PubMed

Ion channel regulation by AMPK: the route of hypoxia-response coupling in thecarotid body and pulmonary artery.

Evans AM, Hardie DG, Peers C, Wyatt CN, Viollet B, Kumar P, Dallas ML, Ross F, Ikematsu N, Jordan HL, Barr BL, Rafferty JN, Ogunbayo O.

Ann N Y Acad Sci. 2009 Oct;1177:89-100.PMID: 19845611 [PubMed - indexed for MEDLINE]Related articles

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

Fogarty S, Hardie DG.

Biochim Biophys Acta. 2009 Sep 22. [Epub ahead of print]PMID: 19778642 [PubMed - as supplied by publisher]Related articles

Histological evaluation of AMPK signalling in primary breast cancer.

Hadad SM, Baker L, Quinlan PR, Robertson KE, Bray SE, Thomson G, Kellock D, Jordan LB, Purdie CA, Hardie DG, Fleming S, Thompson AM.

BMC Cancer. 2009 Sep 1;9:307.PMID: 19723334 [PubMed - in process]Related articlesFree article

Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation.

Timmers S, de Vogel-van den Bosch J, Towler MC, Schaart G, Moonen-Kornips E, Mensink RP, Hesselink MK, Hardie DG, Schrauwen P.

J Lipid Res. 2009 Aug 18. [Epub ahead of print]PMID: 19690335 [PubMed - as supplied by publisher]Related articlesFree article

Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase.

Dallas ML, Scragg JL, Wyatt CN, Ross F, Hardie DG, Evans AM, Peers C.

Adv Exp Med Biol. 2009;648:57-63.PMID: 19536465 [PubMed - indexed for MEDLINE]Related articles

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle.

Pehmøller C, Treebak JT, Birk JB, Chen S, Mackintosh C, Hardie DG, Richter EA, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E665-75. Epub 2009 Jun 16.PMID: 19531644 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.

Treebak JT, Frøsig C, Pehmøller C, Chen S, Maarbjerg SJ, Brandt N, MacKintosh C, Zierath JR, Hardie DG, Kiens B, Richter EA, Pilegaard H, Wojtaszewski JF.

Diabetologia. 2009 May;52(5):891-900. Epub 2009 Feb 28.PMID: 19252894 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase--a sensor of glycogen as well as AMP and ATP?

McBride A, Hardie DG.

Acta Physiol (Oxf). 2009 May;196(1):99-113. Epub 2009 Feb 19.PMID: 19245651 [PubMed - in process]Related articles

Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status.

Babraj JA, Mustard K, Sutherland C, Towler MC, Chen S, Smith K, Green K, Leese G, Hardie DG, Rennie MJ, Cuthbertson DJ.

Am J Physiol Endocrinol Metab. 2009 May;296(5):E1042-8. Epub 2009 Feb 3.PMID: 19190259 [PubMed - indexed for MEDLINE]Related articles

The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor.

McBride A, Ghilagaber S, Nikolaev A, Hardie DG.

Cell Metab. 2009 Jan 7;9(1):23-34.PMID: 19117544 [PubMed - indexed for MEDLINE]Related articlesFree article

C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.

Fogarty S, Hardie DG.

J Biol Chem. 2009 Jan 2;284(1):77-84. Epub 2008 Oct 14.PMID: 18854318 [PubMed - indexed for MEDLINE]Related articlesFree article

Small molecules can have big effects on endurance.

Baar K, Hardie DG.

Nat Chem Biol. 2008 Oct;4(10):583-4. No abstract available. PMID: 18800044 [PubMed - indexed for MEDLINE]Related articles

AMPK: a key regulator of energy balance in the single cell and the whole organism.

Hardie DG.

Int J Obes (Lond). 2008 Sep;32 Suppl 4:S7-12. Review.PMID: 18719601 [PubMed - indexed for MEDLINE]Related articles

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.

Towler MC, Fogarty S, Hawley SA, Pan DA, Martin DM, Morrice NA, McCarthy A, Galardo MN, Meroni SB, Cigorraga SB, Ashworth A, Sakamoto K, Hardie DG.

Biochem J. 2008 Nov 15;416(1):1-14.PMID: 18774945 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase and hypoxic pulmonary vasoconstriction.

Robertson TP, Mustard KJ, Lewis TH, Clark JH, Wyatt CN, Blanco EA, Peers C, Hardie DG, Evans AM.

Eur J Pharmacol. 2008 Oct 24;595(1-3):39-43. Epub 2008 Jul 30.PMID: 18703047 [PubMed - indexed for MEDLINE]Related articles

AMPK and Raptor: matching cell growth to energy supply.

