PubMed

Clonal relationships between thyroid-stimulating hormone receptor-stimulating antibodies illustrate the effect of hypermutation on antibody function.

Padoa CJ, Larsen SL, Hampe CS, Gilbert JA, Dagdan E, Hegedus L, Dunn-Walters D, Banga JP.

Immunology. 2009 Oct 21. [Epub ahead of print]PMID: 19845794 [PubMed - as supplied by publisher]Related articles

Comparison of three assays for the detection of GAD65Ab-specific anti-idiotypic antibodies.

Oak S, Radtke J, Landin-Olsson M, Törn C, Lernmark A, Hampe CS.

J Immunol Methods. 2009 Dec 31;351(1-2):55-61. Epub 2009 Sep 23.PMID: 19781546 [PubMed - in process]Related articles

Animal insulin therapy induces a biased insulin antibody response that persists for years after introduction of human insulin.

Oak S, Phan TH, Gilliam LK, Hirsch IB, Hampe CS.

Acta Diabetol. 2009 Jun 23. [Epub ahead of print]PMID: 19547910 [PubMed - as supplied by publisher]Related articles

Engineered antibodies for type 1 diabetes.

Hampe CS.

Curr Opin Investig Drugs. 2009 Apr;10(4):336-45. Review.PMID: 19337954 [PubMed - indexed for MEDLINE]Related articles

A-beta-subtype of ketosis-prone diabetes is not predominantly a monogenic diabetic syndrome.

Haaland WC, Scaduto DI, Maldonado MR, Mansouri DL, Nalini R, Iyer D, Patel S, Guthikonda A, Hampe CS, Balasubramanyam A, Metzker ML.

Diabetes Care. 2009 May;32(5):873-7. Epub 2009 Feb 19.PMID: 19228875 [PubMed - indexed for MEDLINE]Related articlesFree article

Latent autoimmune diabetes in an adult.

Maruyama T, Koyama A, Hampe CS.

Ann N Y Acad Sci. 2008 Dec;1150:267-9.PMID: 19120310 [PubMed - indexed for MEDLINE]Related articles

GAD65 autoantibody responses in Japanese latent autoimmune diabetes in adult patients.

Maruyama T, Oak S, Shimada A, Hampe CS.

Diabetes Care. 2008 Aug;31(8):1602-7. Epub 2008 May 16.PMID: 18487477 [PubMed - indexed for MEDLINE]Related articlesFree article

The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes.

Oak S, Gilliam LK, Landin-Olsson M, Törn C, Kockum I, Pennington CR, Rowley MJ, Christie MR, Banga JP, Hampe CS.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5471-6. Epub 2008 Mar 26.PMID: 18367670 [PubMed - indexed for MEDLINE]Related articlesFree article

Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein.

Steed J, Gilliam LK, Harris RA, Lernmark A, Hampe CS.

J Immunol Methods. 2008 May 20;334(1-2):114-21. Epub 2008 Mar 7.PMID: 18353353 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA class II alleles specify phenotypes of ketosis-prone diabetes.

Nalini R, Gaur LK, Maldonado M, Hampe CS, Rodriguez L, Garza G, Lernmark A, Balasubramanyam A.

Diabetes Care. 2008 Jun;31(6):1195-200. Epub 2008 Mar 3.PMID: 18316396 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunobiology of stiff-person syndrome.

Raju R, Hampe CS.

Int Rev Immunol. 2008 Jan-Apr;27(1-2):79-92. Review.PMID: 18300057 [PubMed - indexed for MEDLINE]Related articles

Syndromes of ketosis-prone diabetes mellitus.

Balasubramanyam A, Nalini R, Hampe CS, Maldonado M.

Endocr Rev. 2008 May;29(3):292-302. Epub 2008 Feb 21. Review.PMID: 18292467 [PubMed - indexed for MEDLINE]Related articlesFree article

COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity.

Fenalti G, Hampe CS, Arafat Y, Law RH, Banga JP, Mackay IR, Whisstock JC, Buckle AM, Rowley MJ.

Diabetes. 2008 May;57(5):1293-301. Epub 2008 Jan 9.PMID: 18184926 [PubMed - indexed for MEDLINE]Related articlesFree article

Seasonality of month of birth differs between type 1 diabetes patients with pronounced beta-cell autoimmunity and individuals with lesser or no beta-cell autoimmunity.

