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    Results: 1 to 50 of 612

    1.

    Twenty-seven years of phase III trials for patients with extensive disease small-cell lung cancer: disappointing results.

    Oze I, Hotta K, Kiura K, Ochi N, Takigawa N, Fujiwara Y, Tabata M, Tanimoto M.

    PLoS One. 2009 Nov 13;4(11):e7835.PMID: 19915681 [PubMed - in process]Related articlesFree article

    2.

    A Phase II Trial of Erlotinib Monotherapy in Pretreated Patients with Advanced Non-small Cell Lung Cancer Who Do Not Possess Active EGFR Mutations: Okayama Lung Cancer Study Group Trial 0705.

    Yoshioka H, Hotta K, Kiura K, Takigawa N, Hayashi H, Harita S, Kuyama S, Segawa Y, Kamei H, Umemura S, Bessho A, Tabata M, Tanimoto M.

    J Thorac Oncol. 2009 Nov 5. [Epub ahead of print]PMID: 19898258 [PubMed - as supplied by publisher]Related articles

    3.

    Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils.

    Matsuwaki Y, Wada K, White TA, Benson LM, Charlesworth MC, Checkel JL, Inoue Y, Hotta K, Ponikau JU, Lawrence CB, Kita H.

    J Immunol. 2009 Nov 15;183(10):6708-16. Epub 2009 Oct 28.PMID: 19864598 [PubMed - in process]Related articles

    4.

    Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.

    Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Kawamoto M, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y.

    J Hum Genet. 2009 Oct 23. [Epub ahead of print]PMID: 19851340 [PubMed - as supplied by publisher]Related articles

    5.

    Clinical importance of B7-H3 expression in human pancreatic cancer.

    Yamato I, Sho M, Nomi T, Akahori T, Shimada K, Hotta K, Kanehiro H, Konishi N, Yagita H, Nakajima Y.

    Br J Cancer. 2009 Nov 17;101(10):1709-16. Epub 2009 Oct 20.PMID: 19844235 [PubMed - in process]Related articles

    6.

    Distribution and structural diversity of cilia in tadpole larvae of the ascidian Ciona intestinalis.

    Konno A, Kaizu M, Hotta K, Horie T, Sasakura Y, Ikeo K, Inaba K.

    Dev Biol. 2010 Jan 1;337(1):42-62. Epub 2009 Oct 14.PMID: 19835854 [PubMed - as supplied by publisher]Related articles

    7.

    Bleeding angiodysplasia of the jejunum without a visible vessel.

    Hotta K, Yoshida K.

    Endoscopy. 2009;41 Suppl 2:E253. Epub 2009 Sep 28. No abstract available. PMID: 19787577 [PubMed - in process]Related articles

    8.

    Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation.

    Fallang LE, Bergseng E, Hotta K, Berg-Larsen A, Kim CY, Sollid LM.

    Nat Immunol. 2009 Oct;10(10):1096-101. Epub 2009 Aug 30.PMID: 19718029 [PubMed - indexed for MEDLINE]Related articles

    9.

    Usefulness of cumulative smoking dose for identifying the EGFR mutation and patients with non-small-cell lung cancer for gefitinib treatment.

    Jida M, Toyooka S, Mitsudomi T, Takano T, Matsuo K, Hotta K, Tsukuda K, Kubo T, Yamamoto H, Yamane M, Oto T, Sano Y, Kiura K, Yatabe Y, Ohe Y, Date H, Miyoshi S.

    Cancer Sci. 2009 Oct;100(10):1931-4. Epub 2009 Jul 2.PMID: 19650855 [PubMed - indexed for MEDLINE]Related articles

    10.

    Influence of inducible nitric oxide synthase polymorphisms in Japanese patients with non-alcoholic fatty liver disease.

    Yoneda M, Hotta K, Nozaki Y, Endo H, Tomeno W, Watanabe S, Hosono K, Mawatari H, Iida H, Fujita K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Kubota K, Shimamura T, Saito S, Maeyama S, Wada K, Nakajima A.

    Hepatol Res. 2009 Oct;39(10):963-71. Epub 2009 Jul 13.PMID: 19624767 [PubMed - in process]Related articles

    11.

    Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli.

    Watanabe K, Hotta K, Praseuth AP, Searcey M, Wang CC, Oguri H, Oikawa H.

    Chembiochem. 2009 Aug 17;10(12):1965-8. No abstract available. PMID: 19588480 [PubMed - in process]Related articles

    12.

    Simultaneous live cell imaging using dual FRET sensors with a single excitation light.

    Niino Y, Hotta K, Oka K.

    PLoS One. 2009 Jun 24;4(6):e6036.PMID: 19551140 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    PPARG genotype accounts for part of individual variation in body weight reduction in response to calorie restriction.

    Matsuo T, Nakata Y, Katayama Y, Iemitsu M, Maeda S, Okura T, Kim MK, Ohkubo H, Hotta K, Tanaka K.

    Obesity (Silver Spring). 2009 Oct;17(10):1924-31. Epub 2009 Jun 18.PMID: 19543210 [PubMed - in process]Related articles

    14.

    Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.

    Watanabe K, Hotta K, Nakaya M, Praseuth AP, Wang CC, Inada D, Takahashi K, Fukushi E, Oguri H, Oikawa H.

    J Am Chem Soc. 2009 Jul 8;131(26):9347-53.PMID: 19514719 [PubMed - indexed for MEDLINE]Related articles

    15.

    Second-generation histamine H(2)-receptor antagonists with gastric mucosal defensive properties.

    Ichikawa T, Hotta K, Ishihara K.

    Mini Rev Med Chem. 2009 May;9(5):581-9. Review.PMID: 19456288 [PubMed - indexed for MEDLINE]Related articles

    16.

    A neutralization test for specific detection of Nipah virus antibodies using pseudotyped vesicular stomatitis virus expressing green fluorescent protein.

    Kaku Y, Noguchi A, Marsh GA, McEachern JA, Okutani A, Hotta K, Bazartseren B, Fukushi S, Broder CC, Yamada A, Inoue S, Wang LF.

    J Virol Methods. 2009 Sep;160(1-2):7-13. Epub 2009 May 9.PMID: 19433112 [PubMed - indexed for MEDLINE]Related articles

    17.

    Chapter 15. Plasmid-borne gene cluster assemblage and heterologous biosynthesis of nonribosomal peptides in Escherichia coli.

    Watanabe K, Praseuth AP, Praseuth MB, Hotta K.

    Methods Enzymol. 2009;458:379-99.PMID: 19374991 [PubMed - indexed for MEDLINE]Related articles

    18.

    Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC.

    Hotta K, Hosaka M, Tanabe A, Takeuchi T.

    J Endocrinol. 2009 Jul;202(1):111-21. Epub 2009 Apr 8.PMID: 19357184 [PubMed - indexed for MEDLINE]Related articles

    19.

    Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease.

    Yoneda M, Hotta K, Nozaki Y, Endo H, Uchiyama T, Mawatari H, Iida H, Kato S, Fujita K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Abe Y, Kubota K, Saito S, Maeyama S, Wada K, Nakajima A.

    Liver Int. 2009 Aug;29(7):1078-85. Epub 2009 Mar 3.PMID: 19302184 [PubMed - indexed for MEDLINE]Related articles

    20.

    Serum Ferritin Is a Clinical Biomarker in Japanese Patients with Nonalcoholic Steatohepatitis (NASH) Independent of HFE Gene Mutation.

    Yoneda M, Nozaki Y, Endo H, Mawatari H, Iida H, Fujita K, Yoneda K, Takahashi H, Kirikoshi H, Inamori M, Kobayashi N, Kubota K, Saito S, Maeyama S, Hotta K, Nakajima A.

    Dig Dis Sci. 2009 Mar 7. [Epub ahead of print]PMID: 19267193 [PubMed - as supplied by publisher]Related articles

    21.

    Screening of 336 single-nucleotide polymorphisms in 85 obesity-related genes revealed McKusick-Kaufman syndrome gene variants are associated with metabolic syndrome.

    Hotta K, Nakamura T, Takasaki J, Takahashi H, Takahashi A, Nakata Y, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y.

