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Toward an Antibody-Based HIV Vaccine.

Hoxie JA.

Annu Rev Med. 2009 Oct 13. [Epub ahead of print]PMID: 19824826 [PubMed - as supplied by publisher]Related articles

Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.

Agrawal-Gamse C, Lee FH, Haggarty B, Jordan AP, Yi Y, Lee B, Collman RG, Hoxie JA, Doms RW, Laakso MM.

J Virol. 2009 Nov;83(21):11005-15. Epub 2009 Aug 19.PMID: 19692476 [PubMed - in process]Related articles

Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4.

Del Prete GQ, Haggarty B, Leslie GJ, Jordan AP, Romano J, Wang N, Wang J, Holmes MC, Montefiori DC, Hoxie JA.

J Virol. 2009 Oct;83(19):9911-22. Epub 2009 Jul 15.PMID: 19605489 [PubMed - indexed for MEDLINE]Related articles

Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain.

Wu L, Zhou T, Yang ZY, Svehla K, O'Dell S, Louder MK, Xu L, Mascola JR, Burton DR, Hoxie JA, Doms RW, Kwong PD, Nabel GJ.

J Virol. 2009 May;83(10):5077-86. Epub 2009 Mar 4.PMID: 19264769 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor.

Nolan KM, Del Prete GQ, Jordan AP, Haggarty B, Romano J, Leslie GJ, Hoxie JA.

J Virol. 2009 Apr;83(8):3798-809. Epub 2009 Feb 4.PMID: 19193800 [PubMed - indexed for MEDLINE]Related articlesFree article

Human immunodeficiency virus type 2 (HIV-2)/HIV-1 envelope chimeras detect high titers of broadly reactive HIV-1 V3-specific antibodies in human plasma.

Davis KL, Bibollet-Ruche F, Li H, Decker JM, Kutsch O, Morris L, Salomon A, Pinter A, Hoxie JA, Hahn BH, Kwong PD, Shaw GM.

J Virol. 2009 Feb;83(3):1240-59. Epub 2008 Nov 19.PMID: 19019969 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV vaccine research: the way forward.

Fauci AS, Johnston MI, Dieffenbach CW, Burton DR, Hammer SM, Hoxie JA, Martin M, Overbaugh J, Watkins DI, Mahmoud A, Greene WC.

Science. 2008 Jul 25;321(5888):530-2.PMID: 18653883 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization.

Crooks ET, Jiang P, Franti M, Wong S, Zwick MB, Hoxie JA, Robinson JE, Moore PL, Binley JM.

Virology. 2008 Aug 1;377(2):364-78. Epub 2008 Jun 9.PMID: 18539308 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of partial deletions within the human immunodeficiency virus type 1 V3 loop on coreceptor tropism and sensitivity to entry inhibitors.

Nolan KM, Jordan AP, Hoxie JA.

J Virol. 2008 Jan;82(2):664-73. Epub 2007 Oct 31.PMID: 17977968 [PubMed - indexed for MEDLINE]Related articlesFree article

Tuberculosis and HIV coinfection: genesis of the supplement and sponsors' contribution.

Hoxie JA, Miller V, Walker B.

J Infect Dis. 2007 Aug 15;196 Suppl 1:S4. No abstract available. PMID: 17624824 [PubMed - indexed for MEDLINE]Related articles

V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodies.

Laakso MM, Lee FH, Haggarty B, Agrawal C, Nolan KM, Biscone M, Romano J, Jordan AP, Leslie GJ, Meissner EG, Su L, Hoxie JA, Doms RW.

PLoS Pathog. 2007 Aug 24;3(8):e117.PMID: 17722977 [PubMed - indexed for MEDLINE]Related articlesFree article

Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists.

Lin G, Bertolotti-Ciarlet A, Haggarty B, Romano J, Nolan KM, Leslie GJ, Jordan AP, Huang CC, Kwong PD, Doms RW, Hoxie JA.

J Virol. 2007 Sep;81(18):9956-66. Epub 2007 Jul 3.PMID: 17609282 [PubMed - indexed for MEDLINE]Related articlesFree article

Vaccine-delivered HIV envelope inhibits CD4(+) T-cell activation, a mechanism for poor HIV vaccine responses.

Fernando K, Hu H, Ni H, Hoxie JA, Weissman D.

Blood. 2007 Mar 15;109(6):2538-44. Epub 2006 Dec 7.PMID: 17158230 [PubMed - indexed for MEDLINE]Related articlesFree article

A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.

Byland R, Vance PJ, Hoxie JA, Marsh M.

