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Up-regulation of Na+ and Ca2+ transporters in arterial smooth muscle from ouabain hypertensive rats.

Pulina MV, Zulian A, Berra-Romani R, Beskina O, Mazzocco-Spezzia A, Baryshnikov SG, Papparella I, Hamlyn JM, Blaustein MP, Golovina VA.

Am J Physiol Heart Circ Physiol. 2009 Nov 6. [Epub ahead of print]PMID: 19897708 [PubMed - as supplied by publisher]Related articles

Low-dose ouabain constricts small arteries from ouabain-hypertensive rats: implications for sustained elevation of vascular resistance.

Zhang J, Hamlyn JM, Karashima E, Raina H, Mauban JR, Izuka M, Berra-Romani R, Zulian A, Wier WG, Blaustein MP.

Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1140-50. Epub 2009 Jul 17.PMID: 19617413 [PubMed - indexed for MEDLINE]Related articles

Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain.

Tripodi G, Citterio L, Kouznetsova T, Lanzani C, Florio M, Modica R, Messaggio E, Hamlyn JM, Zagato L, Bianchi G, Staessen JA, Manunta P.

Am J Hypertens. 2009 Apr;22(4):357-63. Epub 2009 Feb 5.PMID: 19197249 [PubMed - indexed for MEDLINE]Related articles

The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension.

Blaustein MP, Zhang J, Chen L, Song H, Raina H, Kinsey SP, Izuka M, Iwamoto T, Kotlikoff MI, Lingrel JB, Philipson KD, Wier WG, Hamlyn JM.

Hypertension. 2009 Feb;53(2):291-8. Epub 2008 Dec 22. Review. No abstract available. PMID: 19104005 [PubMed - indexed for MEDLINE]Related articles

Endogenous ouabain in cardiovascular function and disease.

Manunta P, Ferrandi M, Bianchi G, Hamlyn JM.

J Hypertens. 2009 Jan;27(1):9-18. Review.PMID: 19050443 [PubMed - indexed for MEDLINE]Related articles

Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension.

Manunta P, Maillard M, Tantardini C, Simonini M, Lanzani C, Citterio L, Stella P, Casamassima N, Burnier M, Hamlyn JM, Bianchi G.

J Hypertens. 2008 May;26(5):914-20.PMID: 18398333 [PubMed - indexed for MEDLINE]Related articles

Endogenous ouabain and cardiomyopathy in dialysis patients.

Stella P, Manunta P, Mallamaci F, Melandri M, Spotti D, Tripepi G, Hamlyn JM, Malatino LS, Bianchi G, Zoccali C.

J Intern Med. 2008 Mar;263(3):274-80. Epub 2007 Dec 7.PMID: 18070001 [PubMed - indexed for MEDLINE]Related articles

Sodium pumps: ouabain, ion transport, and signaling in hypertension.

Blaustein MP, Hamlyn JM, Pallone TL.

Am J Physiol Renal Physiol. 2007 Jul;293(1):F438; author reply F439. No abstract available. PMID: 17616574 [PubMed - indexed for MEDLINE]Related articlesFree article

Salt intake and depletion increase circulating levels of endogenous ouabain in normal men.

Manunta P, Hamilton BP, Hamlyn JM.

Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R553-9.PMID: 16467503 [PubMed - indexed for MEDLINE]Related articles

Independent and incremental prognostic value of endogenous ouabain in idiopathic dilated cardiomyopathy.

Pitzalis MV, Hamlyn JM, Messaggio E, Iacoviello M, Forleo C, Romito R, de Tommasi E, Rizzon P, Bianchi G, Manunta P.

Eur J Heart Fail. 2006 Mar;8(2):179-86. Epub 2005 Sep 26.PMID: 16188497 [PubMed - indexed for MEDLINE]Related articles

Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice.

Zhang J, Lee MY, Cavalli M, Chen L, Berra-Romani R, Balke CW, Bianchi G, Ferrari P, Hamlyn JM, Iwamoto T, Lingrel JB, Matteson DR, Wier WG, Blaustein MP.

J Physiol. 2005 Nov 15;569(Pt 1):243-56. Epub 2005 Sep 15.PMID: 16166162 [PubMed - indexed for MEDLINE]Related articlesFree article

High circulating levels of endogenous ouabain in the offspring of hypertensive and normotensive individuals.

