PubMed

Tumor platinum concentration following intraperitoneal administration of cisplatin versus carboplatin in an ovarian cancer model.

Jandial DD, Messer K, Farshchi-Heydari S, Pu M, Howell SB.

Gynecol Oncol. 2009 Dec;115(3):362-6. Epub 2009 Sep 22.PMID: 19775736 [PubMed - in process]Related articles

Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane.

Feng Z, Zhao G, Yu L, Gough D, Howell SB.

Cancer Chemother Pharmacol. 2009 Aug 15. [Epub ahead of print]PMID: 19685054 [PubMed - as supplied by publisher]Related articles

Pharmacokinetics and tissue distribution of PGG-paclitaxel, a novel macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460 lung cancer xenografts.

Wang X, Zhao G, Van S, Jiang N, Yu L, Vera D, Howell SB.

Cancer Chemother Pharmacol. 2009 Jul 11. [Epub ahead of print]PMID: 19593566 [PubMed - as supplied by publisher]Related articles

Recombinant CPE fused to tumor necrosis factor targets human ovarian cancer cells expressing the claudin-3 and claudin-4 receptors.

Yuan X, Lin X, Manorek G, Kanatani I, Cheung LH, Rosenblum MG, Howell SB.

Mol Cancer Ther. 2009 Jul;8(7):1906-15. Epub 2009 Jun 30.PMID: 19567823 [PubMed - indexed for MEDLINE]Related articles

Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin.

Blair BG, Larson CA, Safaei R, Howell SB.

Clin Cancer Res. 2009 Jul 1;15(13):4312-21. Epub 2009 Jun 9.PMID: 19509135 [PubMed - indexed for MEDLINE]Related articles

Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1.

Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, Howell SB.

Clin Cancer Res. 2009 Jan 15;15(2):553-60.PMID: 19147760 [PubMed - indexed for MEDLINE]Related articles

Effects of the loss of Atox1 on the cellular pharmacology of cisplatin.

Safaei R, Maktabi MH, Blair BG, Larson CA, Howell SB.

J Inorg Biochem. 2009 Mar;103(3):333-41. Epub 2008 Nov 30.PMID: 19124158 [PubMed - indexed for MEDLINE]Related articles

Prevalence of anthelmintic resistance on sheep and goat farms in the southeastern United States.

Howell SB, Burke JM, Miller JE, Terrill TH, Valencia E, Williams MJ, Williamson LH, Zajac AM, Kaplan RM.

J Am Vet Med Assoc. 2008 Dec 15;233(12):1913-9.PMID: 19072608 [PubMed - indexed for MEDLINE]Related articles

The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs.

Larson CA, Blair BG, Safaei R, Howell SB.

Mol Pharmacol. 2009 Feb;75(2):324-30. Epub 2008 Nov 7.PMID: 18996970 [PubMed - indexed for MEDLINE]Related articles

Dysregulation of purine nucleotide biosynthesis pathways modulates cisplatin cytotoxicity in Saccharomyces cerevisiae.

Kowalski D, Pendyala L, Daignan-Fornier B, Howell SB, Huang RY.

Mol Pharmacol. 2008 Oct;74(4):1092-100. Epub 2008 Jul 8.PMID: 18612078 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacologic principles of intraperitoneal chemotherapy for the treatment of ovarian cancer.

Howell SB.

Int J Gynecol Cancer. 2008 Mar-Apr;18 Suppl 1:20-5. Review.PMID: 18336394 [PubMed - indexed for MEDLINE]Related articles

Transport of cisplatin by the copper efflux transporter ATP7B.

Safaei R, Otani S, Larson BJ, Rasmussen ML, Howell SB.

Mol Pharmacol. 2008 Feb;73(2):461-8. Epub 2007 Oct 31.PMID: 17978167 [PubMed - indexed for MEDLINE]Related articlesFree article

NMR and mutagenesis of human copper transporter 1 (hCtr1) show that Cys-189 is required for correct folding and dimerization.

Lee S, Howell SB, Opella SJ.

