PubMed

Retinal basement membrane abnormalities and the retinopathy of Alport syndrome.

Savige J, Liu J, Cabrera Debuc D, Handa JT, Hageman GS, Wang YY, Parkin JD, Vote B, Fassett R, Sarks S, Colville D.

Invest Ophthalmol Vis Sci. 2009 Oct 22. [Epub ahead of print]PMID: 19850830 [PubMed - as supplied by publisher]Related articles

Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration.

Cano M, Thimmalappula R, Fujihara M, Nagai N, Sporn M, Wang AL, Neufeld AH, Biswal S, Handa JT.

Vision Res. 2009 Aug 22. [Epub ahead of print]PMID: 19703486 [PubMed - as supplied by publisher]Related articles

Efficacy and pharmacokinetics of intravitreal non-steroidal anti-inflammatory drugs for intraocular inflammation.

Barañano DE, Kim SJ, Edelhauser HF, Durairaj C, Kompella UB, Handa JT.

Br J Ophthalmol. 2009 Oct;93(10):1387-90. Epub 2009 Jul 23.PMID: 19628498 [PubMed - indexed for MEDLINE]Related articles

A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD.

Fujihara M, Bartels E, Nielsen LB, Handa JT.

Exp Eye Res. 2009 Jun;88(6):1115-23. Epub 2009 Feb 7.PMID: 19450445 [PubMed - indexed for MEDLINE]Related articles

Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells.

Wu T, Tian J, Cutler RG, Telljohann RS, Bernlohr DA, Mattson MP, Handa JT.

Lab Invest. 2009 May 11. [Epub ahead of print]PMID: 19434059 [PubMed - as supplied by publisher]Related articles

Nrf2 is a critical modulator of the innate immune response in a model of uveitis.

Nagai N, Thimmulappa RK, Cano M, Fujihara M, Izumi-Nagai K, Kong X, Sporn MB, Kensler TW, Biswal S, Handa JT.

Free Radic Biol Med. 2009 Aug 1;47(3):300-6. Epub 2009 May 3.PMID: 19410644 [PubMed - in process]Related articles

Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degeneration.

Wang AL, Lukas TJ, Yuan M, Du N, Handa JT, Neufeld AH.

PLoS One. 2009;4(4):e5304. Epub 2009 Apr 24.PMID: 19390692 [PubMed - indexed for MEDLINE]Related articlesFree article

Diagnostic and therapeutic challenges.

Leath JD, Eller AW, Freund KB, Handa JT.

Retina. 2009 Apr;29(4):556-9. No abstract available. PMID: 19289989 [PubMed - indexed for MEDLINE]Related articles

CTGF is increased in basal deposits and regulates matrix production through the ERK (p42/p44mapk) MAPK and the p38 MAPK signaling pathways.

Nagai N, Klimava A, Lee WH, Izumi-Nagai K, Handa JT.

Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1903-10. Epub 2008 Nov 14.PMID: 19011018 [PubMed - indexed for MEDLINE]Related articles

Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice.

Fujihara M, Nagai N, Sussan TE, Biswal S, Handa JT.

PLoS One. 2008 Sep 1;3(9):e3119.PMID: 18769672 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved systemic chemotherapy for metastatic testicular choriocarcinoma can result in excellent prognosis for life and vision.

Khurana RN, DiBernardo C, Handa JT.

Arch Ophthalmol. 2008 Jul;126(7):1008-9. No abstract available. PMID: 18625957 [PubMed - indexed for MEDLINE]Related articles

Macular retinal detachment in Hallermann-Streiff syndrome.

Adyanthaya RS, Ying HS, Handa JT, Repka MX.

Arch Ophthalmol. 2008 Feb;126(2):271-3. No abstract available. PMID: 18268225 [PubMed - indexed for MEDLINE]Related articles

Recent trends in the management of rhegmatogenous retinal detachment.

Sodhi A, Leung LS, Do DV, Gower EW, Schein OD, Handa JT.

Surv Ophthalmol. 2008 Jan-Feb;53(1):50-67. Review.PMID: 18191657 [PubMed - indexed for MEDLINE]Related articles

Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells.

Yamada Y, Tian J, Yang Y, Cutler RG, Wu T, Telljohann RS, Mattson MP, Handa JT.

J Neurochem. 2008 May;105(4):1187-97. Epub 2008 Jan 7.PMID: 18182060 [PubMed - indexed for MEDLINE]Related articles

Impact of optical coherence tomography on surgical decision making for epiretinal membranes and vitreomacular traction.

Do DV, Cho M, Nguyen QD, Shah SM, Handa JT, Campochiaro PA, Zimmer-Galler I, Sung JU, Haller JA.

Retina. 2007 Jun;27(5):552-6.PMID: 17558315 [PubMed - indexed for MEDLINE]Related articles

The impact of optical coherence tomography on surgical decision making in epiretinal membrane and vitreomacular traction.

Do DV, Cho M, Nguyen QD, Shah SM, Handa JT, Campochiaro PA, Zimmer-Galler I, Sung JU, Haller JA.