Manunta P, Iacoviello M, Forleo C, Messaggio E, Hamlyn JM, Lucarelli K, Guida P, Romito R, De Tommasi E, Bianchi G, Rizzon P, Pitzalis MV.

J Hypertens. 2005 Sep;23(9):1677-81.PMID: 16093912 [PubMed - indexed for MEDLINE]Related articles

Role of the adducin family genes in human essential hypertension.

Lanzani C, Citterio L, Jankaricova M, Sciarrone MT, Barlassina C, Fattori S, Messaggio E, Serio CD, Zagato L, Cusi D, Hamlyn JM, Stella A, Bianchi G, Manunta P.

J Hypertens. 2005 Mar;23(3):543-9.PMID: 15716695 [PubMed - indexed for MEDLINE]Related articles

Identification of salt-sensitive genes in the kidneys of Dahl rats.

Lighthall GK, Hamilton BP, Hamlyn JM.

J Hypertens. 2004 Aug;22(8):1487-94.PMID: 15257170 [PubMed - indexed for MEDLINE]Related articles

Sex, digitalis, and the sodium pump.

Blaustein MP, Robinson SW, Gottlieb SS, Balke CW, Hamlyn JM.

Mol Interv. 2003 Mar;3(2):68-72, 50. Review.PMID: 14993426 [PubMed - indexed for MEDLINE]Related articlesFree article

Biosynthesis of endogenous cardiac glycosides by mammalian adrenocortical cells: three steps forward.

Hamlyn JM.

Clin Chem. 2004 Mar;50(3):469-70. No abstract available. PMID: 14981025 [PubMed - indexed for MEDLINE]Related articlesFree article

Salt, endogenous ouabain and blood pressure interactions in the general population.

Wang JG, Staessen JA, Messaggio E, Nawrot T, Fagard R, Hamlyn JM, Bianchi G, Manunta P.

J Hypertens. 2003 Aug;21(8):1475-81.PMID: 12872040 [PubMed - indexed for MEDLINE]Related articles

11-hydroxylation in the biosynthesis of endogenous ouabain: multiple implications.

Hamlyn JM, Laredo J, Shah JR, Lu ZR, Hamilton BP.

Ann N Y Acad Sci. 2003 Apr;986:685-93. Review.PMID: 12763919 [PubMed - indexed for MEDLINE]Related articles

Novel receptors for ouabain: studies in adrenocortical cells and membranes.

Ward SC, Hamilton BP, Hamlyn JM.

Hypertension. 2002 Feb;39(2 Pt 2):536-42.PMID: 11882604 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension.

Manunta P, Messaggio E, Ballabeni C, Sciarrone MT, Lanzani C, Ferrandi M, Hamlyn JM, Cusi D, Galletti F, Bianchi G; Salt Sensitivity Study Group of the Italian Society of Hypertension.

Hypertension. 2001 Aug;38(2):198-203.PMID: 11509476 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptic plasticity in sympathetic ganglia from acquired and inherited forms of ouabain-dependent hypertension.

Aileru AA, De Albuquerque A, Hamlyn JM, Manunta P, Shah JR, Hamilton MJ, Weinreich D.

Am J Physiol Regul Integr Comp Physiol. 2001 Aug;281(2):R635-44.PMID: 11448869 [PubMed - indexed for MEDLINE]Related articles

Biological implication of conformational flexibility in ouabain: observations with two ouabain phosphate isomers.

Kawamura A, Abrell LM, Maggiali F, Berova N, Nakanishi K, Labutti J, Magil S, Haupert GT Jr, Hamlyn JM.

Biochemistry. 2001 May 15;40(19):5835-44.PMID: 11341849 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationships for the hypertensinogenic activity of ouabain: role of the sugar and lactone ring.

Manunta P, Hamilton BP, Hamlyn JM.

Hypertension. 2001 Feb;37(2 Part 2):472-7.PMID: 11230321 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous ouabain and hemodynamic and left ventricular geometric patterns in essential hypertension.

Pierdomenico SD, Bucci A, Manunta P, Rivera R, Ferrandi M, Hamlyn JM, Lapenna D, Cuccurullo F, Mezzetti A.

