PubMed

Regulation of Insulin Secretion by Phosphatidylinositol-4,5-Bisphosphate.

Tomas A, Yermen B, Regazzi R, Pessin JE, Halban PA.

Traffic. 2009 Sep 28. [Epub ahead of print]PMID: 19845918 [PubMed - as supplied by publisher]Related articles

Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion.

Bouzakri K, Ribaux P, Halban PA.

J Biol Chem. 2009 Oct 9;284(41):27892-8. Epub 2009 Aug 18.PMID: 19690174 [PubMed - indexed for MEDLINE]Related articles

Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix.

Parnaud G, Hammar E, Ribaux P, Donath MY, Berney T, Halban PA.

Mol Endocrinol. 2009 Aug;23(8):1264-71. Epub 2009 May 14.PMID: 19443607 [PubMed - in process]Related articles

Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function.

Hammar E, Tomas A, Bosco D, Halban PA.

Endocrinology. 2009 May;150(5):2072-9. Epub 2008 Dec 23.PMID: 19106222 [PubMed - indexed for MEDLINE]Related articles

Cell therapy for type 2 diabetes: is it desirable and can we get it?

Halban PA.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:205-11. Review.PMID: 18834449 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 regulates pancreatic alpha-cell mass expansion.

Ellingsgaard H, Ehses JA, Hammar EB, Van Lommel L, Quintens R, Martens G, Kerr-Conte J, Pattou F, Berney T, Pipeleers D, Halban PA, Schuit FC, Donath MY.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13163-8. Epub 2008 Aug 21.PMID: 18719127 [PubMed - indexed for MEDLINE]Related articlesFree article

The right stuff: beta-cell channels, cycles, and sensors.

Halban PA.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1277-8. Epub 2008 Aug 19. No abstract available. PMID: 18713957 [PubMed - indexed for MEDLINE]Related articles

Order! Order! Order in the House! DIAMAP: a road map for European diabetes research.

Halban PA, Smith U.

Diabetologia. 2008 Oct;51(10):1765-7. No abstract available. PMID: 18696048 [PubMed - indexed for MEDLINE]Related articles

Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.

Marzban L, Tomas A, Becker TC, Rosenberg L, Oberholzer J, Fraser PE, Halban PA, Verchere CB.

Diabetes. 2008 Nov;57(11):3045-55. Epub 2008 Aug 11.PMID: 18694973 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, Pattou F, Halban PA, Weir GC, Donath MY.

J Clin Endocrinol Metab. 2008 Oct;93(10):4065-74. Epub 2008 Jul 29.PMID: 18664535 [PubMed - indexed for MEDLINE]Related articlesFree article

[How to explain the rebirth of the beta cell in terms of sacrifice and delivery]

Halban PA.

Journ Annu Diabetol Hotel Dieu. 2007:171-9. French. No abstract available. PMID: 18610768 [PubMed - indexed for MEDLINE]Related articles

Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.

Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.

Diabetes. 2008 May;57(5):1195-204. Epub 2008 Feb 14.PMID: 18276765 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion.

Jaques F, Jousset H, Tomas A, Prost AL, Wollheim CB, Irminger JC, Demaurex N, Halban PA.

Endocrinology. 2008 May;149(5):2494-505. Epub 2008 Jan 24.PMID: 18218692 [PubMed - indexed for MEDLINE]Related articlesFree article

Munc 18-1 and granuphilin collaborate during insulin granule exocytosis.

Tomas A, Meda P, Regazzi R, Pessin JE, Halban PA.

Traffic. 2008 May;9(5):813-32. Epub 2008 Jan 19.PMID: 18208509 [PubMed - indexed for MEDLINE]Related articles

Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.

Klinger S, Poussin C, Debril MB, Dolci W, Halban PA, Thorens B.

Diabetes. 2008 Mar;57(3):584-93. Epub 2007 Nov 19.PMID: 18025410 [PubMed - indexed for MEDLINE]Related articlesFree article

Proliferation of sorted human and rat beta cells.

Parnaud G, Bosco D, Berney T, Pattou F, Kerr-Conte J, Donath MY, Bruun C, Mandrup-Poulsen T, Billestrup N, Halban PA.