Lewy H, Hampe CS, Kordonouri O, Haberland H, Landin-Olsson M, Torn C, Laron Z.

Pediatr Diabetes. 2008 Feb;9(1):46-52. Epub 2007 Nov 23.PMID: 18036133 [PubMed - indexed for MEDLINE]Related articles

Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies.

Hall TR, Bogdani M, Leboeuf RC, Kirk EA, Maziarz M, Banga JP, Oak S, Pennington CA, Hampe CS.

Immunology. 2008 Apr;123(4):547-54. Epub 2007 Nov 14.PMID: 18005036 [PubMed - indexed for MEDLINE]Related articlesFree article

Epitope analysis of GAD65 binding in both cord blood and at the time of clinical diagnosis of childhood type 1 diabetes.

Elfving M, Lindberg B, Lynch K, Ivarsson SA, Lernmark A, Hampe CS.

Horm Metab Res. 2007 Nov;39(11):790-6. Erratum in: Horm Metab Res. 2007 Dec;39(12):922. PMID: 17992632 [PubMed - indexed for MEDLINE]Related articles

Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high-risk human leucocyte antigen class II alleles.

Maruyama T, Oak S, Hall TR, Banga JP, Ortqvist E, Ettinger RA, Endl J, Hampe CS.

Clin Exp Immunol. 2007 Dec;150(3):416-21. Epub 2007 Oct 22.PMID: 17956579 [PubMed - indexed for MEDLINE]Related articlesFree article

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.

Fenalti G, Law RH, Buckle AM, Langendorf C, Tuck K, Rosado CJ, Faux NG, Mahmood K, Hampe CS, Banga JP, Wilce M, Schmidberger J, Rossjohn J, El-Kabbani O, Pike RN, Smith AI, Mackay IR, Rowley MJ, Whisstock JC.

Nat Struct Mol Biol. 2007 Apr;14(4):280-6. Epub 2007 Mar 25.PMID: 17384644 [PubMed - indexed for MEDLINE]Related articles

GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination.

Bekris LM, Jensen RA, Lagerquist E, Hall TR, Agardh CD, Cilio CM, Lethagen AL, Lernmark A, Robertson JA, Hampe CS.

Diabet Med. 2007 May;24(5):521-6. Epub 2007 Mar 15.PMID: 17367313 [PubMed - indexed for MEDLINE]Related articles

Antibodies to GAD65 and peripheral nerve function in the DCCT.

Hoeldtke RD, Hampe CS, Bekris LM, Hobbs G, Bryner KD, Lernmark A; DCCT Research Group.

J Neuroimmunol. 2007 Apr;185(1-2):182-9. Epub 2007 Feb 27.PMID: 17328966 [PubMed - indexed for MEDLINE]Related articles

Longitudinal changes in epitope recognition of autoantibodies against glutamate decarboxylase 65 (GAD65Ab) in prediabetic adults developing diabetes.

Hampe CS, Hall TR, Agren A, Rolandsson O.

Clin Exp Immunol. 2007 Apr;148(1):72-8.PMID: 17286757 [PubMed - indexed for MEDLINE]Related articlesFree article

Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays.

Rui M, Hampe CS, Wang C, Ling Z, Gorus FK, Lernmark A, Pipeleers DG, De Pauw PE.

J Immunol Methods. 2007 Jan 30;319(1-2):133-43. Epub 2006 Dec 14.PMID: 17210161 [PubMed - indexed for MEDLINE]Related articles

Accuracy and predictive value of classification schemes for ketosis-prone diabetes.

Balasubramanyam A, Garza G, Rodriguez L, Hampe CS, Gaur L, Lernmark A, Maldonado MR.

Diabetes Care. 2006 Dec;29(12):2575-9.PMID: 17130187 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of amino-terminal-specific antiglutamate decarboxylase (GAD65) autoantibodies with beta-cell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis-prone diabetes mellitus.

Hampe CS, Nalini R, Maldonado MR, Hall TR, Garza G, Iyer D, Balasubramanyam A.

J Clin Endocrinol Metab. 2007 Feb;92(2):462-7. Epub 2006 Nov 7.PMID: 17090641 [PubMed - indexed for MEDLINE]Related articlesFree article

Longitudinal epitope analysis of insulin-binding antibodies in type 1 diabetes.