Am J Hypertens. 2001 Jan;14(1):44-50.PMID: 11206678 [PubMed - indexed for MEDLINE]Related articles

Chronic hypertension induced by ouabain but not digoxin in the rat: antihypertensive effect of digoxin and digitoxin.

Manunta P, Hamilton J, Rogowski AC, Hamilton BP, Hamlyn JM.

Hypertens Res. 2000 Sep;23 Suppl:S77-85.PMID: 11016824 [PubMed - indexed for MEDLINE]Related articles

Different effects of in vivo ouabain and digoxin on renal artery function and blood pressure in the rat.

Kimura K, Manunta P, Hamilton BP, Hamlyn JM.

Hypertens Res. 2000 Sep;23 Suppl:S67-76.PMID: 11016823 [PubMed - indexed for MEDLINE]Related articles

Ouabain augments Ca(2+) transients in arterial smooth muscle without raising cytosolic Na(+).

Arnon A, Hamlyn JM, Blaustein MP.

Am J Physiol Heart Circ Physiol. 2000 Aug;279(2):H679-91.PMID: 10924067 [PubMed - indexed for MEDLINE]Related articlesFree article

Regioselective derivatization of ouabain with trialkylsilyl reagents and selective oxidation of the unprotected alcohols.

Templeton JF, Hamlyn JM, Hamilton BP, Ayotte J, Majgier-Baranowska H, Lester A, Marat K, Perreault H.

Steroids. 2000 Jul;65(7):379-86.PMID: 10899537 [PubMed - indexed for MEDLINE]Related articles

Na(+) entry via store-operated channels modulates Ca(2+) signaling in arterial myocytes.

Arnon A, Hamlyn JM, Blaustein MP.

Am J Physiol Cell Physiol. 2000 Jan;278(1):C163-73.PMID: 10644524 [PubMed - indexed for MEDLINE]Related articlesFree article

Left ventricular mass, stroke volume, and ouabain-like factor in essential hypertension.

Manunta P, Stella P, Rivera R, Ciurlino D, Cusi D, Ferrandi M, Hamlyn JM, Bianchi G.

Hypertension. 1999 Sep;34(3):450-6.PMID: 10489392 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of angiotensin II on sodium potassium pumps, endogenous ouabain, and aldosterone in bovine zona glomerulosa cells.

Shah JR, Laredo J, Hamilton BP, Hamlyn JM.

Hypertension. 1999 Jan;33(1 Pt 2):373-7.PMID: 9931132 [PubMed - indexed for MEDLINE]Related articlesFree article

Observations on the nature, biosynthesis, secretion and significance of endogenous ouabain.

Hamlyn JM, Lu ZR, Manunta P, Ludens JH, Kimura K, Shah JR, Laredo J, Hamilton JP, Hamilton MJ, Hamilton BP.

Clin Exp Hypertens. 1998 Jul-Aug;20(5-6):523-33. Review.PMID: 9682908 [PubMed - indexed for MEDLINE]Related articles

Different signaling pathways mediate stimulated secretions of endogenous ouabain and aldosterone from bovine adrenocortical cells.

Shah JR, Laredo J, Hamilton BP, Hamlyn JM.

Hypertension. 1998 Jan;31(1 Pt 2):463-8.PMID: 9453346 [PubMed - indexed for MEDLINE]Related articlesFree article

Ouabain-like factor quantification in mammalian tissues and plasma: comparison of two independent assays.

Ferrandi M, Manunta P, Balzan S, Hamlyn JM, Bianchi G, Ferrari P.

Hypertension. 1997 Oct;30(4):886-96.PMID: 9336389 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II stimulates secretion of endogenous ouabain from bovine adrenocortical cells via angiotensin type 2 receptors.

Laredo J, Shah JR, Lu ZR, Hamilton BP, Hamlyn JM.

Hypertension. 1997 Jan;29(1 Pt 2):401-7.PMID: 9039134 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous ouabain, sodium balance and blood pressure: a review and a hypothesis.

Hamlyn JM, Hamilton BP, Manunta P.

J Hypertens. 1996 Feb;14(2):151-67. Review.PMID: 8728291 [PubMed - indexed for MEDLINE]Related articles

Immunoreactive endogenous ouabain in primary aldosteronism and essential hypertension: relationship with plasma renin, aldosterone and blood pressure levels.