Diabetologia. 2008 Jan;51(1):91-100. Epub 2007 Nov 10.PMID: 17994216 [PubMed - indexed for MEDLINE]Related articles

Dynamin is functionally coupled to insulin granule exocytosis.

Min L, Leung YM, Tomas A, Watson RT, Gaisano HY, Halban PA, Pessin JE, Hou JC.

J Biol Chem. 2007 Nov 16;282(46):33530-6. Epub 2007 Sep 11.PMID: 17848579 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells.

Ribaux P, Ehses JA, Lin-Marq N, Carrozzino F, Böni-Schnetzler M, Hammar E, Irminger JC, Donath MY, Halban PA.

Endocrinology. 2007 Nov;148(11):5582-90. Epub 2007 Aug 16.PMID: 17702850 [PubMed - indexed for MEDLINE]Related articlesFree article

The innovative medicines initiative (IMI): a shot in the arm for European diabetes research?

Halban PA.

Diabetologia. 2007 Sep;50(9):1791-4. Epub 2007 Jul 5. No abstract available. PMID: 17611733 [PubMed - indexed for MEDLINE]Related articles

Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity.

Bosco D, Rouiller DG, Halban PA.

J Endocrinol. 2007 Jul;194(1):21-9.PMID: 17592017 [PubMed - indexed for MEDLINE]Related articlesFree article

Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice.

Herbach N, Rathkolb B, Kemter E, Pichl L, Klaften M, de Angelis MH, Halban PA, Wolf E, Aigner B, Wanke R.

Diabetes. 2007 May;56(5):1268-76. Epub 2007 Feb 15.PMID: 17303807 [PubMed - indexed for MEDLINE]Related articlesFree article

The Fas pathway is involved in pancreatic beta cell secretory function.

Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. Epub 2007 Feb 13.PMID: 17299038 [PubMed - indexed for MEDLINE]Related articlesFree article

Pro-survival role of gelsolin in mouse beta-cells.

Yermen B, Tomas A, Halban PA.

Diabetes. 2007 Jan;56(1):80-7.PMID: 17192468 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.

Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, Verchere CB.

Diabetes. 2006 Aug;55(8):2192-201.PMID: 16873681 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockade of beta1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix.

Parnaud G, Hammar E, Rouiller DG, Armanet M, Halban PA, Bosco D.

Diabetes. 2006 May;55(5):1413-20.PMID: 16644699 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway.

Tomas A, Yermen B, Min L, Pessin JE, Halban PA.

J Cell Sci. 2006 May 15;119(Pt 10):2156-67. Epub 2006 Apr 25.PMID: 16638805 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes research investment in the European Union.

Halban PA, Ferrannini E, Nerup J.

Nat Med. 2006 Jan;12(1):70-2. No abstract available. PMID: 16397573 [PubMed - indexed for MEDLINE]Related articles

Activation of NF-kappaB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells.

Hammar EB, Irminger JC, Rickenbach K, Parnaud G, Ribaux P, Bosco D, Rouiller DG, Halban PA.

J Biol Chem. 2005 Aug 26;280(34):30630-7. Epub 2005 Jun 30.PMID: 15994334 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells.

Wang H, Iezzi M, Theander S, Antinozzi PA, Gauthier BR, Halban PA, Wollheim CB.

Diabetologia. 2005 Apr;48(4):720-31. Epub 2005 Mar 9.PMID: 15756539 [PubMed - indexed for MEDLINE]Related articles

Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine.

Halban PA.

Nat Cell Biol. 2004 Nov;6(11):1021-5. Review.PMID: 15516994 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta.

Zeender E, Maedler K, Bosco D, Berney T, Donath MY, Halban PA.

J Clin Endocrinol Metab. 2004 Oct;89(10):5059-66.PMID: 15472206 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways.

Hammar E, Parnaud G, Bosco D, Perriraz N, Maedler K, Donath M, Rouiller DG, Halban PA.

Diabetes. 2004 Aug;53(8):2034-41.PMID: 15277383 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, Dayer JM, Reinecke M, Halban PA, Donath MY.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8138-43. Epub 2004 May 12.PMID: 15141093 [PubMed - indexed for MEDLINE]Related articlesFree article

Towards a perfect beta cell replacement.