Hall TR, Thomas JW, Padoa CJ, Torn C, Landin-Olsson M, Ortqvist E, Hampe CS.

Clin Exp Immunol. 2006 Oct;146(1):9-14.PMID: 16968392 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11.

Fenalti G, Hampe CS, O'connor K, Banga JP, Mackay IR, Rowley MJ, El-Kabbani O.

Mol Immunol. 2007 Feb;44(6):1178-89. Epub 2006 Aug 22.PMID: 16930708 [PubMed - indexed for MEDLINE]Related articles

A highly sensitive immunoassay resistant to autoantibody interference for detection of the diabetes-associated autoantigen glutamic acid decarboxylase 65 in blood and other biological samples.

Waldrop MA, Suckow AT, Hall TR, Hampe CS, Marcovina SM, Chessler SD.

Diabetes Technol Ther. 2006 Apr;8(2):207-18.PMID: 16734550 [PubMed - indexed for MEDLINE]Related articles

Is latent autoimmune diabetes in adults distinct from type 1 diabetes or just type 1 diabetes at an older age?

Palmer JP, Hampe CS, Chiu H, Goel A, Brooks-Worrell BM.

Diabetes. 2005 Dec;54 Suppl 2:S62-7. Review.PMID: 16306342 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoantibodies in diabetes.

Pihoker C, Gilliam LK, Hampe CS, Lernmark A.

Diabetes. 2005 Dec;54 Suppl 2:S52-61. Review.PMID: 16306341 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients.

Raju R, Foote J, Banga JP, Hall TR, Padoa CJ, Dalakas MC, Ortqvist E, Hampe CS.

J Immunol. 2005 Dec 1;175(11):7755-62.PMID: 16301686 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative evaluation of a monoclonal antibody and its fragment as potential markers for pancreatic beta cell mass.

Hampe CS, Wallen AR, Schlosser M, Ziegler M, Sweet IR.

Exp Clin Endocrinol Diabetes. 2005 Jul;113(7):381-7.PMID: 16025399 [PubMed - indexed for MEDLINE]Related articles

Epitope analysis of insulin autoantibodies using recombinant Fab.

Padoa CJ, Crowther NJ, Thomas JW, Hall TR, Bekris LM, Torn C, Landin-Olsson M, Ortqvist E, Palmer JP, Lernmark A, Hampe CS.

Clin Exp Immunol. 2005 Jun;140(3):564-71.PMID: 15932520 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes.

Schlosser M, Banga JP, Madec AM, Binder KA, Strebelow M, Rjasanowski I, Wassmuth R, Gilliam LK, Luo D, Hampe CS.

Diabetologia. 2005 May;48(5):922-30. Epub 2005 Apr 16.PMID: 15834701 [PubMed - indexed for MEDLINE]Related articles

Epitope analysis of GAD65Ab using fusion proteins and rFab.

Binder KA, Banga JP, Madec AM, Ortqvist E, Luo D, Hampe CS.

J Immunol Methods. 2004 Dec;295(1-2):101-9. Epub 2004 Oct 30.PMID: 15627615 [PubMed - indexed for MEDLINE]Related articles

Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.

Maioli M, Alejandro E, Tonolo G, Gilliam LK, Bekris L, Hampe CS, Obinu DA, Manconi A, Puddu L, Lynch K, Lernmark A; Study Group for the Genetics of Diabetes in Sardinia.

J Clin Endocrinol Metab. 2004 Nov;89(11):5675-82.PMID: 15531528 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiplicity of the antibody response to GAD65 in Type I diabetes.

Gilliam LK, Binder KA, Banga JP, Madec AM, Ortqvist E, Kockum I, Luo D, Hampe CS.

Clin Exp Immunol. 2004 Nov;138(2):337-41.PMID: 15498046 [PubMed - indexed for MEDLINE]Related articlesFree article

Conformation-dependent GAD65 autoantibodies in diabetes.

Luo D, Gilliam LK, Greenbaum C, Bekris L, Hampe CS, Daniels T, Richter W, Marcovina SM, Rolandsson O, Landin-Olsson M, Kockum I, Lernmark A.

Diabetologia. 2004 Sep;47(9):1581-91. Epub 2004 Sep 8.PMID: 15365614 [PubMed - indexed for MEDLINE]Related articles

Development of glutamic acid decarboxylase 65 (GAD65) autoantibody assay using biotin-GAD65 fusion protein.

