PubMed

Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus.

Højlund K, Birk JB, Klein DK, Levin K, Rose AJ, Hansen BF, Nielsen JN, Beck-Nielsen H, Wojtaszewski JF.

J Clin Endocrinol Metab. 2009 Nov;94(11):4547-56. Epub 2009 Oct 16.PMID: 19837931 [PubMed - in process]Related articles

Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes Mellitus.

Hwang H, Bowen BP, Lefort N, Flynn CR, De Filippis EA, Roberts C, Smoke CC, Meyer C, Højlund K, Yi Z, Mandarino LJ.

Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833877 [PubMed - as supplied by publisher]Related articles

In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS.

Højlund K, Bowen BP, Hwang H, Flynn CR, Madireddy L, Geetha T, Langlais P, Meyer C, Mandarino LJ, Yi Z.

J Proteome Res. 2009 Nov;8(11):4954-65.PMID: 19764811 [PubMed - in process]Related articles

Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals.

Finucane FM, Luan J, Wareham NJ, Sharp SJ, O'Rahilly S, Balkau B, Flyvbjerg A, Walker M, Højlund K, Nolan JJ; (on behalf of the European Group for the Study of Insulin Resistance: Relationship between Insulin Sensitivity and Cardiovascular Disease Risk Study Group), Savage DB.

Diabetologia. 2009 Sep 12. [Epub ahead of print]PMID: 19756488 [PubMed - as supplied by publisher]Related articlesFree article

The assembly of lipid droplets and its relation to cellular insulin sensitivity.

Boström P, Andersson L, Li L, Perkins R, Højlund K, Borén J, Olofsson SO.

Biochem Soc Trans. 2009 Oct;37(Pt 5):981-5.PMID: 19754436 [PubMed - in process]Related articles

Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.

Lefort N, Yi Z, Bowen B, Glancy B, De Filippis EA, Mapes R, Hwang H, Flynn CR, Willis WT, Civitarese A, Højlund K, Mandarino LJ.

J Proteomics. 2009 Aug 20;72(6):1046-60. Epub 2009 Jun 28.PMID: 19567276 [PubMed - indexed for MEDLINE]Related articles

Maximal lipid oxidation in patients with type 2 diabetes is normal and shows an adequate increase in response to aerobic training.

Mogensen M, Vind BF, Højlund K, Beck-Nielsen H, Sahlin K.

Diabetes Obes Metab. 2009 Sep;11(9):874-83. Epub 2009 Jun 16.PMID: 19531056 [PubMed - in process]Related articles

Lipid droplets interact with mitochondria using SNAP23.

Jägerström S, Polesie S, Wickström Y, Johansson BR, Schröder HD, Højlund K, Boström P.

Cell Biol Int. 2009 Sep;33(9):934-40. Epub 2009 Jun 12.PMID: 19524684 [PubMed - in process]Related articles

Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: the RISC study.

de Rooij SR, Dekker JM, Kozakova M, Mitrakou A, Melander O, Gabriel R, Guidone C, Højlund K, Murphy MS, Nijpels G; RISC Group Investigators.

Eur J Endocrinol. 2009 Aug;161(2):223-30. Epub 2009 May 13.PMID: 19439511 [PubMed - indexed for MEDLINE]Related articles

Acute hyperinsulinemia decreases plasma osteoprotegerin with diminished effect in type 2 diabetes and obesity.

Jørgensen GM, Vind B, Nybo M, Rasmussen LM, Højlund K.

Eur J Endocrinol. 2009 Jul;161(1):95-101. Epub 2009 Apr 20.PMID: 19380455 [PubMed - indexed for MEDLINE]Related articles

Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population.

Gastaldelli A, Kozakova M, Højlund K, Flyvbjerg A, Favuzzi A, Mitrakou A, Balkau B; RISC Investigators.

Hepatology. 2009 May;49(5):1537-44.PMID: 19291789 [PubMed - indexed for MEDLINE]Related articles

Circulating soluble CD36 is a novel marker of liver injury in subjects with altered glucose tolerance.

Fernández-Real JM, Handberg A, Ortega F, Højlund K, Vendrell J, Ricart W.