Mol Biol Cell. 2007 Feb;18(2):414-25. Epub 2006 Nov 15.PMID: 17108326 [PubMed - indexed for MEDLINE]Related articlesFree article

A plea for justice for jailed medical workers.

Ahuja SK, Aiuti F, Berkhout B, Biberfeld P, Burton DR, Colizzi V, Deeks SG, Desrosiers RC, Dierich MP, Doms RW, Emerman M, Gallo RC, Girard M, Greene WC, Hoxie JA, Hunter E, Klein G, Korber B, Kuritzkes DR, Lederman MM, Malim MH, Marx PA, McCune JM, McMichael A, Miller C, Miller V, Montagnier L, Montefiori DC, Moore JP, Nixon DF, Overbaugh J, Pauza CD, Richman DD, Saag MS, Sattentau Q, Schooley RT, Shattock R, Shaw GM, Stevenson M, Trkola A, Wainberg MA, Weiss RA, Wolinsky S, Zack JA.

Science. 2006 Nov 10;314(5801):924-5. Epub 2006 Oct 24. No abstract available. PMID: 17062652 [PubMed - indexed for MEDLINE]Related articlesFree article

DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets.

Chaipan C, Soilleux EJ, Simpson P, Hofmann H, Gramberg T, Marzi A, Geier M, Stewart EA, Eisemann J, Steinkasserer A, Suzuki-Inoue K, Fuller GL, Pearce AC, Watson SP, Hoxie JA, Baribaud F, Pöhlmann S.

J Virol. 2006 Sep;80(18):8951-60.PMID: 16940507 [PubMed - indexed for MEDLINE]Related articlesFree article

Simian immunodeficiency virus (SIV)/immunoglobulin G immune complexes in SIV-infected macaques block detection of CD16 but not cytolytic activity of natural killer cells.

Wei Q, Stallworth JW, Vance PJ, Hoxie JA, Fultz PN.

Clin Vaccine Immunol. 2006 Jul;13(7):768-78.PMID: 16829614 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of human immunodeficiency virus type 1 envelope glycoprotein fusion by a membrane-interactive domain in the gp41 cytoplasmic tail.

Wyss S, Dimitrov AS, Baribaud F, Edwards TG, Blumenthal R, Hoxie JA.

J Virol. 2005 Oct;79(19):12231-41.PMID: 16160149 [PubMed - indexed for MEDLINE]Related articlesFree article

Modification of a viral envelope glycoprotein cell-cell fusion assay by utilizing plasmid encoded bacteriophage RNA polymerase.

Lin G, Murphy SL, Gaulton GN, Hoxie JA.

J Virol Methods. 2005 Sep;128(1-2):135-42.PMID: 15941597 [PubMed - indexed for MEDLINE]Related articles

Antigenic conservation and immunogenicity of the HIV coreceptor binding site.

Decker JM, Bibollet-Ruche F, Wei X, Wang S, Levy DN, Wang W, Delaporte E, Peeters M, Derdeyn CA, Allen S, Hunter E, Saag MS, Hoxie JA, Hahn BH, Kwong PD, Robinson JE, Shaw GM.

J Exp Med. 2005 May 2;201(9):1407-19.PMID: 15867093 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of neutralizing antibodies to West Nile virus.

Sánchez MD, Pierson TC, McAllister D, Hanna SL, Puffer BA, Valentine LE, Murtadha MM, Hoxie JA, Doms RW.

Virology. 2005 May 25;336(1):70-82.PMID: 15866072 [PubMed - indexed for MEDLINE]Related articles

Vaccination with an inactivated virulent feline immunodeficiency virus engineered to express high levels of Env.

Hosie MJ, Klein D, Binley JM, Dunsford TH, Jarrett O, Neil JC, Knapp E, Giannecchini S, Matteucci D, Bendinelli M, Hoxie JA, Willett BJ.

J Virol. 2005 Feb;79(3):1954-7.PMID: 15650222 [PubMed - indexed for MEDLINE]Related articlesFree article

Public health. A sound rationale needed for phase III HIV-1 vaccine trials.

Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, Stevenson M, Watkins DI, Wolinsky SM, Zack JA.

Science. 2004 Jan 16;303(5656):316. No abstract available. PMID: 14726576 [PubMed - indexed for MEDLINE]Related articles

CCR5 mimicry by sulfated human anti-HIV-1 antibodies.

Lin G, Hoxie JA.

Cell. 2003 Jul 25;114(2):147-8.PMID: 12887913 [PubMed - indexed for MEDLINE]Related articles

Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.