Hardie DG.

Mol Cell. 2008 May 9;30(3):263-5.PMID: 18471972 [PubMed - indexed for MEDLINE]Related articles

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice.

Mooney MH, Fogarty S, Stevenson C, Gallagher AM, Palit P, Hawley SA, Hardie DG, Coxon GD, Waigh RD, Tate RJ, Harvey AL, Furman BL.

Br J Pharmacol. 2008 Apr;153(8):1669-77. Epub 2008 Feb 25.PMID: 18297106 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice.

McGee SL, Mustard KJ, Hardie DG, Baar K.

J Physiol. 2008 Mar 15;586(6):1731-41. Epub 2008 Jan 17.PMID: 18202101 [PubMed - indexed for MEDLINE]Related articlesFree article

How I became a biochemist.

Hardie DG.

IUBMB Life. 2007 Dec;59(12):793-6. No abstract available. PMID: 18085479 [PubMed - indexed for MEDLINE]Related articles

Key roles for AMP-activated protein kinase in the function of the carotid body?

Wyatt CN, Pearson SA, Kumar P, Peers C, Hardie DG, Evans AM.

Adv Exp Med Biol. 2008;605:63-8.PMID: 18085248 [PubMed - indexed for MEDLINE]Related articles

Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation.

Pallottini V, Martini C, Cavallini G, Bergamini E, Mustard KJ, Hardie DG, Trentalance A.

Mech Ageing Dev. 2007 Nov-Dec;128(11-12):688-95. Epub 2007 Oct 16.PMID: 18031790 [PubMed - indexed for MEDLINE]Related articles

Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.

Hardie DG.

FEBS Lett. 2008 Jan 9;582(1):81-9. Epub 2007 Nov 20. Review.PMID: 18022388 [PubMed - indexed for MEDLINE]Related articles

AMPK and SNF1: Snuffing Out Stress.

Hardie DG.

Cell Metab. 2007 Nov;6(5):339-40.PMID: 17983576 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K.

J Biol Chem. 2007 Nov 9;282(45):32549-60. Epub 2007 Sep 12.PMID: 17855357 [PubMed - indexed for MEDLINE]Related articlesFree article

De-phosphorylation of MyoD is linking nerve-evoked activity to fast myosin heavy chain expression in rodent adult skeletal muscle.

Ekmark M, Rana ZA, Stewart G, Hardie DG, Gundersen K.

J Physiol. 2007 Oct 15;584(Pt 2):637-50. Epub 2007 Aug 30.PMID: 17761773 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

Hardie DG.

Nat Rev Mol Cell Biol. 2007 Oct;8(10):774-85. Review.PMID: 17712357 [PubMed - indexed for MEDLINE]Related articles

Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase.

Akman HO, Sampayo JN, Ross FA, Scott JW, Wilson G, Benson L, Bruno C, Shanske S, Hardie DG, Dimauro S.

Pediatr Res. 2007 Oct;62(4):499-504.PMID: 17667862 [PubMed - indexed for MEDLINE]Related articles

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

Geraghty KM, Chen S, Harthill JE, Ibrahim AF, Toth R, Morrice NA, Vandermoere F, Moorhead GB, Hardie DG, MacKintosh C.

Biochem J. 2007 Oct 15;407(2):231-41.PMID: 17617058 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells.

Woollhead AM, Sivagnanasundaram J, Kalsi KK, Pucovsky V, Pellatt LJ, Scott JW, Mustard KJ, Hardie DG, Baines DL.

Br J Pharmacol. 2007 Aug;151(8):1204-15. Epub 2007 Jul 2.PMID: 17603555 [PubMed - indexed for MEDLINE]Related articlesFree article

5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.

Cuthbertson DJ, Babraj JA, Mustard KJ, Towler MC, Green KA, Wackerhage H, Leese GP, Baar K, Thomason-Hughes M, Sutherland C, Hardie DG, Rennie MJ.

Diabetes. 2007 Aug;56(8):2078-84. Epub 2007 May 18.PMID: 17513706 [PubMed - indexed for MEDLINE]Related articlesFree article

A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.

Viana R, Towler MC, Pan DA, Carling D, Viollet B, Hardie DG, Sanz P.

J Biol Chem. 2007 Jun 1;282(22):16117-25. Epub 2007 Apr 2.PMID: 17403675 [PubMed - indexed for MEDLINE]Related articlesFree article

Biochemistry. Balancing cellular energy.

Hardie DG.

Science. 2007 Mar 23;315(5819):1671-2. No abstract available. PMID: 17379794 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase in metabolic control and insulin signaling.

Towler MC, Hardie DG.