Rossi G, Manunta P, Hamlyn JM, Pavan E, De Toni R, Semplicini A, Pessina AC.

J Hypertens. 1995 Oct;13(10):1181-91.PMID: 8586810 [PubMed - indexed for MEDLINE]Related articles

Secretion of endogenous ouabain from bovine adrenocortical cells: role of the zona glomerulosa and zona fasciculata.

Laredo J, Hamilton BP, Hamlyn JM.

Biochem Biophys Res Commun. 1995 Jul 17;212(2):487-93.PMID: 7626063 [PubMed - indexed for MEDLINE]Related articles

Ouabain is secreted by bovine adrenocortical cells.

Laredo J, Hamilton BP, Hamlyn JM.

Endocrinology. 1994 Aug;135(2):794-7.PMID: 8033829 [PubMed - indexed for MEDLINE]Related articles

Smooth muscle hypertrophy and arterial remodelling in deoxycorticosterone acetate-salt hypertension.

Ashen MD, Hamlyn JM.

Clin Exp Hypertens. 1994 May;16(3):261-82.PMID: 8038754 [PubMed - indexed for MEDLINE]Related articles

Ouabain-induced hypertension in the rat: relationships among plasma and tissue ouabain and blood pressure.

Manunta P, Rogowski AC, Hamilton BP, Hamlyn JM.

J Hypertens. 1994 May;12(5):549-60.PMID: 7930555 [PubMed - indexed for MEDLINE]Related articles

Long-term ouabain administration produces hypertension in rats.

Yuan CM, Manunta P, Hamlyn JM, Chen S, Bohen E, Yeun J, Haddy FJ, Pamnani MB.

Hypertension. 1993 Aug;22(2):178-87.PMID: 8340153 [PubMed - indexed for MEDLINE]Related articlesFree article

Ouabain is secreted by the adrenal gland in awake dogs.

Boulanger BR, Lilly MP, Hamlyn JM, Laredo J, Shurtleff D, Gann DS.

Am J Physiol. 1993 Mar;264(3 Pt 1):E413-9.PMID: 8460688 [PubMed - indexed for MEDLINE]Related articles

Digitalis-like factor and ouabain-like compound in plasma of volume-expanded dogs.

Ludens JH, Clark MA, Kolbasa KP, Hamlyn JM.

J Cardiovasc Pharmacol. 1993;22 Suppl 2:S38-41.PMID: 7508024 [PubMed - indexed for MEDLINE]Related articles

Role of ouabain-like factors in hypertension: effects of ouabain and certain endogenous ouabain-like factors in hypertension.

Yuan C, Manunta P, Chen S, Hamlyn JM, Haddy FJ, Pamnani MB.

J Cardiovasc Pharmacol. 1993;22 Suppl 2:S10-2.PMID: 7508010 [PubMed - indexed for MEDLINE]Related articles

Ouabain, digitalis-like factors and hypertension.

Hamlyn JM, Manunta P.

J Hypertens Suppl. 1992 Dec;10(7):S99-111. Review.PMID: 1337913 [PubMed - indexed for MEDLINE]Related articles

Vasopressin gene transcripts in mineralocorticoid hypertension: an in situ study.

Ashen MD, Hartman RD, Barraclough CA, Petersen SL, Hamlyn JM.

J Hypertens. 1992 Nov;10(11):1317-26.PMID: 1336517 [PubMed - indexed for MEDLINE]Related articles

Elevated concentrations of endogenous ouabain in patients with congestive heart failure.

Gottlieb SS, Rogowski AC, Weinberg M, Krichten CM, Hamilton BP, Hamlyn JM.

Circulation. 1992 Aug;86(2):420-5.PMID: 1322253 [PubMed - indexed for MEDLINE]Related articles

Endogenous ouabain: implications for cardiovascular disease diagnosis and therapy.

Blaustein MP, Hamlyn JM.

Md Med J. 1992 Jun;41(6):501-4. Review. No abstract available. PMID: 1614290 [PubMed - indexed for MEDLINE]Related articles

[Endogenous ouabain--key to the genesis of hypertension?]

Blaustein MP, Hamlyn JM.

Dtsch Med Wochenschr. 1991 Nov 2;116(44):1689-91. German. No abstract available. PMID: 1657565 [PubMed - indexed for MEDLINE]Related articles