Biochim Biophys Acta. 2007 Dec;1768(12):3127-34. Epub 2007 Sep 21.PMID: 17959139 [PubMed - indexed for MEDLINE]Related articlesFree article

Phase I and pharmacokinetic trial of AP5346, a DACH-platinum-polymer conjugate, administered weekly for three out of every 4 weeks to advanced solid tumor patients.

Campone M, Rademaker-Lakhai JM, Bennouna J, Howell SB, Nowotnik DP, Beijnen JH, Schellens JH.

Cancer Chemother Pharmacol. 2007 Sep;60(4):523-33. Epub 2007 Feb 17.PMID: 17308894 [PubMed - indexed for MEDLINE]Related articles

A novel approach for combining the use of in vitro and in vivo data to measure and detect emerging moxidectin resistance in gastrointestinal nematodes of goats.

Kaplan RM, Vidyashankar AN, Howell SB, Neiss JM, Williamson LH, Terrill TH.

Int J Parasitol. 2007 Jun;37(7):795-804. Epub 2007 Jan 14.PMID: 17307184 [PubMed - indexed for MEDLINE]Related articles

Acidic hydrolysis of N-Ethoxybenzylimidazoles (NEBIs): potential applications as pH-sensitive linkers for drug delivery.

Kong SD, Luong A, Manorek G, Howell SB, Yang J.

Bioconjug Chem. 2007 Mar-Apr;18(2):293-6. Epub 2007 Jan 30.PMID: 17261055 [PubMed - indexed for MEDLINE]Related articles

The internalization and degradation of human copper transporter 1 following cisplatin exposure.

Holzer AK, Howell SB.

Cancer Res. 2006 Nov 15;66(22):10944-52.PMID: 17108132 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin.

Holzer AK, Manorek GH, Howell SB.

Mol Pharmacol. 2006 Oct;70(4):1390-4. Epub 2006 Jul 17.PMID: 16847145 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel mechanisms of platinum drug resistance identified in cells selected for resistance to JM118 the active metabolite of satraplatin.

Samimi G, Kishimoto S, Manorek G, Breaux JK, Howell SB.

Cancer Chemother Pharmacol. 2007 Feb;59(3):301-12. Epub 2006 Jun 13.PMID: 16770583 [PubMed - indexed for MEDLINE]Related articles

DNA mismatch repair and p53 function are major determinants of the rate of development of cisplatin resistance.

Lin X, Howell SB.

Mol Cancer Ther. 2006 May;5(5):1239-47.PMID: 16731756 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the human copper influx transporter 1 in normal and malignant human tissues.

Holzer AK, Varki NM, Le QT, Gibson MA, Naredi P, Howell SB.

J Histochem Cytochem. 2006 Sep;54(9):1041-9. Epub 2006 May 18.PMID: 16709730 [PubMed - indexed for MEDLINE]Related articlesFree article

Preclinical efficacy and pharmacokinetics of AP5346, a novel diaminocyclohexane-platinum tumor-targeting drug delivery system.

Rice JR, Gerberich JL, Nowotnik DP, Howell SB.

Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2248-54.PMID: 16609041 [PubMed - indexed for MEDLINE]Related articlesFree article

Human REV1 modulates the cytotoxicity and mutagenicity of cisplatin in human ovarian carcinoma cells.

Lin X, Okuda T, Trang J, Howell SB.

Mol Pharmacol. 2006 May;69(5):1748-54. Epub 2006 Feb 22.PMID: 16495473 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA polymerase zeta accounts for the reduced cytotoxicity and enhanced mutagenicity of cisplatin in human colon carcinoma cells that have lost DNA mismatch repair.

Lin X, Trang J, Okuda T, Howell SB.

Clin Cancer Res. 2006 Jan 15;12(2):563-8.PMID: 16428501 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of genes whose expression is associated with cisplatin resistance in human ovarian carcinoma cells.

Cheng TC, Manorek G, Samimi G, Lin X, Berry CC, Howell SB.