Circ Res. 2007 Feb 16;100(3):328-41. Review.PMID: 17307971 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.

Reihill JA, Ewart MA, Hardie DG, Salt IP.

Biochem Biophys Res Commun. 2007 Mar 23;354(4):1084-8. Epub 2007 Jan 29.PMID: 17276402 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.

Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ, Liu ZX, Dong J, Mustard KJ, Hawley SA, Befroy D, Pypaert M, Hardie DG, Young LH, Shulman GI.

Cell Metab. 2007 Feb;5(2):151-6.PMID: 17276357 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit.

Scott JW, Ross FA, Liu JK, Hardie DG.

EMBO J. 2007 Feb 7;26(3):806-15. Epub 2007 Jan 25.PMID: 17255938 [PubMed - indexed for MEDLINE]Related articlesFree article

A neural protection racket: AMPK and the GABA(B) receptor.

Hardie DG, Frenguelli BG.

Neuron. 2007 Jan 18;53(2):159-62.PMID: 17224398 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase mediates carotid body excitation by hypoxia.

Wyatt CN, Mustard KJ, Pearson SA, Dallas ML, Atkinson L, Kumar P, Peers C, Hardie DG, Evans AM.

J Biol Chem. 2007 Mar 16;282(11):8092-8. Epub 2006 Dec 19.PMID: 17179156 [PubMed - indexed for MEDLINE]Related articlesFree article

PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion.

Pilegaard H, Birk JB, Sacchetti M, Mourtzakis M, Hardie DG, Stewart G, Neufer PD, Saltin B, van Hall G, Wojtaszewski JF.

Diabetes. 2006 Nov;55(11):3020-7.PMID: 17065338 [PubMed - indexed for MEDLINE]Related articlesFree article

Neither LKB1 nor AMPK are the direct targets of metformin.

Hardie DG.

Gastroenterology. 2006 Sep;131(3):973; author reply 974-5. No abstract available. PMID: 16952573 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase as a drug target.

Hardie DG.

Annu Rev Pharmacol Toxicol. 2007;47:185-210. Review.PMID: 16879084 [PubMed - indexed for MEDLINE]Related articles

Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise.

Roepstorff C, Donsmark M, Thiele M, Vistisen B, Stewart G, Vissing K, Schjerling P, Hardie DG, Galbo H, Kiens B.

Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1106-14. Epub 2006 Jul 5.PMID: 16822962 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

Tamás P, Hawley SA, Clarke RG, Mustard KJ, Green K, Hardie DG, Cantrell DA.

J Exp Med. 2006 Jul 10;203(7):1665-70. Epub 2006 Jul 3.PMID: 16818670 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells.

Evans AM, Hardie DG, Galione A, Peers C, Kumar P, Wyatt CN.

Novartis Found Symp. 2006;272:234-52; discussion 252-8, 274-9. Review.PMID: 16686439 [PubMed - indexed for MEDLINE]Related articles

Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation?

Wyatt CN, Kumar P, Aley P, Peers C, Hardie DG, Evans AM.

Adv Exp Med Biol. 2006;580:191-6; discussion 351-9. No abstract available. PMID: 16683718 [PubMed - indexed for MEDLINE]Related articles

Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to pulmonary artery constriction?

Evans AM, Mustard KJ, Wyatt CN, Dipp M, Kinnear NP, Hardie DG.

Adv Exp Med Biol. 2006;580:147-54; discussion 351-9. No abstract available. PMID: 16683711 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase--development of the energy sensor concept.

Hardie DG, Hawley SA, Scott JW.

J Physiol. 2006 Jul 1;574(Pt 1):7-15. Epub 2006 Apr 27. Review.PMID: 16644800 [PubMed - indexed for MEDLINE]Related articlesFree article

Plectin scaffolds recruit energy-controlling AMP-activated protein kinase (AMPK) in differentiated myofibres.

Gregor M, Zeöld A, Oehler S, Marobela KA, Fuchs P, Weigel G, Hardie DG, Wiche G.

J Cell Sci. 2006 May 1;119(Pt 9):1864-75. Epub 2006 Apr 11.PMID: 16608880 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK: a key sensor of fuel and energy status in skeletal muscle.

Hardie DG, Sakamoto K.

Physiology (Bethesda). 2006 Feb;21:48-60. Review.PMID: 16443822 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK regulation of mouse oocyte meiotic resumption in vitro.

Chen J, Hudson E, Chi MM, Chang AS, Moley KH, Hardie DG, Downs SM.

Dev Biol. 2006 Mar 15;291(2):227-38. Epub 2006 Jan 26.PMID: 16443210 [PubMed - indexed for MEDLINE]Related articles