    J Hum Genet. 2009 Apr;54(4):230-5. Epub 2009 Feb 27.PMID: 19247371 [PubMed - in process]Related articles

    22.

    Association between incremental gains in the objective response rate and survival improvement in phase III trials of first-line chemotherapy for extensive disease small-cell lung cancer.

    Hotta K, Kiura K, Fujiwara Y, Takigawa N, Oze I, Ochi N, Tabata M, Tanimoto M.

    Ann Oncol. 2009 May;20(5):829-34. Epub 2009 Feb 16.PMID: 19221150 [PubMed - indexed for MEDLINE]Related articles

    23.

    [New insights about obesity-related genes]

    Hotta K.

    Nippon Rinsho. 2009 Feb;67(2):253-6. Japanese. PMID: 19202896 [PubMed - indexed for MEDLINE]Related articles

    24.

    Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus.

    Praseuth AP, Wang CC, Watanabe K, Hotta K, Oguri H, Oikawa H.

    Biotechnol Prog. 2008 Nov-Dec;24(6):1226-31.PMID: 19194935 [PubMed - indexed for MEDLINE]Related articles

    25.

    Time to progression as a surrogate marker for overall survival in patients with advanced non-small cell lung cancer.

    Hotta K, Fujiwara Y, Matsuo K, Kiura K, Takigawa N, Tabata M, Tanimoto M.

    J Thorac Oncol. 2009 Mar;4(3):311-7. Review.PMID: 19190515 [PubMed - indexed for MEDLINE]Related articles

    26.

    Comprehensive analysis of EGFR signaling pathways in Japanese patients with non-small cell lung cancer.

    Hosokawa S, Toyooka S, Fujiwara Y, Tokumo M, Soh J, Takigawa N, Hotta K, Yoshino T, Date H, Tanimoto M, Kiura K.

    Lung Cancer. 2009 Oct;66(1):107-13. Epub 2009 Jan 31.PMID: 19185949 [PubMed - indexed for MEDLINE]Related articles

    27.

    Interaction of notochord-derived fibrinogen-like protein with Notch regulates the patterning of the central nervous system of Ciona intestinalis embryos.

    Yamada S, Hotta K, Yamamoto TS, Ueno N, Satoh N, Takahashi H.

    Dev Biol. 2009 Apr 1;328(1):1-12. Epub 2009 Jan 8.PMID: 19171129 [PubMed - indexed for MEDLINE]Related articles

    28.

    Genome-wide searching with base-pairing kernel functions for noncoding RNAs: computational and expression analysis of snoRNA families in Caenorhabditis elegans.

    Morita K, Saito Y, Sato K, Oka K, Hotta K, Sakakibara Y.

    Nucleic Acids Res. 2009 Feb;37(3):999-1009. Epub 2009 Jan 7.PMID: 19129214 [PubMed - indexed for MEDLINE]Related articlesFree article

    29.

    A phase I study of combination S-1 plus cisplatin chemotherapy with concurrent thoracic radiation for locally advanced non-small cell lung cancer.

    Chikamori K, Kishino D, Takigawa N, Hotta K, Nogami N, Kamei H, Kuyama S, Gemba K, Takemoto M, Kanazawa S, Ueoka H, Segawa Y, Takata S, Tabata M, Kiura K, Tanimoto M; Okayama Lung Cancer Study Group.

    Lung Cancer. 2009 Jul;65(1):74-9. Epub 2008 Dec 3.PMID: 19056143 [PubMed - indexed for MEDLINE]Related articles

    30.

    Optical waveguide sensor based on a porous anodic alumina/aluminum multilayer film.

    Yamaguchi A, Hotta K, Teramae N.

    Anal Chem. 2009 Jan 1;81(1):105-11.PMID: 19049367 [PubMed - indexed for MEDLINE]Related articles

    31.

    Effect of cellular cholesterol depletion on rabies virus infection.

    Hotta K, Bazartseren B, Kaku Y, Noguchi A, Okutani A, Inoue S, Yamada A.

    Virus Res. 2009 Jan;139(1):85-90. Epub 2008 Nov 28.PMID: 19010362 [PubMed - indexed for MEDLINE]Related articles

    32.