Cancer Chemother Pharmacol. 2006 Sep;58(3):384-95. Epub 2006 Jan 11.PMID: 16404635 [PubMed - indexed for MEDLINE]Related articles

Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells.

Safaei R, Larson BJ, Cheng TC, Gibson MA, Otani S, Naerdemann W, Howell SB.

Mol Cancer Ther. 2005 Oct;4(10):1595-604.PMID: 16227410 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of the cellular pharmacology of JM118, the major metabolite of satraplatin, by copper influx and efflux transporters.

Samimi G, Howell SB.

Cancer Chemother Pharmacol. 2006 Jun;57(6):781-8. Epub 2005 Sep 17.PMID: 16170571 [PubMed - indexed for MEDLINE]Related articles

Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers.

Wilczynski SP, Chen YY, Chen W, Howell SB, Shively JE, Alberts DS.

Hum Pathol. 2005 Mar;36(3):242-9.PMID: 15791568 [PubMed - indexed for MEDLINE]Related articles

Suppression of hREV1 expression reduces the rate at which human ovarian carcinoma cells acquire resistance to cisplatin.

Okuda T, Lin X, Trang J, Howell SB.

Mol Pharmacol. 2005 Jun;67(6):1852-60. Epub 2005 Mar 9.PMID: 15758147 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular localization and trafficking of fluorescein-labeled cisplatin in human ovarian carcinoma cells.

Safaei R, Katano K, Larson BJ, Samimi G, Holzer AK, Naerdemann W, Tomioka M, Goodman M, Howell SB.

Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):756-67.PMID: 15701866 [PubMed - indexed for MEDLINE]Related articlesFree article

Copper transporters regulate the cellular pharmacology and sensitivity to Pt drugs.

Safaei R, Howell SB.

Crit Rev Oncol Hematol. 2005 Jan;53(1):13-23. Review.PMID: 15607932 [PubMed - indexed for MEDLINE]Related articles

DNA polymerase zeta regulates cisplatin cytotoxicity, mutagenicity, and the rate of development of cisplatin resistance.

Wu F, Lin X, Okuda T, Howell SB.

Cancer Res. 2004 Nov 1;64(21):8029-35.PMID: 15520212 [PubMed - indexed for MEDLINE]Related articlesFree article

Cisplatin rapidly down-regulates its own influx transporter hCTR1 in cultured human ovarian carcinoma cells.

Holzer AK, Katano K, Klomp LW, Howell SB.

Clin Cancer Res. 2004 Oct 1;10(19):6744-9.PMID: 15475465 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of copper transporters in the development of resistance to Pt drugs.

Safaei R, Holzer AK, Katano K, Samimi G, Howell SB.

J Inorg Biochem. 2004 Oct;98(10):1607-13. Review.PMID: 15458823 [PubMed - indexed for MEDLINE]Related articles

cDNA microarray-based identification of genes and pathways associated with oxaliplatin resistance.

Samimi G, Manorek G, Castel R, Breaux JK, Cheng TC, Berry CC, Los G, Howell SB.

Cancer Chemother Pharmacol. 2005 Jan;55(1):1-11. Epub 2004 Sep 16.PMID: 15378272 [PubMed - indexed for MEDLINE]Related articles

Increased expression of the copper efflux transporter ATP7A mediates resistance to cisplatin, carboplatin, and oxaliplatin in ovarian cancer cells.

Samimi G, Safaei R, Katano K, Holzer AK, Rochdi M, Tomioka M, Goodman M, Howell SB.

Clin Cancer Res. 2004 Jul 15;10(14):4661-9.PMID: 15269138 [PubMed - indexed for MEDLINE]Related articlesFree article

Confocal microscopic analysis of the interaction between cisplatin and the copper transporter ATP7B in human ovarian carcinoma cells.

Katano K, Safaei R, Samimi G, Holzer A, Tomioka M, Goodman M, Howell SB.

Clin Cancer Res. 2004 Jul 1;10(13):4578-88.PMID: 15240550 [PubMed - indexed for MEDLINE]Related articlesFree article

The copper influx transporter human copper transport protein 1 regulates the uptake of cisplatin in human ovarian carcinoma cells.