Lin G, Simmons G, Pöhlmann S, Baribaud F, Ni H, Leslie GJ, Haggarty BS, Bates P, Weissman D, Hoxie JA, Doms RW.

J Virol. 2003 Jan;77(2):1337-46.PMID: 12502850 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins.

Lin G, Baribaud F, Romano J, Doms RW, Hoxie JA.

J Virol. 2003 Jan;77(2):931-42.PMID: 12502809 [PubMed - indexed for MEDLINE]Related articlesFree article

Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus.

Chertova E, Bess Jr JW Jr, Crise BJ, Sowder II RC, Schaden TM, Hilburn JM, Hoxie JA, Benveniste RE, Lifson JD, Henderson LE, Arthur LO.

J Virol. 2002 Jun;76(11):5315-25.PMID: 11991960 [PubMed - indexed for MEDLINE]Related articlesFree article

Truncation of the cytoplasmic domain induces exposure of conserved regions in the ectodomain of human immunodeficiency virus type 1 envelope protein.

Edwards TG, Wyss S, Reeves JD, Zolla-Pazner S, Hoxie JA, Doms RW, Baribaud F.

J Virol. 2002 Mar;76(6):2683-91.PMID: 11861835 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex.

Liu J, Wang S, Hoxie JA, LaBranche CC, Lu M.

J Biol Chem. 2002 Apr 12;277(15):12891-900. Epub 2002 Feb 5.PMID: 11830586 [PubMed - indexed for MEDLINE]Related articlesFree article

Trophoblasts are productively infected by CD4-independent isolate of HIV type 1.

Al-Harthi L, Guilbert LJ, Hoxie JA, Landay A.

AIDS Res Hum Retroviruses. 2002 Jan 1;18(1):13-7.PMID: 11804552 [PubMed - indexed for MEDLINE]Related articles

CD4-independent use of Rhesus CCR5 by human immunodeficiency virus Type 2 implicates an electrostatic interaction between the CCR5 N terminus and the gp120 C4 domain.

Lin G, Lee B, Haggarty BS, Doms RW, Hoxie JA.

J Virol. 2001 Nov;75(22):10766-78.PMID: 11602718 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN.

Baribaud F, Pöhlmann S, Sparwasser T, Kimata MT, Choi YK, Haggarty BS, Ahmad N, Macfarlan T, Edwards TG, Leslie GJ, Arnason J, Reinhart TA, Kimata JT, Littman DR, Hoxie JA, Doms RW.

J Virol. 2001 Nov;75(21):10281-9.PMID: 11581396 [PubMed - indexed for MEDLINE]Related articlesFree article

The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments.

Kim M, Chen B, Hussey RE, Chishti Y, Montefiori D, Hoxie JA, Byron O, Campbell G, Harrison SC, Reinherz EL.

J Biol Chem. 2001 Nov 16;276(46):42667-76. Epub 2001 Sep 5.PMID: 11544255 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein.

Edwards TG, Hoffman TL, Baribaud F, Wyss S, LaBranche CC, Romano J, Adkinson J, Sharron M, Hoxie JA, Doms RW.

J Virol. 2001 Jun;75(11):5230-9.PMID: 11333905 [PubMed - indexed for MEDLINE]Related articlesFree article

Ability of the V3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4.

Means RE, Matthews T, Hoxie JA, Malim MH, Kodama T, Desrosiers RC.

J Virol. 2001 Apr;75(8):3903-15.PMID: 11264379 [PubMed - indexed for MEDLINE]Related articlesFree article

The simian immunodeficiency virus envelope glycoprotein contains multiple signals that regulate its cell surface expression and endocytosis.

Bowers K, Pelchen-Matthews A, Höning S, Vance PJ, Creary L, Haggarty BS, Romano J, Ballensiefen W, Hoxie JA, Marsh M.

Traffic. 2000 Aug;1(8):661-74.PMID: 11208154 [PubMed - indexed for MEDLINE]Related articles

In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail.

Fultz PN, Vance PJ, Endres MJ, Tao B, Dvorin JD, Davis IC, Lifson JD, Montefiori DC, Marsh M, Malim MH, Hoxie JA.

J Virol. 2001 Jan;75(1):278-91.PMID: 11119598 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization and epitope mapping of neutralizing monoclonal antibodies produced by immunization with oligomeric simian immunodeficiency virus envelope protein.

Edinger AL, Ahuja M, Sung T, Baxter KC, Haggarty B, Doms RW, Hoxie JA.

J Virol. 2000 Sep;74(17):7922-35.PMID: 10933700 [PubMed - indexed for MEDLINE]Related articlesFree article

CXCR4 on human endothelial cells can serve as both a mediator of biological responses and as a receptor for HIV-2.

