PubMed

Identification of two calcineurin B-binding proteins: tubulin and heat shock protein 60.

Li W, Handschumacher RE.

Biochim Biophys Acta. 2002 Sep 23;1599(1-2):72-81.PMID: 12479407 [PubMed - indexed for MEDLINE]Related articles

Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update.

Pizzorno G, Cao D, Leffert JJ, Russell RL, Zhang D, Handschumacher RE.

Biochim Biophys Acta. 2002 Jul 18;1587(2-3):133-44. Review.PMID: 12084455 [PubMed - indexed for MEDLINE]Related articles

Uridine phosphorylase association with vimentin. Intracellular distribution and localization.

Russell RL, Cao D, Zhang D, Handschumacher RE, Pizzorno G.

J Biol Chem. 2001 Apr 20;276(16):13302-7. Epub 2001 Jan 24.PMID: 11278417 [PubMed - indexed for MEDLINE]Related articlesFree article

Genomic structure, chromosomal mapping, and promoter region analysis of murine uridine phosphorylase gene.

Cao D, Nimmakayalu MA, Wang F, Zhang D, Handschumacher RE, Bray-Ward P, Pizzorno G.

Cancer Res. 1999 Oct 1;59(19):4997-5001.PMID: 10519414 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-alanine and alpha-fluoro-beta-alanine concentrative transport in rat hepatocytes is mediated by GABA transporter GAT-2.

Liu M, Russell RL, Beigelman L, Handschumacher RE, Pizzorno G.

Am J Physiol. 1999 Jan;276(1 Pt 1):G206-10.PMID: 9886997 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors.

Liu M, Cao D, Russell R, Handschumacher RE, Pizzorno G.

Cancer Res. 1998 Dec 1;58(23):5418-24.PMID: 9850074 [PubMed - indexed for MEDLINE]Related articlesFree article

Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis.

Liu MP, Beigelman L, Levy E, Handschumacher RE, Pizzorno G.

Am J Physiol. 1998 Jun;274(6 Pt 1):G1018-23.PMID: 9696700 [PubMed - indexed for MEDLINE]Related articlesFree article

Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor.

Pizzorno G, Yee L, Burtness BA, Marsh JC, Darnowski JW, Chu MY, Chu SH, Chu E, Leffert JJ, Handschumacher RE, Calabresi P.

Clin Cancer Res. 1998 May;4(5):1165-75.PMID: 9607574 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV protease substrate conformation: modulation by cyclophilin A.

McCornack MA, Kakalis LT, Caserta C, Handschumacher RE, Armitage IM.

FEBS Lett. 1997 Sep 1;414(1):84-8.PMID: 9305737 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic and phase I trial of intraperitoneal carboplatin and cyclosporine in refractory ovarian cancer patients.

Chambers SK, Chambers JT, Davis CA, Kohorn EI, Schwartz PE, Lorber MI, Handschumacher RE, Pizzorno G.

J Clin Oncol. 1997 May;15(5):1945-52.PMID: 9164206 [PubMed - indexed for MEDLINE]Related articles

Regulation of the nuclear factor of activated T cells in stably transfected Jurkat cell clones.

Li W, Handschumacher RE.

Biochem Biophys Res Commun. 1996 Feb 6;219(1):96-9.PMID: 8619834 [PubMed - indexed for MEDLINE]Related articles

Tamoxifen induces Na+ -dependent uridine transport and dome formation in a human breast tumor cell line.

Liu MP, Handschumacher RE.

Cancer J Sci Am. 1995 Sep-Oct;1(3):210-4.PMID: 9166478 [PubMed - indexed for MEDLINE]Related articles

The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor.

Owens-Grillo JK, Hoffmann K, Hutchison KA, Yem AW, Deibel MR Jr, Handschumacher RE, Pratt WB.

J Biol Chem. 1995 Sep 1;270(35):20479-84.PMID: 7657624 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: a possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression.

Renoir JM, Mercier-Bodard C, Hoffmann K, Le Bihan S, Ning YM, Sanchez ER, Handschumacher RE, Baulieu EE.

Proc Natl Acad Sci U S A. 1995 May 23;92(11):4977-81.PMID: 7539138 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of human cyclophilin-40 and the effect of the His141-->Trp mutation on catalysis and cyclosporin A binding.

Hoffmann K, Kakalis LT, Anderson KS, Armitage IM, Handschumacher RE.

Eur J Biochem. 1995 Apr 1;229(1):188-93.PMID: 7744028 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclophilin-40: evidence for a dimeric complex with hsp90.

Hoffmann K, Handschumacher RE.

Biochem J. 1995 Apr 1;307 ( Pt 1):5-8.PMID: 7717993 [PubMed - indexed for MEDLINE]Related articlesFree article

Toxoplasma gondii tachyzoites possess an unusual plasma membrane adenosine transporter.

Schwab JC, Afifi Afifi M, Pizzorno G, Handschumacher RE, Joiner KA.