Trans Am Ophthalmol Soc. 2006;104:161-6.PMID: 17471336 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end products and receptors in Fuchs' dystrophy corneas undergoing Descemet's stripping with endothelial keratoplasty.

Wang Z, Handa JT, Green WR, Stark WJ, Weinberg RS, Jun AS.

Ophthalmology. 2007 Aug;114(8):1453-60. Epub 2007 Feb 22.PMID: 17320180 [PubMed - indexed for MEDLINE]Related articles

New molecular histopathologic insights into the pathogenesis of age-related macular degeneration.

Handa JT.

Int Ophthalmol Clin. 2007 Winter;47(1):15-50. Review. No abstract available. PMID: 17237672 [PubMed - indexed for MEDLINE]Related articles

Keratoprosthesis in high-risk pediatric corneal transplantation: first 2 cases.

Botelho PJ, Congdon NG, Handa JT, Akpek EK.

Arch Ophthalmol. 2006 Sep;124(9):1356-7. No abstract available. PMID: 16966638 [PubMed - indexed for MEDLINE]Related articles

A novel mutation in intron 11 of the COL2A1 gene in a patient with type 1 Stickler syndrome.

Leung L, Hyland JC, Young A, Goldberg MF, Handa JT.

Retina. 2006 Jan;26(1):106-9. No abstract available. PMID: 16395149 [PubMed - indexed for MEDLINE]Related articles

The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas.

Yamada Y, Ishibashi K, Ishibashi K, Bhutto IA, Tian J, Lutty GA, Handa JT.

Exp Eye Res. 2006 May;82(5):840-8. Epub 2005 Dec 20.PMID: 16364296 [PubMed - indexed for MEDLINE]Related articles

The expression of native and cultured human retinal pigment epithelial cells grown in different culture conditions.

Tian J, Ishibashi K, Honda S, Boylan SA, Hjelmeland LM, Handa JT.

Br J Ophthalmol. 2005 Nov;89(11):1510-7.PMID: 16234463 [PubMed - indexed for MEDLINE]Related articlesFree article

A phase I trial of stereotactic external beam radiation for subfoveal choroidal neovascular membranes in age-related macular degeneration.

Barak A, Hauser D, Yipp P, Morse L, Leigh B, Kubo D, Goldberg Z, Earle J, Handa JT.

Br J Radiol. 2005 Sep;78(933):827-31.PMID: 16110105 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response.

Tian J, Ishibashi K, Ishibashi K, Reiser K, Grebe R, Biswal S, Gehlbach P, Handa JT.

Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11846-51. Epub 2005 Aug 4.PMID: 16081535 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of retrobulbar and sub-Tenon's capsule injection of local anesthetic in vitreoretinal surgery.

Lai MM, Lai JC, Lee WH, Huang JJ, Patel S, Ying HS, Melia M, Haller JA, Handa JT.

Ophthalmology. 2005 Apr;112(4):574-9.PMID: 15808246 [PubMed - indexed for MEDLINE]Related articles

Light-induced oxidative stress in choroidal endothelial cells in mice.

Wu T, Handa JT, Gottsch JD.

Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1117-23.PMID: 15790868 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal vascular occlusion with overlying vitreous hemorrhage masquerading as a tumor.

Apte RS, Schachat AP, DiBernardo C, Handa JT.

Arch Ophthalmol. 2005 Feb;123(2):272-4. No abstract available. PMID: 15710833 [PubMed - indexed for MEDLINE]Related articles

Systemic non-Hodgkin B-cell lymphoma encountered as a vanishing choroidal mass.

Apte RS, Al-Abdulla NA, Green WR, Schachat AP, DeJong MR, DiBernardo C, Handa JT.

Arch Ophthalmol. 2005 Jan;123(1):105-9. No abstract available. PMID: 15642822 [PubMed - indexed for MEDLINE]Related articles

Similarity of mRNA phenotypes of morphologically normal macular and peripheral retinal pigment epithelial cells in older human eyes.

Ishibashi K, Tian J, Handa JT.

Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3291-301.PMID: 15326154 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of cell cycle related proteins in a rapidly growing uveal malignant melanoma.

Honda S, Hirai T, Handa JT, Okuno T, Saito I.

Retina. 2004 Aug;24(4):646-9.PMID: 15300098 [PubMed - indexed for MEDLINE]Related articles

Ultrastructural aging of the RPE-Bruch's membrane-choriocapillaris complex in the D-galactose-treated mouse.

Ida H, Ishibashi K, Reiser K, Hjelmeland LM, Handa JT.

Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2348-54.PMID: 15223816 [PubMed - indexed for MEDLINE]Related articlesFree article

Topographic and age-dependent expression of heme oxygenase-1 and catalase in the human retinal pigment epithelium.

Miyamura N, Ogawa T, Boylan S, Morse LS, Handa JT, Hjelmeland LM.

Invest Ophthalmol Vis Sci. 2004 May;45(5):1562-5.PMID: 15111615 [PubMed - indexed for MEDLINE]Related articlesFree article

The expression of native and cultured RPE grown on different matrices.