    Paradoxical clinical effects of epidermal growth factor receptor-tyrosine kinase inhibitors for acute myelogenous leukemia.

    Hotta K, Kiura K, Takigawa N, Matsuo K, Tabata M, Fujiwara Y, Tanimoto M.

    J Clin Oncol. 2008 Dec 10;26(35):5826-7; author reply 5827. Epub 2008 Nov 10. No abstract available. PMID: 19001344 [PubMed - indexed for MEDLINE]Related articles

    33.

    The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.

    Fox DT, Hotta K, Kim CY, Koppisch AT.

    Biochemistry. 2008 Nov 25;47(47):12251-3.PMID: 18975921 [PubMed - indexed for MEDLINE]Related articles

    34.

    Local recurrence after endoscopic resection of colorectal tumors.

    Hotta K, Fujii T, Saito Y, Matsuda T.

    Int J Colorectal Dis. 2009 Feb;24(2):225-30. Epub 2008 Oct 30.PMID: 18972121 [PubMed - indexed for MEDLINE]Related articles

    35.

    A case of advanced non-small-cell lung cancer who responded slowly to gefitinib monotherapy after long-term disease stabilization.

    Hotta K, Kiura K, Shirahige A, Takata S, Takigawa N, Tabata M, Watanabe H, Tanimoto M.

    Acta Oncol. 2009;48(3):471-3. No abstract available. PMID: 18855159 [PubMed - indexed for MEDLINE]Related articles

    36.

    Improved genome assembly and evidence-based global gene model set for the chordate Ciona intestinalis: new insight into intron and operon populations.

    Satou Y, Mineta K, Ogasawara M, Sasakura Y, Shoguchi E, Ueno K, Yamada L, Matsumoto J, Wasserscheid J, Dewar K, Wiley GB, Macmil SL, Roe BA, Zeller RW, Hastings KE, Lemaire P, Lindquist E, Endo T, Hotta K, Inaba K.

    Genome Biol. 2008 Oct 14;9(10):R152. [Epub ahead of print]PMID: 18854010 [PubMed - as supplied by publisher]Related articlesFree article

    37.

    [Successful treatment with 5-fluorouracil and cis-dichlorodiammineplatinum combined with 60Gy of radiation in a case of advanced esophageal cancer complicated with chronic renal failure treated with hemodialysis]

    Arai Y, Oyama T, Hotta K, Tomori A, Miyata Y.

    Nippon Shokakibyo Gakkai Zasshi. 2008 Oct;105(10):1482-8. Japanese. PMID: 18840986 [PubMed - indexed for MEDLINE]Related articles

    38.

    Thyroglobulin may affect telomerase activity in thyroid follicular cells.

    Nagasaka A, Oda N, Nakai A, Hotta K, Nagata M, Kato T, Suzuki A, Itoh M, Miura H, Hakuta M, Yoshida S, Hibi Y, Iwase K.

    J Enzyme Inhib Med Chem. 2009 Apr;24(2):524-30.PMID: 18830915 [PubMed - indexed for MEDLINE]Related articles

    39.

    The basic study of a bi-material range compensator for improving dose uniformity for proton therapy.

    Takada Y, Himukai T, Takizawa K, Terashita Y, Kamimura S, Matsuda H, Hotta K, Kohno R, Komori M, Kanai T.

    Phys Med Biol. 2008 Oct 7;53(19):5555-69. Epub 2008 Sep 9.PMID: 18780957 [PubMed - indexed for MEDLINE]Related articles

    40.

    Pediatric kidney transplantation is safe and available for patients with urological anomalies as well as those with primary renal diseases.

    Morita K, Iwami D, Hotta K, Shimoda N, Miura M, Watarai Y, Hoshii S, Obikane K, Nakashima T, Sasaki S, Nonomura K.

    Pediatr Transplant. 2009 Mar;13(2):200-5. Epub 2008 Jul 25.PMID: 18662371 [PubMed - indexed for MEDLINE]Related articles

    41.

    [Ultrasound-guided combined femoral nerve and lateral femoral cutaneous nerve blocks for femur neck fracture surgery--case report]

    Hotta K, Sata N, Suzuki H, Takeuchi M, Seo N.