Luo D, Rogers CN, Steed JT, Gilliam LK, Hampe CS, Lernmark A.

J Biotechnol. 2004 Jul 1;111(1):97-104.PMID: 15196774 [PubMed - indexed for MEDLINE]Related articles

Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes.

Maldonado M, Hampe CS, Gaur LK, D'Amico S, Iyer D, Hammerle LP, Bolgiano D, Rodriguez L, Rajan A, Lernmark A, Balasubramanyam A.

J Clin Endocrinol Metab. 2003 Nov;88(11):5090-8.PMID: 14602731 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Abs.

Padoa CJ, Banga JP, Madec AM, Ziegler M, Schlosser M, Ortqvist E, Kockum I, Palmer J, Rolandsson O, Binder KA, Foote J, Luo D, Hampe CS.

Diabetes. 2003 Nov;52(11):2689-95.PMID: 14578287 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular engineering of biotin-glutamic acid decarboxylase 65 fusion protein (Biotin-GAD65) for non-radioactive GAD65 antibody assay.

Luo D, Rogers CN, Hampe CS, Lernmark A.

J Biotechnol. 2003 Aug 15;103(3):249-55.PMID: 12890611 [PubMed - indexed for MEDLINE]Related articles

Islet cell autoantibodies in cord blood from children with blood group incompatibility or hyperbilirubinemia.

Elfving AM, Lindberg BA, Landin-Olsson M, Hampe CS, Lernmark A, Ivarsson SA.

Autoimmunity. 2003 Mar;36(2):111-5.PMID: 12820693 [PubMed - indexed for MEDLINE]Related articles

Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.

Niklasson B, Heller KE, Schønecker B, Bildsøe M, Daniels T, Hampe CS, Widlund P, Simonson WT, Schaefer JB, Rutledge E, Bekris L, Lindberg AM, Johansson S, Ortqvist E, Persson B, Lernmark A.

Int J Exp Diabesity Res. 2003 Jan-Mar;4(1):35-44.PMID: 12745669 [PubMed - indexed for MEDLINE]Related articlesFree article

Immune reactivity to GAD25 in type 1 diabetes mellitus.

Chessler SD, Hampe CS, Ortqvist E, Simonson WT, Bekris L.

Autoimmunity. 2002 Aug;35(5):335-41.PMID: 12515288 [PubMed - indexed for MEDLINE]Related articles

GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoimmune diabetes.

Hampe CS, Kockum I, Landin-Olsson M, Törn C, Ortqvist E, Persson B, Rolandsson O, Palmer J, Lernmark A.

Diabetes Care. 2002 Aug;25(8):1481-2. No abstract available. PMID: 12145258 [PubMed - indexed for MEDLINE]Related articlesFree article

Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65.

Plesner A, Hampe CS, Daniels TL, Hammerle LP, Lernmark A.

Autoimmunity. 2001;34(4):221-30.PMID: 11905848 [PubMed - indexed for MEDLINE]Related articles

Stable GAD65 autoantibody epitope patterns in type 1 diabetes children five years after onset.

Hampe CS, Hammerle LP, Bekris L, Ortqvist E, Persson B, Lernmark A.

J Autoimmun. 2002 Feb;18(1):49-53.PMID: 11869046 [PubMed - indexed for MEDLINE]Related articles

Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.

Hampe CS, Hammerle LP, Falorni A, Robertson J, Lernmark A.

FEBS Lett. 2001 Jan 19;488(3):185-9.PMID: 11163769 [PubMed - indexed for MEDLINE]Related articles

A novel monoclonal antibody specific for the N-terminal end of GAD65.

Hampe CS, Lundgren P, Daniels TL, Hammerle LP, Marcovina SM, Lernmark A.

J Neuroimmunol. 2001 Feb 1;113(1):63-71.PMID: 11137577 [PubMed - indexed for MEDLINE]Related articles

Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes.

Hampe CS, Hammerle LP, Bekris L, Ortqvist E, Kockum I, Rolandsson O, Landin-Olsson M, Törn C, Persson B, Lernmark A.

J Clin Endocrinol Metab. 2000 Dec;85(12):4671-9.PMID: 11134126 [PubMed - indexed for MEDLINE]Related articlesFree article