J Nutr Biochem. 2009 Jun;20(6):477-84. Epub 2008 Sep 11.PMID: 18789673 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dysfunction in type 2 diabetes and obesity.

Højlund K, Mogensen M, Sahlin K, Beck-Nielsen H.

Endocrinol Metab Clin North Am. 2008 Sep;37(3):713-31, x. Review.PMID: 18775360 [PubMed - indexed for MEDLINE]Related articles

Transcriptional profiling of myotubes from patients with type 2 diabetes: no evidence for a primary defect in oxidative phosphorylation genes.

Frederiksen CM, Højlund K, Hansen L, Oakeley EJ, Hemmings B, Abdallah BM, Brusgaard K, Beck-Nielsen H, Gaster M.

Diabetologia. 2008 Nov;51(11):2068-77. Epub 2008 Aug 22.PMID: 18719883 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome.

Skov V, Glintborg D, Knudsen S, Tan Q, Jensen T, Kruse TA, Beck-Nielsen H, Højlund K.

PLoS One. 2008 Jun 18;3(6):e2466.PMID: 18560589 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin activation and dephosphorylation of glycogen synthase in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

Glintborg D, Højlund K, Andersen NR, Hansen BF, Beck-Nielsen H, Wojtaszewski JF.

J Clin Endocrinol Metab. 2008 Sep;93(9):3618-26. Epub 2008 Jun 10.PMID: 18544618 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin and its response to thiazolidinediones are associated with insulin-mediated glucose metabolism in type 2 diabetic patients and their first-degree relatives.

Hulstrøm V, Højlund K, Vinten J, Beck-Nielsen H, Levin K.

Diabetes Obes Metab. 2008 Nov;10(11):1019-28. Epub 2008 Feb 18.PMID: 18284435 [PubMed - indexed for MEDLINE]Related articles

Impaired glycogen synthase activity and mitochondrial dysfunction in skeletal muscle: markers or mediators of insulin resistance in type 2 diabetes?

Højlund K, Beck-Nielsen H.

Curr Diabetes Rev. 2006 Nov;2(4):375-95. Review.PMID: 18220643 [PubMed - indexed for MEDLINE]Related articles

Soluble CD36 and risk markers of insulin resistance and atherosclerosis are elevated in polycystic ovary syndrome and significantly reduced during pioglitazone treatment.

Glintborg D, Højlund K, Andersen M, Henriksen JE, Beck-Nielsen H, Handberg A.

Diabetes Care. 2008 Feb;31(2):328-34. Epub 2007 Nov 13.PMID: 18000176 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

Højlund K, Glintborg D, Andersen NR, Birk JB, Treebak JT, Frøsig C, Beck-Nielsen H, Wojtaszewski JF.

Diabetes. 2008 Feb;57(2):357-66. Epub 2007 Oct 31.PMID: 17977950 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the human skeletal muscle proteome by one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.

Højlund K, Yi Z, Hwang H, Bowen B, Lefort N, Flynn CR, Langlais P, Weintraub ST, Mandarino LJ.

Mol Cell Proteomics. 2008 Feb;7(2):257-67. Epub 2007 Oct 1.PMID: 17911086 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of fasting glucagon and proinsulin concentrations with insulin resistance.

Ferrannini E, Muscelli E, Natali A, Gabriel R, Mitrakou A, Flyvbjerg A, Golay A, Hojlund K; Relationship between Insulin Sensitivity and Cardiovascular Disease Risk (RISC) Project Investigators.

Diabetologia. 2007 Nov;50(11):2342-7. Epub 2007 Sep 11.PMID: 17846745 [PubMed - indexed for MEDLINE]Related articles

Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic ovary syndrome.

Glintborg D, Frystyk J, Højlund K, Andersen KK, Henriksen JE, Hermann AP, Hagen C, Flyvbjerg A, Andersen M.

Clin Endocrinol (Oxf). 2008 Feb;68(2):165-74. Epub 2007 Sep 4.PMID: 17803698 [PubMed - in process]Related articles

Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals.

Kase ET, Thoresen GH, Westerlund S, Højlund K, Rustan AC, Gaster M.