Mol Biochem Parasitol. 1995 Mar;70(1-2):59-69.PMID: 7637715 [PubMed - indexed for MEDLINE]Related articles

Effect of clinically modeled regimens on the growth response and development of resistance in human colon carcinoma cell lines.

Pizzorno G, Handschumacher RE.

Biochem Pharmacol. 1995 Feb 14;49(4):559-65.PMID: 7872962 [PubMed - indexed for MEDLINE]Related articles

Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil.

Pizzorno G, Sun Z, Handschumacher RE.

Biochem Pharmacol. 1995 Feb 14;49(4):553-7.PMID: 7872961 [PubMed - indexed for MEDLINE]Related articles

Concentrative transport of adenosine in murine splenocytes: limitation by an ecto-adenosine deaminase.

Lee CW, Handschumacher RE.

In Vivo. 1995 Jan-Feb;9(1):1-6.PMID: 7669942 [PubMed - indexed for MEDLINE]Related articles

Differentiation of HL-60 cells by dimethylsulfoxide activates a Na(+)-dependent nucleoside transport system.

Lee CW, Sokoloski JA, Sartorelli AC, Handschumacher RE.

In Vivo. 1994 Nov-Dec;8(5):795-801.PMID: 7727727 [PubMed - indexed for MEDLINE]Related articles

Isolation, cDNA sequences, and biochemical characterization of the major cyclosporin-binding proteins of Toxoplasma gondii.

High KP, Joiner KA, Handschumacher RE.

J Biol Chem. 1994 Mar 25;269(12):9105-12.PMID: 8132648 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific interaction of the cyclophilin-cyclosporin complex with the B subunit of calcineurin.

Li W, Handschumacher RE.

J Biol Chem. 1993 Jul 5;268(19):14040-4.PMID: 7686148 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization.

Kieffer LJ, Seng TW, Li W, Osterman DG, Handschumacher RE, Bayney RM.

J Biol Chem. 1993 Jun 15;268(17):12303-10.PMID: 8509368 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease.

Kratz A, Harding MW, Craft J, Mackworth-Young CG, Handschumacher RE.

Clin Exp Immunol. 1992 Dec;90(3):422-7.PMID: 1458678 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunofluorescent localization and immunochemical determination of cyclophilin-A with specific rabbit antisera.

Sarris AH, Harding MW, Jiang TR, Aftab D, Handschumacher RE.

Transplantation. 1992 Nov;54(5):904-10.PMID: 1440857 [PubMed - indexed for MEDLINE]Related articles

Leukocyte chemotactic activity of cyclophilin.

Xu Q, Leiva MC, Fischkoff SA, Handschumacher RE, Lyttle CR.

J Biol Chem. 1992 Jun 15;267(17):11968-71.PMID: 1601866 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunity, microbial pathogenesis, and immunophilins: finding the keys, now where are the locks?

High KP, Handschumacher RE.

Infect Agents Dis. 1992 Jun;1(3):121-35. Review.PMID: 1285413 [PubMed - indexed for MEDLINE]Related articles

Isolation and partial characterization of membrane-associated cyclophilin and a related 22-kDa glycoprotein.

Thalhammer T, Kieffer LJ, Jiang T, Handschumacher RE.

Eur J Biochem. 1992 May 15;206(1):31-7.PMID: 1587281 [PubMed - indexed for MEDLINE]Related articlesFree article

Brequinar potentiates 5-fluorouracil antitumor activity in a murine model colon 38 tumor by tissue-specific modulation of uridine nucleotide pools.

Pizzorno G, Wiegand RA, Lentz SK, Handschumacher RE.

Cancer Res. 1992 Apr 1;52(7):1660-5.PMID: 1551097 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolation and characterization of a 40-kDa cyclophilin-related protein.

Kieffer LJ, Thalhammer T, Handschumacher RE.

J Biol Chem. 1992 Mar 15;267(8):5503-7.PMID: 1544925 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition by pertussis toxin of the activation of Na(+)-dependent uridine transport in dimethyl-sulphoxide-induced HL-60 leukaemia cells.

Sokoloski JA, Sartorelli AC, Handschumacher RE, Lee CW.

Biochem J. 1991 Dec 1;280 ( Pt 2):515-9.PMID: 1747127 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific expansion of uridine pools in mice. Effects of benzylacyclouridine, dipyridamole and exogenous uridine.

Darnowski JW, Handschumacher RE, Wiegand RA, Goulette FA, Calabresi P.

Biochem Pharmacol. 1991 Jun 15;41(12):2031-6.PMID: 2039551 [PubMed - indexed for MEDLINE]Related articles

A phase II trial of cyclosporin A in the treatment of refractory metastatic colorectal cancer.

Murren JR, Ganpule S, Sarris A, Durivage H, Davis C, Makuch R, Handschumacher RE, Marsh JC.

Am J Clin Oncol. 1991 Jun;14(3):208-10.PMID: 2031507 [PubMed - indexed for MEDLINE]Related articles

Induction of the differentiation of HL-60 cells by phorbol 12-myristate 13-acetate activates a Na(+)-dependent uridine-transport system. Involvement of protein kinase C.

