455-61. Review.PMID: 12475790 [PubMed - indexed for MEDLINE]Related articlesFree article

Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.

Kimball SR, Horetsky RL, Ron D, Jefferson LS, Harding HP.

Am J Physiol Cell Physiol. 2003 Feb;284(2):C273-84. Epub 2002 Oct 3.PMID: 12388085 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of GCN2 in UV-irradiated cells inhibits translation.

Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N.

Curr Biol. 2002 Aug 6;12(15):1279-86.PMID: 12176355 [PubMed - indexed for MEDLINE]Related articles

Transcriptional and translational control in the Mammalian unfolded protein response.

Harding HP, Calfon M, Urano F, Novoa I, Ron D.

Annu Rev Cell Dev Biol. 2002;18:575-99. Epub 2002 Apr 2. Review.PMID: 12142265 [PubMed - indexed for MEDLINE]Related articles

Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease.

Hori O, Ichinoda F, Tamatani T, Yamaguchi A, Sato N, Ozawa K, Kitao Y, Miyazaki M, Harding HP, Ron D, Tohyama M, M Stern D, Ogawa S.

J Cell Biol. 2002 Jun 24;157(7):1151-60. Epub 2002 Jun 24.PMID: 12082077 [PubMed - indexed for MEDLINE]Related articlesFree article

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.

Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D.

Nature. 2002 Jan 3;415(6867):92-6. Erratum in: Nature 2002 Nov 14;420(6912):202. PMID: 11780124 [PubMed - indexed for MEDLINE]Related articles

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival.

Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron D.

Mol Cell. 2001 Jun;7(6):1153-63.PMID: 11430819 [PubMed - indexed for MEDLINE]Related articles

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.

Kumar R, Azam S, Sullivan JM, Owen C, Cavener DR, Zhang P, Ron D, Harding HP, Chen JJ, Han A, White BC, Krause GS, DeGracia DJ.

J Neurochem. 2001 Jun;77(5):1418-21.PMID: 11389192 [PubMed - indexed for MEDLINE]Related articles

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha.

Novoa I, Zeng H, Harding HP, Ron D.

J Cell Biol. 2001 May 28;153(5):1011-22.PMID: 11381086 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulated translation initiation controls stress-induced gene expression in mammalian cells.

Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D.

Mol Cell. 2000 Nov;6(5):1099-108.PMID: 11106749 [PubMed - indexed for MEDLINE]Related articles

Perk is essential for translational regulation and cell survival during the unfolded protein response.

Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D.

Mol Cell. 2000 May;5(5):897-904.PMID: 10882126 [PubMed - indexed for MEDLINE]Related articles

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response.

Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D.

Nat Cell Biol. 2000 Jun;2(6):326-32.PMID: 10854322 [PubMed - indexed for MEDLINE]Related articles

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D.

Science. 2000 Jan 28;287(5453):664-6.PMID: 10650002 [PubMed - indexed for MEDLINE]Related articlesFree article