    Masui. 2008 Jul;57(7):892-4. Japanese. PMID: 18649647 [PubMed - indexed for MEDLINE]Related articles

    42.

    Gene expression profiling of non-alcoholic steatohepatitis using gene set enrichment analysis.

    Yoneda M, Endo H, Mawatari H, Nozaki Y, Fujita K, Akiyama T, Higurashi T, Uchiyama T, Yoneda K, Takahashi H, Kirikoshi H, Inamori M, Abe Y, Kubota K, Saito S, Kobayashi N, Yamaguchi N, Maeyama S, Yamamoto S, Tsutsumi S, Aburatani H, Wada K, Hotta K, Nakajima A.

    Hepatol Res. 2008 Dec;38(12):1204-12. Epub 2008 Jul 4.PMID: 18637145 [PubMed - in process]Related articles

    43.

    Sex difference in the influence of smoking status on the responsiveness to gefitinib monotherapy in adenocarcinoma of the lung: Okayama Lung Cancer Study Group experience.

    Hotta K, Kiura K, Takigawa N, Kuyama S, Segawa Y, Yonei T, Gemba K, Aoe K, Shibayama T, Matsuo K, Kamei H, Fujiwara Y, Bessho A, Moritaka T, Sugimoto K, Tabata M, Ueoka H, Tanimoto M.

    J Cancer Res Clin Oncol. 2009 Jan;135(1):117-23. Epub 2008 Jul 11.PMID: 18618142 [PubMed - indexed for MEDLINE]Related articles

    44.

    INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.

    Hotta K, Nakamura M, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y.

    J Hum Genet. 2008;53(9):857-62. Epub 2008 Jul 10.PMID: 18615239 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD).

    Yoneda M, Hotta K, Nozaki Y, Endo H, Uchiyama T, Mawatari H, Iida H, Kato S, Hosono K, Fujita K, Yoneda K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Abe Y, Kubota K, Saito S, Maeyama S, Wada K, Nakajima A.

    BMC Gastroenterol. 2008 Jun 27;8:27.PMID: 18588668 [PubMed - indexed for MEDLINE]Related articlesFree article

    46.

    Biosynthesis of the 3,4-dihydroxybenzoate moieties of petrobactin by Bacillus anthracis.

    Koppisch AT, Hotta K, Fox DT, Ruggiero CE, Kim CY, Sanchez T, Iyer S, Browder CC, Unkefer PJ, Unkefer CJ.

    J Org Chem. 2008 Aug 1;73(15):5759-65. Epub 2008 Jun 27.PMID: 18582113 [PubMed - indexed for MEDLINE]Related articles

    47.

    [Ultrasound-guided epidural block]

    Hotta K.

    Masui. 2008 May;57(5):556-63. Review. Japanese. PMID: 18516882 [PubMed - indexed for MEDLINE]Related articles

    48.

    Association of the benefit from gefitinib monotherapy with smoking status in Japanese patients with non-small-cell lung cancer.

    Hotta K, Kiura K, Takigawa N, Fujiwara Y, Tabata M, Ueoka H, Tanimoto M.

    Lung Cancer. 2008 Nov;62(2):236-41. Epub 2008 May 15.PMID: 18485523 [PubMed - indexed for MEDLINE]Related articles

    49.

    A novel biological role of tachykinins as an up-regulator of oocyte growth: identification of an evolutionary origin of tachykininergic functions in the ovary of the ascidian, Ciona intestinalis.

    Aoyama M, Kawada T, Fujie M, Hotta K, Sakai T, Sekiguchi T, Oka K, Satoh N, Satake H.

    Endocrinology. 2008 Sep;149(9):4346-56. Epub 2008 May 15.PMID: 18483149 [PubMed - indexed for MEDLINE]Related articlesFree article

    50.

    Remarkable shrinkage of sarcomatoid renal cell carcinoma with single-agent gemcitabine.

    Fujiwara Y, Kiura K, Tabata M, Takigawa N, Hotta K, Umemura S, Omori M, Gemba K, Ueoka H, Tanimoto M.

    Anticancer Drugs. 2008 Apr;19(4):431-3.PMID: 18454054 [PubMed - indexed for MEDLINE]Related articles

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