Lee CW, Sokoloski JA, Sartorelli AC, Handschumacher RE.

Biochem J. 1991 Feb 15;274 ( Pt 1):85-90.PMID: 2001255 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclophilin binding: a more accurate measure of cyclosporine immunosuppressive activity after renal transplantation.

Paul K, Harding MW, Marks WH, Handschumacher RE, Lorber MI.

Transplant Proc. 1991 Feb;23(1 Pt 2):974-5. No abstract available. PMID: 1989349 [PubMed - indexed for MEDLINE]Related articles

Effects of uridine on the growth and differentiation of HL-60 leukemia cells.

Sokoloski JA, Lee CW, Handschumacher RE, Nigam A, Sartorelli AC.

Leuk Res. 1991;15(11):1051-8.PMID: 1961008 [PubMed - indexed for MEDLINE]Related articles

Bradykinin and its Gly6 analogue are substrates of cyclophilin: a fluorine-19 magnetization transfer study.

London RE, Davis DG, Vavrek RJ, Stewart JM, Handschumacher RE.

Biochemistry. 1990 Nov 13;29(45):10298-302.PMID: 2261473 [PubMed - indexed for MEDLINE]Related articles

An overview of recent progress in ligand-receptor research based on nuclear magnetic resonance spectroscopy.

Handschumacher RE, Armitage IM.

Biochem Pharmacol. 1990 Jul 1;40(1):3-5. No abstract available. PMID: 2372308 [PubMed - indexed for MEDLINE]Related articles

Structural elements pertinent to the interaction of cyclosporin A with its specific receptor protein, cyclophilin.

Hsu VL, Heald SL, Harding MW, Handschumacher RE, Armitage IM.

Biochem Pharmacol. 1990 Jul 1;40(1):131-40.PMID: 2196880 [PubMed - indexed for MEDLINE]Related articles

Cyclophilin binding: a receptor-mediated approach to monitoring cyclosporine immunosuppressive activity following organ transplantation.

Lorber MI, Paul K, Harding MW, Handschumacher RE, Marks WH.

Transplant Proc. 1990 Jun;22(3):1240-4. No abstract available. PMID: 2190386 [PubMed - indexed for MEDLINE]Related articles

1H NMR studies on bovine cyclophilin: preliminary structural characterization of its complex with cyclosporin A.

Heald SL, Harding MW, Handschumacher RE, Armitage IM.

Biochemistry. 1990 May 8;29(18):4466-78.PMID: 2190633 [PubMed - indexed for MEDLINE]Related articles

Effect of herpes simplex virus type 1 infection on nucleoside transport in HeLa S3 cells.

Palú G, Handschumacher RE, Parolin C, Stefanelli S, Palatini P.

J Gen Virol. 1990 Mar;71 ( Pt 3):673-9.PMID: 2156000 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of anthracycline growth inhibition in parent and multidrug-resistant Chinese hamster ovary cells by cyclosporin A and its analogues.

Chambers SK, Hait WN, Kacinski BM, Keyes SR, Handschumacher RE.

Cancer Res. 1989 Nov 15;49(22):6275-9.PMID: 2804973 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of fluorouracil therapy by the manipulation of tissue uridine pools.

Darnowski JW, Handschumacher RE.

Pharmacol Ther. 1989;41(1-2):381-92. Review.PMID: 2652156 [PubMed - indexed for MEDLINE]Related articles

Activity of cyclosporin A and a non-immunosuppressive cyclosporin against multidrug resistant leukemic cell lines.

Hait WN, Stein JM, Koletsky AJ, Harding MW, Handschumacher RE.

Cancer Commun. 1989;1(1):35-43.PMID: 2640154 [PubMed - indexed for MEDLINE]Related articles

Cyclophilin, a primary molecular target for cyclosporine. Structural and functional implications.

Harding MW, Handschumacher RE.

Transplantation. 1988 Aug;46(2 Suppl):29S-35S. Review.PMID: 3043795 [PubMed - indexed for MEDLINE]Related articles

Benzylacyclouridine. Pharmacokinetics, metabolism and biochemical effects in mice.

Darnowski JW, Handschumacher RE.

Biochem Pharmacol. 1988 Jul 1;37(13):2613-8.PMID: 3390221 [PubMed - indexed for MEDLINE]Related articles

Cyclosporine--mechanism of action.

Drugge RJ, Handschumacher RE.

Transplant Proc. 1988 Apr;20(2 Suppl 2):301-9. Review. No abstract available. PMID: 3284073 [PubMed - indexed for MEDLINE]Related articles

Concentrative uridine transport by murine splenocytes: kinetics, substrate specificity, and sodium dependency.

Darnowski JW, Holdridge C, Handschumacher RE.

Cancer Res. 1987 May 15;47(10):2614-9.PMID: 3567894 [PubMed - indexed for MEDLINE]Related articlesFree article