Diabetologia. 2007 Oct;50(10):2171-80. Epub 2007 Jul 28.PMID: 17661008 [PubMed - indexed for MEDLINE]Related articles

Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome.

Skov V, Glintborg D, Knudsen S, Jensen T, Kruse TA, Tan Q, Brusgaard K, Beck-Nielsen H, Højlund K.

Diabetes. 2007 Sep;56(9):2349-55. Epub 2007 Jun 11.PMID: 17563058 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes.

Mogensen M, Sahlin K, Fernström M, Glintborg D, Vind BF, Beck-Nielsen H, Højlund K.

Diabetes. 2007 Jun;56(6):1592-9. Epub 2007 Mar 9.PMID: 17351150 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance.

Handberg A, Levin K, Højlund K, Beck-Nielsen H.

Circulation. 2006 Sep 12;114(11):1169-76. Epub 2006 Sep 4.PMID: 16952981 [PubMed - indexed for MEDLINE]Related articlesFree article

Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene.

Højlund K, Wojtaszewski JF, Birk J, Hansen BF, Vestergaard H, Beck-Nielsen H.

Diabetologia. 2006 Aug;49(8):1827-37. Epub 2006 Jun 8.PMID: 16761106 [PubMed - indexed for MEDLINE]Related articles

Energy expenditure, body composition and insulin response to glucose in male twins discordant for the Trp64Arg polymorphism of the beta3-adrenergic receptor gene.

Højlund K, Christiansen C, Bjørnsbo KS, Poulsen P, Bathum L, Henriksen JE, Lammert O, Beck-Nielsen H.

Diabetes Obes Metab. 2006 May;8(3):322-30.PMID: 16634992 [PubMed - indexed for MEDLINE]Related articles

Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes.

Højlund K, Frystyk J, Levin K, Flyvbjerg A, Wojtaszewski JF, Beck-Nielsen H.

Diabetologia. 2006 Jun;49(6):1283-91. Epub 2006 Apr 12.PMID: 16609880 [PubMed - indexed for MEDLINE]Related articles

Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect.

Ortenblad N, Mogensen M, Petersen I, Højlund K, Levin K, Sahlin K, Beck-Nielsen H, Gaster M.

Biochim Biophys Acta. 2005 Jun 30;1741(1-2):206-14. Epub 2005 Apr 22.PMID: 15894466 [PubMed - indexed for MEDLINE]Related articles

Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathway.

Kase ET, Wensaas AJ, Aas V, Højlund K, Levin K, Thoresen GH, Beck-Nielsen H, Rustan AC, Gaster M.

Diabetes. 2005 Apr;54(4):1108-15.PMID: 15793250 [PubMed - indexed for MEDLINE]Related articlesFree article

Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects.

Espelund U, Hansen TK, Højlund K, Beck-Nielsen H, Clausen JT, Hansen BS, Orskov H, Jørgensen JO, Frystyk J.

J Clin Endocrinol Metab. 2005 Feb;90(2):741-6. Epub 2004 Nov 2.PMID: 15522942 [PubMed - indexed for MEDLINE]Related articlesFree article

Free rather than total circulating insulin-like growth factor-I determines the feedback on growth hormone release in normal subjects.

Chen JW, Højlund K, Beck-Nielsen H, Sandahl Christiansen J, Orskov H, Frystyk J.

J Clin Endocrinol Metab. 2005 Jan;90(1):366-71. Epub 2004 Oct 27.PMID: 15509643 [PubMed - indexed for MEDLINE]Related articlesFree article

The primary defect in glycogen synthase activity is not based on increased glycogen synthase kinase-3alpha activity in diabetic myotubes.

Gaster M, Brusgaard K, Handberg A, Højlund K, Wojtaszewski JF, Beck-Nielsen H.

Biochem Biophys Res Commun. 2004 Jul 9;319(4):1235-40.PMID: 15194499 [PubMed - indexed for MEDLINE]Related articles

A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene.

Højlund K, Hansen T, Lajer M, Henriksen JE, Levin K, Lindholm J, Pedersen O, Beck-Nielsen H.

Diabetes. 2004 Jun;53(6):1592-8.PMID: 15161766 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes.