Tian J, Ishibashi K, Handa JT.

Physiol Genomics. 2004 Apr 13;17(2):170-82.PMID: 14982971 [PubMed - indexed for MEDLINE]Related articles

Human RPE cells express the FGFR2IIIc and FGFR3IIIc splice variants and FGF9 as a potential high affinity ligand.

Alizadeh M, Miyamura N, Handa JT, Hjelmeland LM.

Exp Eye Res. 2003 Feb;76(2):249-56.PMID: 12565813 [PubMed - indexed for MEDLINE]Related articles

Distribution of the collagen IV isoforms in human Bruch's membrane.

Chen L, Miyamura N, Ninomiya Y, Handa JT.

Br J Ophthalmol. 2003 Feb;87(2):212-5.PMID: 12543754 [PubMed - indexed for MEDLINE]Related articlesFree article

Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells.

Weigel AL, Handa JT, Hjelmeland LM.

Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.PMID: 12419474 [PubMed - indexed for MEDLINE]Related articles

Senescence associated beta galactosidase activity in human retinal pigment epithelial cells exposed to mild hyperoxia in vitro.

Honda S, Hjelmeland LM, Handa JT.

Br J Ophthalmol. 2002 Feb;86(2):159-62.PMID: 11815340 [PubMed - indexed for MEDLINE]Related articlesFree article

Density-dependent expression of FGF-2 in response to oxidative stress in RPE cells in vitro.

Wada M, Gelfman CM, Matsunaga H, Alizadeh M, Morse L, Handa JT, Hjelmeland LM.

Curr Eye Res. 2001 Sep;23(3):226-31.PMID: 11803485 [PubMed - indexed for MEDLINE]Related articles

Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD).

Rasmussen H, Chu KW, Campochiaro P, Gehlbach PL, Haller JA, Handa JT, Nguyen QD, Sung JU.

Hum Gene Ther. 2001 Nov 1;12(16):2029-32.PMID: 11727737 [PubMed - indexed for MEDLINE]Related articles

Downregulation of differentiation specific gene expression by oxidative stress in ARPE-19 cells.

Alizadeh M, Wada M, Gelfman CM, Handa JT, Hjelmeland LM.

Invest Ophthalmol Vis Sci. 2001 Oct;42(11):2706-13.PMID: 11581219 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of an aging mRNA retinal pigment epithelial cell phenotype by matrix-containing advanced glycation end products in vitro.

Honda S, Farboud B, Hjelmeland LM, Handa JT.

Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2419-25.PMID: 11527959 [PubMed - indexed for MEDLINE]Related articlesFree article

An optimized protocol for first strand cDNA synthesis from laser capture microdissected tissue.

Boylan S, Honda S, Hjelmeland LM, Handa JT.

Lab Invest. 2001 Aug;81(8):1167-9. No abstract available. PMID: 11502868 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress--induced single-strand breaks in chromosomal telomeres of human retinal pigment epithelial cells in vitro.

Honda S, Hjelmeland LM, Handa JT.

Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2139-44.PMID: 11481283 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of telomere shortening and replicative senescence by cryopreservation.

Honda S, Weigel A, Hjelmeland LM, Handa JT.

Biochem Biophys Res Commun. 2001 Mar 30;282(2):493-8.PMID: 11401486 [PubMed - indexed for MEDLINE]Related articles

Age and topographic variation of insulin-like growth factor-binding protein 2 in the human rpe.

Miyamura N, Mishima K, Honda S, Aotaki-Keen AE, Morse LS, Handa JT, Hjelmeland LM.

Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1626-30.PMID: 11381070 [PubMed - indexed for MEDLINE]Related articlesFree article

The use of hyperoxia to induce chronic mild oxidative stress in RPE cells in vitro.

Honda S, Hjelmeland LM, Handa JT.

Mol Vis. 2001 Mar 14;7:63-70.PMID: 11249881 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of advanced glycation end products on lens epithelial cells in vitro.

Hong SB, Lee KW, Handa JT, Joo CK.

Biochem Biophys Res Commun. 2000 Aug 18;275(1):53-9.PMID: 10944440 [PubMed - indexed for MEDLINE]Related articles

The mRNA phenotype of a human RPE cell line at replicative senescence.

Matsunaga H, Handa JT, Gelfman CM, Hjelmeland LM.

Mol Vis. 1999 Dec 29;5:39.PMID: 10617776 [PubMed - indexed for MEDLINE]Related articlesFree article

Utility of pupillary dilation for detecting leukocoria in patients with retinoblastoma.

Canzano JC, Handa JT.

Pediatrics. 1999 Oct;104(4):e44.PMID: 10506269 [PubMed - indexed for MEDLINE]Related articles

Development of a polyclonal antibody with broad epitope specificity for advanced glycation endproducts and localization of these epitopes in Bruch's membrane of the aging eye.

Farboud B, Aotaki-Keen A, Miyata T, Hjelmeland LM, Handa JT.

Mol Vis. 1999 Jul 14;5:11.PMID: 10407062 [PubMed - indexed for MEDLINE]Related articlesFree article