Molino M, Woolkalis MJ, Prevost N, Praticó D, Barnathan ES, Taraboletti G, Haggarty BS, Hesselgesser J, Horuk R, Hoxie JA, Brass LF.

Biochim Biophys Acta. 2000 Feb 21;1500(2):227-40.PMID: 10657592 [PubMed - indexed for MEDLINE]Related articles

Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity.

LaBranche CC, Hoffman TL, Romano J, Haggarty BS, Edwards TG, Matthews TJ, Doms RW, Hoxie JA.

J Virol. 1999 Dec;73(12):10310-9.PMID: 10559349 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection.

Murakami T, Zhang TY, Koyanagi Y, Tanaka Y, Kim J, Suzuki Y, Minoguchi S, Tamamura H, Waki M, Matsumoto A, Fujii N, Shida H, Hoxie JA, Peiper SC, Yamamoto N.

J Virol. 1999 Sep;73(9):7489-96. Erratum in: J Virol 2002 Jan;76(2):933. PMID: 10438838 [PubMed - indexed for MEDLINE]Related articlesFree article

Exclusion of HIV coreceptors CXCR4, CCR5, and CCR3 from the HIV envelope.

Lallos LB, Laal S, Hoxie JA, Zolla-Pazner S, Bandres JC.

AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):895-7.PMID: 10408726 [PubMed - indexed for MEDLINE]Related articles

Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein.

Hoffman TL, LaBranche CC, Zhang W, Canziani G, Robinson J, Chaiken I, Hoxie JA, Doms RW.

Proc Natl Acad Sci U S A. 1999 May 25;96(11):6359-64.PMID: 10339592 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4-independent utilization of the CXCR4 chemokine receptor by HIV-1 and HIV-2.

Hoxie JA, LaBranche CC, Endres MJ, Turner JD, Berson JF, Doms RW, Matthews TJ.

J Reprod Immunol. 1998 Dec;41(1-2):197-211. Review.PMID: 10213311 [PubMed - indexed for MEDLINE]Related articles

Identification of CXCR4 domains that support coreceptor and chemokine receptor functions.

Doranz BJ, Orsini MJ, Turner JD, Hoffman TL, Berson JF, Hoxie JA, Peiper SC, Brass LF, Doms RW.

J Virol. 1999 Apr;73(4):2752-61.PMID: 10074122 [PubMed - indexed for MEDLINE]Related articlesFree article

Construction of single-chain antibodies that bind an overlapping epitope of HIV-1 Nef.

Chang AH, Hoxie JA, Cassol S, O'Shaughnessy M, Jirik F.

FEBS Lett. 1998 Dec 18;441(2):307-12.PMID: 9883905 [PubMed - indexed for MEDLINE]Related articles

Determinant in human immunodeficiency virus type 1 for efficient replication under cytokine-induced CD4(+) T-helper 1 (Th1)- and Th2-type conditions.

Suzuki Y, Koyanagi Y, Tanaka Y, Murakami T, Misawa N, Maeda N, Kimura T, Shida H, Hoxie JA, O'Brien WA, Yamamoto N.

J Virol. 1999 Jan;73(1):316-24.PMID: 9847335 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of CXCR4 and CCR5 endocytosis.

Signoret N, Rosenkilde MM, Klasse PJ, Schwartz TW, Malim MH, Hoxie JA, Marsh M.

J Cell Sci. 1998 Sep;111 ( Pt 18):2819-30.PMID: 9718374 [PubMed - indexed for MEDLINE]Related articlesFree article

The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus.

Willett BJ, Adema K, Heveker N, Brelot A, Picard L, Alizon M, Turner JD, Hoxie JA, Peiper S, Neil JC, Hosie MJ.

J Virol. 1998 Aug;72(8):6475-81. Erratum in: J Virol 1998 Oct;72(10):8460. PMID: 9658090 [PubMed - indexed for MEDLINE]Related articlesFree article

Lessons from the cat: feline immunodeficiency virus as a tool to develop intervention strategies against human immunodeficiency virus type 1.

Elder JH, Dean GA, Hoover EA, Hoxie JA, Malim MH, Mathes L, Neil JC, North TW, Sparger E, Tompkins MB, Tompkins WA, Yamamoto J, Yuhki N, Pedersen NC, Miller RH.

AIDS Res Hum Retroviruses. 1998 Jun 10;14(9):797-801. No abstract available. PMID: 9643379 [PubMed - indexed for MEDLINE]Related articles