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    Results: 30

    1.

    Basic fibroblast growth factor impact on retinoblastoma progression and survival.

    Cebulla CM, Jockovich ME, Piña Y, Boutrid H, Alegret A, Kulak A, Hackam AS, Bhattacharya SK, Feuer WJ, Murray TG.

    Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5215-21. Epub 2008 Jul 9.PMID: 18614803 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Translation of genetic discoveries into clinical therapies.

    Hackam DG, Hackam AS.

    Ann Intern Med. 2008 Feb 5;148(3):246-7. No abstract available. PMID: 18252690 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Regulation of neurotrophin expression and activity in the retina.

    Hackam AS.

    Adv Exp Med Biol. 2008;613:343-9. Review. No abstract available. PMID: 18188963 [PubMed - indexed for MEDLINE]Related articles

    4.

    Identification of two novel activities of the Wnt signaling regulator Dickkopf 3 and characterization of its expression in the mouse retina.

    Nakamura RE, Hunter DD, Yi H, Brunken WJ, Hackam AS.

    BMC Cell Biol. 2007 Dec 19;8:52.PMID: 18093317 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Characterization of Wnt signaling during photoreceptor degeneration.

    Yi H, Nakamura RE, Mohamed O, Dufort D, Hackam AS.

    Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5733-41.PMID: 18055826 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Human embryonic and neuronal stem cell markers in retinoblastoma.

    Seigel GM, Hackam AS, Ganguly A, Mandell LM, Gonzalez-Fernandez F.

    Mol Vis. 2007 Jun 8;13:823-32.PMID: 17615543 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    The Wnt signaling pathway has tumor suppressor properties in retinoblastoma.

    Tell S, Yi H, Jockovich ME, Murray TG, Hackam AS.

    Biochem Biophys Res Commun. 2006 Oct 13;349(1):261-9. Epub 2006 Aug 15.PMID: 16930536 [PubMed - indexed for MEDLINE]Related articles

    8.

    The Wnt signaling pathway in retinal degenerations.

    Hackam AS.

    IUBMB Life. 2005 Jun;57(6):381-8. Review.PMID: 16012046 [PubMed - indexed for MEDLINE]Related articles

    9.

    Comparative gene expression analysis of murine retina and brain.

    Hackam AS, Qian J, Liu D, Gunatilaka T, Farkas RH, Chowers I, Kageyama M, Parmigiani G, Zack DJ.

    Mol Vis. 2004 Aug 31;10:637-49.PMID: 15359217 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse.

    Hackam AS, Strom R, Liu D, Qian J, Wang C, Otteson D, Gunatilaka T, Farkas RH, Chowers I, Kageyama M, Leveillard T, Sahel JA, Campochiaro PA, Parmigiani G, Zack DJ.

    Invest Ophthalmol Vis Sci. 2004 Sep;45(9):2929-42.PMID: 15326104 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Changes in retinal pigment epithelial gene expression induced by rod outer segment uptake.

    Chowers I, Kim Y, Farkas RH, Gunatilaka TL, Hackam AS, Campochiaro PA, Finnemann SC, Zack DJ.

    Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2098-106.PMID: 15223782 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Increased expression of iron-regulating genes in monkey and human glaucoma.

    Farkas RH, Chowers I, Hackam AS, Kageyama M, Nickells RW, Otteson DC, Duh EJ, Wang C, Valenta DF, Gunatilaka TL, Pease ME, Quigley HA, Zack DJ.

    Invest Ophthalmol Vis Sci. 2004 May;45(5):1410-7.PMID: 15111596 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

    Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM.

    Cell Death Differ. 2004 Apr;11(4):424-38.PMID: 14713958 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Gene expression variation in the adult human retina.

    Chowers I, Liu D, Farkas RH, Gunatilaka TL, Hackam AS, Bernstein SL, Campochiaro PA, Parmigiani G, Zack DJ.

    Hum Mol Genet. 2003 Nov 15;12(22):2881-93. Epub 2003 Sep 30.PMID: 14519682 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Identification of novel genes preferentially expressed in the retina using a custom human retina cDNA microarray.