Højlund K, Mustard KJ, Staehr P, Hardie DG, Beck-Nielsen H, Richter EA, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2004 Feb;286(2):E239-44. Epub 2003 Oct 7.PMID: 14532170 [PubMed - indexed for MEDLINE]Related articlesFree article

Does overnight normalization of plasma glucose by insulin infusion affect assessment of glucose metabolism in Type 2 diabetes?

Staehr P, Hojlund K, Hother-Nielsen O, Holst JJ, Beck-Nielsen H.

Diabet Med. 2003 Oct;20(10):816-22.PMID: 14510862 [PubMed - indexed for MEDLINE]Related articles

[Admission prevents violence]

Højlund K.

Ugeskr Laeger. 2003 Apr 28;165(18):1844-6. Danish. No abstract available. PMID: 12772389 [PubMed - indexed for MEDLINE]Related articles

[Physicians take care of violent events themselves]

Højlund K.

Ugeskr Laeger. 2003 Apr 28;165(18):1841-3. Danish. No abstract available. PMID: 12772388 [PubMed - indexed for MEDLINE]Related articles

Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes.

Højlund K, Staehr P, Hansen BF, Green KA, Hardie DG, Richter EA, Beck-Nielsen H, Wojtaszewski JF.

Diabetes. 2003 Jun;52(6):1393-402.PMID: 12765949 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of insulin on protein phosphatase 2A expression in muscle in type 2 diabetes.

Højlund K, Poulsen M, Staehr P, Brusgaard K, Beck-Nielsen H.

Eur J Clin Invest. 2002 Dec;32(12):918-23.PMID: 12534451 [PubMed - indexed for MEDLINE]Related articles

Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes.

Højlund K, Wrzesinski K, Larsen PM, Fey SJ, Roepstorff P, Handberg A, Dela F, Vinten J, McCormack JG, Reynet C, Beck-Nielsen H.

J Biol Chem. 2003 Mar 21;278(12):10436-42. Epub 2003 Jan 16.PMID: 12531894 [PubMed - indexed for MEDLINE]Related articlesFree article

[New actors in type 2 diabetes]

Højlund K, Beck-Nielsen H.

Ugeskr Laeger. 2002 Apr 1;164(14):1937. Danish. No abstract available. PMID: 11957431 [PubMed - indexed for MEDLINE]Related articles

The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity.

Gaster M, Petersen I, Højlund K, Poulsen P, Beck-Nielsen H.

Diabetes. 2002 Apr;51(4):921-7.PMID: 11916908 [PubMed - indexed for MEDLINE]Related articlesFree article

Development and clinical evaluation of a novel immunoassay for the binary complex of IGF-I and IGF-binding protein-1 in human serum.

Frystyk J, Højlund K, Rasmussen KN, Jørgensen SP, Wildner-Christensen M, Ørskov H.

J Clin Endocrinol Metab. 2002 Jan;87(1):260-6.PMID: 11788656 [PubMed - indexed for MEDLINE]Related articlesFree article

Reference intervals for glucose, beta-cell polypeptides, and counterregulatory factors during prolonged fasting.

Hojlund K, Wildner-Christensen M, Eshøj O, Skjaerbaek C, Holst JJ, Koldkjaer O, Møller Jensen D, Beck-Nielsen H.

Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E50-8.PMID: 11120658 [PubMed - indexed for MEDLINE]Related articlesFree article

[Rational transfusion therapy. A study of transfusion practice and possibilities of optimization in elective coronary bypass surgery]

Højlund K, Andersen LI, Hüttel MS, Lahrmann C, Kristensen T, Georgsen J.

Ugeskr Laeger. 1996 Dec 9;158(50):7237-40. Danish. PMID: 9012040 [PubMed - indexed for MEDLINE]Related articles

[Use of fresh frozen plasma in patient treatment. Indications illustrated by a literature review and a study of practice at a university hospital]

Lahrmann C, Højlund K, Kristensen T, Georgsen J.

Ugeskr Laeger. 1996 Jun 10;158(24):3467-70. Danish. PMID: 8650817 [PubMed - indexed for MEDLINE]Related articles