Holzer AK, Samimi G, Katano K, Naerdemann W, Lin X, Safaei R, Howell SB.

Mol Pharmacol. 2004 Oct;66(4):817-23. Epub 2004 Jun 30.PMID: 15229296 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B.

Samimi G, Katano K, Holzer AK, Safaei R, Howell SB.

Mol Pharmacol. 2004 Jul;66(1):25-32.PMID: 15213293 [PubMed - indexed for MEDLINE]Related articlesFree article

A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors.

Rademaker-Lakhai JM, Terret C, Howell SB, Baud CM, De Boer RF, Pluim D, Beijnen JH, Schellens JH, Droz JP.

Clin Cancer Res. 2004 May 15;10(10):3386-95.PMID: 15161693 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved targeting of platinum chemotherapeutics. the antitumour activity of the HPMA copolymer platinum agent AP5280 in murine tumour models.

Lin X, Zhang Q, Rice JR, Stewart DR, Nowotnik DP, Howell SB.

Eur J Cancer. 2004 Jan;40(2):291-7.PMID: 14728945 [PubMed - indexed for MEDLINE]Related articles

Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients.

Samimi G, Varki NM, Wilczynski S, Safaei R, Alberts DS, Howell SB.

Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):5853-9.PMID: 14676106 [PubMed - indexed for MEDLINE]Related articlesFree article

Cross-resistance to cisplatin in cells with acquired resistance to copper.

Safaei R, Katano K, Samimi G, Naerdemann W, Stevenson JL, Rochdi M, Howell SB.

Cancer Chemother Pharmacol. 2004 Mar;53(3):239-46. Epub 2003 Nov 28.PMID: 14648017 [PubMed - indexed for MEDLINE]Related articles

The copper export pump ATP7B modulates the cellular pharmacology of carboplatin in ovarian carcinoma cells.

Katano K, Safaei R, Samimi G, Holzer A, Rochdi M, Howell SB.

Mol Pharmacol. 2003 Aug;64(2):466-73.PMID: 12869652 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites.

Fedier A, Schlamminger M, Schwarz VA, Haller U, Howell SB, Fink D.

Ann Oncol. 2003 Jun;14(6):938-45.PMID: 12796033 [PubMed - indexed for MEDLINE]Related articlesFree article

Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.

Cruz-Monserrate Z, Vervoort HC, Bai R, Newman DJ, Howell SB, Los G, Mullaney JT, Williams MD, Pettit GR, Fenical W, Hamel E.

Mol Pharmacol. 2003 Jun;63(6):1273-80.PMID: 12761336 [PubMed - indexed for MEDLINE]Related articlesFree article

Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper.

Katano K, Kondo A, Safaei R, Holzer A, Samimi G, Mishima M, Kuo YM, Rochdi M, Howell SB.

Cancer Res. 2002 Nov 15;62(22):6559-65.PMID: 12438251 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of transdominant-negative genetic suppressor elements derived from hMSH2 that mediate resistance to 6-thioguanine.

de las Alas MM, Los G, Lin X, Kurdi-Haidar B, Manorek G, Howell SB.

Mol Pharmacol. 2002 Nov;62(5):1198-206.PMID: 12391284 [PubMed - indexed for MEDLINE]Related articlesFree article

The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae.

Lin X, Okuda T, Holzer A, Howell SB.

Mol Pharmacol. 2002 Nov;62(5):1154-9. Erratum in: Mol Pharmacol. 2003 Apr;63(4):957. PMID: 12391279 [PubMed - indexed for MEDLINE]Related articlesFree article

Intraperitoneal therapy for stage III ovarian cancer: a therapy whose time has come!

Alberts DS, Markman M, Armstrong D, Rothenberg ML, Muggia F, Howell SB.

J Clin Oncol. 2002 Oct 1;20(19):3944-6. No abstract available. PMID: 12351590 [PubMed - indexed for MEDLINE]Related articles