    Chowers I, Gunatilaka TL, Farkas RH, Qian J, Hackam AS, Duh E, Kageyama M, Wang C, Vora A, Campochiaro PA, Zack DJ.

    Invest Ophthalmol Vis Sci. 2003 Sep;44(9):3732-41.PMID: 12939286 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Gene discovery in the embryonic chick retina.

    Hackam AS, Bradford RL, Bakhru RN, Shah RM, Farkas R, Zack DJ, Adler R.

    Mol Vis. 2003 Jun 20;9:262-76.PMID: 12819621 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

    Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW.

    Nat Cell Biol. 2002 Feb;4(2):95-105.PMID: 11788820 [PubMed - indexed for MEDLINE]Related articles

    18.

    Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.

    Hackam AS, Yassa AS, Singaraja R, Metzler M, Gutekunst CA, Gan L, Warby S, Wellington CL, Vaillancourt J, Chen N, Gervais FG, Raymond L, Nicholson DW, Hayden MR.

    J Biol Chem. 2000 Dec 29;275(52):41299-308.PMID: 11007801 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.

    Hackam AS, Hodgson JG, Singaraja R, Zhang T, Gan L, Gutekunst CA, Hersch SM, Hayden MR.

    Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1047-55. Review.PMID: 10434304 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.

    Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE.

    J Biol Chem. 1999 Mar 26;274(13):8730-6.PMID: 10085113 [PubMed - indexed for MEDLINE]Related articlesFree article

    21.

    In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.

    Hackam AS, Singaraja R, Zhang T, Gan L, Hayden MR.

    Hum Mol Genet. 1999 Jan;8(1):25-33.PMID: 9887328 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity.

    Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE.

    J Neurochem. 1999 Jan;72(1):185-95.PMID: 9886069 [PubMed - indexed for MEDLINE]Related articles

    23.

    The fatal attraction of polyglutamine-containing proteins.

    Hackam AS, Wellington CL, Hayden MR.

    Clin Genet. 1998 Apr;53(4):233-42. Review. No abstract available. PMID: 9650759 [PubMed - indexed for MEDLINE]Related articles

    24.

    The influence of huntingtin protein size on nuclear localization and cellular toxicity.

    Hackam AS, Singaraja R, Wellington CL, Metzler M, McCutcheon K, Zhang T, Kalchman M, Hayden MR.

    J Cell Biol. 1998 Jun 1;141(5):1097-105.PMID: 9606203 [PubMed - indexed for MEDLINE]Related articlesFree article

    25.

    Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.

    Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR.

    J Biol Chem. 1998 Apr 10;273(15):9158-67.PMID: 9535906 [PubMed - indexed for MEDLINE]Related articlesFree article

    26.

    Sequences in the amino termini of GABA rho and GABA(A) subunits specify their selective interaction in vitro.

    Hackam AS, Wang TL, Guggino WB, Cutting GR.

    J Neurochem. 1998 Jan;70(1):40-6.PMID: 9422345 [PubMed - indexed for MEDLINE]Related articles

    27.

    A comparison of GABAC and rho subunit receptors from the white perch retina.

    Qian H, Hyatt G, Schanzer A, Hazra R, Hackam AS, Cutting GR, Dowling JE.

    Vis Neurosci. 1997 Sep-Oct;14(5):843-51.PMID: 9364723 [PubMed - indexed for MEDLINE]Related articles

    28.

    The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.

    Hackam AS, Wang TL, Guggino WB, Cutting GR.

    J Biol Chem. 1997 May 23;272(21):13750-7.PMID: 9153229 [PubMed - indexed for MEDLINE]Related articlesFree article

    29.

    A 100 amino acid region in the GABA rho 1 subunit confers robust homo-oligomeric expression.

    Hackam AS, Wang TL, Guggino WB, Cutting GR.

    Neuroreport. 1997 Apr 14;8(6):1425-30.PMID: 9172147 [PubMed - indexed for MEDLINE]Related articles

    30.

    A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition.

    Wang TL, Hackam AS, Guggino WB, Cutting GR.

    Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11751-5.PMID: 8524842 [PubMed - indexed for MEDLINE]Related articlesFree article

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