Halban PA.

Semin Cell Dev Biol. 2004 Jun;15(3):325-6. No abstract available. PMID: 15125895 [PubMed - indexed for MEDLINE]Related articles

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.

Donath MY, Halban PA.

Diabetologia. 2004 Mar;47(3):581-9. Epub 2004 Feb 7. Review.PMID: 14767595 [PubMed - indexed for MEDLINE]Related articles

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.

Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB.

Diabetes. 2004 Jan;53(1):141-8.PMID: 14693708 [PubMed - indexed for MEDLINE]Related articlesFree article

Sorting ourselves out: seeking consensus on trafficking in the beta-cell.

Arvan P, Halban PA.

Traffic. 2004 Jan;5(1):53-61.PMID: 14675425 [PubMed - indexed for MEDLINE]Related articles

Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription.

Ritz-Laser B, Gauthier BR, Estreicher A, Mamin A, Brun T, Ris F, Salmon P, Halban PA, Trono D, Philippe J.

Diabetologia. 2003 Jun;46(6):810-21. Epub 2003 Jun 3.PMID: 12783165 [PubMed - indexed for MEDLINE]Related articles

Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines.

Lilla V, Webb G, Rickenbach K, Maturana A, Steiner DF, Halban PA, Irminger JC.

Endocrinology. 2003 Apr;144(4):1368-79.PMID: 12639920 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway.

Halban PA, Irminger JC.

Mol Biol Cell. 2003 Mar;14(3):1195-203.PMID: 12631734 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex.

Thurmond DC, Gonelle-Gispert C, Furukawa M, Halban PA, Pessin JE.

Mol Endocrinol. 2003 Apr;17(4):732-42. Epub 2003 Jan 16.PMID: 12554769 [PubMed - indexed for MEDLINE]Related articlesFree article

Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse.

Izumi T, Yokota-Hashimoto H, Zhao S, Wang J, Halban PA, Takeuchi T.

Diabetes. 2003 Feb;52(2):409-16.PMID: 12540615 [PubMed - indexed for MEDLINE]Related articlesFree article

Truncated (des-[27-31]) C-peptide is not a major secretory product of human islets.

Paoletta M, Kahn SE, Halban PA.

Diabetologia. 2002 Nov;45(11):1523-7. Epub 2002 Oct 9.PMID: 12436335 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis.

Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ.

J Biol Chem. 2003 Jan 3;278(1):471-8. Epub 2002 Oct 29.PMID: 12409292 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY.

J Clin Invest. 2002 Sep;110(6):851-60.PMID: 12235117 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro.

Ris F, Hammar E, Bosco D, Pilloud C, Maedler K, Donath MY, Oberholzer J, Zeender E, Morel P, Rouiller D, Halban PA.

Diabetologia. 2002 Jun;45(6):841-50. Epub 2002 May 8.PMID: 12107728 [PubMed - indexed for MEDLINE]Related articles

Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor.

Trani E, Giorgi A, Canu N, Amadoro G, Rinaldi AM, Halban PA, Ferri GL, Possenti R, Schininà ME, Levi A.

J Neurochem. 2002 May;81(3):565-74.PMID: 12065665 [PubMed - indexed for MEDLINE]Related articles

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication.

Maedler K, Fontana A, Ris F, Sergeev P, Toso C, Oberholzer J, Lehmann R, Bachmann F, Tasinato A, Spinas GA, Halban PA, Donath MY.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8236-41.PMID: 12060768 [PubMed - indexed for MEDLINE]Related articlesFree article

Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells.

Jain RK, Joyce PB, Molinete M, Halban PA, Gorr SU.

Biochem J. 2001 Dec 15;360(Pt 3):645-9.PMID: 11736655 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of clathrin in the regulated secretory pathway of pancreatic beta-cells.

Molinete M, Dupuis S, Brodsky FM, Halban PA.

J Cell Sci. 2001 Aug;114(Pt 16):3059-66.PMID: 11686308 [PubMed - indexed for MEDLINE]Related articlesFree article